BLASTX 2.2.6 [Apr-09-2003]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Candida_albicans_chr7-r1-126245-122844-21
         (3399 letters)

Database: sptrembl 
           1,070,300 sequences; 339,323,595 total letters

Searching.................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

P50942|YNL106C|YNK6_YEAST (SP: Saccharomyces cerevisiae (Baker's...   777   0.0  
Q12271|INP53|Q12271 (TrEMBL: Saccharomyces cerevisiae (Baker's y...   775   0.0  
O43001|SPBC2G2.02|O43001 (TrEMBL: Schizosaccharomyces pombe (Fis...   594   e-168
P40559|YIL002C|YIA2_YEAST (SP: Saccharomyces cerevisiae (Baker's...   445   e-123
Q8I7P4||Q8I7P4 (TrEMBL: Dictyostelium discoideum (Slime mold)) I...   405   e-111
O94984|KIAA0910|O94984 (TrEMBL: Homo sapiens (Human)) Hypothetic...   385   e-105
O43426|SYNJ1|SYJ1_HUMAN (SP: Homo sapiens (Human)) Synaptojanin ...   385   e-105
Q8CHC4|MKIAA0910|Q8CHC4 (TrEMBL: Mus musculus (Mouse)) MKIAA0910...   384   e-105
Q62910|SYNJ1|SYJ1_RAT (SP: Rattus norvegicus (Rat)) Synaptojanin...   382   e-104
O18964|SYNJ1|SYJ1_BOVIN (SP: Bos taurus (Bovine)) Synaptojanin 1...   381   e-104
Q9USQ6|SPBC577.13|Q9USQ6 (TrEMBL: Schizosaccharomyces pombe (Fis...   374   e-102
Q8IZA8||Q8IZA8 (TrEMBL: Homo sapiens (Human)) Synaptojanin 2A.        372   e-101
O15056|SYNJ2|SYJ2_HUMAN (SP: Homo sapiens (Human)) Synaptojanin ...   372   e-101
Q9H226||Q9H226 (TrEMBL: Homo sapiens (Human)) Synaptojanin 2.         372   e-101
Q9XUD3|JC8.10|Q9XUD3 (TrEMBL: Caenorhabditis elegans) JC8.10a pr...   371   e-101
Q9W296|SYNAPTOJANIN|Q9W296 (TrEMBL: Drosophila melanogaster (Fru...   370   e-101
Q9GT42|JC8.10|Q9GT42 (TrEMBL: Caenorhabditis elegans) Synaptojan...   366   e-100
Q91ZD8||Q91ZD8 (TrEMBL: Rattus norvegicus (Rat)) Synaptojanin 2B2.    358   3e-97
Q91ZD9||Q91ZD9 (TrEMBL: Rattus norvegicus (Rat)) Synaptojanin 2B1.    358   3e-97
O55207|SYNJ2|SYJ2_RAT (SP: Rattus norvegicus (Rat)) Synaptojanin...   358   3e-97
O88399|SYNJ2|O88399 (TrEMBL: Mus musculus (Mouse)) Synaptojanin ...   356   1e-96
Q9DGN7||Q9DGN7 (TrEMBL: Lampetra fluviatilis (River lamprey)) Sy...   352   1e-95
Q8MR94|SYNAPTOJANIN|Q8MR94 (TrEMBL: Drosophila melanogaster (Fru...   309   2e-82
Q9D2G5|SYNJ2|Q9D2G5 (TrEMBL: Mus musculus (Mouse)) Synaptojanin 2.    278   2e-73
O60162|SPBC19F5.03|O60162 (TrEMBL: Schizosaccharomyces pombe (Fi...   209   2e-52
P32368|RSD1|RSD1_YEAST (SP: Saccharomyces cerevisiae (Baker's ye...   206   1e-51
Q8MRH8|CG7956|Q8MRH8 (TrEMBL: Drosophila melanogaster (Fruit fly...   203   1e-50
Q9VD98|CG7956|Q9VD98 (TrEMBL: Drosophila melanogaster (Fruit fly...   203   1e-50
Q86AE0||Q86AE0 (TrEMBL: Dictyostelium discoideum (Slime mold)) S...   202   2e-50
Q93641|F30A10.6|Q93641 (TrEMBL: Caenorhabditis elegans) F30A10.6...   201   4e-50

>P50942|YNL106C|YNK6_YEAST (SP: Saccharomyces cerevisiae (Baker's
            yeast)) Hypothetical 133.3 kDa protein in CYB5-LEU4
            intergenic region.
          Length = 1183

 Score =  777 bits (2006), Expect = 0.0
 Identities = 428/927 (46%), Positives = 590/927 (63%), Gaps = 28/927 (3%)
 Frame = +1

Query: 7    LLYKEHPRTLVLYSDTFSLSFRIKSSKELDSKKPTVNVDLIPNTNITKEQGYRTLIRRDV 186
            LL K+  R + + S+T  L FR  +SK  +S++ T  V+L+P   +    G+R L   ++
Sbjct: 4    LLSKQQTRKIAIVSETHGLVFRPINSK--NSRRSTCAVELVPKAELNGN-GFRRLSNHEI 60

Query: 187  FGCLGLIYVEDQIYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVELDSSGY 366
            +G +GLI +E  +++A ITG  + VA+PI N+TV+KIY+VDF  LNN  WDF+++DSSGY
Sbjct: 61   YGFIGLIEIEGLMFIATITGK-SKVAQPIPNKTVNKIYAVDFFCLNNSKWDFMDIDSSGY 119

Query: 367  PIVVNE-------------EQXXXXXXITSDRYARVQ-----HPCFELRKLLSNGSFYYS 492
            PIV N+                      +S R    Q     HPC ELRKLLSNGSFYYS
Sbjct: 120  PIVTNDGDFAISSPPSISTHSSRSSLRSSSSRSLNAQEQAPKHPCHELRKLLSNGSFYYS 179

