BLASTX 2.2.6 [Apr-09-2003]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Candida_albicans_chr7-f1-209137-211125-18
         (1986 letters)

Database: sptrembl 
           1,070,300 sequences; 339,323,595 total letters

Searching.................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

Q04119|PPN1|Q04119 (TrEMBL: Saccharomyces cerevisiae (Baker's ye...   483   e-135
Q9P3S1|B24P7.140|Q9P3S1 (TrEMBL: Neurospora crassa) Conserved hy...   312   8e-84
Q9C1W8|SPBC713.07C|Q9C1W8 (TrEMBL: Schizosaccharomyces pombe (Fi...   284   2e-75
Q8WV13||Q8WV13 (TrEMBL: Homo sapiens (Human)) Hypothetical protein.   105   3e-21
P70158|ASML3A|AS3A_MOUSE (SP: Mus musculus (Mouse)) Acid sphingo...   100   7e-20
Q92485|ASML3B|AS3B_HUMAN (SP: Homo sapiens (Human)) Acid sphingo...    99   2e-19
Q96CB7||Q96CB7 (TrEMBL: Homo sapiens (Human)) Similar to acid sp...    99   2e-19
Q9W188|CG3376|Q9W188 (TrEMBL: Drosophila melanogaster (Fruit fly...    96   1e-18
Q8MLP3|CG3376|Q8MLP3 (TrEMBL: Drosophila melanogaster (Fruit fly...    96   1e-18
P58242|ASML3B|AS3B_MOUSE (SP: Mus musculus (Mouse)) Acid sphingo...    92   2e-17
Q23498|ASM-2|ASM2_CAEEL (SP: Caenorhabditis elegans) Sphingomyel...    77   8e-13
Q04519|SMPD1|ASM_MOUSE (SP: Mus musculus (Mouse)) Sphingomyelin ...    75   4e-12
P17405|SMPD1|ASM_HUMAN (SP: Homo sapiens (Human)) Sphingomyelin ...    74   5e-12
Q8K011|SMPD1|Q8K011 (TrEMBL: Mus musculus (Mouse)) Sphingomyelin...    72   3e-11
Q8IQD3|CG32052|Q8IQD3 (TrEMBL: Drosophila melanogaster (Fruit fl...    68   5e-10
Q9UAY4|W03G1.7|ASM3_CAEEL (SP: Caenorhabditis elegans) Putative ...    65   2e-09
Q9VA77|CG15534|Q9VA77 (TrEMBL: Drosophila melanogaster (Fruit fl...    61   6e-08
Q10916|ASM-1|ASM1_CAEEL (SP: Caenorhabditis elegans) Sphingomyel...    60   8e-08
Q9VA78|CG15533|Q9VA78 (TrEMBL: Drosophila melanogaster (Fruit fl...    51   6e-05
Q95T74|CG3376|Q95T74 (TrEMBL: Drosophila melanogaster (Fruit fly...    50   1e-04
Q871S2|7F4.170|Q871S2 (TrEMBL: Neurospora crassa) Related to aci...    47   0.001
Q8MVM5|ASML|Q8MVM5 (TrEMBL: Boltenia villosa) Acid sphingomyelin...    43   0.012
Q8IUN0||Q8IUN0 (TrEMBL: Homo sapiens (Human)) Similar to sphingo...    42   0.021
Q23640|ZK856.5|Q23640 (TrEMBL: Caenorhabditis elegans) ZK856.5 p...    42   0.036
Q98PQ2|MYPU_6670|Q98PQ2 (TrEMBL: Mycoplasma pulmonis) Isoleucyl-...    39   0.31 
Q8G6Z0|BL0490|Q8G6Z0 (TrEMBL: Bifidobacterium longum) Hypothetic...    37   0.89 
Q8MSD7|BEST:HL01355|Q8MSD7 (TrEMBL: Drosophila melanogaster (Fru...    35   2.6  
Q99707|MTR|METH_HUMAN (SP: Homo sapiens (Human)) 5-methyltetrahy...    35   2.6  
Q9KYP9|SCO4483|Q9KYP9 (TrEMBL: Streptomyces coelicolor) Hypothet...    35   4.4  
Q8ILU0|PF14_0154|Q8ILU0 (TrEMBL: Plasmodium falciparum (isolate ...    35   4.4  

>Q04119|PPN1|Q04119 (TrEMBL: Saccharomyces cerevisiae (Baker's yeast))
            D9461.37P (ENDOPOLYPHOSPHATASE).
          Length = 674

 Score =  483 bits (1242), Expect = e-135
 Identities = 256/603 (42%), Positives = 355/603 (58%), Gaps = 49/603 (8%)
 Frame = +1

Query: 181  LNDTQIDDLKRLGLTPKKSVEIVKPDNSKQT-IHGRFLHITDFHIDHHYQKGSDIDKVCH 357
            LND +     RLGLTP++ V I      K+  +HGRFLHITD H D +Y +GS ID VCH
Sbjct: 64   LNDIEFT---RLGLTPREPVIIKDVKTGKERKLHGRFLHITDIHPDPYYVEGSSIDAVCH 120

Query: 358  GGEGK-----ASKYGDAILGCDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDNDRE 522
             G+       A K+G A+ GCDSP IL+EET +WI +NL DKIDF+++TGD+ RHDNDR+
Sbjct: 121  TGKPSKKKDVAPKFGKAMSGCDSPVILMEETLRWIKENLRDKIDFVIWTGDNIRHDNDRK 180

Query: 523  YPRTRQHIFNMNKEISDKFVTLTSESDGQP-------LIYPVSNNDIMPHNLMDTGPSLQ 681
            +PRT   IF+MN  ++DK   L S  + +        +I  + NND+ PHN+   GP+LQ
Sbjct: 181  HPRTEAQIFDMNNIVADKMTELFSAGNEEDPRDFDVSVIPSLGNNDVFPHNMFALGPTLQ 240

Query: 682  TRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGD 861
            TRE +  W+ F+PQ Q  T+   A +  EVIP +LAVLS+NT+Y F +NP+VD+C++K +
Sbjct: 241  TREYYRIWKNFVPQQQQRTFDRSASFLTEVIPGKLAVLSINTLYLFKANPLVDNCNSKKE 300

Query: 862  PGYKLFEWLGYVLKEMRARNMKVWLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLY 1041
            PGY+L  W GYVL+E+R+R MKVWL GHVPP  KN+D +C  K+  WTHEYRD+I+GGLY
Sbjct: 301  PGYQLLLWFGYVLEELRSRGMKVWLSGHVPPIAKNFDQSCYDKFTLWTHEYRDIIIGGLY 360

Query: 1042 GHMNLDHFIPLDSVQAYKSIQKDFKDEFKQKSVFSVEDEDDLALEDSNLYKALDENFSDK 1221
            GHMN+DHFIP D  +A KS+ K  +   + +      +ED    E++ L + LD   + K
Sbjct: 361  GHMNIDHFIPTDGKKARKSLLKAMEQSTRVQQGEDSNEED----EETELNRILDHAMAAK 416

Query: 1222 FFRVTGGVPNNKVTYLETLREELYAPL---------------------KGKKKS-----G 1323
               + G  P+NK  Y+ T+R+  Y  +                     K KKK       
Sbjct: 417  EVFLMGAKPSNKEAYMNTVRDTYYRKVWNKLERVDEKNVENEKKKKEKKDKKKKKPITRK 476

Query: 1324 EHFERYSIAHVTASIIPTFNPGMRVWEYNITDL--EDKLQQVKFEPWDKFFAGVERMIEV 1497
            E  ERYSI ++  S+IPTFNP  R+WEYNITD+  +      +++PWD+FF  + +++E 
Sbjct: 477  ELIERYSIVNIGGSVIPTFNPSFRIWEYNITDIVNDSNFAVSEYKPWDEFFESLNKIME- 535

Query: 1498 QSNYVDEKDNDEMNWQEMDDITIERXXXXXXXXXXXXXDHTFPKPMPENLPLGPAYIEQT 1677
                 D    DEM+   ++                   D T P  MP+   LGPAY+ Q 
Sbjct: 536  -----DSLLEDEMDSSNIEVGINREKMGEKKNKKKKKNDKTMPIEMPDKYELGPAYVPQL 590

