BLASTX 2.2.6 [Apr-09-2003]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Candida_albicans_chr7-f3-64158-65279-9
         (1119 letters)

Database: sptrembl 
           1,070,300 sequences; 339,323,595 total letters

Searching.................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

P87186|LEU2|LEU3_CANAL (SP: Candida albicans (Yeast)) 3-isopropy...   653   0.0  
Q12591|LEU2|Q12591 (TrEMBL: Candida maltosa (Yeast)) 3-isopropyl...   643   0.0  
P07139|LEU2|LEU3_CANMA (SP: Candida maltosa (Yeast)) 3-isopropyl...   643   0.0  
Q12590|LEU2|Q12590 (TrEMBL: Candida maltosa (Yeast)) 3-isopropyl...   637   0.0  
O94114|LEU2|LEU3_PICST (SP: Pichia stipitis (Yeast)) 3-isopropyl...   588   e-167
P41926|LEU2|LEU3_YAMOH (SP: Yamadazyma ohmeri (Yeast) (Pichia oh...   571   e-162
P08791|LEU2|LEU3_PICJA (SP: Pichia jadinii (Yeast) (Candida util...   533   e-150
Q9HDQ1|LEU2|Q9HDQ1 (TrEMBL: Hansenula anomala (Yeast) (Candida p...   526   e-148
Q96WT9|LEU2|LEU3_SACEX (SP: Saccharomyces exiguus (Yeast)) 3-iso...   523   e-147
P41766|LEU2|LEU3_KLUMA (SP: Kluyveromyces marxianus (Yeast) (Klu...   520   e-146
O14429|LEU2|LEU3_CANGA (SP: Candida glabrata (Yeast) (Torulopsis...   519   e-146
P23390|LEU2|LEU3_KLULA (SP: Kluyveromyces lactis (Yeast)) 3-isop...   515   e-145
Q01987|LEU2|LEU3_CANBO (SP: Candida boidinii (Yeast)) 3-isopropy...   508   e-143
P04173|LEU2|LEU3_YEAST (SP: Saccharomyces cerevisiae (Baker's ye...   508   e-143
Q8NKB8|LEU2|Q8NKB8 (TrEMBL: Arxula adeninivorans (Yeast)) 3-isop...   503   e-141
Q9P3Y0|LEU2|Q9P3Y0 (TrEMBL: Zygosaccharomyces bailii) Beta-isopr...   502   e-141
Q96WI0|LEU2|Q96WI0 (TrEMBL: Zygosaccharomyces rouxii (Candida mo...   500   e-140
Q9HDQ5|LEU2|Q9HDQ5 (TrEMBL: Candida rugosa (Yeast) (Candida cyli...   496   e-139
P34733|LEU2|LEU3_PICAN (SP: Pichia angusta (Yeast) (Hansenula po...   489   e-137
O60027|LEU2|LEU3_ASHGO (SP: Ashbya gossypii (Yeast) (Eremotheciu...   467   e-130
Q12592|LEU2|Q12592 (TrEMBL: Candida maltosa (Yeast)) 3-isopropyl...   444   e-124
Q877A9||Q877A9 (TrEMBL: Aspergillus oryzae) Hypothetical protein.     400   e-110
P18120|LEU2|LEU3_YARLI (SP: Yarrowia lipolytica (Candida lipolyt...   395   e-109
P34738|LEU-1|LEU3_NEUCR (SP: Neurospora crassa) 3-isopropylmalat...   387   e-106
P87256|LEU2A|LE3A_ASPNG (SP: Aspergillus niger) 3-isopropylmalat...   380   e-104
Q9P8C1|LEUA|Q9P8C1 (TrEMBL: Phaeosphaeria nodorum (Septoria nodo...   378   e-104
Q9Y897|LEUC|LEU3_MYCGR (SP: Mycosphaerella graminicola (Septoria...   373   e-102
P18869|LEU1|LEU3_SCHPO (SP: Schizosaccharomyces pombe (Fission y...   345   4e-94
O59930|LEU2|LEU3_PHACH (SP: Phanerochaete chrysosporium) 3-isopr...   317   2e-85
Q12545|LEU2|LEU3_CEPAC (SP: Cephalosporium acremonium (Acremoniu...   294   1e-78

>P87186|LEU2|LEU3_CANAL (SP: Candida albicans (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 373

 Score =  653 bits (1685), Expect = 0.0
 Identities = 338/373 (90%), Positives = 342/373 (91%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MSVKT+TITVLPGDHVGTEIVNE  KVLKAIEA TPYQKIQFDFKHHLIGGAAIDATGVP
Sbjct: 1    MSVKTQTITVLPGDHVGTEIVNEPTKVLKAIEAPTPYQKIQFDFKHHLIGGAAIDATGVP 60

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL
Sbjct: 61   LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 120

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESED +TAW   KYTVDEVTRITRMA
Sbjct: 121  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDHQTAWYRPKYTVDEVTRITRMA 180

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
            AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN
Sbjct: 181  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 240

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PTKL+GIIITSNMFGDIISDEASVI                DTNTAFGLYEPCHGSAPDL
Sbjct: 241  PTKLSGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTAFGLYEPCHGSAPDL 300

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            PANKVNPIATILSAASMLRL+LDCVK        VKQVLDSGIRTADLRGTSSTTEVGDA
Sbjct: 301  PANKVNPIATILSAASMLRLALDCVKETEALEEAVKQVLDSGIRTADLRGTSSTTEVGDA 360

Query: 1081 IAETVTKILKQNT 1119
            IAETVTKILKQNT
Sbjct: 361  IAETVTKILKQNT 373


>Q12591|LEU2|Q12591 (TrEMBL: Candida maltosa (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85).
          Length = 373

 Score =  643 bits (1659), Expect = 0.0
 Identities = 327/371 (88%), Positives = 339/371 (91%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MSVKTKTIT+LPGDHVGTEIVNEAIKVL+AIEAATPYQKI FDFKHHLIGG+AIDATGVP
Sbjct: 1    MSVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGSAIDATGVP 60

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPDDALESAK+SDAVLLGAVGGPKWGTG +RPEQGLLKIRKELNLYANIRPCNFASDSLL
Sbjct: 61   LPDDALESAKNSDAVLLGAVGGPKWGTGALRPEQGLLKIRKELNLYANIRPCNFASDSLL 120

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            ELSPL+ EVVKGTNLIIVRELVGGIYFG+R+EQEESEDK+TAWDTEKYTVDEVTRITR+A
Sbjct: 121  ELSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESEDKQTAWDTEKYTVDEVTRITRIA 180

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
            AFMALQHNPPLPIWSLDKANVLASSRLWR+TVDKVISEEFP LSVQHQLIDSAAMILIQN
Sbjct: 181  AFMALQHNPPLPIWSLDKANVLASSRLWRRTVDKVISEEFPTLSVQHQLIDSAAMILIQN 240

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PTKLNGIIITSNMFGDIISDEASVI                DTNT FGLYEPCHGSAPDL
Sbjct: 241  PTKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTVFGLYEPCHGSAPDL 300

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            PANKVNPIATILSAASMLRLSLDCVK        VKQVLD GIRTADLRGTSSTTEVGDA
Sbjct: 301  PANKVNPIATILSAASMLRLSLDCVKEAEALEEAVKQVLDKGIRTADLRGTSSTTEVGDA 360

Query: 1081 IAETVTKILKQ 1113
            I E VTKILK+
Sbjct: 361  IVEAVTKILKE 371


>P07139|LEU2|LEU3_CANMA (SP: Candida maltosa (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 373

 Score =  643 bits (1658), Expect = 0.0
 Identities = 328/371 (88%), Positives = 338/371 (91%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MSVKTKTIT+LPGDHVGTEIVNEAIKVL+AIEAATPYQKI FDFKHHLIGGAAIDATGVP
Sbjct: 1    MSVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVP 60

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPDDALESAK+SDAVLLGAVGGPKWGTG +RPEQGLLKIRKELNLYANIRPCNFASDSLL
Sbjct: 61   LPDDALESAKNSDAVLLGAVGGPKWGTGALRPEQGLLKIRKELNLYANIRPCNFASDSLL 120

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            ELSPL+ EVVKGTNLIIVRELVGGIYFG+R+EQEES DK+TAWDTEKYTVDEVTRITRMA
Sbjct: 121  ELSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESADKQTAWDTEKYTVDEVTRITRMA 180

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
            AFMALQH PPLPIWSLDKANVLASSRLWR+TVDKVISEEFP LSVQHQLIDSAAMILIQN
Sbjct: 181  AFMALQHTPPLPIWSLDKANVLASSRLWRRTVDKVISEEFPTLSVQHQLIDSAAMILIQN 240