Query: 493  NDFDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNR 672
             DFDLT  LQ RG +       S D +  E+MWNSFLMDE+I +R  LD   + +LD   
Sbjct: 180  TDFDLTCTLQKRGFTEHSL---SFDDFDREFMWNSFLMDEIITYRDRLDVTAKELLDQRG 236

Query: 673  FLTTVIRGFAKT--TPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIY 846
            FLTTVIRGFA+T  + I      LTIIS+QSWKRAGTR+N RGIDD+G+VANFVETE I 
Sbjct: 237  FLTTVIRGFAETIFSYINRLKVGLTIISRQSWKRAGTRFNARGIDDDGHVANFVETEMIM 296

Query: 847  YNPSKSSIFTFTQIRGSVPTFWEQDSSLMNPKITLTRSTQATQPVFNKHFGDILQSYGVC 1026
            Y  S    + FTQIRGS+P FWEQD+SL++PKI +TRS +ATQP F++HF  + + YG  
Sbjct: 297  Y--SSQYCYAFTQIRGSLPIFWEQDTSLISPKIQITRSVEATQPTFDEHFIRLFKKYGPV 354

Query: 1027 HIVDLLSKTKSSEVQISQRYQQLYNHCDKKE---EIDYTAFDFHHETKIAGGFAGATKIL 1197
            HI++LLS TKSSE+Q+S+RY++   + +K +   ++  T+FDFH ET    GFA A++I+
Sbjct: 355  HIINLLS-TKSSEIQLSRRYKEQLKNSEKMKIGRDVFLTSFDFHRETS-QDGFAAASRII 412

Query: 1198 PYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQ 1377
            P +++++   G+F+YD+    +I+ QDG+FR NCLDCLDRTNLI+Q I  +V +  L + 
Sbjct: 413  PKIRNTILDAGYFSYDVKEGRLISEQDGVFRTNCLDCLDRTNLIQQTISLAVFKLFLEDF 472

Query: 1378 GIYNNRMAFEG--MIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTK 1551
             +       +    +QK N LWADNGD ISQIYTGTNALKSS+SR GKM+F+GALSD TK
Sbjct: 473  RLVKPSSFIDDNEFVQKVNALWADNGDQISQIYTGTNALKSSYSRKGKMSFSGALSDATK 532

Query: 1552 SVSRMYQNTFVDGKKQLTIDILVGVDGRNSCKVKVYNPASEYIKSKLKEQENSFTSFENV 1731
            SVSRMY N FVD  KQ  ID L+G        V++Y+P  EY+  +L E E  FT+  N+
Sbjct: 533  SVSRMYINNFVDKGKQQNIDTLLGKLPHQQV-VELYDPICEYVNERLLESEEKFTTHSNI 591

Query: 1732 KIFTGTYNVNAFNPLMTKNIDLTSWLFPSSVQNGDGSLPDMYAIGLQELIELNASSILNA 1911
             +F GT+NVN      ++  DL+ WLFP     GD   PD+  +GLQE+IEL A SILNA
Sbjct: 592  NLFVGTFNVNG----NSRRADLSKWLFPI----GDKFKPDVVVLGLQEVIELTAGSILNA 643

Query: 1912 DGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYVTRVAGSSKKT 2091
            D +++  W  ++ + LN  Q +E+Y+LLR E ++++ +  + +  +   +  V GS+KKT
Sbjct: 644  DYTKSSFWETMVTDCLN--QYEEKYLLLRVEQMSSLLILFFARSDRAYNIKEVGGSTKKT 701

Query: 2092 GLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQGLVFPRNYYIK 2271
            G GG+  NKGA  IR  +G TSF FV  HL+AG   + ER NDY+ I + + FPR+  I 
Sbjct: 702  GFGGITGNKGAVAIRFDYGATSFCFVNTHLSAGASNIDERRNDYNNIYRNITFPRSKTIP 761

Query: 2272 DHDHVIWFGDLNYRIDIPNLECRQLV---ANGAYKELLENDQLTRERRDRGAFNEFKEGL 2442
             HD + W GDLNYRI + N E R+ +    +G    LL+ DQLT+E  +   F  FKE  
Sbjct: 762  HHDSLFWLGDLNYRITLTNDEVRRELRAQKDGYIDRLLQYDQLTQEINEGVVFQGFKEPT 821

Query: 2443 VKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSAIDVLYSD 2622
            ++F PTYK+D  T++YDTSEK RTPSWTDR+++  +              D+ + +  SD
Sbjct: 822  LQFRPTYKYDYGTDNYDTSEKARTPSWTDRIIYKGENLHPLAYS------DAPLKI--SD 873

Query: 2623 HKAVYASFETTAKIINEQIKKNKLNEI 2703
            HK VYA++    K ++E+ K N + ++
Sbjct: 874  HKPVYAAYRANVKFVDEKEKLNLVEKL 900


>Q12271|INP53|Q12271 (TrEMBL: Saccharomyces cerevisiae (Baker's
            yeast)) YOR3231W from chromosome XV.
          Length = 1107

 Score =  775 bits (2002), Expect = 0.0
 Identities = 419/897 (46%), Positives = 580/897 (64%), Gaps = 10/897 (1%)
 Frame = +1

Query: 16   KEHPRTLVLYSDTFSLSFRIKSSKELDSKKPTVNVDLIPNTNITKEQGYRTLIRRDVFGC 195
            +E  R L + S+ ++L  +    K  D  KP   ++L+   ++ K+ G++ L   ++FG 
Sbjct: 7    EEPERRLAIVSNLYALVLKPVGKKPSD--KPLCAIELLQKNDL-KKYGFKRLTSHEIFGV 63