Query: 1678 FTPERYVQYYADLESIN--------KGKKEFDYEIEYSTDDSLYGLKALTVEEWIKFGRK 1833
            FTP R+VQ+YADLE IN        + K  F YEIEY++D+  Y + +LTV  ++    +
Sbjct: 591  FTPTRFVQFYADLEKINQELHNSFVESKDIFRYEIEYTSDEKPYSMDSLTVGSYLDLAGR 650

Query: 1834 LGE 1842
            L E
Sbjct: 651  LYE 653


>Q9P3S1|B24P7.140|Q9P3S1 (TrEMBL: Neurospora crassa) Conserved
            hypothetical protein.
          Length = 734

 Score =  312 bits (800), Expect = 8e-84
 Identities = 205/613 (33%), Positives = 302/613 (49%), Gaps = 82/613 (13%)
 Frame = +1

Query: 259  NSKQTIHGRFLHIT--DFHIDHHYQK---GSDIDKVCHGGEGKASKYGDAILGCDSPPIL 423
            NS + +HG+FLHIT      D  + K    +D    CH G+G A  YG  +  CDSP  L
Sbjct: 48   NSARKLHGKFLHITGGQSRDDRKFYKPHSSTDEADACHRGKGPAGVYGAEVSDCDSPFAL 107

Query: 424  VEETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESD 603
            +  TF WI  N+ D IDF+++TGD+ARHD+D   PR    +   N+ I+DK   L S+S 
Sbjct: 108  INATFDWIAANVKDDIDFVIWTGDTARHDSDEGVPRNADQVLGTNRWIADKMAELFSDST 167

Query: 604  GQ----PLIYPVSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEV 771
            G+    P++  + NNDI+PHN++  GP+   +     WR F+P+ Q H++  G +++ EV
Sbjct: 168  GRHLEIPIVPTLGNNDILPHNILLPGPNSWLQHYTHIWRRFVPEAQRHSFQFGGWFYVEV 227

Query: 772  IPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVP 951
            IPN+LA+ SLNT+Y+FD N   D C +  +PGYK  EWL   L  MR R MK  L GHVP
Sbjct: 228  IPNRLAIFSLNTLYFFDRNAGTDGCASPSEPGYKQMEWLRIQLHIMRERGMKAILMGHVP 287

Query: 952  P----NEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLDHFIPLDSVQAYKSIQKDFKD 1119
            P    ++K +D  C +KY  W  +YRDV+V G++GHMN+DHF   D        ++D   
Sbjct: 288  PARTDSKKLWDENCWQKYSLWLRQYRDVVVSGVFGHMNIDHFFIHD--------ERD--- 336

Query: 1120 EFKQKSVFSVEDEDDLALEDSNLYKALDENFSDKFFRVTGGVPNNKVTYLETLRE---EL 1290
                    +V     LA    ++ +A+D+  S     VTG        YL  LR+   +L
Sbjct: 337  -------INVGQLAGLADNSIDIREAMDDELS-----VTGA-----ADYLRELRQNWAKL 379

Query: 1291 YAP----------------LKGKKKSGEHF-ERYSIAHVTASIIPTFNPGMRVWEYNITD 1419
              P                 KGKKK  + + ERYS++ V+ SI+P + P +R+ EYNI+ 
Sbjct: 380  QPPPTDSKNSGQLKKGKKGRKGKKKKPDVWGERYSLSLVSPSIVPNYYPALRIVEYNISG 439

Query: 1420 LEDKLQQVKFEPWDKFFAGVERMIEVQSN----YVDEKDNDEMNWQEMDDITIERXXXXX 1587
            LED        P  +  A     IE++ N    ++D K     + ++ D+I  ++     
Sbjct: 440  LED-------TPVWRDAAKDAMSIELEQNDRQKHLDLKRQHPSHMEDDDEIDAQKKKGKK 492

Query: 1588 XXXXXX---XXDHTFPKPMPENLPLGPAYIEQTFTPERYVQYYADLESIN---------- 1728
                       D   P P  ++ P GPAY  Q  T   Y QY+A+L  IN          
Sbjct: 493  HKGGDSKPKKPDFLIPHPPAKSSPPGPAYSPQPLTLTGYTQYFANLTHINNITTEASSAL 552

Query: 1729 ------------------KGK-------------KEFDYEIEYST-DDSLYGLKALTVEE 1812
                              KG+             +EF +E+EYST +D LY L+ LTV+ 
Sbjct: 553  LDHDEEEETWVDWLLRWRKGRHGNRKPIHPKPDPREFQFEVEYSTFNDKLYKLRDLTVKN 612

Query: 1813 WIKFGRKLGEPVK 1851
            +++   ++ +  K
Sbjct: 613  YVELAYRISKQPK 625


>Q9C1W8|SPBC713.07C|Q9C1W8 (TrEMBL: Schizosaccharomyces pombe (Fission
            yeast)) Putative vacuolar polyphosphatase.
          Length = 577

 Score =  284 bits (727), Expect = 2e-75
 Identities = 176/548 (32%), Positives = 270/548 (49%), Gaps = 22/548 (4%)
 Frame = +1

Query: 259  NSK-QTIHGRFLHITDFHIDHHYQKGSDIDKVCHGGEGKA-------SKYGDAILG---- 402
            NSK + + GRFLHITD H D +Y+KGS +D  CH  +  +       SK G    G    
Sbjct: 39   NSKGKPLVGRFLHITDMHPDIYYEKGSTVDHYCHSYDHNSDDTPLGKSKVGYLSPGPGYE 98

Query: 403  CDSPPILVEETFKWIT---DNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISD 573
            CDS P L+++T +W+    D+++  IDFI++TGD++RHDND  +PRT+  I   N+++ +
Sbjct: 99   CDSSPALIDKTLEWLKEHQDDVLGGIDFILWTGDNSRHDNDNHFPRTQSEILASNEDLVN 158

Query: 574  KFVTLTSESDGQPLIYPVSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGA 753
            K +    +    P++  + NNDI PHN+M+ GPS  TR+L  AW   IP  + HT+  G+
Sbjct: 159  KMIEAFPDV---PIVSAIGNNDIYPHNIMEAGPSSMTRQLAGAWDALIPYEERHTFEKGS 215

Query: 754  YYFQEVIPNQLAVLSLNTMYWFDSNPMVDDC--DNKGDPGYKLFEWLGYVLKEMRARNMK 927
            YY  +VIP++LA +S+NT+Y  + N  VD C  DN  +PG     W    L+  R + MK
Sbjct: 216  YYLCDVIPDKLAAISINTLYLSNKNAAVDGCPDDNLDEPGSLFMRWFKIQLEAYRLKGMK 275

Query: 928  VWLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLDHFIPLDSVQAYKSIQK 1107
            VWL GH+PP    +   C   +    +E+RD+IVG LYGHMN++HF+ L+  +     + 
Sbjct: 276  VWLLGHIPPTRGQWYEDCYTSFTDLLYEFRDIIVGQLYGHMNINHFVFLEFDKLPVDTES 335

Query: 1108 DFKDEFKQKSVFSVEDEDDLALEDSNLYKALDENFSDKFFRVTGGVPNNKVTYLETLREE 1287
                  + K V S+ D     L          EN +++F   T G               
Sbjct: 336  YGIKSAQPKYVKSLIDAQYAEL------PTFPENLTEEFLNGTVG--------------- 374

Query: 1288 LYAPLKGKKKSGEHFERYSIAHVTASIIPTFNPGMRVWEYNITDLEDKLQQVKFEPWDKF 1467
                             YS+A V  SIIP   P  RV+EYNI+D+ ++L           
Sbjct: 375  ----------------NYSLATVGGSIIPEMFPTFRVYEYNISDIANQLDD--------- 409

Query: 1468 FAGVERMIEVQSNYVDEKDNDEMNWQEMDDITIERXXXXXXXXXXXXXDHTFPKPMPENL 1647
                E + E+ S           NW+ +++ +                +    K   +N+
Sbjct: 410  ---REELTEITS----------FNWETLEEQSQSDYEIDKKKKKKKKNNKKKKKNKRKNI 456