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PTKLNGIIITSNMFGDIISDEASVI                DTNTAFGLYEPCHGSAPDL
Sbjct: 241  PTKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTAFGLYEPCHGSAPDL 300

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            PANKVNPIATILSAASMLRLSLDCVK        VKQVLD GIRTADLRGTSSTTEVGDA
Sbjct: 301  PANKVNPIATILSAASMLRLSLDCVKEAEALEEAVKQVLDKGIRTADLRGTSSTTEVGDA 360

Query: 1081 IAETVTKILKQ 1113
            I E VTKILK+
Sbjct: 361  IVEAVTKILKE 371


>Q12590|LEU2|Q12590 (TrEMBL: Candida maltosa (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85).
          Length = 373

 Score =  637 bits (1642), Expect = 0.0
 Identities = 326/371 (87%), Positives = 335/371 (90%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MSVKTKTIT+LPGDHVGTEIVNEAIKVL+AIEAATPYQKI FDFKHHLIGGAAIDATGVP
Sbjct: 1    MSVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVP 60

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPDDALESAK SDAVLLGAVGGPKW TG +RPEQGLLKIRKELNLYANIRPCNFASDSLL
Sbjct: 61   LPDDALESAKKSDAVLLGAVGGPKWWTGALRPEQGLLKIRKELNLYANIRPCNFASDSLL 120

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            ELSPL+ EVVKGTNLIIVRELVGGIYFG+R+EQEESEDK+TAWDTEKYTVDEVTRITRMA
Sbjct: 121  ELSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESEDKQTAWDTEKYTVDEVTRITRMA 180

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
            AFM LQ NPPLPIWSLDKANVLASSRLWR+TVDKVISEEFP LSVQHQLIDSAAMILIQN
Sbjct: 181  AFMPLQDNPPLPIWSLDKANVLASSRLWRRTVDKVISEEFPTLSVQHQLIDSAAMILIQN 240

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PTKLNGIIITSNMFGDIISDEASVI                DTNTAFGLYEPCHGSAPDL
Sbjct: 241  PTKLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTAFGLYEPCHGSAPDL 300

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            PANKVNPIATILSAASMLRLSLDCVK        VKQVLD GIRTADLRGT STTEVGDA
Sbjct: 301  PANKVNPIATILSAASMLRLSLDCVKEAEALEEAVKQVLDKGIRTADLRGTRSTTEVGDA 360

Query: 1081 IAETVTKILKQ 1113
            I E VTKILK+
Sbjct: 361  IVEAVTKILKE 371


>O94114|LEU2|LEU3_PICST (SP: Pichia stipitis (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 373

 Score =  588 bits (1517), Expect = e-167
 Identities = 296/370 (80%), Positives = 322/370 (87%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MS  TKTITVLPGDHVGTEI NEAIKVL+AIE ATPYQKI F+FKHHLIGGAAID+TGVP
Sbjct: 1    MSTVTKTITVLPGDHVGTEICNEAIKVLEAIEQATPYQKIHFEFKHHLIGGAAIDSTGVP 60

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPDD+L +AK SDAVLLGAVGGPKWGTG VRPEQGLLKIRKELNLYAN+RPCNFASD+LL
Sbjct: 61   LPDDSLAAAKLSDAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFASDALL 120

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            ELSPLK+E+VKGTN  +VRELVGGIYFGERQEQEES D ++AWDTEKY+V EVTRITRMA
Sbjct: 121  ELSPLKSEIVKGTNFTVVRELVGGIYFGERQEQEESADGESAWDTEKYSVAEVTRITRMA 180

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
            AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKV+ EEFP L++QHQLIDSAAMIL+Q+
Sbjct: 181  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVMKEEFPQLTIQHQLIDSAAMILVQS 240

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PTKLNGI+ITSNMFG IISDEASVI                DTN+AFGLYEPCHGSAPDL
Sbjct: 241  PTKLNGIVITSNMFGYIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDL 300

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            P NKVNPIATILS A MLRLSLD +K        V+QVLDSG+RTADLRGT+ST EVG+A
Sbjct: 301  PENKVNPIATILSVAMMLRLSLDSLKEAEALEEAVRQVLDSGVRTADLRGTNSTKEVGEA 360

Query: 1081 IAETVTKILK 1110
            +   VTKILK
Sbjct: 361  VVAGVTKILK 370


>P41926|LEU2|LEU3_YAMOH (SP: Yamadazyma ohmeri (Yeast) (Pichia
            ohmeri)) 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
            (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 368

 Score =  571 bits (1472), Expect = e-162
 Identities = 287/369 (77%), Positives = 318/369 (86%)
 Frame = +1

Query: 7    VKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLP 186
            + TKTITV+PGDHVGTEI +EAIKVLKAIE  +P   ++F+FKHHLIGGAAIDATGVPLP
Sbjct: 1    MSTKTITVVPGDHVGTEICDEAIKVLKAIEKVSP---VKFEFKHHLIGGAAIDATGVPLP 57

Query: 187  DDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLEL 366
            D+ LE+AKSSDAVLLGAVGGPKWGTG VRPEQGLLKIRKELNLYAN+RPCNF SDSLLEL
Sbjct: 58   DETLEAAKSSDAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFVSDSLLEL 117

Query: 367  SPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAF 546
            SPLK+E+VKGTN  +VRELVGGIYFGERQEQEES D ++AWDTEKY+V+EVTRITRMAAF
Sbjct: 118  SPLKSEIVKGTNFTVVRELVGGIYFGERQEQEESSDGQSAWDTEKYSVEEVTRITRMAAF 177

Query: 547  MALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPT 726
            MALQHNPPLPIWSLDKANVLA SRLWRKTVD V+S EFP L VQHQLIDSAAMIL+++P+
Sbjct: 178  MALQHNPPLPIWSLDKANVLALSRLWRKTVDHVMSTEFPQLKVQHQLIDSAAMILVKSPS 237

Query: 727  KLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPA 906
            +LNG+IITSNMFGDIISDEASVI                DTN+AFGLYEPCHGSAPDLPA
Sbjct: 238  QLNGVIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNSAFGLYEPCHGSAPDLPA 297

Query: 907  NKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIA 1086
            NKVNP+ATILS A MLRLSLDC+K        V QVLD+GIRTADLRG+SST EVGDA+A
Sbjct: 298  NKVNPVATILSVAMMLRLSLDCLKEAEALEKAVGQVLDAGIRTADLRGSSSTKEVGDAVA 357

Query: 1087 ETVTKILKQ 1113
              V KIL +
Sbjct: 358  AAVEKILAE 366


>P08791|LEU2|LEU3_PICJA (SP: Pichia jadinii (Yeast) (Candida utilis))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 363

 Score =  533 bits (1372), Expect = e-150
 Identities = 275/364 (75%), Positives = 305/364 (83%)
 Frame = +1

Query: 16   KTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDA 195
            KTI VLPGDHVGTEI  EAIKVLKAIE   P  +I+F+F+HHLIGGAAIDATGVPLPDDA
Sbjct: 4    KTIVVLPGDHVGTEITAEAIKVLKAIEEVKP--EIKFNFQHHLIGGAAIDATGVPLPDDA 61

Query: 196  LESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPL 375
            LE++K +DAVLLGAVGGPKWGTG VRPEQGLLKIRKELNLYAN+RPCNFAS+SLL+LSP+
Sbjct: 62   LEASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFASESLLDLSPI 121

Query: 376  KAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMAL 555
            KAEVVKGT+ ++VRELVGGIYFGER+E + S     A DTE Y+V EV RITRMAAFMAL
Sbjct: 122  KAEVVKGTDFVVVRELVGGIYFGERKEDDGSG---VASDTETYSVPEVQRITRMAAFMAL 178

Query: 556  QHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLN 735
            QHNPPLPIWSLDKANVLASSRLWRK V + I +EFP L+VQHQLIDSAAMILI+ PT+LN
Sbjct: 179  QHNPPLPIWSLDKANVLASSRLWRKVVTETIEKEFPQLTVQHQLIDSAAMILIKYPTQLN 238

Query: 736  GIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANKV 915
            GI+ITSNMFGDIISDEASVI                D+N AFGLYEPCHGSAPDLPANKV
Sbjct: 239  GIVITSNMFGDIISDEASVIPGSLGLLPSASLASLPDSNKAFGLYEPCHGSAPDLPANKV 298

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            NPIATILSAA ML+LSLD  +        VKQVLD+GIRT DL+GT+STTEVGDA+AE V
Sbjct: 299  NPIATILSAAMMLKLSLDLYEEGVAVETAVKQVLDAGIRTGDLKGTNSTTEVGDAVAEAV 358