Query: 196  LGLIYVEDQIYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVELDSSGYPIV 375
            +GLI V   +++  ITG  + VA+P   ETV+KI++VDF  LN++ WDF+E+DSSGYP++
Sbjct: 64   IGLIEVNGLLFVGAITGK-SKVAQPCPGETVNKIFAVDFFCLNDNSWDFIEIDSSGYPVL 122

Query: 376  VNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSNDFDLTSLLQNRGVSSPDTRI 555
                        T  + A  +HPC+EL+KLLSNGSFYYS+DFDLTS LQ+RG        
Sbjct: 123  PETAS-------TEYQDALPKHPCYELKKLLSNGSFYYSSDFDLTSTLQHRGYGQHSL-- 173

Query: 556  NSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIRGFAKT--TPIGSNG 729
             S D Y+ EYMWNSFLM E+I +R +LDT  + ILDD  FLTTVIRGFA+T  + +    
Sbjct: 174  -STDTYEEEYMWNSFLMQEMITYRDHLDTNLKQILDDEGFLTTVIRGFAETFVSYVKKLK 232

Query: 730  DSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIFTFTQIRGSVPTF 909
             +LTIISKQSWKRAGTR+N RG+DD  NVANFVETE+I Y  S    + FTQIRGS+P F
Sbjct: 233  VALTIISKQSWKRAGTRFNARGVDDEANVANFVETEFIMY--SSQYCYAFTQIRGSIPVF 290

Query: 910  WEQDSSLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQ 1089
            WEQ +SL+NP++ +TRS +ATQPVF+KH    ++ YG  H+V+LLS TKSSE+++S+RY+
Sbjct: 291  WEQGTSLINPRVQITRSFEATQPVFDKHIMKSVEKYGPVHVVNLLS-TKSSEIELSKRYK 349

Query: 1090 QLYNHCDK---KEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQE 1260
            +   H  K    ++I  T FDFH ET    GF+G  K++P + DSL   G+++YD+  ++
Sbjct: 350  EHLTHSKKLNFNKDIFLTEFDFHKETS-QEGFSGVRKLIPLILDSLLSSGYYSYDVREKK 408

Query: 1261 VITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIY--NNRMAFEGMIQKHNTL 1434
             I+ Q GIFR NCLDCLDRTNL +Q+I  +     L +  +   N+ +  +  + KHNTL
Sbjct: 409  NISEQHGIFRTNCLDCLDRTNLAQQIISLAAFRTFLEDFRLISSNSFIDDDDFVSKHNTL 468

Query: 1435 WADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDI 1614
            WAD+GD ISQIYTGTNALKSSFSR GKM+ AGALSD TKSVSR+Y N F+D +KQ  ID 
Sbjct: 469  WADHGDQISQIYTGTNALKSSFSRKGKMSLAGALSDATKSVSRIYINNFMDKEKQQNIDT 528

Query: 1615 LVGVDGRNSCKVKVYNPASEYIKSKLKEQENSFTSFENVKIFTGTYNVNAFNPLMTKNID 1794
            L+G        V++Y+P +EY+ +KL+   + FTS  N+ +  G++NVN      TK +D
Sbjct: 529  LLGRLPYQKA-VQLYDPVNEYVSTKLQSMSDKFTSTSNINLLIGSFNVNG----ATKKVD 583

Query: 1795 LTSWLFPSSVQNGDGSLPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQM 1974
            L+ WLFP     G+   PD+  +GLQE+IEL+A SILNAD S++  W  L+ + LN  Q 
Sbjct: 584  LSKWLFPI----GEKFKPDIVVLGLQEVIELSAGSILNADYSKSSFWENLVGDCLN--QY 637

Query: 1975 DEEYVLLRTESIATMALFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTT 2154
            D++Y+LLR E + ++ +  +VK  K  YV +V G++KKTG  GMA NKGA  IR  +G T
Sbjct: 638  DDKYLLLRVEQMTSLLILFFVKADKAKYVKQVEGATKKTGFRGMAGNKGAVSIRFEYGAT 697

Query: 2155 SFAFVTCHLAAGTLAVTERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLE 2334
            SF FV  HLAAG   V ER +DY +I++G+ F R   I  HD + W GD+NYRI++PN +
Sbjct: 698  SFCFVNSHLAAGATNVEERRSDYESIVRGITFTRTKMIPHHDSIFWLGDMNYRINLPNED 757

Query: 2335 CRQLVAN---GAYKELLENDQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEK 2505
             R+ + N   G   +LL  DQLT        F  FKE  +KF PTYK+D  T  YD+SEK
Sbjct: 758  VRRELLNQEEGYIDKLLHFDQLTLGINSGSVFEGFKEPTLKFRPTYKYDPGTGTYDSSEK 817

Query: 2506 QRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSAIDVLYSDHKAVYASFETTAKIINEQ 2676
            +RTPSWTDR+++  +               S   ++ SDH+ VYA++      ++++
Sbjct: 818  ERTPSWTDRIIYKGENLLPLSY--------SDAPIMISDHRPVYAAYRAKITFVDDK 866


>O43001|SPBC2G2.02|O43001 (TrEMBL: Schizosaccharomyces pombe (Fission
            yeast)) Phosphatidylinositol phosphate phosphatase,
            synaptojanin-like.
          Length = 1076

 Score =  594 bits (1532), Expect = e-168
 Identities = 349/909 (38%), Positives = 518/909 (56%), Gaps = 8/909 (0%)
 Frame = +1

Query: 1    MKLLYKEHPRTLVLYSDTFSLSFRIKSSKELDSKKPTVNVDLIPNTNITKE--QGYRTLI 174
            M+ L +E PR+L L +   +L F       +   K +++V +   T ++++  +G+R + 
Sbjct: 1    MQCLLREKPRSLALVNKDHALMFH-----SVPQNKNSLSVCVAEFTALSEKPLEGFRKIS 55