Query: 1648 ---PLGPAYIEQTFTPERYVQYYADLESINKGKK--EFDYEIEYSTDDSLYGLKALTVEE 1812
               PLGPAY+   FTP  + QY+ +  +     K  E  YE+ Y++ DS Y +  LTV E
Sbjct: 457  KPGPLGPAYVPSLFTPISFKQYFLNTSNYMDATKDTEISYELLYTSKDSPYNMPDLTVPE 516

Query: 1813 WIKFGRKL 1836
            +++  +++
Sbjct: 517  YMRLAKRI 524


>Q8WV13||Q8WV13 (TrEMBL: Homo sapiens (Human)) Hypothetical protein.
          Length = 453

 Score =  105 bits (261), Expect = 3e-21
 Identities = 82/279 (29%), Positives = 126/279 (45%), Gaps = 14/279 (5%)
 Frame = +1

Query: 280  GRFLHITDFHIDHHYQKGSDIDKVCHGGEG----KASKYGDAILGCDSPPILVEETFKWI 447
            G+F H+TD H+D  Y    D  KVC   +G        +GD +  CDSP  L+   F +I
Sbjct: 38   GQFWHVTDLHLDPTYHITDDHTKVCASSKGANASNPGPFGDVL--CDSPYQLILSAFDFI 95

Query: 448  TDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIYPV 627
              N   +  F+++TGDS  H      P        +   I++   T+ S      +   +
Sbjct: 96   -KNSGQEASFMIWTGDSPPH-----VPVPELSTDTVINVITNMTTTIQSLFPNLQVFPAL 149

Query: 628  SNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPN-QLAVLSLN 804
             N+D  P + +    S     +   W+P++ +  + T   G +Y Q+V  N  L ++SLN
Sbjct: 150  GNHDYWPQDQLPVVTSKVYNAVANLWKPWLDEEAISTLRKGGFYSQKVTTNPNLRIISLN 209

Query: 805  TMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVP----PNEKNYD 972
            T  ++  N M     NK DP  + FEWL   L   +    KV++  HVP    P+ +N  
Sbjct: 210  TNLYYGPNIMT---LNKTDPANQ-FEWLESTLNNSQQNKEKVYIIAHVPVGYLPSSQN-- 263

Query: 973  TTCLRKY-----IAWTHEYRDVIVGGLYGHMNLDHFIPL 1074
             T +R+Y     I    +Y DVI G  YGH + D  + L
Sbjct: 264  ITAMREYYNEKLIDIFQKYSDVIAGQFYGHTHRDSIMVL 302


>P70158|ASML3A|AS3A_MOUSE (SP: Mus musculus (Mouse)) Acid
            sphingomyelinase-like phosphodiesterase 3a precursor (EC
            3.1.4.-) (ASM-like phosphodiesterase 3a).
          Length = 445

 Score =  100 bits (249), Expect = 7e-20
 Identities = 80/277 (28%), Positives = 123/277 (44%), Gaps = 12/277 (4%)
 Frame = +1

Query: 280  GRFLHITDFHIDHHYQKGSDIDKVCHGGEG----KASKYGDAILGCDSPPILVEETFKWI 447
            G+F H+TD H+D  Y    D  KVC   +G        +GD +  CDSP  L+   F +I
Sbjct: 35   GQFWHVTDLHLDPTYHITDDRTKVCASSKGANASNPGPFGDVL--CDSPYQLILSAFDFI 92

Query: 448  TDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIYPV 627
              N   +  F+++TGDS  H      P        + K I++  +T+ +      +   +
Sbjct: 93   -KNSGQEASFMIWTGDSPPH-----VPVPELSTGTVIKVITNMTMTVQNLFPNLQVFPAL 146

Query: 628  SNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQ-LAVLSLN 804
             N+D  P + +    S     + + W+P++ +  + T   G +Y Q+V  N  L ++SLN
Sbjct: 147  GNHDYWPQDQLPIVTSKVYSAVADLWKPWLGEEAISTLKKGGFYSQKVASNPGLRIISLN 206

Query: 805  TMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPNEKNY--DTT 978
            T  ++  N M     NK DP  + FEWL   L        KV+   HVP     Y  DT 
Sbjct: 207  TNLYYGPNIMT---LNKTDPANQ-FEWLENTLNSSLWNKEKVYXIAHVPVGYLPYATDTP 262

Query: 979  CLRKY-----IAWTHEYRDVIVGGLYGHMNLDHFIPL 1074
             +R+Y     +     Y  VI G  YGH + D  + L
Sbjct: 263  AIRQYYNEKLLDIFRRYSSVIAGQFYGHTHRDSLMVL 299


>Q92485|ASML3B|AS3B_HUMAN (SP: Homo sapiens (Human)) Acid
            sphingomyelinase-like phosphodiesterase 3b precursor (EC
            3.1.4.-) (ASM-like phosphodiesterase 3b).
          Length = 465

 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 76/276 (27%), Positives = 124/276 (44%), Gaps = 14/276 (5%)
 Frame = +1

Query: 280  GRFLHITDFHIDHHYQKGSDIDKVCHGGEGK----ASKYGDAILGCDSPPILVEETFKWI 447
            G+F HI D H+D  Y+   D  +VC     +    A  +GD +  CDSP  L+  +  + 
Sbjct: 21   GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYL--CDSPWALINSSI-YA 77

Query: 448  TDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIYP- 624
               +  + DFI++TGD   H  D +             EI ++   L  E      +Y  
Sbjct: 78   MKEIEPEPDFILWTGDDTPHVPDEKLGEAAV------LEIVERLTKLIREVFPDTKVYAA 131

Query: 625  VSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLA--VLS 798
            + N+D  P N    G +    ++ E W+P++    +  +  GA+Y +++     A  ++ 
Sbjct: 132  LGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVV 191

Query: 799  LNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPN--EKNYD 972
            LNT  ++ SN +  D     DPG + F+WL  VL +       V++ GHVPP   EK  +
Sbjct: 192  LNTNLYYTSNALTAD---MADPGQQ-FQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQN 247

Query: 973  TTCLR-----KYIAWTHEYRDVIVGGLYGHMNLDHF 1065
                R     KY+    ++  VI G  +GH + D F
Sbjct: 248  KAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSF 283


>Q96CB7||Q96CB7 (TrEMBL: Homo sapiens (Human)) Similar to acid
            sphingomyelinase-like phosphodiesterase.
          Length = 373

 Score = 98.6 bits (244), Expect = 2e-19
 Identities = 76/276 (27%), Positives = 124/276 (44%), Gaps = 14/276 (5%)
 Frame = +1

Query: 280  GRFLHITDFHIDHHYQKGSDIDKVCHGGEGK----ASKYGDAILGCDSPPILVEETFKWI 447
            G+F HI D H+D  Y+   D  +VC     +    A  +GD +  CDSP  L+  +  + 
Sbjct: 21   GKFWHIADLHLDPDYKVSKDPFQVCPSAGSQPVPDAGPWGDYL--CDSPWALINSSI-YA 77

Query: 448  TDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIYP- 624
               +  + DFI++TGD   H  D +             EI ++   L  E      +Y  
Sbjct: 78   MKEIEPEPDFILWTGDDTPHVPDEKLGEAAV------LEIVERLTKLIREVFPDTKVYAA 131

Query: 625  VSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLA--VLS 798
            + N+D  P N    G +    ++ E W+P++    +  +  GA+Y +++     A  ++ 
Sbjct: 132  LGNHDFHPKNQFPAGSNNIYNQIAELWKPWLSNESIALFKKGAFYCEKLPGPSGAGRIVV 191

Query: 799  LNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPN--EKNYD 972
            LNT  ++ SN +  D     DPG + F+WL  VL +       V++ GHVPP   EK  +
Sbjct: 192  LNTNLYYTSNALTAD---MADPGQQ-FQWLEDVLTDASKAGDMVYIVGHVPPGFFEKTQN 247

Query: 973  TTCLR-----KYIAWTHEYRDVIVGGLYGHMNLDHF 1065
                R     KY+    ++  VI G  +GH + D F
Sbjct: 248  KAWFREGFNEKYLKVVRKHHRVIAGQFFGHHHTDSF 283


>Q9W188|CG3376|Q9W188 (TrEMBL: Drosophila melanogaster (Fruit fly))
            CG3376 protein (LD42214P).
          Length = 735

