| Acc# | Gene | Locus | DB | Organism | Product | Score | E-value | Identities | Positives | Gaps |
|---|---|---|---|---|---|---|---|---|---|---|
| P15442 | GCN2 | GCN2_YEAST | SP | Saccharomyces cerevisiae (Baker's yeast) | Protein kinase GCN2 (EC 2.7.1.-). | 881 | 0.0 | 593/1746 (33%) | 883/1746 (50%) | 52/1746 (2%) |
| O74297 | CPC-3 | TrEMBL | Neurospora crassa | CPC3 protein. | 471 | e-131 | 433/1811 (23%) | 769/1811 (42%) | 62/1811 (3%) | |
| Q9HGN1 | SPBC36B7.09 | TrEMBL | Schizosaccharomyces pombe (Fission yeast) | Eif-2alpha kinase (Fragment). | 297 | 1e-78 | 280/1054 (26%) | 438/1054 (41%) | 32/1054 (3%) | |
| Q9ESB7 | EIF2AK4 | TrEMBL | Mus musculus (Mouse) | GCN2beta. | 294 | 7e-78 | 326/1275 (25%) | 526/1275 (41%) | 52/1275 (4%) | |
| Q9ESB6 | EIF2AK4 | TrEMBL | Mus musculus (Mouse) | GCN2gamma. | 294 | 7e-78 | 326/1275 (25%) | 526/1275 (41%) | 52/1275 (4%) | |
| Q9ESB8 | EIF2AK4 | TrEMBL | Mus musculus (Mouse) | GCN2alpha. | 294 | 7e-78 | 326/1275 (25%) | 526/1275 (41%) | 52/1275 (4%) | |
| Q9QZ05 | EIF2AK4 | TrEMBL | Mus musculus (Mouse) | GCN2 eIF2alpha kinase. | 293 | 2e-77 | 325/1275 (25%) | 526/1275 (41%) | 52/1275 (4%) | |
| Q9P2K8 | KIAA1338 | TrEMBL | Homo sapiens (Human) | Hypothetical protein KIAA1338 (Fragment). | 291 | 5e-77 | 317/1265 (25%) | 530/1265 (41%) | 42/1265 (3%) | |
| Q9HDW2 | SPBP18G5.01 | TrEMBL | Schizosaccharomyces pombe (Fission yeast) | Putative eif-2alpha kinase, possibly involved in involved in general amino acid control response by similarity to yeast gcn2 (Fragment). | 274 | 1e-71 | 222/824 (26%) | 371/824 (45%) | 18/824 (2%) | |
| Q86B04 | TrEMBL | Dictyostelium discoideum (Slime mold) | Similar to derepression of GCN4 expression; Gcn2p. | 268 | 7e-70 | 234/771 (30%) | 359/771 (46%) | 91/771 (11%) | ||
| Q869P4 | TrEMBL | Dictyostelium discoideum (Slime mold) | Similar to derepression of GCN4 expression; Gcn2p. | 266 | 2e-69 | 233/771 (30%) | 358/771 (46%) | 91/771 (11%) | ||
| Q9NSQ3 | DKFZP434F1312 | TrEMBL | Homo sapiens (Human) | Hypothetical protein (Fragment). | 239 | 3e-61 | 202/684 (29%) | 330/684 (48%) | 31/684 (4%) | |
| Q8H2D3 | GCN2 | TrEMBL | Arabidopsis thaliana (Mouse-ear cress) | GCN2 homologue. | 206 | 2e-51 | 196/700 (28%) | 326/700 (46%) | 25/700 (3%) | |
| Q9V9X8 | GCN2 | TrEMBL | Drosophila melanogaster (Fruit fly) | GCN2 protein. | 205 | 4e-51 | 208/726 (28%) | 330/726 (45%) | 50/726 (6%) | |
| O61651 | GCN2 | TrEMBL | Drosophila melanogaster (Fruit fly) | EIF-2ALPHA kinase. | 205 | 4e-51 | 208/726 (28%) | 330/726 (45%) | 50/726 (6%) | |
| O01712 | GCN2 | TrEMBL | Drosophila melanogaster (Fruit fly) | Eukaryotic initiation factor EIF-2 alpha kinase. | 204 | 9e-51 | 207/726 (28%) | 330/726 (45%) | 50/726 (6%) | |