Query: 175  RRDVFGCLGLIYVEDQIYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVELD 354
               ++G LGLI +E   +L +I+GA + VAR  + E V +I  V F S+N  +WD +  +
Sbjct: 56   SHRIYGTLGLIELEGSNFLCVISGA-SEVARVRDKERVFRIMEVCFYSVNRSNWDHIRQE 114

Query: 355  SSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSNDFDLTSLLQNRGV 534
            +    I    +          D Y     P   LRKLL+NGSFY+S DFD+T+ LQ R  
Sbjct: 115  NYSPDIPDGYDTDTQGY----DSYKYAAEPFSSLRKLLTNGSFYFSLDFDITTRLQLR-- 168

Query: 535  SSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIRGFAKTTP 714
            +S        D    ++MWN F++ +LI FRS+L+   +  LD  RF T  IRGFA T  
Sbjct: 169  TSQTMTEPQYDSMHTQFMWNEFMLRQLIKFRSHLNGDEKSALDGCRFFTCAIRGFASTEQ 228

Query: 715  --IGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIFTFTQI 888
              +G     L++IS+ S  RAGTR+ +RG+DD+GNVANFVETE I    S     ++ Q+
Sbjct: 229  FKLGIQTIRLSLISRLSSLRAGTRFLSRGVDDDGNVANFVETETIL--DSSKYCVSYCQV 286

Query: 889  RGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSKTKSSE 1065
            RGS+P FWEQ+   +   KI +TRS +AT+  F KHF  +++ YG  HI++LL  T S E
Sbjct: 287  RGSIPIFWEQEGVQMFGQKIDITRSLEATRAAFEKHFTSLIEEYGPVHIINLLG-TGSGE 345

Query: 1066 VQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFGWFTYD 1245
              +S+R +Q      +K+ I  T FD+H + +    F  A KI P +      FG++ ++
Sbjct: 346  RSLSERLRQHIQLSPEKDLIHLTEFDYHSQIR---SFEDANKIRPMIYSDAETFGFY-FE 401

Query: 1246 MNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAFEGMIQKH 1425
             N  + I  QDG+FR NCLDCLDRTN+I+ ++ R  LE ++    IY  + A     Q H
Sbjct: 402  NNEGQSIVVQDGVFRTNCLDCLDRTNVIQNLVSRVFLEQVM----IYTRQNAGYDFWQVH 457

Query: 1426 NTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQLT 1605
            +T+WA+NGDA+++IYTGT ALKSSF+R GK++ AGAL+D++KSV RMY N F D  +Q T
Sbjct: 458  STIWANNGDALARIYTGTGALKSSFTRKGKLSIAGALNDLSKSVGRMYINNFQDKGRQET 517

Query: 1606 IDILVG--VDGRNSCKVKVYNPASEYIKSKLKEQENSFTSFENVKIFTGTYNVNAFNPLM 1779
            ID+L+G  +D      V +Y+P  EY+  +L+++EN F+  +NVKIF  +YN+N      
Sbjct: 518  IDLLLGRLIDQH---PVILYDPIHEYVNHELRKRENEFSEHKNVKIFVASYNLNG----C 570

Query: 1780 TKNIDLTSWLFPSSVQNGDGSLPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQL 1959
            +    L +WLFP +       L D+Y +G QE+++L    +++AD ++  +W   +   L
Sbjct: 571  SATTKLENWLFPENTP-----LADIYVVGFQEIVQLTPQQVISADPAKRREWESCVKRLL 625

Query: 1960 NS-FQMDEEYVLLRTESIATMALFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIR 2136
            N        YV LR+  +   AL ++ K+S +  +  V G+ KKTGLGG++ NKGA  IR
Sbjct: 626  NGKCTSGPGYVQLRSGQLVGTALMIFCKESCLPSIKNVEGTVKKTGLGGVSGNKGAVAIR 685

Query: 2137 CLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRI 2316
              +  T   F+T HLAAG     ER +DY TI  GL F R   I +HD+V+WFGD NYRI
Sbjct: 686  FDYEDTGLCFITSHLAAGYTNYDERDHDYRTIASGLRFRRGRSIFNHDYVVWFGDFNYRI 745

Query: 2317 DIPNLECRQLVANGAYKELLENDQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDT 2496
             +   E    +A G    L E DQL ++      F  F E  + FPPTYKFD  T+ YDT
Sbjct: 746  SLTYEEVVPCIAQGKLSYLFEYDQLNKQMLTGKVFPFFSELPITFPPTYKFDIGTDIYDT 805

Query: 2497 SEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSAIDVLYSDHKAVYASFETTAKIINEQ 2676
            S+K R P+WTDR+L+  +                ++ + YSDH+ +YA++E     ++ +
Sbjct: 806  SDKHRVPAWTDRILYRGELVPHSY---------QSVPLYYSDHRPIYATYEANIVKVDRE 856

Query: 2677 IKKNKLNEI 2703
             KK    E+
Sbjct: 857  KKKILFEEL 865


>P40559|YIL002C|YIA2_YEAST (SP: Saccharomyces cerevisiae (Baker's
            yeast)) Hypothetical 108.4 kDa protein in BET1-PAN1
            intergenic region.
          Length = 946

 Score =  445 bits (1145), Expect = e-123
 Identities = 279/917 (30%), Positives = 462/917 (50%), Gaps = 23/917 (2%)
 Frame = +1

Query: 1    MKLLYKEHPRTLVLYSDTFSLSFR-------IKSSKELDSKKPTVNVDLIPNTNITKEQG 159
            M+L      R++V+ S+ + LSF+         S +   SK P+V +   P+T+++ +  
Sbjct: 1    MRLFIGRRSRSIVISSNNYCLSFQRLRSIPGASSQQRQLSKTPSVTIKSYPDTDLSSDSN 60