 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 82/285 (28%), Positives = 118/285 (41%), Gaps = 24/285 (8%)
 Frame = +1

Query: 283  RFLHITDFHIDHHYQKGSDID----KVCHGGEGK-------ASKYGDAILGCDSPPILVE 429
            + LHI+D H D HY +GS+ D      C    G+       A K+GD    CD+P   V+
Sbjct: 271  KVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGD-YRKCDTPKRTVD 329

Query: 430  ETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKE-----ISDKFVTLTS 594
                 I +   D ID+I++TGD   HD           ++N  KE     I D    +  
Sbjct: 330  HMLSHIAETHKD-IDYILWTGDLPPHD-----------VWNQTKEENLAIIKDTVKQMVE 377

Query: 595  ESDGQPLIYPVSNNDIMPHNL--------MDTGPSLQTRELFEAWRPFIPQVQMHTYLMG 750
               G P+   + N++  P N         +D   S    EL   WR ++PQ   HT   G
Sbjct: 378  MFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRG 437

Query: 751  AYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKV 930
            A+Y   V P    ++SLN  Y  + N  +    N  DP  +L +W  Y L+     N KV
Sbjct: 438  AFYSVLVRPG-FRIISLNMNYCNNKNWWL--LLNSTDPATEL-QWFIYELQSAEFSNEKV 493

Query: 931  WLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLDHF 1065
             + GH+PP   +      R +      Y   +    YGH + D F
Sbjct: 494  HVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEF 538


>Q8MLP3|CG3376|Q8MLP3 (TrEMBL: Drosophila melanogaster (Fruit fly))
            CG3376-PB.
          Length = 708

 Score = 96.3 bits (238), Expect = 1e-18
 Identities = 82/285 (28%), Positives = 118/285 (41%), Gaps = 24/285 (8%)
 Frame = +1

Query: 283  RFLHITDFHIDHHYQKGSDID----KVCHGGEGK-------ASKYGDAILGCDSPPILVE 429
            + LHI+D H D HY +GS+ D      C    G+       A K+GD    CD+P   V+
Sbjct: 271  KVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGD-YRKCDTPKRTVD 329

Query: 430  ETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKE-----ISDKFVTLTS 594
                 I +   D ID+I++TGD   HD           ++N  KE     I D    +  
Sbjct: 330  HMLSHIAETHKD-IDYILWTGDLPPHD-----------VWNQTKEENLAIIKDTVKQMVE 377

Query: 595  ESDGQPLIYPVSNNDIMPHNL--------MDTGPSLQTRELFEAWRPFIPQVQMHTYLMG 750
               G P+   + N++  P N         +D   S    EL   WR ++PQ   HT   G
Sbjct: 378  MFPGVPIFPALGNHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRG 437

Query: 751  AYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKV 930
            A+Y   V P    ++SLN  Y  + N  +    N  DP  +L +W  Y L+     N KV
Sbjct: 438  AFYSVLVRPG-FRIISLNMNYCNNKNWWL--LLNSTDPATEL-QWFIYELQSAEFSNEKV 493

Query: 931  WLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLDHF 1065
             + GH+PP   +      R +      Y   +    YGH + D F
Sbjct: 494  HVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEF 538


>P58242|ASML3B|AS3B_MOUSE (SP: Mus musculus (Mouse)) Acid
            sphingomyelinase-like phosphodiesterase 3b precursor (EC
            3.1.4.-) (ASM-like phosphodiesterase 3b).
          Length = 456

 Score = 92.0 bits (227), Expect = 2e-17
 Identities = 75/276 (27%), Positives = 119/276 (43%), Gaps = 14/276 (5%)
 Frame = +1

Query: 280  GRFLHITDFHIDHHYQKGSDIDKVCHGGEGK----ASKYGDAILGCDSPPILVEETFKWI 447
            GRF HI+D H+D +Y    D  +VC     +    A  +GD +  CDSP  L+  +  + 
Sbjct: 21   GRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYL--CDSPWALINSSL-YA 77

Query: 448  TDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIY-P 624
               +  K DFI++TGD   H  +                I ++   L  E      +Y  
Sbjct: 78   MKEIEPKPDFILWTGDDTPHVPNESLGEAAV------LAIVERLTNLIKEVFPDTKVYAA 131

Query: 625  VSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLA--VLS 798
            + N+D  P N      +    ++ E WRP++       +  GA+Y +++     A  V+ 
Sbjct: 132  LGNHDFHPKNQFPAQSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPSRAGRVVV 191

Query: 799  LNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPN--EKNYD 972
            LNT  ++ +N   +      DPG + F WLG VL         V++ GHVPP   EK  +
Sbjct: 192  LNTNLYYSNN---EQTAGMADPG-EQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQN 247

Query: 973  TTCLR-----KYIAWTHEYRDVIVGGLYGHMNLDHF 1065
                R     +Y+    ++  VI G  +GH + D F
Sbjct: 248  KAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSF 283


>Q23498|ASM-2|ASM2_CAEEL (SP: Caenorhabditis elegans) Sphingomyelin
            phosphodiesterase 2 precursor (EC 3.1.4.12) (Acid
            sphingomyelinase 2).
          Length = 618

 Score = 77.0 bits (188), Expect = 8e-13
 Identities = 84/312 (26%), Positives = 128/312 (41%), Gaps = 40/312 (12%)
 Frame = +1

Query: 253  PDNSKQTIHGRFLHITDFHIDHHYQKGSD----IDKVC-----------HGGEGKASKYG 387
            PDN K T   + LH++D HIDH Y  G++    +D                 +G  +   
Sbjct: 176  PDN-KPTF--KVLHLSDIHIDHQYVVGTEAYCQLDSALGTYAMCCRDYSQDSQGAPTNLK 232

Query: 388  DAILG-----------CDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDN-DREYPR 531
            D  +            CD P    E   K I+    D +D+I+ TGD   HD+ D     
Sbjct: 233  DKPIYVPAGPWGMPYLCDLPYQTFESAMKHISKTFKD-LDYIIITGDFEAHDSWDYTEDL 291

Query: 532  TRQHIFNMNKEISDKFVTLTSESDGQPLIYPVSNNDIMPHNLM--------DT-GPSLQT 684
            TR+++ NM     + F        G P+   + N++ +P + M        DT GP    
Sbjct: 292  TRENMNNMTNVFLEYF-------PGVPVYVSIGNHEGVPQDAMAPHTMPEYDTRGPQWLY 344

Query: 685  RELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDP 864
            + + E W  +IPQ  + T    A Y     P  L ++SLNT+Y  + N  +    N+ DP
Sbjct: 345  KIMSEMWSHWIPQEALDTVQYRASYAVYPKPG-LKLISLNTIYCSEFNFYL--YVNEVDP 401

Query: 865  GYKLFEWLGYVLKEMRARNMKVWLCGHVPPNEKNYDTTCLR----KYIAWTHEYRDVIVG 1032
               L EWL   L++   +   V +  H+PP     D  CL+     +      Y + I  
Sbjct: 402  DATL-EWLIEELQDSENKGELVHIISHIPPG----DNYCLKGWSWNFFEIVKRYENTIAQ 456

Query: 1033 GLYGHMNLDHFI 1068
              YGH + D F+
Sbjct: 457  MFYGHTHYDQFM 468


>Q04519|SMPD1|ASM_MOUSE (SP: Mus musculus (Mouse)) Sphingomyelin
            phosphodiesterase precursor (EC 3.1.4.12) (Acid
            sphingomyelinase) (aSMase).
          Length = 627

 Score = 74.7 bits (182), Expect = 4e-12
 Identities = 76/284 (26%), Positives = 121/284 (42%), Gaps = 23/284 (8%)
 Frame = +1

Query: 283  RFLHITDFHIDHHYQKGSD---IDKV-CHGGEG------KASKYGDAILGCDSPPILVEE 432
            R L +TD H DH Y +G+D    D + C  G G      K + +      CD P   +E 
Sbjct: 198  RVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLES 257

Query: 433  TFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQP 612
              K +        + + +TGD   HD    + ++RQ        I+D    L  +  G  
Sbjct: 258  LLKGL--GPAGPFEMVYWTGDIPAHD---VWQQSRQDQLRALTTITD----LVRKFLGPV 308