| Q9LX30 | F25L23_270 | TrEMBL | Arabidopsis thaliana (Mouse-ear cress) | Protein kinase like. | 200 | 2e-49 | 193/702 (27%) | 323/702 (46%) | 27/702 (3%) | |
| Q9H5K1 | TrEMBL | Homo sapiens (Human) | Hypothetical protein FLJ23358. | 185 | 6e-45 | 178/637 (27%) | 295/637 (46%) | 31/637 (4%) | ||
| Q96GN6 | TrEMBL | Homo sapiens (Human) | Hypothetical protein. | 184 | 8e-45 | 178/637 (27%) | 295/637 (46%) | 31/637 (4%) | ||
| Q9XVY4 | Y81G3A.3 | TrEMBL | Caenorhabditis elegans | Y81G3A.3 protein. | 182 | 3e-44 | 187/731 (25%) | 322/731 (44%) | 62/731 (8%) | |
| Q86A61 | TrEMBL | Dictyostelium discoideum (Slime mold) | Similar to derepression of GCN4 expression; Gcn2p. | 176 | 4e-42 | 197/780 (25%) | 322/780 (41%) | 189/780 (24%) | ||
| Q8I739 | TrEMBL | Bombyx mori (Silk moth) | EIF 2a kinase. | 144 | 9e-33 | 130/469 (27%) | 193/469 (41%) | 39/469 (8%) | ||
| Q8C5S0 | TrEMBL | Mus musculus (Mouse) | Eukaryotic translation initiation factor 2 alpha kinase 4. | 132 | 3e-29 | 98/309 (31%) | 164/309 (53%) | 24/309 (7%) | ||
| Q9Z1Z1 | EIF2AK3 | E2K3_RAT | SP | Rattus norvegicus (Rat) | Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase). | 121 | 1e-25 | 90/290 (31%) | 138/290 (47%) | 7/290 (2%) |
| Q9NZJ5 | EIF2AK3 | E2K3_HUMAN | SP | Homo sapiens (Human) | Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase) (HsPEK). | 117 | 2e-24 | 74/203 (36%) | 109/203 (53%) | 7/203 (3%) |
| Q9Z2B5 | EIF2AK3 | E2K3_MOUSE | SP | Mus musculus (Mouse) | Eukaryotic translation initiation factor 2-alpha kinase 3 precursor (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase) (Pancreatic eIF2-alpha kinase). | 117 | 1e-24 | 73/203 (35%) | 109/203 (53%) | 7/203 (3%) |
| Q9NIV1 | EIF2AK3 | E2K3_DROME | SP | Drosophila melanogaster (Fruit fly) | Eukaryotic translation initiation factor 2-alpha kinase precursor (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase) (PERK) (PEK) (DmPEK). | 112 | 5e-23 | 71/195 (36%) | 105/195 (53%) | 5/195 (2%) |
| Q8GRP7 | PPCK1 | TrEMBL | Glycine max (Soybean) | Phosphoenolpyruvate carboxylase kinase. | 107 | 1e-21 | 66/194 (34%) | 100/194 (51%) | 3/194 (1%) | |
| Q9SDY1 | TrEMBL | Glycine max (Soybean) | Phosphoenolpyruvate carboxylase kinase (Fragment). | 107 | 1e-21 | 66/194 (34%) | 100/194 (51%) | 3/194 (1%) | ||
| Q98SS6 | TrEMBL | Gallus gallus (Chicken) | Eukaryotic initiation factor 2 alpha kinase. | 106 | 4e-21 | 80/240 (33%) | 122/240 (50%) | 18/240 (7%) |
Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- pkinase Protein kinase domain 184.0 2.4e-51 1 RWD RWD domain 52.0 1.3e-11 1 RPEL RPEL repeat 14.0 0.49 1 UQ_con Ubiquitin-conjugating enzyme -48.3 1 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- RWD 1/1 9 125 .. 1 120 [] 52.0 1.3e-11 UQ_con 1/1 2 156 .. 1 178 [] -48.3 1 RPEL 1/1 539 564 .. 1 26 [] 14.0 0.49 pkinase 1/1 656 1051 .. 1 294 [] 184.0 2.4e-51
CDS Sequence
atgccagaaa catcaattac tctggattta gaacatagac aacaagatga aattagtagt atatcatcaa tttatggtga tatctttaaa gatattactc caacgggttt agtttggaat aaaaaaccca gtccgcattt ccaagtattt ttatcatcgt caaataatcc tgatcgaccg actgtttcca ttacattaga tatagaattc actcctactt atcctttatc acctccaaaa gtaaaactac taaatgctcg taatttattg aaaattaata ttgctaaatt agaaaagaaa tgtaaagatt taatcaaaga atatcccgaa caagaagttt ctttcacgat aatttccgaa ttgattttca tgttagatga aatacaaaca acaactgaaa aagtattatc attagaagaa gaaagagaat taagattaag aaatgaaaga agggcattag aagaaaaaga ggcgaaacag aagaaggatg aagaattggc tcgaaagaaa caaaataaag aattgaatga acaaattcaa aaaattcaag gtgaatttga tgatgatttt actgatgatc aagatttaga tatgtcaact actaatgata ataataattc attaatccca cttgataaag atcaattttt catttttgaa aatgccatgg aagcaaccat tcctaataca agacggaaat ttaagtttcg agcaatactg ggattcataa gatataatca aaagggggtt ttcaattcaa ttggatccca atatattgtt aaaccattta ttgataatga aatccggaat aaaattgaaa ataaaggttc tgatttggca ttcttattaa cagtgattga tttaaccaat gaatattggc aaactgacaa ggggaagcga gaaattcaag atttagaatc ggaattacaa tcaattatga gtataaatca tagtaatata ttaaaattaa ttggatttca aatagataaa acaaatgttt ggagagtaag attgttaacg gaattttctc cagttagtga aacattatat gatattctcc ctactgccga atttattaat tgggcattag caagaacttg gcttattcaa ttattaccag caatggaata tcttcataat gccggattca tccataaact tatatgtccc atgaccatag ttatatttca agagaaggac caattgtatt atcaaaattc aactaatgaa ttattaagta atagtattgg tggtggtggt ggtggtgggg aagactcatt aaccatcagt gctaaaaaag tgttgaaatt atgtcatcct tcatatgggt atcgtttatt agagatgatt ctgttacatc caaatgaggg agaaacatta gatcgatctc cacaagtaaa tccaccagca tggttagcac cagaattgaa aacttctggg tatcattaca aatctgatat ttgggattta ggagtacttt tcttaagagt aatgttagga tttgatattt taaacaccac ataccataca cctagtgatt ttataaataa attttccgtt aaagattttg ttggagcaga agaatatgct tcattagtgt atgatgtatt atcgaaaatg ttacaagtta aattatcaaa acgaccatct cctttggaat taaatgccgt aaaattttta cgagatggtc ccataatttc aaaattacaa tcggaaacta acttatcacg aatgaaaaaa aatgtcgaaa ctgatttggt atcatcaacc aatacaagac atgttcaaat acaaggacat gaacaggatt cgactgcaac aacaaaacat ttgaatattt atcatcaaaa tatttcacgc agacggttat ctaaccagaa tactcaacat ccatattttg gtgaaaattc tagtcttatc atgccttcag ggtcacaacg aaatatgggg agatacgcca gagattttga agaaattggg aaattgggtc gtggtggatt tggtgaagtt gttaaagcta gaagtagaat ggaagggata ttttatgctg tgaaaaaaat taaacatcga gctgataaat tggattcttt attaagtgaa gttttatctt tagctagatt gaaccatcaa tatattgttc gttattatgg tacttgggtt gaagaattag aagatacatc tgcgattcca tccaatagca catctgctat