Query: 1096 TKIL 1107
             KIL
Sbjct: 359  KKIL 362


>Q9HDQ1|LEU2|Q9HDQ1 (TrEMBL: Hansenula anomala (Yeast) (Candida
            pelliculosa)) Beta-isopropylmalate dehydrogenase (EC
            1.1.1.85).
          Length = 364

 Score =  526 bits (1355), Expect = e-148
 Identities = 271/365 (74%), Positives = 300/365 (82%)
 Frame = +1

Query: 16   KTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDA 195
            KTI VLPGDHVGTEI NEAIKVLKAIE   P   ++F+F+HHLIGGAAIDATGVPLPD+A
Sbjct: 4    KTIVVLPGDHVGTEITNEAIKVLKAIEEVRP--NVKFNFQHHLIGGAAIDATGVPLPDEA 61

Query: 196  LESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPL 375
            LE+AK +DAVLLGAVGGPKWGTG VRPEQGLLKIRKELNLYAN+RPCNFAS+SLLELSP+
Sbjct: 62   LEAAKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFASESLLELSPI 121

Query: 376  KAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMAL 555
            KAE  KGT+  +VRELVGGIYFGER+E + S     A DTE Y+V EV RITRMAAFMAL
Sbjct: 122  KAEFAKGTDFTVVRELVGGIYFGERKEDDGSG---VASDTETYSVPEVQRITRMAAFMAL 178

Query: 556  QHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLN 735
            QHNPPLPIWSLDKANVLASSRLWRKTV + I +EFP L+VQHQLIDSAAMILI++PT LN
Sbjct: 179  QHNPPLPIWSLDKANVLASSRLWRKTVTETIEKEFPQLTVQHQLIDSAAMILIKSPTTLN 238

Query: 736  GIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANKV 915
            GI+ITSNMFGDIISDEASVI                DTN AFGLYEPCHGSAPDLPANKV
Sbjct: 239  GIVITSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNKAFGLYEPCHGSAPDLPANKV 298

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            NPIATILSAA ML+LSLD  +        VK+VLD+G+RT DLRG++ST EVGDA  E  
Sbjct: 299  NPIATILSAAMMLKLSLDLFEEGVALEKAVKEVLDAGVRTGDLRGSNSTKEVGDAAVEAA 358

Query: 1096 TKILK 1110
             +ILK
Sbjct: 359  KRILK 363


>Q96WT9|LEU2|LEU3_SACEX (SP: Saccharomyces exiguus (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 365

 Score =  523 bits (1348), Expect = e-147
 Identities = 264/369 (71%), Positives = 301/369 (81%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            M+  TK I VLPGDHVG EI  EAIKVL AI +  P   + FDF+HHLIGGAAIDATGVP
Sbjct: 1    MAQTTKHIVVLPGDHVGQEITEEAIKVLNAISSVRP--NVNFDFQHHLIGGAAIDATGVP 58

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPD+ALE++K +DAVLLGAVGGPKWGTG+VRPEQGLLKIRKEL LYAN+RPCNFASDSLL
Sbjct: 59   LPDEALEASKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLL 118

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            +LSPLK E+VKGT++ IVRELVGGIYFGER+E E       AWD+EKY+V EV RITRMA
Sbjct: 119  DLSPLKPEIVKGTDICIVRELVGGIYFGERKEDEGDG---VAWDSEKYSVSEVQRITRMA 175

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
             F+ALQHNPPLP+WSLDKANVLASSRLWRKTV++ I  EFP L+VQHQLIDSAAMIL++N
Sbjct: 176  GFLALQHNPPLPVWSLDKANVLASSRLWRKTVEETIKNEFPTLTVQHQLIDSAAMILVKN 235

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PT LNG++I +NMFGDIISDEASVI                DTNTAFGLYEPCHGSAPDL
Sbjct: 236  PTHLNGVVIANNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTAFGLYEPCHGSAPDL 295

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            P  KVNP+ATILS A ML+LSL+  +        VKQVLDSG+RTADLRG++ST+EVGDA
Sbjct: 296  PKGKVNPVATILSVAMMLKLSLNMTEEGIAVEKAVKQVLDSGVRTADLRGSNSTSEVGDA 355

Query: 1081 IAETVTKIL 1107
            IA+ V +IL
Sbjct: 356  IAKAVKEIL 364


>P41766|LEU2|LEU3_KLUMA (SP: Kluyveromyces marxianus (Yeast)
            (Kluyveromyces fragilis)) 3-isopropylmalate dehydrogenase
            (EC 1.1.1.85) (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 359

 Score =  520 bits (1338), Expect = e-146
 Identities = 267/365 (73%), Positives = 301/365 (82%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I VLPGDHVGTEI NEAIKVL AI  A P   I+F+F+HHLIGGAAIDATGVPLPD+
Sbjct: 2    SKNIVVLPGDHVGTEITNEAIKVLNAISEARP--SIKFNFEHHLIGGAAIDATGVPLPDE 59

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            A   +K +DAVLLGAVGGPKWGTG+VRPEQGLLKIRKEL LYAN+RPCNFASDSLL+LSP
Sbjct: 60   A---SKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELGLYANLRPCNFASDSLLDLSP 116

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK E  KGT+ ++VRELVGGIYFGER+E E       AWD+EKY+V EV RITRMAAF+A
Sbjct: 117  LKPEYAKGTDFVVVRELVGGIYFGERKEDEGDG---VAWDSEKYSVPEVQRITRMAAFLA 173

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQHNPPLPIWSLDKANVLASSRLWRKTV++ I  EFP L+VQHQLIDSAAMIL+++PTKL
Sbjct: 174  LQHNPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVQHQLIDSAAMILVKSPTKL 233

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NGI+IT+NMFGDIISDEASVI                DTN AFGLYEPCHGSAPDLPANK
Sbjct: 234  NGIVITNNMFGDIISDEASVIPGSLGLLPSASLASLPDTNKAFGLYEPCHGSAPDLPANK 293

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNPIATILSAA ML+LSLD V+        V++VLDSGIRT DL G++STTEVGDA+A+ 
Sbjct: 294  VNPIATILSAAMMLKLSLDLVEEGRAVEEAVRKVLDSGIRTGDLGGSNSTTEVGDAVAKA 353

Query: 1093 VTKIL 1107
            V +IL
Sbjct: 354  VKEIL 358


>O14429|LEU2|LEU3_CANGA (SP: Candida glabrata (Yeast) (Torulopsis
            glabrata)) 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
            (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 365

 Score =  519 bits (1336), Expect = e-146
 Identities = 264/365 (72%), Positives = 296/365 (81%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            TKTI V PGDHVG EI  EA KVL AI+   P  K+ F F HHLIGGA IDATGVPLPD+
Sbjct: 4    TKTIVVPPGDHVGQEITEEANKVLNAIQECRP-DKVNFKFDHHLIGGAPIDATGVPLPDE 62

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            ALE++K +DAVLLGAVGGPKWGTG VRPEQGLLKIRKEL LYAN+RPCNFASDSLL+LSP
Sbjct: 63   ALEASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSP 122

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK E+ +GT+ ++VRELVGGIYFGER+E E       AWD+EKY+V EV RITRMAAFMA
Sbjct: 123  LKPEIARGTDFVVVRELVGGIYFGERKEDEGDG---VAWDSEKYSVPEVQRITRMAAFMA 179

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQHNPPLPIWSLDKANVLASSRLWRKTV++ I  EFP L+VQHQLIDSAAMIL++NPT L
Sbjct: 180  LQHNPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVQHQLIDSAAMILVKNPTHL 239

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NGIIIT+NMFGDIISDEASVI                D NTAFGLYEPCHGSAPDLP  K
Sbjct: 240  NGIIITNNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKGK 299

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNP+ATILSAA ML+LSLD  +        VK+VLDSGIRTADL+GT+STTEVGDA+A+ 
Sbjct: 300  VNPVATILSAAMMLKLSLDLFEEGEIIEQAVKKVLDSGIRTADLKGTNSTTEVGDAVAKA 359

Query: 1093 VTKIL 1107
            V ++L
Sbjct: 360  VRELL 364


>P23390|LEU2|LEU3_KLULA (SP: Kluyveromyces lactis (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 362

 Score =  515 bits (1327), Expect = e-145
 Identities = 261/365 (71%), Positives = 299/365 (81%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I VLPGDHVG E+ +EAIKVL AI    P  +I+F+F+HHLIGGAAIDATG PLPD+
Sbjct: 2    SKNIVVLPGDHVGKEVTDEAIKVLNAIAEVRP--EIKFNFQHHLIGGAAIDATGTPLPDE 59