Query: 613  LIYP-VSNNDIMPHN-----LMDTGPSLQ--TRELFEAWRPFIPQVQMHTYLMGAYYFQE 768
             +YP V N++  P N      +    S Q     + +AW P++P   +HT  +G +Y   
Sbjct: 309  PVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALT 368

Query: 769  VIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHV 948
              P  L ++SLN  +    N  +    N  DP  +L +WL   L+    R  KV + GH+
Sbjct: 369  PRPG-LRLISLNMNFCSRENFWL--LINSTDPAGQL-QWLVEELQAAENRGDKVHIIGHI 424

Query: 949  PPNEKNYDTTCLRKYIAWTH-----EYRDVIVGGLYGHMNLDHF 1065
            PP        CL+ + +W +      Y + + G  +GH ++D F
Sbjct: 425  PPGH------CLKSW-SWNYYKIIARYENTLAGQFFGHTHVDEF 461


>P17405|SMPD1|ASM_HUMAN (SP: Homo sapiens (Human)) Sphingomyelin
            phosphodiesterase precursor (EC 3.1.4.12) (Acid
            sphingomyelinase) (aSMase).
          Length = 629

 Score = 74.3 bits (181), Expect = 5e-12
 Identities = 78/285 (27%), Positives = 121/285 (42%), Gaps = 24/285 (8%)
 Frame = +1

Query: 283  RFLHITDFHIDHHYQKGSDID----KVCHGGEG--KASKYGDAILG----CDSPPILVEE 432
            R L +TD H DH Y +G+D D      C  G G   AS+ G    G    CD P   +E 
Sbjct: 200  RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLES 259

Query: 433  TFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQP 612
                +        D + +TGD   HD    + +TRQ        ++     L  +  G  
Sbjct: 260  LLSGL--GPAGPFDMVYWTGDIPAHD---VWHQTRQDQLRALTTVT----ALVRKFLGPV 310

Query: 613  LIYP-VSNNDIMPHNLMDTGPSLQ----TRELFE----AWRPFIPQVQMHTYLMGAYYFQ 765
             +YP V N++  P N     P ++    +R L+E    AW P++P   + T  +G +Y  
Sbjct: 311  PVYPAVGNHESTPVNSFPP-PFIEGNHSSRWLYEAMAKAWEPWLPAEALRTLRIGGFYAL 369

Query: 766  EVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGH 945
               P  L ++SLN  +    N  +    N  DP  +L +WL   L+    R  KV + GH
Sbjct: 370  SPYPG-LRLISLNMNFCSRENFWL--LINSTDPAGQL-QWLVGELQAAEDRGDKVHIIGH 425

Query: 946  VPPNEKNYDTTCLRKYIAWTH-----EYRDVIVGGLYGHMNLDHF 1065
            +PP        CL+ + +W +      Y + +    +GH ++D F
Sbjct: 426  IPPGH------CLKSW-SWNYYRIVARYENTLAAQFFGHTHVDEF 463


>Q8K011|SMPD1|Q8K011 (TrEMBL: Mus musculus (Mouse)) Sphingomyelin
            phosphodiesterase 1, acid lysosomal.
          Length = 627

 Score = 72.0 bits (175), Expect = 3e-11
 Identities = 76/284 (26%), Positives = 120/284 (42%), Gaps = 23/284 (8%)
 Frame = +1

Query: 283  RFLHITDFHIDHHYQKGSD---IDKV-CHGGEG------KASKYGDAILGCDSPPILVEE 432
            R L +TD H DH Y +G+D    D + C  G G      K + +      CD P   +E 
Sbjct: 198  RVLFLTDLHWDHEYLEGTDPYCADPLCCRRGSGWPPNSQKGAGFWGEYSKCDLPLRTLES 257

Query: 433  TFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQP 612
              K +        +   +TGD   HD    + ++RQ        I+D    L  +  G  
Sbjct: 258  LLKGL--GPAGPFEMGYWTGDIPAHD---VWQQSRQDQLRALTTITD----LVRKFLGPV 308

Query: 613  LIYP-VSNNDIMPHN-----LMDTGPSLQ--TRELFEAWRPFIPQVQMHTYLMGAYYFQE 768
             +YP V N++  P N      +    S Q     + +AW P++P   +HT  +G +Y   
Sbjct: 309  PVYPAVGNHESTPVNGFPPPFIKGNQSSQWLYEAMAKAWEPWLPADALHTLRIGGFYALT 368

Query: 769  VIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHV 948
              P  L ++SLN  +    N  +    N  DP  +L +WL   L+    R  KV + GH+
Sbjct: 369  PRPG-LRLISLNMNFCSRENFWL--LINSTDPAGQL-QWLVEELQAAENRGDKVHIIGHI 424

Query: 949  PPNEKNYDTTCLRKYIAWTH-----EYRDVIVGGLYGHMNLDHF 1065
            PP        CL+ + +W +      Y + + G  +GH ++D F
Sbjct: 425  PPGH------CLKSW-SWNYYKIIARYENTLAGQFFGHTHVDEF 461


>Q8IQD3|CG32052|Q8IQD3 (TrEMBL: Drosophila melanogaster (Fruit fly))
            CG32052-PA.
          Length = 479

 Score = 67.8 bits (164), Expect = 5e-10
 Identities = 58/254 (22%), Positives = 102/254 (40%), Gaps = 33/254 (12%)
 Frame = +1

Query: 403  CDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFV 582
            CDSP  L+E   K +     D ++F+++TGD+  H + +     +QH      EI     
Sbjct: 48   CDSPWRLIESAVKTMKAKQGDNVEFVLWTGDALSH-SAQPLSEQKQH------EILRNIT 100

Query: 583  TLTSESDGQPLIYPVSNNDIMPHNLMDTGPSLQTRELFEAWRPFIPQVQMHTYLMGAYYF 762
             L   S     I+PV  ++           S   R L E WR ++P   + T+  G YY 
Sbjct: 101  ELLGRSFSSQFIFPVLGHE---------DGSGSYRRLGELWRHWLPSEALVTFDQGGYYS 151

Query: 763  QEVIPNQLAVLSLNT---------------------MYWFDSNPMVDDCDNKGD-PGYKL 876
             E   ++L +++LNT                      Y+ +    V     + +    + 
Sbjct: 152  IEQTKSRLRIVALNTNFMRLDPDPDPRASLSLRWPAEYFAEPKASVSSISAEDELLAEQQ 211

Query: 877  FEWLGYVLKEMRARNMKVWLCGHVPP-----------NEKNYDTTCLRKYIAWTHEYRDV 1023
            + WL  VL + + +   V++ GH+PP           N+  +     ++Y+     +  V
Sbjct: 212  WLWLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPV 271

Query: 1024 IVGGLYGHMNLDHF 1065
            I G  +GH++ D F
Sbjct: 272  IQGQFFGHLHSDTF 285


>Q9UAY4|W03G1.7|ASM3_CAEEL (SP: Caenorhabditis elegans) Putative
            sphingomyelin phosphodiesterase W03G1.7 precursor (EC
            3.1.4.12).
          Length = 589

 Score = 65.5 bits (158), Expect = 2e-09
 Identities = 93/424 (21%), Positives = 169/424 (39%), Gaps = 39/424 (9%)
 Frame = +1

Query: 97   CADYVS--YNIWNSVTSKSNKPYISIKTLDLNDTQIDDLKRLGLTPKKSVEIVKPDNSKQ 270
            C D+V     IWN     +  P++                     PK   ++V P N   
Sbjct: 97   CGDFVDPLATIWNMTIPGNQPPFV---------------------PK---QVVPPGNPTL 132

Query: 271  TIHGRFLHITDFHIDHHYQKGSDID--------------KVCHGGEGK--ASKYGDAILG 402
                R LH+TD H+D  Y  G + D              ++   G+ K  A  +G ++  
Sbjct: 133  ----RALHLTDLHVDMFYTVGLEADCGTPQCCRPQDMNVEIVENGDVKQPAGPWG-SVGS 187