Query: 160  YRTLIRRDVFGCLGLIYVEDQIYLAIITGA----------LTNVARPIENETVDKIYSVD 309
            Y  +      G LGL+ +   IY+A+I+G           + +  RP  +E++ K+  VD
Sbjct: 61   YLEVKSCIFNGLLGLVCLNGDIYVAVISGVQNVGFPRWKLIDHQVRP--SESIYKVLDVD 118

Query: 310  FVSLNNDDWDFV--ELDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSF 483
            F SL ND +D++  E     Y  +++E                  HPC  L+KL S+G+F
Sbjct: 119  FYSLENDVFDYLLCERSEQNYDKLIHE------------------HPCGPLKKLFSDGTF 160

Query: 484  YYSNDFDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILD 663
            YYS DFD++++++N G+S       ++D+    ++WN+ L  E+I++RS +    + +  
Sbjct: 161  YYSRDFDISNIVKNHGLSH--NLEYTVDNQDLSFIWNANLASEVINWRSKISNEEKQLFA 218

Query: 664  DNRFLTTVIRGFAKTTPI--GSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETE 837
            +  FLT VIRG+ KT  I  G N  S+TIIS+ S +         GI ++G V+ FVETE
Sbjct: 219  NAGFLTFVIRGYCKTALIEDGPNTASITIISRISTESKQDTLELEGISEDGRVSLFVETE 278

Query: 838  YIYYNPSKSSIFTFTQIRGSVPTFWEQDSS--LMNPKITLTRSTQATQPVFNKHFGDILQ 1011
             +    ++  IF++TQ+ GS+P FWE   S  L   KI +T+ +   Q  F++HF ++  
Sbjct: 279  IVV--TTEKFIFSYTQVNGSIPLFWESVESQLLYGKKIKVTKDSIEAQGAFDRHFDNLTS 336

Query: 1012 SYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATK 1191
             YGV  IV+++     S+ +++  Y+     C + + I  T  ++              K
Sbjct: 337  KYGVVSIVNIIKPKSESQEKLALTYKD----CAESKGIKITNIEYSSSVLTKSPH----K 388

Query: 1192 ILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILT 1371
            +L  L+  +  FG F YD++R     +Q G+ R++  D +++ N +E+++ + VLE    
Sbjct: 389  LLYLLKQDIYEFGAFAYDISRGIYFAKQTGVLRISAFDSIEKPNTVERLVSKEVLELTTN 448

Query: 1372 NQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTK 1551
               ++     F   +  H+ LW++N   + + YT           SGK          TK
Sbjct: 449  EIDVFELTSPF---LDAHDKLWSENYYWLDRTYT------KHTKNSGKY---------TK 490

Query: 1552 SVSRMYQNTFVDGKKQLTIDILVGVDGRNSCKVKVYNPASEYIKSKLKEQENSFTSFENV 1731
              S+++ +                       +V++Y+P   YI   LK+  + +T  +++
Sbjct: 491  VYSKLFGS-----------------------RVRLYDPLHIYISQYLKQLRSKYTFEKDI 527

Query: 1732 KIFTGTYNVNAFNPLMTKNIDLTSWLFPSSVQNGDGSLPDMYAIGLQELIELNASSILNA 1911
             IF GT+N++   P      D+  W+FP S+   D  + D+Y IGL+E++EL    +L  
Sbjct: 528  SIFAGTFNISGKIP----KDDIKDWIFPKSMSKED-EMADLYVIGLEEVVELTPGHMLAT 582

Query: 1912 DGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYVTRVAGSSKKT 2091
            D      W + +   LN     ++Y+ L +  +  + L L++ +++ S V  + G  KKT
Sbjct: 583  DPYVRQFWEKKILTLLNGPGRKKKYIRLWSTQLGGILLLLFMNETEYSKVKHIEGDVKKT 642

Query: 2092 GLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQGLVFPRNYYIK 2271
            G GGMA+NKGA  +   +  T F  +  HLAAG   V +R+NDY TI + + F +   IK
Sbjct: 643  GFGGMASNKGAVAVSFKYSATRFCVLVSHLAAGLENVEQRHNDYKTIAKSIRFSKGLRIK 702

Query: 2272 DHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRGAFNEFKEGLVKF 2451
            DHD +IW GD NYRI + N + R+ + +  Y  L E DQL ++     +F  F E  + F
Sbjct: 703  DHDAIIWMGDFNYRILMSNEDVRRKIVSKEYASLFEKDQLNQQMIAGESFPYFHEMAIDF 762

Query: 2452 PPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSAIDVLYSDHKA 2631
            PPTYKFD  T +YDTSEK R P+WTDR+L   +             Y    D+L+SDH+ 
Sbjct: 763  PPTYKFDPGTKNYDTSEKMRIPAWTDRILSRGE-------VLEQLEYKCCEDILFSDHRP 815

Query: 2632 VYASFETTAKIINEQIK 2682
            VYA F     +++EQ K
Sbjct: 816  VYAIFRARVTVVDEQKK 832


>Q8I7P4||Q8I7P4 (TrEMBL: Dictyostelium discoideum (Slime mold))
            Inositol 5-phosphatase 3.
          Length = 1379

 Score =  405 bits (1040), Expect = e-111
 Identities = 294/944 (31%), Positives = 455/944 (48%), Gaps = 64/944 (6%)
 Frame = +1

Query: 64   SFRIKSSKELDSKKPTVN------VDLIPNTNITKEQGYRTLIRRDVFGCLGLIYVEDQI 225
            SF IK    L SK   +N      +D+I    I  +Q  R+   R V+  LG+  + ++ 
Sbjct: 14   SFIIKRDS-LHSKALVINRRDPSKIDIIQPDQI--DQSLRS--ERSVYCVLGIFRLVNEC 68