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            ALE++K +DAVLLGAVGGPKWGTG VRPEQGLLKIRKEL LYAN+RPCNFASDSLL+LSP
Sbjct: 60   ALEASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELGLYANLRPCNFASDSLLDLSP 119

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK E  KGT+ ++VRELVGGIYFGER+E E       AWD+EKY+V EV RITRMAAF+A
Sbjct: 120  LKPEYAKGTDFVVVRELVGGIYFGERKEDEGDG---VAWDSEKYSVPEVQRITRMAAFLA 176

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQ NPPLPIWSLDKANVLASSRLWRKTV++ I  EFP L+VQHQLIDSAAMIL+++PTKL
Sbjct: 177  LQQNPPLPIWSLDKANVLASSRLWRKTVEETIKTEFPQLTVQHQLIDSAAMILVKSPTKL 236

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NG++IT+NMFGDIISDEASVI                DTN AFGLYEPCHGSAPDLPANK
Sbjct: 237  NGVVITNNMFGDIISDEASVIPGSLGLLPSASLASLPDTNKAFGLYEPCHGSAPDLPANK 296

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNPIATILSAA ML+LSLD V+        V+ VLD+G+RT DL G++STTEVGDAIA+ 
Sbjct: 297  VNPIATILSAAMMLKLSLDLVEEGRALEEAVRNVLDAGVRTGDLGGSNSTTEVGDAIAKA 356

Query: 1093 VTKIL 1107
            V +IL
Sbjct: 357  VKEIL 361


>Q01987|LEU2|LEU3_CANBO (SP: Candida boidinii (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 365

 Score =  508 bits (1309), Expect = e-143
 Identities = 261/369 (70%), Positives = 301/369 (81%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MS+  K I +LPGDHVG E+V EA+K+LK+I    P  +IQF F++HLIGGAAIDATGVP
Sbjct: 1    MSIIEKKIVLLPGDHVGVEVVEEAVKILKSISEVKP--EIQFKFENHLIGGAAIDATGVP 58

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
            LPD+ALE+AK SDAVLLGAVGGPKWGTG VRPEQGLLKIRKELNLYAN+RPCNFASD LL
Sbjct: 59   LPDEALEAAKKSDAVLLGAVGGPKWGTGEVRPEQGLLKIRKELNLYANLRPCNFASDKLL 118

Query: 361  ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
            +LSPLK+++VKGT+  +VRELVGGIYFG+R E + S     A D+E Y+V EV RITRMA
Sbjct: 119  DLSPLKSDIVKGTDFTVVRELVGGIYFGDRVEDDGSG---FASDSESYSVPEVERITRMA 175

Query: 541  AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
            AF++LQ++PPLPIWSLDKANVLASSRLWRKTVD+VI EEFP L+VQHQLIDSAAMIL+++
Sbjct: 176  AFLSLQNDPPLPIWSLDKANVLASSRLWRKTVDRVIKEEFPKLTVQHQLIDSAAMILVKS 235

Query: 721  PTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDL 900
            PTKLNGI+IT+NMFGDIISDEASVI                DTN AFGLYEPCHGSAPDL
Sbjct: 236  PTKLNGIVITNNMFGDIISDEASVIPGSLGLLPSASLASLPDTNQAFGLYEPCHGSAPDL 295

Query: 901  PANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDA 1080
            P NKVNPIATILSAA ML+LSL+ VK        V++VLD GI T DL G +STTEVGDA
Sbjct: 296  PKNKVNPIATILSAAMMLKLSLNLVKEGNAVEEAVRKVLDQGIMTGDLGGNNSTTEVGDA 355

Query: 1081 IAETVTKIL 1107
            IA+ V  +L
Sbjct: 356  IAKEVKLLL 364


>P04173|LEU2|LEU3_YEAST (SP: Saccharomyces cerevisiae (Baker's yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 364

 Score =  508 bits (1307), Expect = e-143
 Identities = 261/364 (71%), Positives = 294/364 (80%)
 Frame = +1

Query: 16   KTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDA 195
            K I VLPGDHVG EI  EAIKVLKAI        ++FDF++HLIGGAAIDATGVPLPD+A
Sbjct: 5    KKIVVLPGDHVGQEITAEAIKVLKAISDVR--SNVKFDFENHLIGGAAIDATGVPLPDEA 62

Query: 196  LESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPL 375
            LE++K  DAVLLGAVGGPKWGTG+VRPEQGLLKIRKEL LYAN+RPCNFASDSLL+LSP+
Sbjct: 63   LEASKKVDAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASDSLLDLSPI 122

Query: 376  KAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMAL 555
            K +  KGT+ ++VRELVGGIYFG+R+E +       AWD+E+YTV EV RITRMAAFMAL
Sbjct: 123  KPQFAKGTDFVVVRELVGGIYFGKRKEDDGDG---VAWDSEQYTVPEVQRITRMAAFMAL 179

Query: 556  QHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLN 735
            QH PPLPIWSLDKANVLASSRLWRKTV++ I  EFP L VQHQLIDSAAMIL++NPT LN
Sbjct: 180  QHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVKNPTHLN 239

Query: 736  GIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANKV 915
            GIIITSNMFGDIISDEASVI                D NTAFGLYEPCHGSAPDLP NKV
Sbjct: 240  GIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPDLPKNKV 299

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            +PIATILSAA ML+LSL+  +        VK+VLD+GIRT DL G++STTEVGDA+AE V
Sbjct: 300  DPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDLGGSNSTTEVGDAVAEEV 359

Query: 1096 TKIL 1107
             KIL
Sbjct: 360  KKIL 363


>Q8NKB8|LEU2|Q8NKB8 (TrEMBL: Arxula adeninivorans (Yeast))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85).
          Length = 362

 Score =  503 bits (1296), Expect = e-141
 Identities = 255/366 (69%), Positives = 295/366 (80%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I +L GDHVG E+  EAIKVL+AI  A P   ++F+F H LIGGAAIDATG PLPD+
Sbjct: 2    SKNIIILSGDHVGPEVTAEAIKVLEAITQARP--NVKFNFDHKLIGGAAIDATGSPLPDE 59

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
             LE++K +DAVLLGAVGGPKWGTG VRPEQGLLKIRKELNLYAN+RPCNF S+ LL+LSP
Sbjct: 60   TLEASKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELNLYANLRPCNFMSEKLLDLSP 119

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            L++E+VKGTN  +VRELVGGIYFG R+E E + +   AWDTEKYTV+EV RITRMAAF+A
Sbjct: 120  LRSEIVKGTNFTVVRELVGGIYFGTRKEDEGNGE---AWDTEKYTVEEVKRITRMAAFLA 176

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQ NPPLP+WSLDKANVLASSRLWRKTV + I +EFP L++ HQLIDSAAMILIQNP+K+
Sbjct: 177  LQSNPPLPVWSLDKANVLASSRLWRKTVTETIEKEFPQLTLNHQLIDSAAMILIQNPSKM 236

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NG+I+TSNMFGDIISDEASVI                D NTAFGLYEPCHGSAPDLP NK
Sbjct: 237  NGVIVTSNMFGDIISDEASVIPGSLGLLPSASLSSLPDKNTAFGLYEPCHGSAPDLPPNK 296

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNPIATILSAA MLRLSL+  +        V +V+D+GI TADL+G SSTTEVGDA+A  
Sbjct: 297  VNPIATILSAAMMLRLSLNLKEEADAVEKAVSKVIDNGIVTADLKGASSTTEVGDAVAAE 356

Query: 1093 VTKILK 1110
            V K+LK
Sbjct: 357  VQKLLK 362


>Q9P3Y0|LEU2|Q9P3Y0 (TrEMBL: Zygosaccharomyces bailii)
            Beta-isopropylmalate dehydrogenase (EC 1.1.1.85).
          Length = 362

 Score =  502 bits (1292), Expect = e-141
 Identities = 257/365 (70%), Positives = 294/365 (80%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I VLPGDHVG EI  EAIKVL+AI   +P  K +F+F+HHLIGG+AIDATG PLPD+
Sbjct: 2    SKNIVVLPGDHVGQEIAQEAIKVLEAISEVSP--KAKFNFQHHLIGGSAIDATGSPLPDE 59

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            AL +AK +DAVLLGAVGGPKWGTG VRPEQGLLKIRKEL LYAN+RPCNFAS+SLLELSP
Sbjct: 60   ALAAAKKADAVLLGAVGGPKWGTGAVRPEQGLLKIRKELQLYANLRPCNFASESLLELSP 119