Query: 403  CDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFV 582
            CD+P  L+    + I  +   K+D+I+ +GD   H      P T  H F M K +SD   
Sbjct: 188  CDTPYWLLTNMLQNIA-STAGKLDYIMVSGDLVSHTVWAYTPET--HSF-MVKNLSD--- 240

Query: 583  TLTSESDGQPLIYPVSNNDIMPHNLMDTGPSLQTRE---------LFEAWRPFIPQVQMH 735
            T+ S     P+ + V N++ +P  + +  P    ++         +  AW+ +IP  Q  
Sbjct: 241  TIRSYFPKTPVYFAVGNHEGVP--VDNIAPHFTPKKYHMDWLYKAMSNAWQGWIPADQEK 298

Query: 736  TYLMGAYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRA 915
            +      Y +++  + L ++SLN +Y    N  +    N+ DP   L +WL   L++   
Sbjct: 299  SLEYNGCYMKKIY-DGLRMISLNNVYGDRINFWL--YINQTDPDGTL-QWLINQLQDAEN 354

Query: 916  RNMKVWLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLDHF---------- 1065
               KV +  H+P ++          Y    + Y + +VG  +GH + + F          
Sbjct: 355  VGDKVHIVAHIPGSDGEALEGYALNYYKIINRYANTVVGQFFGHTHSEKFYMMYANPDDY 414

Query: 1066 --IPLDSVQAYKSIQKDFKDEFKQKSVFSVEDEDDLALEDSNLYKALDENFSDKFFRVTG 1239
               P + V +  S+   + D F    +++++      +   + Y+ +D  + + FF +T 
Sbjct: 415  KSTPTNVVYSAPSV-TPYSDYFPAYRIYTID-----GVHKGSTYQVID--YEEWFFNLTS 466

Query: 1240 GVPN 1251
               N
Sbjct: 467  NNAN 470


>Q9VA77|CG15534|Q9VA77 (TrEMBL: Drosophila melanogaster (Fruit fly))
            CG15534 protein.
          Length = 666

 Score = 60.8 bits (146), Expect = 6e-08
 Identities = 89/383 (23%), Positives = 148/383 (38%), Gaps = 34/383 (8%)
 Frame = +1

Query: 13   GPNRLSARQYLLITFLITFVVSISTYLYCADYVSYN------IWNSVTSKSNKPYISIKT 174
            GP R    + L++     F  +IST   C+     N      I N   +KSN  + S+  
Sbjct: 120  GPERDDEAKKLMLGMCDYF--AISTQEVCSGLFDLNWPILDFILNETVAKSNT-FCSMLP 176

Query: 175  LDLNDTQIDD----LKRLGLTPKKSVEIVKPDNSKQTIHGRFLHITDFHIDHHYQKGS-- 336
            + +   + D+    L   G  P++S   +    S+  +    LH+TD H D  Y +GS  
Sbjct: 177  IPICQVKQDEYNLTLSIQGDLPQESNSNLPAKTSEDIL---VLHLTDIHYDPEYAEGSNA 233

Query: 337  --DIDKVCHGG--EGK----ASKYGDAILGCDSPPILVEETFKWITDNLIDKIDFIVYTG 492
              D    C     EG     A+ +      CD P  L+   F+ I +N   KI++I +TG
Sbjct: 234  ACDEPMCCRNSLPEGSDSSAAAGFWSDYRDCDCPKRLILSAFEHIKEN--HKIEWIYHTG 291

Query: 493  DSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQPLIYP-VSNNDIMPHNLM--- 660
            D   H+    +  TRQ   +M  EI +       ++     IYP + N++  P N+    
Sbjct: 292  DVPPHN---VWSTTRQGNLDMLSEIDELLAKYFPDTP----IYPCLGNHEPHPANVFGND 344

Query: 661  DTGPSLQTRELFE----AWRPFIPQVQMHTYLMGAYYFQEVIPNQLAVLSLNTM------ 810
            +   SL+   L+E     W  ++P     T L G YY          +++LN+M      
Sbjct: 345  EIPSSLRVDWLYEHVWSLWSKWLPAEAEETVLRGGYYTASPSKGH-RIVALNSMDCYLYN 403

Query: 811  YWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPNEKNYDTTCLRK 990
            +W   N  +           +  +W    L         V +  H+P  + +      ++
Sbjct: 404  WWLFYNATLIQ---------EQLQWFHDTLLSAEEAGESVHILTHIPAGDGDCWCNWSQE 454

Query: 991  YIAWTHEYRDVIVGGLYGHMNLD 1059
            Y      +  +I G   GH + D
Sbjct: 455  YNRVLTRFNGIITGVFSGHTHKD 477


>Q10916|ASM-1|ASM1_CAEEL (SP: Caenorhabditis elegans) Sphingomyelin
            phosphodiesterase 1 precursor (EC 3.1.4.12) (Acid
            sphingomyelinase 1).
          Length = 564

 Score = 60.5 bits (145), Expect = 8e-08
 Identities = 76/304 (25%), Positives = 126/304 (41%), Gaps = 18/304 (5%)
 Frame = +1

Query: 208  KRLGLTPKKSVEIVKPDNSKQTIHGRFLHITDFHIDHHYQKGSDI---DKVCH----GGE 366
            KR  ++ KK   + K  N   + +   L +TD H+D  Y+  S+    D VC        
Sbjct: 137  KRTRISKKK---VQKKPNMSMSQNLNVLQLTDLHVDFEYKYPSEANCDDPVCCRVSVSEP 193

Query: 367  GKASKYGDAILGCDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHI 546
             KA+ Y  ++  CD P   VE     I  N    ID ++ TGD   H  D EY    +H+
Sbjct: 194  KKAAGYWGSVGKCDIPFWTVENMLSHI--NKTHMIDMVIMTGDYINHV-DWEYS-IEEHL 249

Query: 547  FNMNKEISDKFVTLTSESDGQPLIYPVSN------NDIMPHNLMDT-GPSLQTRELFEAW 705
              + K    + V  T  S   P+ + + N      N   PH++ +   P+   +E     
Sbjct: 250  SVLRK--LHRLVQNTFPST--PIYWALGNHEGVPVNSFAPHSVDERFWPTWLYKEFQTMS 305

Query: 706  RPFIPQVQMHTYLMGAYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEW 885
             P++ +    + L    Y  +V+   L +++LNT +   +N  +    N+ DP   +  W
Sbjct: 306  GPWLSEGAKDSLLKRGSYSTQVMDG-LKLITLNTGFCEVTNFFL--YLNQSDPDSSM-SW 361

Query: 886  LGYVLKEMRARNMKVWLCGHVPPNEKNYDTTCLR----KYIAWTHEYRDVIVGGLYGHMN 1053
                L E   +  +V++  H+PP     D+ CL      Y      +   I    +GH +
Sbjct: 362  FVKELFESEKKGEQVYVLAHIPPG----DSECLEGWAFNYYRVIQRFSSTIAAQFFGHDH 417

Query: 1054 LDHF 1065
            LD+F
Sbjct: 418  LDYF 421


>Q9VA78|CG15533|Q9VA78 (TrEMBL: Drosophila melanogaster (Fruit fly))
            CG15533 protein.
          Length = 692

 Score = 50.8 bits (120), Expect = 6e-05
 Identities = 76/348 (21%), Positives = 126/348 (36%), Gaps = 26/348 (7%)
 Frame = +1

Query: 94   YCADYVSYNIWNSVTSKSNKPYISIKTLDLNDT-QIDDLKRLGLTPKKSVEIVKPDNSKQ 270
            +C+ ++ +N  N+ T++           D N T  ID+       PK      +  +   
Sbjct: 173  FCSLFMEFNFCNTGTNQ-----------DYNWTLTIDNTGEASAGPKSDTPTFQDSDI-- 219

Query: 271  TIHGRFLHITDFHIDHHYQKGS----------DIDKVCHGGEGKASKYGDAILGCDSPPI 420
                R    +D H D +Y  GS            +K    G   A+ Y      CD P  
Sbjct: 220  ----RICQFSDIHHDPYYTPGSLATCAEPMCCQRNKETTEGTSDAAGYWGDYRDCDLP-- 273

Query: 421  LVEETFKWITDNLI--DKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTS 594
                 F+   DN +   K DFI  TGD   H            ++  + E +   +T  S
Sbjct: 274  --WHAFESALDNAVANSKCDFIYQTGDIVDH-----------MVWATSVEKNTMVLTKVS 320