Query: 226  YLAIITGA--LTNVARPIENETVDKIYSVDFVSLNNDDWDFVELDSSGYPIVVNEEQXXX 399
            YL ++T +    N     +   + KI   DF+S              G     N E    
Sbjct: 69   YLVVVTESDIAANFQFQGQPNVIRKIRCTDFISFQTGRGHISIGGGGGGGGSGNGESKE- 127

Query: 400  XXXITSDRYARVQHPCFELRKLLSNGSFYYS---NDFDLTSLLQNRGVSSPDTRINSIDH 570
                  DR      P  ++  LL++G FY++   + FD+T   Q++ +  P + +   + 
Sbjct: 128  -----DDR------PYVQVMNLLNSGHFYWTPPNSSFDITRTYQSQCLE-PKSDLPVWER 175

Query: 571  YKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIRGFAKTTPIGS-NGDSL--T 741
                + WN +L  + I +R          L D  F   +I+GF  +  +G   G ++  T
Sbjct: 176  VDKRFYWNKYLQKDFIAYR----------LYDWCF--PIIQGFVVSDHLGHIQGKNVVYT 223

Query: 742  IISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIFTFTQIRGSVPTFWEQD 921
            +IS++S  RAGTR+ TRGIDD+GNVANF E+E I    S   +  F QIRGSVP FW Q 
Sbjct: 224  LISRRSRFRAGTRFVTRGIDDDGNVANFCESEQILSIESYG-VLAFLQIRGSVPVFWNQS 282

Query: 922  SSLMNP-----------------KITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSK 1050
            S  M+                  KIT+ R+TQAT P F  H  +  + YG   IV+LLSK
Sbjct: 283  SPQMSDLKIKMSNLSKIGKISKKKITIARNTQATTPAFQLHLKEQTKKYGNIVIVNLLSK 342

Query: 1051 TKSSEVQISQRYQQ----------LYNHCDKKEEIDYTAFD-------FHHETKIAGGFA 1179
             KS E  +   Y++           YNH D  E+      D       +     I+GG  
Sbjct: 343  LKSGECDLVNAYEEQIRILRSPQVFYNHFDLNEQTKGNRMDPLDSLINYIDNQSISGG-G 401

Query: 1180 GATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLE 1359
            G T  +     S  + G+F  + N Q +I++Q+GI R NC DCLDRTN+++  +   + E
Sbjct: 402  GTTGGV-----SEKIVGYFFQNSNGQ-IISKQNGIIRTNCKDCLDRTNIVQSRVSWVLFE 455

Query: 1360 NILTNQGIYNNRMA---FEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAG 1530
            + L   G++    +   +  + Q   T WADNGDA+S  Y G+ +LKS+ +R G     G
Sbjct: 456  SQLRKLGLFRGHDSIGSYPRVSQTLKTTWADNGDALSIQYAGSGSLKSTLTREGDYGIMG 515

Query: 1531 ALSDVTKSVSRMYQNTFVDGKKQLTIDILVGVDGRNSCKVKVYNPAS-----------EY 1677
             L+D  K+++R Y N F D  +Q  +D+L+G+    S  V   N  +           + 
Sbjct: 516  MLADGKKTMTRFYINNFEDPGRQDVLDLLLGL--HKSMVVNNSNNGNGGNGGNGSGHDDN 573

Query: 1678 IKSKLKEQENSFTSFENVKIFTGTYNVNAFNPLMTKNIDLTSWLFPSSVQNGDGSLPDMY 1857
            I+ +++++   ++  E   +F GTYNV   +   +   DL  WL P      +   PD Y
Sbjct: 574  IRKQVQDRVKEYSKKEWRNVFVGTYNVGGVH---SSYFDLVQWLRPDGA---NCPTPDFY 627

Query: 1858 AIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYV 2037
             +GLQE++EL A  IL  D S   QW   +   L     + +Y+ L++  +  + + +YV
Sbjct: 628  VLGLQEVVELTAGQILATDSSIGKQWEDAIERALPKVSPNVKYIKLQSSQLVGLLMAIYV 687

Query: 2038 KKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYN 2217
            ++  + Y   V   + K G+ G+A NKG  G+R LF  TSF FVT H AAG   V +R +
Sbjct: 688  REDAIHYFREVQIQNVKCGMNGLAGNKGGIGVRLLFSDTSFTFVTAHFAAGQSNVEDRIS 747

Query: 2218 DYSTIMQGLVFPR--NYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQL 2391
            D+  I   L F R   + + D D+  W GD N+RID+P+ E R+ V +  + +L   DQL
Sbjct: 748  DFREIDSTLAFGRQGQFKVSDSDYSFWLGDFNFRIDLPDEEIRRCVYDQQFPKLYNYDQL 807

Query: 2392 TRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXX 2571
             +       FN ++E  + FPPTYK+D  +  YDTS+KQR+P+WTDR+++          
Sbjct: 808  RKCMEAGRVFNGYREETIAFPPTYKYDLNSTQYDTSQKQRSPAWTDRIVW-----SNKVH 862

Query: 2572 XXXXXXYDSAIDVLYSDHKAVYASFETTAKIINEQIKKNKLNEI 2703
                  Y    ++L SDH+ V + F+     I++  ++    E+
Sbjct: 863  HDLRQLYYHRQEILASDHRPVSSYFQLEVTKIDKDKERTLRQEL 906


>O94984|KIAA0910|O94984 (TrEMBL: Homo sapiens (Human)) Hypothetical
            protein KIAA0910 (Fragment).
          Length = 1315

 Score =  385 bits (990), Expect = e-105
 Identities = 263/823 (31%), Positives = 403/823 (48%), Gaps = 36/823 (4%)
 Frame = +1

Query: 181  DVFGCLGLIYVE--DQI--YLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +G LG++ +   D +  YL ++TG ++     I+   V ++ S +F+SL  D  D   
Sbjct: 94   DAYGLLGVLRLNLGDTMLHYLVLVTGCMS--VGKIQESEVFRVTSTEFISLRIDSSD--- 148