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK +  +GT+ I+VRELVGGIYFG+R+E +       AWD+E+YT  EV RITRMAAF+A
Sbjct: 120  LKPQHARGTDFIVVRELVGGIYFGQRKEDDGDG---VAWDSERYTKPEVQRITRMAAFLA 176

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQHNPPLPIWSLDKANVLASSRLWRKTV++ I  EFP L+V+HQLIDSAAMILI+NPT+L
Sbjct: 177  LQHNPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPQLTVKHQLIDSAAMILIKNPTQL 236

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NGIIITSNMF DIISDEASVI                DTN AFGLYEPCHGSAPDLP  K
Sbjct: 237  NGIIITSNMFEDIISDEASVIPGSLGLLPSASLASLPDTNEAFGLYEPCHGSAPDLPKGK 296

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNP+A ILSAA ML+LSL+  K        VKQVLDSG+RT DL G++ST+EVGDAIA+ 
Sbjct: 297  VNPVAMILSAAMMLKLSLNMAKEGEALETAVKQVLDSGVRTGDLGGSNSTSEVGDAIAKA 356

Query: 1093 VTKIL 1107
            V +IL
Sbjct: 357  VKQIL 361


>Q96WI0|LEU2|Q96WI0 (TrEMBL: Zygosaccharomyces rouxii (Candida mogii))
            Isopropylmalate dehydrogenase.
          Length = 362

 Score =  500 bits (1288), Expect = e-140
 Identities = 255/365 (69%), Positives = 292/365 (80%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I VLPGDH G EI  EAIKVL+AI   +P  K  F+F+HHLIGGAAIDATG PLPDD
Sbjct: 2    SKNIVVLPGDHAGQEIAQEAIKVLEAISEVSPEAK--FNFQHHLIGGAAIDATGSPLPDD 59

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            AL +AK +DAVLLGAVGGPKWGTG+VRPEQGLLKIRKEL LYAN+RPCNFAS+SLL+LSP
Sbjct: 60   ALAAAKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELQLYANLRPCNFASESLLDLSP 119

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK +  KGT+ ++VRELVGGIYFGER+E E       AWD+EKYT  EV R+TRMAAF+A
Sbjct: 120  LKPQHAKGTDFVVVRELVGGIYFGERKEDEGDG---VAWDSEKYTKPEVQRLTRMAAFLA 176

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQHNPPLPIWSLDKANVLASSRLWRKTV++ I  EFP L + HQLIDSAAMIL+++PT+L
Sbjct: 177  LQHNPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPQLKLNHQLIDSAAMILVKSPTQL 236

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NGI++TSN+FGDIISDEASVI                DTN AFGLYEPCHGSAPDLP  K
Sbjct: 237  NGIVLTSNLFGDIISDEASVIPGSLGLLPSASLASLPDTNEAFGLYEPCHGSAPDLPKGK 296

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNPIA ILSAA ML+LSL+  K        VKQVLDSG+RT DL G++ST+EVGDAIA+ 
Sbjct: 297  VNPIAMILSAAMMLKLSLNLSKEGEAVEKAVKQVLDSGVRTGDLGGSNSTSEVGDAIAKA 356

Query: 1093 VTKIL 1107
            V +IL
Sbjct: 357  VKEIL 361


>Q9HDQ5|LEU2|Q9HDQ5 (TrEMBL: Candida rugosa (Yeast) (Candida
            cylindracea)) Putative beta-isopropylmalate dehydrogenase
            (EC 1.1.1.85).
          Length = 359

 Score =  496 bits (1276), Expect = e-139
 Identities = 253/363 (69%), Positives = 291/363 (80%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K+I +LPGDHVGTE+V EA+KVLKAIE  TP     F F  HLIGGAAIDATGVPLPD+
Sbjct: 2    SKSIVLLPGDHVGTEVVAEAVKVLKAIERTTP--GTSFSFSTHLIGGAAIDATGVPLPDE 59

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            ALE+AK+SDAVLLGAVGGPKWGTG VRPEQGLLKIRKEL LYAN+RPC+FAS  L++LSP
Sbjct: 60   ALEAAKASDAVLLGAVGGPKWGTGDVRPEQGLLKIRKELGLYANLRPCSFASSKLVDLSP 119

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK E+V+GT+ ++VRELVGGIYFGER+E + S     A DTE Y+V EV RITRMAAF+A
Sbjct: 120  LKREIVEGTDFVVVRELVGGIYFGERKEDDGSG---VASDTETYSVPEVERITRMAAFLA 176

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQHNPP  +WSLDKANVLASSRLWRKTV +V++EEFP +  QHQLIDSAAMIL+Q PTKL
Sbjct: 177  LQHNPPQTVWSLDKANVLASSRLWRKTVTRVMTEEFPTVPFQHQLIDSAAMILVQKPTKL 236

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NG+++TSNMFGDIISDEASVI                DTNTAFGLYEPCHGSAPDLPA K
Sbjct: 237  NGVVLTSNMFGDIISDEASVIPGSLGLLPSASLASLPDTNTAFGLYEPCHGSAPDLPAGK 296

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNP+A ILSAA MLRLSLD           V++V+DSG+ TADL G+SST EVGDAI + 
Sbjct: 297  VNPLACILSAAMMLRLSLDNAAAADRIEQAVREVIDSGVATADLGGSSSTGEVGDAIVKA 356

Query: 1093 VTK 1101
            + K
Sbjct: 357  LEK 359


>P34733|LEU2|LEU3_PICAN (SP: Pichia angusta (Yeast) (Hansenula
            polymorpha)) 3-isopropylmalate dehydrogenase (EC
            1.1.1.85) (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 362

 Score =  489 bits (1258), Expect = e-137
 Identities = 249/366 (68%), Positives = 295/366 (80%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I +LPGDHVG E+V EA+KVL+A+ +A     ++F+F  HLIGGA+IDA GVPL D+
Sbjct: 2    SKNIVLLPGDHVGPEVVAEAVKVLEAVSSAIG---VKFNFSKHLIGGASIDAYGVPLSDE 58

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            ALE+AK +DAVLLGAVGGPKWGTG+VRPEQGLLKIRKELNLYAN+RPC+FASD+LL+LSP
Sbjct: 59   ALEAAKKADAVLLGAVGGPKWGTGSVRPEQGLLKIRKELNLYANLRPCSFASDALLKLSP 118

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK+E+VKGT+ ++VRELVGGIYFG+R+E         A DTE Y+V EV RITRMAAF+A
Sbjct: 119  LKSEIVKGTDFVVVRELVGGIYFGDRKEDAGDG---VASDTESYSVPEVQRITRMAAFLA 175

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            LQ +PPLP+WSLDKANVLASSRLWRKTV++ I  EFP L+VQHQLIDSAAMIL+++PTKL
Sbjct: 176  LQSDPPLPLWSLDKANVLASSRLWRKTVEETIKNEFPQLTVQHQLIDSAAMILVKSPTKL 235

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANK 912
            NG+I+T+NMFGDIISDEASVI                DTN AFGLYEPCHGSAPDL   K
Sbjct: 236  NGVIVTNNMFGDIISDEASVIPGSLGLLPSASLASLPDTNKAFGLYEPCHGSAPDLGPGK 295

Query: 913  VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAET 1092
            VNP+ATILSAA ML+LSLD V         VK VLD+GI TADL G+SST EVGDA+A+ 
Sbjct: 296  VNPLATILSAAMMLKLSLDLVDAGRAIEQAVKNVLDAGIMTADLGGSSSTQEVGDAVAQE 355

Query: 1093 VTKILK 1110
            V K+LK
Sbjct: 356  VAKLLK 361


>O60027|LEU2|LEU3_ASHGO (SP: Ashbya gossypii (Yeast) (Eremothecium
            gossypii)) 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
            (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 372

 Score =  467 bits (1202), Expect = e-130
 Identities = 232/368 (63%), Positives = 283/368 (76%)
 Frame = +1

Query: 16   KTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDA 195
            K I VLPGDH+G E+V EA+KVL A+E +     + FDF++HL+GGAAIDATG  LPD+A
Sbjct: 5    KRIVVLPGDHIGREVVEEAVKVLGAVEQSL--SDVHFDFQYHLVGGAAIDATGSALPDEA 62

Query: 196  LESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPL 375
            L +AK +DAVLLGAVGGPKW  G VRPEQGLLK+R+EL +YAN+RPCNFA+DSLLELSPL
Sbjct: 63   LGAAKEADAVLLGAVGGPKWQGGAVRPEQGLLKLRQELGVYANLRPCNFAADSLLELSPL 122