Query: 595  E----SDGQPLIYP-VSNNDIMPHNLMD---TGPSLQTRELFEA----WRPFIPQVQMHT 738
            E    + G   +YP + N++  P NL         + T+ L+E     W  ++P     T
Sbjct: 321  ERLNAAFGDVPVYPCIGNHEPHPLNLFSPEGVPDEISTKWLYEHLYNDWSKWLPAETKET 380

Query: 739  YLMGAYYFQEVIPNQ-LAVLSLNTMYWFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRA 915
             L G YY   V+P +   +++LN+   +  N  +    + G       +W    L E   
Sbjct: 381  ILKGGYY--TVVPRKGFRIIALNSNDCYTDNFWLY---HSGTDKIPQLQWFHDTLLEAEK 435

Query: 916  RNMKVWLCGHVPPNEKNYDTTCLRKYIAWTHEYRDVIVGGLYGHMNLD 1059
                V +  H+P  +    +   R++      +R  I G   GH + D
Sbjct: 436  NGEYVHVLTHIPSGDGTCWSVWAREFNRCVSRFRSTISGIFTGHSHKD 483


>Q95T74|CG3376|Q95T74 (TrEMBL: Drosophila melanogaster (Fruit fly))
           GH14130p.
          Length = 322

 Score = 50.1 bits (118), Expect = 1e-04
 Identities = 41/140 (29%), Positives = 60/140 (42%), Gaps = 16/140 (11%)
 Frame = +1

Query: 283 RFLHITDFHIDHHYQKGSDID----KVCHGGEGK-------ASKYGDAILGCDSPPILVE 429
           + LHI+D H D HY +GS+ D      C    G+       A K+GD    CD+P   V+
Sbjct: 119 KVLHISDTHYDPHYAEGSNADCNEPLCCRLSSGRPATPNAAAGKWGD-YRKCDTPKRTVD 177

Query: 430 ETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKE-----ISDKFVTLTS 594
                I +   D ID+I++TGD   HD           ++N  KE     I D    +  
Sbjct: 178 HMLSHIAETHKD-IDYILWTGDLPPHD-----------VWNQTKEENLAIIKDTVKQMVE 225

Query: 595 ESDGQPLIYPVSNNDIMPHN 654
              G P+   + N++  P N
Sbjct: 226 MFPGVPIFPALGNHESAPVN 245


>Q871S2|7F4.170|Q871S2 (TrEMBL: Neurospora crassa) Related to acid
            sphingomyelinase.
          Length = 705

 Score = 46.6 bits (109), Expect = 0.001
 Identities = 72/315 (22%), Positives = 112/315 (35%), Gaps = 37/315 (11%)
 Frame = +1

Query: 226  PKKSVEIVKPDNSKQTIHGRFLHITDFHIDHHYQKGSDID----KVCHGGEGKAS----- 378
            PKK  E   P  S + +  + LH++D H+D  Y  GS+ +      C   E  A+     
Sbjct: 231  PKKPAE---PRRSGKKV--KVLHLSDLHLDPRYSVGSEANCTSYMCCRYSEPPANGTVPE 285

Query: 379  -KYGDAILG---CDSPPILVEETFKWI----TDNLIDKIDFIVYTGDSARHDNDREYPR- 531
                  + G   CDSP  L     + I      +  +   F +YTGD   HD++ +  R 
Sbjct: 286  ISVSAPLFGYYKCDSPFYLALAALQSIGPLTGTSAKNPPAFSLYTGDLIAHDDENQASRA 345

Query: 532  ----TRQHIFNMNKE-ISDKFVTLTSESDGQPLIY----PVSNNDIMPHNLMDTGPSLQT 684
                T   I+   K  I     T     D  P  Y     + NN  +          + +
Sbjct: 346  YVEATEVAIWETFKAYIGGPIYTALGNHDTTPADYEAPHAIDNNSTLGSQFSWNYAHVSS 405

Query: 685  RELFEAWRPFIPQVQMHTYLMGAYYFQEVIPNQLAVLSLNTMYWFDSNPMVDDCDNKGDP 864
                  W P     Q  T+   AY         L +++LN+  ++  NP      N  +P
Sbjct: 406  LWAHYNWLPSSVAQQASTH-YAAYAVSPPHHPNLKIITLNSDLYYQHNPFA--LLNASNP 462

Query: 865  GYK-LFEWLGYVLKEMRARNMKVWLCGHVP---------PNEKNYDTTCLRKYIAWTHEY 1014
             Y  +F  L   L+       +VW+  H+P         PN  +Y    + +Y       
Sbjct: 463  DYSGMFSCLITELQAAEDAGQRVWIVAHIPTGWDGGSALPNSADYFYQIVERYSP----- 517

Query: 1015 RDVIVGGLYGHMNLD 1059
              VI    +GH + D
Sbjct: 518  -HVIANIFFGHSHED 531


>Q8MVM5|ASML|Q8MVM5 (TrEMBL: Boltenia villosa) Acid
           sphingomyelinase-like phosphodiesterase-like protein
           (Fragment).
          Length = 152

 Score = 43.1 bits (100), Expect = 0.012
 Identities = 29/87 (33%), Positives = 43/87 (49%), Gaps = 6/87 (6%)
 Frame = +1

Query: 280 GRFLHITDFHIDHHYQKG-SDIDKVC-----HGGEGKASKYGDAILGCDSPPILVEETFK 441
           G F HI+D H+D +Y    +D  KVC     H     A  +GD    CDSP  L+  +  
Sbjct: 22  GAFWHISDHHLDPYYSDDPTDRTKVCPSSYNHPVTSAAGPFGD--YRCDSPWKLINSSVH 79

Query: 442 WITDNLIDKIDFIVYTGDSARHDNDRE 522
            +     D  DFI++TGD   H ++++
Sbjct: 80  AMKIYKADP-DFIIWTGDDTLHTSEQD 105


>Q8IUN0||Q8IUN0 (TrEMBL: Homo sapiens (Human)) Similar to
           sphingomyelin phosphodiesterase 1, acid lysosomal (Acid
           sphingomyelinase).
          Length = 364

 Score = 42.4 bits (98), Expect = 0.021
 Identities = 48/171 (28%), Positives = 71/171 (41%), Gaps = 19/171 (11%)
 Frame = +1

Query: 283 RFLHITDFHIDHHYQKGSDID----KVCHGGEG--KASKYGDAILG----CDSPPILVEE 432
           R L +TD H DH Y +G+D D      C  G G   AS+ G    G    CD P   +E 
Sbjct: 200 RILFLTDLHWDHDYLEGTDPDCADPLCCRRGSGLPPASRPGAGYWGEYSKCDLPLRTLES 259

Query: 433 TFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNKEISDKFVTLTSESDGQP 612
               +        D + +TGD   HD    + +TRQ        ++     L  +  G  
Sbjct: 260 LLSGL--GPAGPFDMVYWTGDIPAHD---VWHQTRQDQLRALTTVT----ALVRKFLGPV 310

Query: 613 LIYP-VSNNDIMPHNLMDTGPSLQ----TRELFE----AWRPFIPQVQMHT 738
            +YP V N++  P N     P ++    +R L+E    AW P++P   + T
Sbjct: 311 PVYPAVGNHESTPVNSFPP-PFIEGNHSSRWLYEAMAKAWEPWLPAEALRT 360


>Q23640|ZK856.5|Q23640 (TrEMBL: Caenorhabditis elegans) ZK856.5
           protein.
          Length = 118

 Score = 41.6 bits (96), Expect = 0.036
 Identities = 25/77 (32%), Positives = 39/77 (50%), Gaps = 4/77 (5%)
 Frame = +1

Query: 289 LHITDFHIDHHYQKGSDIDKVCH--GGEGKAS--KYGDAILGCDSPPILVEETFKWITDN 456
           LH+ DFH+D  Y    D   +CH  G E   +  +YGD +  CD+P  L++      +  
Sbjct: 24  LHLADFHLDVQYSINGDNKHMCHDDGTERNTTLGEYGDYM--CDAPKPLIQLAID-ESAR 80