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS-----NDFDLTS 513
                                   DR +       E+RK+L++G+FY++        DL S
Sbjct: 149  ----------------------EDRIS-------EVRKVLNSGNFYFAWSASGISLDL-S 178

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
            L  +R +    T           + WN  L   L H+  N D +   ++     + T+  
Sbjct: 179  LNAHRSMQEQTT--------DNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYA 230

Query: 694  GFAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIF 873
               +            +IS+ S +RAGTR+N RG +D+G+VANFVETE + Y     S+ 
Sbjct: 231  AHKQA--------KACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY--LDDSVS 280

Query: 874  TFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSK 1050
            +F QIRGSVP FWEQ    + + ++ ++R  +A  P F++HF  +   YG   IV+LL  
Sbjct: 281  SFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLG- 339

Query: 1051 TKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFG 1230
            +K  E  +S+ +Q      +   +I    FD+H   K        + + P +Q  L+ +G
Sbjct: 340  SKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD-YG 398

Query: 1231 WFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAFEG 1410
            +F +  N  EV   Q G  R NCLDCLDRTN ++  +   +L   L   G+         
Sbjct: 399  FFYF--NGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 456

Query: 1411 MIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDG 1590
              +   ++W+ NGD+IS+IY GT AL+              L D  +SV+R  QN F D 
Sbjct: 457  FQEVFRSMWSVNGDSISKIYAGTGALEGK----------AKLKDGARSVTRTIQNNFFDS 506

Query: 1591 KKQLTIDILVGVDGRNS----------------CKVKVYNPASEYIKSKLKEQENSFTSF 1722
             KQ  ID+L+  +  NS                   +    AS  +   + E    ++  
Sbjct: 507  SKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKP 566

Query: 1723 ENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPS-------SVQNGDGSLPDMYAIGLQ 1872
            + +++  GT+NVN    F  +  KN  LT WL  +         Q+      D++AIG +
Sbjct: 567  KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFE 626

Query: 1873 ELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKV 2052
            E++ELNA +I++A  +    W+  L + ++    D +YVLL +E +  + LF++++    
Sbjct: 627  EMVELNAGNIVSASTTNQKLWAVELQKTISR---DNKYVLLASEQLVGVCLFVFIRPQHA 683

Query: 2053 SYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTI 2232
             ++  VA  + KTG+GG   NKGA  IR LF TTS  FV  H AAG   V ER  D+  I
Sbjct: 684  PFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEI 743

Query: 2233 MQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDR 2412
             + L FP    +  HD+V W GD NYRID+PN E ++L+    +  L+  DQL  ++   
Sbjct: 744  ARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAG 803

Query: 2413 GAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
              F  F EG V F PTYK+D +++DYDTSEK RTP+WTDRVL+
Sbjct: 804  QVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLW 846


>O43426|SYNJ1|SYJ1_HUMAN (SP: Homo sapiens (Human)) Synaptojanin 1 (EC
            3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate
            5-phosphatase 1).
          Length = 1575

 Score =  385 bits (989), Expect = e-105
 Identities = 263/823 (31%), Positives = 403/823 (48%), Gaps = 36/823 (4%)
 Frame = +1

Query: 181  DVFGCLGLIYVE--DQI--YLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +G LG++ +   D +  YL ++TG ++     I+   V ++ S +F+SL  D  D   
Sbjct: 58   DAYGLLGVLRLNLGDTMLHYLVLVTGCMS--VGKIQESEVFRVTSTEFISLRIDSSD--- 112

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS-----NDFDLTS 513
                                   DR +       E+RK+L++G+FY++        DL S
Sbjct: 113  ----------------------EDRIS-------EVRKVLNSGNFYFAWSASGISLDL-S 142

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
            L  +R +    T           + WN  L   L H+  N D +   ++     + T+  
Sbjct: 143  LNAHRSMQEQTT--------DNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYA 194

Query: 694  GFAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIF 873
               +            +IS+ S +RAGTR+N RG +D+G+VANFVETE + Y     S+ 
Sbjct: 195  AHKQA--------KACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY--LDDSVS 244

Query: 874  TFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSK 1050
            +F QIRGSVP FWEQ    + + ++ ++R  +A  P F++HF  +   YG   IV+LL  
Sbjct: 245  SFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGRQIIVNLLG- 303

Query: 1051 TKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFG 1230
            +K  E  +S+ +Q      +   +I    FD+H   K        + + P +Q  L+ +G
Sbjct: 304  SKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD-YG 362

Query: 1231 WFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAFEG 1410
            +F +  N  EV   Q G  R NCLDCLDRTN ++  +   +L   L   G+         
Sbjct: 363  FFYF--NGSEVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420

Query: 1411 MIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDG 1590
              +   ++W+ NGD+IS+IY GT AL+              L D  +SV+R  QN F D 
Sbjct: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGK----------AKLKDGARSVTRTIQNNFFDS 470

Query: 1591 KKQLTIDILVGVDGRNS----------------CKVKVYNPASEYIKSKLKEQENSFTSF 1722
             KQ  ID+L+  +  NS                   +    AS  +   + E    ++  
Sbjct: 471  SKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKP 530

Query: 1723 ENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPS-------SVQNGDGSLPDMYAIGLQ 1872
            + +++  GT+NVN    F  +  KN  LT WL  +         Q+      D++AIG +
Sbjct: 531  KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFE 590

Query: 1873 ELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKV 2052
            E++ELNA +I++A  +    W+  L + ++    D +YVLL +E +  + LF++++    
Sbjct: 591  EMVELNAGNIVSASTTNQKLWAVELQKTISR---DNKYVLLASEQLVGVCLFVFIRPQHA 647

Query: 2053 SYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTI 2232
             ++  VA  + KTG+GG   NKGA  IR LF TTS  FV  H AAG   V ER  D+  I
Sbjct: 648  PFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFIEI 707