Query: 376  KAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMAL 555
            + E+ + T++++VREL+GG YFGER E E       AWDT+KYTV EV RI RMA F+AL
Sbjct: 123  RPEIARDTDIMVVRELLGGSYFGERHEDEGDG---VAWDTDKYTVKEVQRIARMAGFLAL 179

Query: 556  QHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLN 735
            QH+PPLP+WSLDKANVLASSRLWRKTV++    EFP + +QHQLIDSAAMIL++NP   N
Sbjct: 180  QHDPPLPVWSLDKANVLASSRLWRKTVEETFQSEFPNVQLQHQLIDSAAMILVKNPRAFN 239

Query: 736  GIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPANKV 915
            G+++TSNMFGDIISDEASVI                D+ +AFGLYEPCHGSAPDLPA K 
Sbjct: 240  GVVVTSNMFGDIISDEASVIPGSLGLLPSASLASLPDSKSAFGLYEPCHGSAPDLPAGKA 299

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            NPI  ILSAA ML+LSL+ V         V++VLDSG+RT DL G+SST+EVGDAIA  V
Sbjct: 300  NPIGCILSAAMMLKLSLNMVAAGEAVEQAVQEVLDSGVRTGDLLGSSSTSEVGDAIALAV 359

Query: 1096 TKILKQNT 1119
             + L++ +
Sbjct: 360  KEALRRQS 367


>Q12592|LEU2|Q12592 (TrEMBL: Candida maltosa (Yeast))
           3-isopropylmalate dehydrogenase (EC 1.1.1.85).
          Length = 251

 Score =  444 bits (1142), Expect = e-124
 Identities = 221/244 (90%), Positives = 232/244 (95%)
 Frame = +1

Query: 1   MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
           MSVKTKTIT+LPGDHVGTEIVNEAIKVL+AIEAATPYQKI FDFKHHLIGGAAIDATGVP
Sbjct: 1   MSVKTKTITILPGDHVGTEIVNEAIKVLEAIEAATPYQKIHFDFKHHLIGGAAIDATGVP 60

Query: 181 LPDDALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLL 360
           LPDDALESAK+SDAVLLGAVGGPKWGTG +RPEQGLLKIRKELNLYANIRPCNFASDSLL
Sbjct: 61  LPDDALESAKNSDAVLLGAVGGPKWGTGALRPEQGLLKIRKELNLYANIRPCNFASDSLL 120

Query: 361 ELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMA 540
           ELSPL+ EVVKGTNLIIVRELVGGIYFG+R+EQEESEDK+TAWDTEKYTVDEVTRITRMA
Sbjct: 121 ELSPLRPEVVKGTNLIIVRELVGGIYFGDREEQEESEDKQTAWDTEKYTVDEVTRITRMA 180

Query: 541 AFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQN 720
           AFMALQHNPPLPIWSLDKANVLASSRLWR+TVDKVISEEFP LSVQHQLIDSA       
Sbjct: 181 AFMALQHNPPLPIWSLDKANVLASSRLWRRTVDKVISEEFPTLSVQHQLIDSACHDFNSK 240

Query: 721 PTKL 732
           P ++
Sbjct: 241 PNQI 244


>Q877A9||Q877A9 (TrEMBL: Aspergillus oryzae) Hypothetical protein.
          Length = 364

 Score =  400 bits (1027), Expect = e-110
 Identities = 202/365 (55%), Positives = 264/365 (72%), Gaps = 2/365 (0%)
 Frame = +1

Query: 22   ITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDALE 201
            I V  GDH G E+  EAIKVL+A+E     + + F+ + HL+GGA+IDATG PL D+AL 
Sbjct: 6    IVVFGGDHCGPEVTAEAIKVLRAVEKN---RDVTFNLQDHLLGGASIDATGSPLTDEALN 62

Query: 202  SAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPLKA 381
            +AK++DAVLLGA+GGPKWGTG VRPEQG+LK+RKE+  + N+RPCNFA+ SL+E SPL+A
Sbjct: 63   AAKNADAVLLGAIGGPKWGTGAVRPEQGILKLRKEMGTFGNLRPCNFAAPSLVESSPLRA 122

Query: 382  EVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMALQH 561
            +V +G N  I+REL GGIYFGER+E + S     A DTE Y+  E+ RI R+AA +ALQH
Sbjct: 123  DVCRGVNFNIIRELTGGIYFGERKEDDGS---GYAMDTEPYSRAEIERIIRLAAHLALQH 179

Query: 562  NPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLNGI 741
            +PPLP+WSLDKANVLA+SRLWRK V +V+++EFP L ++HQLIDSAAMI+++NP +LNGI
Sbjct: 180  DPPLPVWSLDKANVLATSRLWRKVVTEVMAKEFPQLKIEHQLIDSAAMIMVKNPRQLNGI 239

Query: 742  IITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAF-GLYEPCHGSAPDLPANK-V 915
            ++TSN+FGDIISDEASVI                D N+   G+YEP HGSAPD+     V
Sbjct: 240  VVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGNSKVNGIYEPIHGSAPDIAGKGIV 299

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            NP+A ILS A M++ S             V  V++SG+RT D+ G ++T EVGDA+A  +
Sbjct: 300  NPVAAILSVAMMMQYSFGLFAEARAIEQAVSNVIESGVRTGDIGGKATTAEVGDAVAAEL 359

Query: 1096 TKILK 1110
             K+LK
Sbjct: 360  EKLLK 364


>P18120|LEU2|LEU3_YARLI (SP: Yarrowia lipolytica (Candida lipolytica))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 405

 Score =  395 bits (1014), Expect = e-109
 Identities = 212/364 (58%), Positives = 261/364 (71%), Gaps = 7/364 (1%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            +K I +L GD  G E++ EA+KVLK++  A+     +F F+  LIGGAAI+  G P+ D 
Sbjct: 12   SKKIVLLGGDFCGPEVIAEAVKVLKSVAEASG---TEFVFEDRLIGGAAIEKEGEPITDA 68

Query: 193  ALESAKSSDAVLLGAVGGPK---W----GTGTVRPEQGLLKIRKELNLYANIRPCNFASD 351
             L+  + +D+++LGAVGG     W    G   VRPEQGLLK+RK+LNLYAN+RPC   S 
Sbjct: 69   TLDICRKADSIMLGAVGGAANTVWTTPDGRTDVRPEQGLLKLRKDLNLYANLRPCQLLSP 128

Query: 352  SLLELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRIT 531
             L +LSP++   V+GT+ IIVRELVGGIYFGER+E + S     A DTE Y+V EV RI 
Sbjct: 129  KLADLSPIRN--VEGTDFIIVRELVGGIYFGERKEDDGSG---VASDTETYSVPEVERIA 183

Query: 532  RMAAFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMIL 711
            RMAAF+ALQHNPPLP+WSLDKANVLASSRLWRKTV +V+ +EFP L + HQLIDSAAMIL
Sbjct: 184  RMAAFLALQHNPPLPVWSLDKANVLASSRLWRKTVTRVLKDEFPQLELNHQLIDSAAMIL 243

Query: 712  IQNPTKLNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSA 891
            I+ P+K+NGIIIT+NMFGDIISDEASVI                DTN AFGLYEPCHGSA
Sbjct: 244  IKQPSKMNGIIITTNMFGDIISDEASVIPGSLGLLPSASLASLPDTNEAFGLYEPCHGSA 303

Query: 892  PDLPANKVNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEV 1071
            PDL   KVNPIATILSAA ML+ SL+           VK+ +++GI TAD+ G+SST+EV
Sbjct: 304  PDLGKQKVNPIATILSAAMMLKFSLNMKPAGDAVEAAVKESVEAGITTADIGGSSSTSEV 363

Query: 1072 GDAI 1083
            GD +
Sbjct: 364  GDLL 367


>P34738|LEU-1|LEU3_NEUCR (SP: Neurospora crassa) 3-isopropylmalate
            dehydrogenase (EC 1.1.1.85) (Beta-IPM dehydrogenase)
            (IMDH) (3-IPM-DH).
          Length = 368

 Score =  387 bits (994), Expect = e-106
 Identities = 206/369 (55%), Positives = 260/369 (70%), Gaps = 3/369 (0%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            T  I V  GDH G E+V EAIKVLKAIE  +P    +F+ ++HL+GGA+ID    PL D+
Sbjct: 3    THNIVVFGGDHCGPEVVLEAIKVLKAIETNSP-SACKFNLQNHLLGGASIDKHNDPLTDE 61

Query: 193  ALESAKSSDAVLLGAVGGPKWGTG-TVRPEQGLLKIRKELNLYANIRPCNFASDSLLELS 369
            AL +AK++DAVLLGA+GGP+WGT  TVRPEQGLLK+RKEL  Y N+RPCNFAS+SL++ S
Sbjct: 62   ALNAAKAADAVLLGAIGGPEWGTSSTVRPEQGLLKLRKELGTYGNLRPCNFASESLVDSS 121