tgcgagcgat gacgaagagg aggaagagga ggaagatgac acagaaggcg actttggtga tgatgatctt gaactgacat tttcaagtcg tgttggtcgt tcatcatctg tgttacctag ttatgataac tcatttcaag tcgattacat ttcaacatct tttgacccta ggatagaatt tgatgaaagt tcagaagaag atgaccaaaa tgaagatgat gatccgtttg tgtttgccaa ttcaactgat gatatctcaa ataatgaaac agaagatcgt tccaaaagtg attcgaaaga agtttctgtt aaaaaaccaa aagatgttgt taactcctct aaaaatgcat caccgaaatc aatattatat atacaaatgg agttttgtga aaataatacc cttctcaatc ttattgaaca aggattacct aataaccctg atgaatattg gagacttttc cgacaattac ttgaagcagt ttcatatatt catcgtgaag gatttattca tcgtgattta aaaccaatga atattttcat tgatagatcc aataatatta aagttgggga tttcggatta gctaaaaatt cacaattttc ttcagttgtt ctgacgaata atcaagtgga agctaaagat aatgaattat ctaccgtggt gggaacatta ttttatactg ccaatgaagt ggccacgggt caatacgatg aaaaagttga tatgtattca cttggaataa ttttctttga aatgtgttat cctcttgcca cgggtatgca aagagctaaa acattaaatg atttacgatt gaaatcagtt gaattcccta caaatttcat tgctagtaaa tataaaactg aaaaaaaaat tattcgatta ttattagatc atgatcctaa aattcgtcct agtgcagcac aacttttaca aagtggttgg ttacccgttg aacatcaaga tcaagttatt caagaagcat taaaatcttt agctgatcca gcatctcctt ggcaacaaca agttcgtgaa gcattgttca atcaaccgta tctgcttgct aaagatttaa tgtttgataa acaaaatgaa cataattccc ataataagca tgttgaattg gatacttcga atgattattt attatttgat aaaatcatga aagaattgac caagattttc actaatcatg gagccattga gaatttaaat acaaatttag ttttaccaaa ggcaccttca caatcaagag aattagttta tgattttttg gatagaagtg gtgcagtttt aactttacct tatgatttga ctttaccaac agcaagattt ttaagtaaaa ccgatatgac aattcctaaa acttttcgac acgaatttgt ctatcgacct aatgttcgag gtattggtat acctgatcgt tatagtgccg ttaattttga tatagccggt ggactggaag ttaacaaggc aacacttttc gctcatgatg ctgaatgttt aaaagtgatt gatgaaattg tcaatacttt accatgtttt aaaaatacca ttattgttat taatcattat gatattttgg atgctgttgt ttcattttct tttggtaata ttggaattga tgataagaaa aaattagata tttttggagt attatcacaa ttgggaattg ataaatcacc cgatgaaata aaacgttact tgagggaaga ttttcaagta ccacatactg ttactaaaga tcttgttgaa aatttcaatt ttacatgtga agtggaacgg gcaagacaaa aattacaaaa attaatggtt gattctcccc cattattaaa agttgaacga gcatatactt atttaattga agtggttaaa attttgaaac acacgaatat taaaacatca atgattttca atccattgag taattataat agtaaatatt atatccatgg aataatgttt caagcagttt ttaaacctga tagatccaaa cgttatacta gagtagttac tggtggacga tatgattcat taattgaatc tttttcaaat gtcaccacaa caactaaaca aatcactcct catggtgttg gattttcatt gactactagt ttacttttca ttcttatgaa aacattaatt tctcgaggga aatctaaatt ggatcttgta aataaatgga agggcaatcg atgtaaagta cttataagtt ctactcaaca acaattttta agtcaagtgg gatatcaatt agtttctaaa ttttggaata aaaacataag tgctgatata acatcagttg cagcaaagac tcaagatgaa atattccaaa atggtaattc agaaggggct atatggatag ttataatacg actgttacct acaacaattg ggaattcatt ctcatctttg aatggtggta gtggtggtag