Query: 457 LIDKIDFIVYTGDSARH 507
           +    D I++TGD+  H
Sbjct: 81  IFPNPDLIIWTGDNVAH 97


>Q98PQ2|MYPU_6670|Q98PQ2 (TrEMBL: Mycoplasma pulmonis) Isoleucyl-tRNA
            synthetase (Isoleucine--tRNA ligase) (ILERS) (EC
            6.1.1.5).
          Length = 888

 Score = 38.5 bits (88), Expect = 0.31
 Identities = 49/244 (20%), Positives = 102/244 (41%), Gaps = 7/244 (2%)
 Frame = +1

Query: 814  WFDSNPMVDDCDNKGDPGYKLFEWLGYVLKEMRARNMKVWLCGHVPPNE--KNYDTTCLR 987
            WF+S+ +++     G   Y+L    G+VL + + + M   L   V P E  + Y    LR
Sbjct: 559  WFNSS-IINSVAYWGQSPYRLLLSHGFVL-DGKGKKMSKQLGNVVDPQEIIQKYGADILR 616

Query: 988  KYIAWTHEYRDVIVGGLYGHMNLDHFIPL-DSVQAYKSIQKDF---KDEFKQKSVFSVED 1155
             ++A      DV V        ++++  + ++++      +D+   K   K + +  + +
Sbjct: 617  LWVANCEYAHDVSVSESIIKQTVENYRKIRNTIKFLLGNLQDYDHSKFNLKLEGIHELIN 676

Query: 1156 EDDLALEDSNLYKALDENFSDKFFRVTGGVPNNKVTYLETLREELYAP-LKGKKKSGEHF 1332
            E    ++   L    D +F+D    +T  + +    YL   ++ LYA  +  K++    +
Sbjct: 677  ERLKKVKFDILQAYNDYDFNDVIKTLTNFLTDLSSFYLSISKDSLYADKINSKERRMIQY 736

Query: 1333 ERYSIAHVTASIIPTFNPGMRVWEYNITDLEDKLQQVKFEPWDKFFAGVERMIEVQSNYV 1512
              Y+I   T  +I    P      Y+  + +DK + V  E   +     +++ +    + 
Sbjct: 737  NMYNILEATLVVIAPIMPTTAEDAYDNFNKQDKQESVHLEKMFEATIADDKLEKTWKEFF 796

Query: 1513 DEKD 1524
            D KD
Sbjct: 797  DLKD 800


>Q8G6Z0|BL0490|Q8G6Z0 (TrEMBL: Bifidobacterium longum) Hypothetical
            protein.
          Length = 523

 Score = 37.0 bits (84), Expect = 0.89
 Identities = 24/60 (40%), Positives = 29/60 (48%), Gaps = 5/60 (8%)
 Frame = +1

Query: 841  DCDNKGDPGYKLFEWLGYVLKEMRARN-----MKVWLCGHVPPNEKNYDTTCLRKYIAWT 1005
            D D  G P  K  EWLG V  E+  RN     +      H+PP E  YD  CL++  AWT
Sbjct: 294  DADGYGTPTPKAIEWLGSVQTELGERNGDGKPVPAIAFQHIPPQE-FYD--CLKEVPAWT 350


>Q8MSD7|BEST:HL01355|Q8MSD7 (TrEMBL: Drosophila melanogaster (Fruit
            fly)) HL01355p.
          Length = 311

 Score = 35.4 bits (80), Expect = 2.6
 Identities = 18/72 (25%), Positives = 33/72 (45%), Gaps = 11/72 (15%)
 Frame = +1

Query: 883  WLGYVLKEMRARNMKVWLCGHVPP-----------NEKNYDTTCLRKYIAWTHEYRDVIV 1029
            WL  VL + + +   V++ GH+PP           N+  +     ++Y+     +  VI 
Sbjct: 46   WLEEVLTKSKEKQETVYIVGHMPPGVDERHLGTQHNQLTFTERNNQRYLDMVRRFAPVIQ 105

Query: 1030 GGLYGHMNLDHF 1065
            G  +GH++ D F
Sbjct: 106  GQFFGHLHSDTF 117


>Q99707|MTR|METH_HUMAN (SP: Homo sapiens (Human))
            5-methyltetrahydrofolate--homocysteine methyltransferase
            (EC 2.1.1.13) (Methionine synthase, vitamin-B12
            dependent) (MS).
          Length = 1265

 Score = 35.4 bits (80), Expect = 2.6
 Identities = 29/93 (31%), Positives = 45/93 (48%), Gaps = 2/93 (2%)
 Frame = +1

Query: 1198 LDENFSDKFFR-VTGGVPNNKVTYLETLREELYAPLKGKKKSGEHFERYSIAHVTASIIP 1374
            LDEN  D++F  +     + +  + E+L+E  Y PL   +KSG   +  S  H    + P
Sbjct: 897  LDENLKDEYFEEIMEEYEDIRQDHYESLKERRYLPLSQARKSGFQMDWLSEPH---PVKP 953

Query: 1375 TFNPGMRVWE-YNITDLEDKLQQVKFEPWDKFF 1470
            TF  G +V+E Y++  L D +       W  FF
Sbjct: 954  TF-IGTQVFEDYDLQKLVDYID------WKPFF 979


>Q9KYP9|SCO4483|Q9KYP9 (TrEMBL: Streptomyces coelicolor) Hypothetical
            protein SCO4483.
          Length = 200

 Score = 34.7 bits (78), Expect = 4.4
 Identities = 18/40 (45%), Positives = 22/40 (55%)
 Frame = +1

Query: 1615 HTFPKPMPENLPLGPAYIEQTFTPERYVQYYADLESINKG 1734
            HTF     E     PA +  TFTP+ YVQY+ DLE +  G
Sbjct: 134  HTFANTTGE-----PARMLSTFTPDLYVQYFRDLEELYAG 168


>Q8ILU0|PF14_0154|Q8ILU0 (TrEMBL: Plasmodium falciparum (isolate 3D7))
            Hypothetical protein.
          Length = 1151

 Score = 34.7 bits (78), Expect = 4.4
 Identities = 48/234 (20%), Positives = 93/234 (39%), Gaps = 20/234 (8%)
 Frame = +1

Query: 211  RLGLTPKKSVEIVKPDNSKQTIHGRFLHITDFHIDHHYQKGSDIDKVCHGGEGKASKYGD 390
            R G   K +   +  D +  + + R+    + +++++Y K ++     H G+ K     +
Sbjct: 793  RFGKINKSNDNYIMNDTNLFSDNQRYFTNNNPYVNNYYYKNNN-----HNGDDKNLHMMN 847

Query: 391  AILGCDSPPILVEETFKWITDNLIDKIDFIVYTGDSARHDNDREYPRTRQHIFNMNK--- 561
             +   D    + E   K+   N I+KI+   Y G +   +N  +Y     +I   NK   
Sbjct: 848  KLKYFDQEHFINEVNPKYFNSN-INKINHYNYNGKNNNKNNINQYENENDNINIYNKKYN 906

Query: 562  ----EISDKF---VTLTSESDGQPLIYPVSNNDIMPHNLMDTGPSLQTRELFEAWRPFIP 720
                E  +K+   +T   E+D   +I  +    I+  +       L+ R+  +  +  I 
Sbjct: 907  SLPYEEDEKYTSNITNMVENDSDYIIKNIGKKYILNEDSDQLNKLLELRKNNKKKKMRIQ 966

Query: 721  QVQMHTYLMGAYYFQEV----IPNQLAVLSLNTMY------WFDSNPMVDDCDN 852
              Q ++Y    Y+  EV    I   L    +NT Y      +   N M D+C++
Sbjct: 967  NNQKYSYQDHFYFDDEVNDKYISKTLNENDMNTSYNSFNSTYNKRNNMSDNCND 1020


  Database: sptrembl
    Posted date:  Oct 14, 2003  6:47 PM
  Number of letters in database: 339,323,595
  Number of sequences in database:  1,070,300
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 604,327,369
Number of Sequences: 1070300
Number of extensions: 13458962
Number of successful extensions: 53612
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51109
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 53524
length of database: 339,323,595
effective HSP length: 128
effective length of database: 202,325,195
effective search space used: 107839328935
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)