Query: 370  PLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFM 549
            PLKAEV +GT+ I+VREL GGIYFG+R E + S     A DTE Y+  E+ RI R+A F+
Sbjct: 122  PLKAEVCRGTDFIVVRELTGGIYFGDRTEDDGSG---YACDTEPYSRAEIVRIARLAGFL 178

Query: 550  ALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTK 729
            AL  N P  +WSLDKANVLA+SRLWRKTV  VIS+E P L ++HQLIDSAAM+L++NP  
Sbjct: 179  ALAKNSPAKVWSLDKANVLATSRLWRKTVTDVISKECPQLQLEHQLIDSAAMLLVKNPRA 238

Query: 730  LNGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNT-AFGLYEPCHGSAPDLPA 906
            LNG++ITSN+FGDIISDEASVI                D      G+YEP HGSAPD+  
Sbjct: 239  LNGVVITSNLFGDIISDEASVIPGSIGLLPSASWGGIPDGKVKCNGIYEPIHGSAPDISG 298

Query: 907  NK-VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAI 1083
               VNP+ TILS A MLR SL+  K        VK  +D+G +T DL G ++T+++G+A+
Sbjct: 299  KGIVNPVCTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDLGGNATTSDMGNAV 358

Query: 1084 AETVTKILK 1110
               + KILK
Sbjct: 359  VAELEKILK 367


>P87256|LEU2A|LE3A_ASPNG (SP: Aspergillus niger) 3-isopropylmalate
            dehydrogenase A (EC 1.1.1.85) (Beta-IPM dehydrogenase A)
            (IMDH A) (3-IPM-DH A).
          Length = 363

 Score =  380 bits (977), Expect = e-104
 Identities = 198/365 (54%), Positives = 256/365 (70%), Gaps = 2/365 (0%)
 Frame = +1

Query: 22   ITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDALE 201
            I V  GDH G E+  EAIKVL+ IE +     I  + + HL+GGA+IDAT  PL D+AL 
Sbjct: 6    IVVFAGDHWGPEVTAEAIKVLRVIEKSR--DDITLNLQDHLLGGASIDATANPLTDEALA 63

Query: 202  SAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPLKA 381
            +AK++DAVLLGA+GGPKWGTG VRPEQGLL +RKE+  + N+RPCNFA+ SL+E SPLKA
Sbjct: 64   AAKNADAVLLGAIGGPKWGTGAVRPEQGLLNVRKEMGTFGNLRPCNFAAPSLVEHSPLKA 123

Query: 382  EVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMALQH 561
             V +G +  I+REL GGIYFG+R++   +       DTE Y+  E+ RIT   A +ALQH
Sbjct: 124  SVCEGVDFNIIRELTGGIYFGDRKKMTAA----ATMDTEPYSRAEIERIT-PRAHLALQH 178

Query: 562  NPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLNGI 741
            NPPLP+WSLDKANVLA+SRLWRKTV +++++EFP L ++HQLIDSAAMI+++NP +LNGI
Sbjct: 179  NPPLPVWSLDKANVLATSRLWRKTVTEIMAKEFPQLKIEHQLIDSAAMIMVKNPRQLNGI 238

Query: 742  IITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXD-TNTAFGLYEPCHGSAPDLPANK-V 915
            I+TSN+FGDIISDEASVI                D      G+YEP HGSAPD+     V
Sbjct: 239  IVTSNLFGDIISDEASVIPGSLGLLPSASLSGIPDGKGRVNGIYEPIHGSAPDIAGKGIV 298

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            NP+A ILS A M++ S             V+ VL+SG+RT D+ G ++T+EVGDA+A  +
Sbjct: 299  NPVAAILSVAMMMQYSFGRFDEARAIEAAVRNVLESGVRTGDIGGKATTSEVGDAVAAEL 358

Query: 1096 TKILK 1110
             K+LK
Sbjct: 359  EKLLK 363


>Q9P8C1|LEUA|Q9P8C1 (TrEMBL: Phaeosphaeria nodorum (Septoria nodorum))
            3-isopropylmalate dehydrogenase (EC 1.1.1.85).
          Length = 365

 Score =  378 bits (970), Expect = e-104
 Identities = 198/366 (54%), Positives = 253/366 (69%), Gaps = 2/366 (0%)
 Frame = +1

Query: 22   ITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDALE 201
            I VL GD VG E+V EA K+LK +E  T      F+F+ HL GG +IDA   PL D+AL 
Sbjct: 6    IVVLAGDGVGPEVVAEAFKILKVVEKHTDNT---FNFQEHLFGGCSIDAHNNPLTDEALA 62

Query: 202  SAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPLKA 381
            +AK +DA++LGAVGGPKWGTG VRPEQG+LK+RKEL  + N+RPC FASDSL++ SPLKA
Sbjct: 63   AAKGADAIILGAVGGPKWGTGKVRPEQGILKLRKELGTFGNLRPCFFASDSLVDSSPLKA 122

Query: 382  EVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMALQH 561
            E V+G N  I+REL GGIYFGER+E +E + K  A DTE Y+V+E+ R+ R+A  +A   
Sbjct: 123  ENVRGVNFNIIRELTGGIYFGERKE-DEGDGK--AMDTEPYSVEEIERVVRLAGSLASAE 179

Query: 562  NPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLNGI 741
            NPP+P+WSLDKANVLA+SRLWRKT ++++ +E+P L     LIDSAAM++I+NP  LNG+
Sbjct: 180  NPPVPVWSLDKANVLATSRLWRKTFERIMKDEYPHLKSGTHLIDSAAMLMIKNPRALNGV 239

Query: 742  IITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXDTNTAF-GLYEPCHGSAPDLPANK-V 915
            ++TSN+FGDIISDEASVI                D  T   G+YEP HGSAPD+     V
Sbjct: 240  VVTSNLFGDIISDEASVIPGSLGLLPSASLGGIPDGKTKLNGIYEPIHGSAPDIAGQGIV 299

Query: 916  NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIAETV 1095
            NPIATILS + M + SL   +         K  +D G+RT D+ GTS T EVGDAIA  +
Sbjct: 300  NPIATILSISMMFKYSLCLPELALKIDEATKITIDKGVRTGDIGGTSKTAEVGDAIAAEL 359

Query: 1096 TKILKQ 1113
              +LK+
Sbjct: 360  ETLLKK 365


>Q9Y897|LEUC|LEU3_MYCGR (SP: Mycosphaerella graminicola (Septoria
            tritici)) 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
            (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 365

 Score =  373 bits (958), Expect = e-102
 Identities = 193/368 (52%), Positives = 251/368 (68%), Gaps = 2/368 (0%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            T  I V  GDH G E+  EA+KVL  I+ +     + F+ + HL+GGA+IDA G PL D+
Sbjct: 3    TYNIVVFGGDHCGPEVTAEALKVLDVIDNSNA--DVHFNIQPHLLGGASIDAHGEPLTDE 60

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
            AL +AK++DAV+LGA+GGPKWGTG VRPEQG+L++RKE+  Y N+RPC FAS+SL++ SP
Sbjct: 61   ALAAAKAADAVILGAIGGPKWGTGKVRPEQGILRLRKEMGTYGNLRPCFFASESLVKTSP 120

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            LK EV +G N  IVREL GGIYFGER E + S     A DTE Y+  E+ R+ R+A F+A
Sbjct: 121  LKEEVCRGVNFNIVRELTGGIYFGERTEDDGS---GYAVDTEPYSRAEIERVARLAGFLA 177

Query: 553  LQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKL 732
            L  +PP P+WSLDKANV+A+SRLWRKTV  V + EFP L + H LIDSAAM++++NP  L
Sbjct: 178  LAEDPPCPVWSLDKANVMATSRLWRKTVTDVFANEFPQLKIGHHLIDSAAMLMVKNPRAL 237

Query: 733  NGIIITSNMFGDIISDEASVIXXXXXXXXXXXXXXXXD-TNTAFGLYEPCHGSAPDLPAN 909
            NG+I+TSN+FGDIISDEASVI                D  +   G+YEP HGSAPD+   
Sbjct: 238  NGVIVTSNLFGDIISDEASVIPGSLGLLPSASLTASPDGKSKCNGIYEPIHGSAPDISGK 297

Query: 910  K-VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDSGIRTADLRGTSSTTEVGDAIA 1086
              VNP+A ILS   M + SL   +        V+ V++ GI TAD+ G++ T EVGDAIA
Sbjct: 298  GIVNPVAMILSLGMMCKYSLQQPELAKKIDEAVRNVIEKGINTADIGGSAKTAEVGDAIA 357