tagtagtagt actactacta ctagcactag cattagaaga agtaaaaaat ctggatctgg atttaaacct ttgaaattga gaaatataat tactggtaaa gatattgatt tagattatga tgaagtgata gattatttgg tgactgaatt attagaagat tcagaacatg aagaaaatga tcaagataat ggtacgatga caaactcaac aacattactt acatcatcat cattatcttc taaaacaaat caagaagaag aattattaaa tggaccaatt gattcagttg aaattgatca aaaaatcatt gttgttaaaa atgatgctcc tcgtagtagg aaaaataaac gagataaatg ggaatcagaa aatgatgcta aattagctgg acaacaatgt ataaaaaatt taagtggtgg acctgttgtt gttattgatg ctagagatga aatattagat atgattagta ttacttcaat tcatcaacaa gatgaatgga ttagaaaagt ggtttataca actaataatt tcccaaaaag ttttgctatg aatatttata atactttgat taaagaattt aataaaggtt caatttggtg tattttggtg tcttcaagaa ctcaacatac aactattgtt gatctacgtc gataa
AA Sequence
MPETSITLDL EHRQQDEISS ISSIYGDIFK DITPTGLVWN KKPSPHFQVF LSSSNNPDRP TVSITLDIEF TPTYPLSPPK VKLLNARNLL KINIAKLEKK CKDLIKEYPE QEVSFTIISE LIFMLDEIQT TTEKVLSLEE ERELRLRNER RALEEKEAKQ KKDEELARKK QNKELNEQIQ KIQGEFDDDF TDDQDLDMST TNDNNNSLIP LDKDQFFIFE NAMEATIPNT RRKFKFRAIL GFIRYNQKGV FNSIGSQYIV KPFIDNEIRN KIENKGSDLA FLLTVIDLTN EYWQTDKGKR EIQDLESELQ SIMSINHSNI LKLIGFQIDK TNVWRVRLLT EFSPVSETLY DILPTAEFIN WALARTWLIQ LLPAMEYLHN AGFIHKLICP MTIVIFQEKD QLYYQNSTNE LLSNSIGGGG GGGEDSLTIS AKKVLKLCHP SYGYRLLEMI LLHPNEGETL DRSPQVNPPA WLAPELKTSG YHYKSDIWDL GVLFLRVMLG FDILNTTYHT PSDFINKFSV KDFVGAEEYA SLVYDVLSKM LQVKLSKRPS PLELNAVKFL RDGPIISKLQ SETNLSRMKK NVETDLVSST NTRHVQIQGH EQDSTATTKH LNIYHQNISR RRLSNQNTQH PYFGENSSLI MPSGSQRNMG RYARDFEEIG KLGRGGFGEV VKARSRMEGI FYAVKKIKHR ADKLDSLLSE VLSLARLNHQ YIVRYYGTWV EELEDTSAIP SNSTSAIASD DEEEEEEEDD TEGDFGDDDL ELTFSSRVGR SSSVLPSYDN SFQVDYISTS FDPRIEFDES SEEDDQNEDD DPFVFANSTD DISNNETEDR SKSDSKEVSV KKPKDVVNSS KNASPKSILY IQMEFCENNT LLNLIEQGLP NNPDEYWRLF RQLLEAVSYI HREGFIHRDL KPMNIFIDRS NNIKVGDFGL AKNSQFSSVV LTNNQVEAKD NELSTVVGTL FYTANEVATG QYDEKVDMYS LGIIFFEMCY PLATGMQRAK TLNDLRLKSV EFPTNFIASK YKTEKKIIRL LLDHDPKIRP SAAQLLQSGW LPVEHQDQVI QEALKSLADP ASPWQQQVRE ALFNQPYLLA KDLMFDKQNE HNSHNKHVEL DTSNDYLLFD KIMKELTKIF TNHGAIENLN TNLVLPKAPS QSRELVYDFL DRSGAVLTLP YDLTLPTARF LSKTDMTIPK TFRHEFVYRP NVRGIGIPDR YSAVNFDIAG GLEVNKATLF AHDAECLKVI DEIVNTLPCF KNTIIVINHY DILDAVVSFS FGNIGIDDKK KLDIFGVLSQ LGIDKSPDEI KRYLREDFQV PHTVTKDLVE NFNFTCEVER ARQKLQKLMV DSPPLLKVER AYTYLIEVVK ILKHTNIKTS MIFNPLSNYN SKYYIHGIMF QAVFKPDRSK RYTRVVTGGR YDSLIESFSN VTTTTKQITP HGVGFSLTTS LLFILMKTLI SRGKSKLDLV NKWKGNRCKV LISSTQQQFL SQVGYQLVSK FWNKNISADI TSVAAKTQDE IFQNGNSEGA IWIVIIRLLP TTIGNSFSSL NGGSGGSSSS TTTTSTSIRR SKKSGSGFKP LKLRNIITGK DIDLDYDEVI DYLVTELLED SEHEENDQDN GTMTNSTTLL TSSSLSSKTN QEEELLNGPI DSVEIDQKII VVKNDAPRSR KNKRDKWESE NDAKLAGQQC IKNLSGGPVV VIDARDEILD MISITSIHQQ DEWIRKVVYT TNNFPKSFAM NIYNTLIKEF NKGSIWCILV SSRTQHTTIV DLRR*