Query: 1087 ETVTKILK 1110
            + +  +LK
Sbjct: 358  KELEALLK 365


>P18869|LEU1|LEU3_SCHPO (SP: Schizosaccharomyces pombe (Fission
            yeast)) 3-isopropylmalate dehydrogenase (EC 1.1.1.85)
            (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 371

 Score =  345 bits (886), Expect = 4e-94
 Identities = 185/373 (49%), Positives = 246/373 (65%), Gaps = 9/373 (2%)
 Frame = +1

Query: 16   KTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDDA 195
            K I VLPGDH+G EIV  A++VLK +E   P  K++F+   H IGGA+IDA G PL D+ 
Sbjct: 4    KKIVVLPGDHIGPEIVASALEVLKVVEKKRPELKLEFE--EHKIGGASIDAYGTPLTDET 61

Query: 196  LESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSPL 375
            +++   +D VLLGAVGGP+W     RPEQGLLK+RK + ++AN+RPCNFAS SL++ SPL
Sbjct: 62   VKACLEADGVLLGAVGGPEWTNPNCRPEQGLLKLRKSMGVWANLRPCNFASKSLVKYSPL 121

Query: 376  KAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMAL 555
            K E+V+G +  +VREL GG YFGER E   S     A DT  Y+++EV+RI R+AA++A 
Sbjct: 122  KPEIVEGVDFCVVRELTGGCYFGERTEDNGS---GYAMDTWPYSLEEVSRIARLAAWLAE 178

Query: 556  QHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQNPTKLN 735
              NPP P+  LDKANVLA+SRLWRKTV K+  EE+P L++++QLIDSAAM+L+++P  LN
Sbjct: 179  TSNPPAPVTLLDKANVLATSRLWRKTVAKIFKEEYPHLTLKNQLIDSAAMLLVKSPRTLN 238

Query: 736  GIIITSNMFGDIISDEASVI--XXXXXXXXXXXXXXXXDTNTAFGLYEPCHGSAPDLPAN 909
            G+++T N+FGDIISDEASVI                         L EP HGSAPD+   
Sbjct: 239  GVVLTDNLFGDIISDEASVIPGSLGLLPSASLSGVVGKSEEKVHCLVEPIHGSAPDIAGK 298

Query: 910  K-VNPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDS------GIRTADLRGTSSTTE 1068
              VNP+ TILSA+ +LR  L+  K        V++VLD       G+ T DL G +ST +
Sbjct: 299  GIVNPVGTILSASLLLRYGLNAPKEAEAIEAAVRKVLDDTSIGGRGLYTRDLGGEASTAD 358

Query: 1069 VGDAIAETVTKIL 1107
            +  A+ E + KIL
Sbjct: 359  ITKAVVEELEKIL 371


>O59930|LEU2|LEU3_PHACH (SP: Phanerochaete chrysosporium)
            3-isopropylmalate dehydrogenase (EC 1.1.1.85) (Beta-IPM
            dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 380

 Score =  317 bits (811), Expect = 2e-85
 Identities = 179/383 (46%), Positives = 236/383 (61%), Gaps = 14/383 (3%)
 Frame = +1

Query: 1    MSVKTKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVP 180
            MS +T  I +LPGD +G E+V EA +VL+ + A++    ++   + H  GG +ID  G P
Sbjct: 1    MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASS--SDVEIKLETHDFGGCSIDKHGEP 58

Query: 181  LPDDALESAKSSDAVLLGAVGGPKWGTGT-VRPEQGLLKIRKELNLYANIRPCNFASDSL 357
            L    LE+ K +DA+LLGA+GGPKWG  + VRPEQ LL +RK L LYANIRP NFASDSL
Sbjct: 59   LTAATLEACKLADAILLGAIGGPKWGVNSKVRPEQALLALRKALGLYANIRPANFASDSL 118

Query: 358  LELSPLKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRM 537
            L  SPLK  V +G ++I++REL+GG YFGER+E      +  AWDT  Y+V EV RITR 
Sbjct: 119  LAYSPLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRS 178

Query: 538  AAFMALQHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILIQ 717
               +A   +PPLP+ S+DKANVLASSRLWRK   + I  EFP L + H L+DSA+M+++ 
Sbjct: 179  RRQVA-SPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVA 237

Query: 718  NPTKLNGIIITSNMFGDIISDEASVI-XXXXXXXXXXXXXXXXDTNTAF------GLYEP 876
            NP KLNG+I+T N+FGDI+SDE+SVI                   NTA        +YEP
Sbjct: 238  NPKKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEP 297

Query: 877  CHGSAPDLPANKV-NPIATILSAASML---RLSLDCVKXXXXXXXXVKQVLD--SGIRTA 1038
             HGSAPD+    + NPI TILSAA +     +     K         ++  D   G+RTA
Sbjct: 298  IHGSAPDIAGQGIANPIGTILSAAMLCGTRSVWRSPAKAIEAAVEGARRQGDRREGLRTA 357

Query: 1039 DLRGTSSTTEVGDAIAETVTKIL 1107
            DL G+S T ++G  + E +   L
Sbjct: 358  DLGGSSKTKDIGHKVVEILKATL 380


>Q12545|LEU2|LEU3_CEPAC (SP: Cephalosporium acremonium (Acremonium
            chrysogenum)) 3-isopropylmalate dehydrogenase (EC
            1.1.1.85) (Beta-IPM dehydrogenase) (IMDH) (3-IPM-DH).
          Length = 380

 Score =  294 bits (752), Expect = 1e-78
 Identities = 162/380 (42%), Positives = 229/380 (60%), Gaps = 14/380 (3%)
 Frame = +1

Query: 13   TKTITVLPGDHVGTEIVNEAIKVLKAIEAATPYQKIQFDFKHHLIGGAAIDATGVPLPDD 192
            T  I VLPGDH+G EI+ EAIKVL  IE   P   + F+    L+GG +ID  GVP+   
Sbjct: 4    TYKILVLPGDHIGPEIMAEAIKVLTTIETHRP--NLHFNLTTDLVGGTSIDTHGVPITQS 61

Query: 193  ALESAKSSDAVLLGAVGGPKWGTGTVRPEQGLLKIRKELNLYANIRPCNFASDSLLELSP 372
             L++AK+SDAVL G++GGP+W      PE GLL++R+ L+ +AN+RPC F   SL+  SP
Sbjct: 62   VLDAAKASDAVLFGSIGGPEWAGVHPTPESGLLQLRQHLDAFANLRPCEFLVPSLVGASP 121

Query: 373  LKAEVVKGTNLIIVRELVGGIYFGERQEQEESEDKKTAWDTEKYTVDEVTRITRMAAFMA 552
            ++  VVKGT  I+VRE  GG YFGE++E+E+      A D   YT  E+ R+ R++A +A
Sbjct: 122  IREHVVKGTRFIVVRENCGGAYFGEKKEEED-----VASDLWVYTRPEIERLARVSAAVA 176

Query: 553  L------QHNPPLPIWSLDKANVLASSRLWRKTVDKVISEEFPALSVQHQLIDSAAMILI 714
                     N    +WS DKANVLAS RLWR+    + ++EFP +++QHQL DS AM+++
Sbjct: 177  RIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSMAMLMV 236

Query: 715  QNPTKLNGIIITSNMFGDIISDEASVIXXXXXXX-XXXXXXXXXDTNTAFGLYEPCHGSA 891
            ++P + NG+I T N FGDI+SD +  I                 + + + G+YEP HGSA
Sbjct: 237  RDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEPVHGSA 296

Query: 892  PDLPANKV-NPIATILSAASMLRLSLDCVKXXXXXXXXVKQVLDS------GIRTADLRG 1050
            PD+    + NP+A ILS A MLR S+   K        V +VLD+       IRT DL G
Sbjct: 297  PDISGKGLANPVAQILSVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRTGDLGG 356

Query: 1051 TSSTTEVGDAIAETVTKILK 1110
             ++ ++VGDA+ E +  +L+
Sbjct: 357  RATCSQVGDAVCEVLGPLLQ 376


  Database: sptrembl
    Posted date:  Oct 14, 2003  6:47 PM
  Number of letters in database: 339,323,595
  Number of sequences in database:  1,070,300
  
Lambda     K      H
   0.315    0.133    0.373 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 300,296,063
Number of Sequences: 1070300
Number of extensions: 5900984
Number of successful extensions: 20432
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 18675
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 19277
length of database: 339,323,595
effective HSP length: 123
effective length of database: 207,676,695
effective search space used: 51711497055
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)