Query: 2233 MQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDR 2412
             + L FP    +  HD+V W GD NYRID+PN E ++L+    +  L+  DQL  ++   
Sbjct: 708  ARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAG 767

Query: 2413 GAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
              F  F EG V F PTYK+D +++DYDTSEK RTP+WTDRVL+
Sbjct: 768  QVFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLW 810


>Q8CHC4|MKIAA0910|Q8CHC4 (TrEMBL: Mus musculus (Mouse)) MKIAA0910
            protein (Fragment).
          Length = 1582

 Score =  384 bits (986), Expect = e-105
 Identities = 261/823 (31%), Positives = 404/823 (49%), Gaps = 36/823 (4%)
 Frame = +1

Query: 181  DVFGCLGLIYVE--DQI--YLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +G LG++ +   D +  YL ++TG ++     I+   V ++ S +F+SL  D  D   
Sbjct: 66   DAYGLLGVLRLNLGDTMLHYLVLVTGCMS--VGKIQESEVFRVTSTEFISLRVDASD--- 120

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSNDFDLTSLLQNR 528
                                   DR +       E+RK+L++G+FY++      SL    
Sbjct: 121  ----------------------EDRIS-------EVRKVLNSGNFYFAWSASGVSL---- 147

Query: 529  GVSSPDTRIN---SIDHYKPE--YMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
                 D  +N   S+  +  +  + WN  L   L H+  N D +   ++     + T+  
Sbjct: 148  -----DLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYA 202

Query: 694  GFAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIF 873
               +            +IS+ S +RAGTR+N RG +D+G+VANFVETE + Y      + 
Sbjct: 203  AHKQA--------KACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIY--LDDCVS 252

Query: 874  TFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSK 1050
            +F QIRGSVP FWEQ    + + ++ ++R  +A  P F++HF  +   YG   +V+LL  
Sbjct: 253  SFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLG- 311

Query: 1051 TKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFG 1230
            +K  E  +S+ +Q      +   +I   +FD+H   K        + + P +Q  L+ +G
Sbjct: 312  SKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSILKPQVQKFLD-YG 370

Query: 1231 WFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAFEG 1410
            +F +D +  EV   Q G  R NCLDCLDRTN ++  +   +L   L   G+         
Sbjct: 371  FFYFDGS--EVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 428

Query: 1411 MIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDG 1590
              +   ++W+ NGD+IS+IY GT AL+              L D  +SV+R  QN F D 
Sbjct: 429  FQEVFRSMWSVNGDSISKIYAGTGALEGK----------AKLKDGARSVTRTIQNNFFDS 478

Query: 1591 KKQLTIDILVGVDGRNS----------------CKVKVYNPASEYIKSKLKEQENSFTSF 1722
             KQ  ID+L+  +  NS                   +    AS  +   + E    ++  
Sbjct: 479  SKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKP 538

Query: 1723 ENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPS-------SVQNGDGSLPDMYAIGLQ 1872
            + +++  GT+NVN    F  +  KN  LT WL  +         Q+      D++AIG +
Sbjct: 539  KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFE 598

Query: 1873 ELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKV 2052
            E++ELNA +I+NA  +    W+  L + ++    D +YVLL +E +  + LF++++    
Sbjct: 599  EMVELNAGNIVNASTTNQKLWAVELQKTISR---DNKYVLLASEQLVGVCLFVFIRPQHA 655

Query: 2053 SYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTI 2232
             ++  VA  + KTG+GG   NKGA  IR LF TTS  FV  H AAG   V ER  D+  I
Sbjct: 656  PFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEI 715

Query: 2233 MQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDR 2412
             + L FP    +  HD+V W GD NYRID+PN E ++L+    +  L+  DQL  ++   
Sbjct: 716  ARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAG 775

Query: 2413 GAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
              F  F EG V F PTYK+D ++ DYDTSEK RTP+WTDRVL+
Sbjct: 776  QIFRGFLEGKVTFAPTYKYDLFSEDYDTSEKCRTPAWTDRVLW 818


>Q62910|SYNJ1|SYJ1_RAT (SP: Rattus norvegicus (Rat)) Synaptojanin 1
            (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate
            5-phosphatase 1).
          Length = 1574

 Score =  382 bits (981), Expect = e-104
 Identities = 260/823 (31%), Positives = 403/823 (48%), Gaps = 36/823 (4%)
 Frame = +1

Query: 181  DVFGCLGLIYVE--DQI--YLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +G LG++ +   D +  YL ++TG ++     I+   V ++ S +F+SL  D  D   
Sbjct: 58   DAYGLLGVLRLNLGDTMLHYLVLVTGCMS--VGKIQESEVFRVTSTEFISLRVDASD--- 112

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSNDFDLTSLLQNR 528
                                   DR +       E+RK+L++G+FY++      SL    
Sbjct: 113  ----------------------EDRIS-------EVRKVLNSGNFYFAWSASGVSL---- 139

Query: 529  GVSSPDTRIN---SIDHYKPE--YMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
                 D  +N   S+  +  +  + WN  L   L H+  N D +   ++     + T+  
Sbjct: 140  -----DLSLNAHRSMQEHTTDNRFFWNQSLHLHLKHYGVNCDDWLLRLMCGGVEIRTIYA 194

Query: 694  GFAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIF 873
               +            +IS+ S +RAGTR+N RG +D+G+VANFVETE + Y      + 
Sbjct: 195  AHKQA--------KACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVIY--LDDCVS 244

Query: 874  TFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSK 1050
            +F QIRGSVP FWEQ    + + ++ ++R  +A  P F++HF  +   YG   +V+LL  
Sbjct: 245  SFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKDLYGKQIVVNLLG- 303

Query: 1051 TKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFG 1230
            +K  E  +S+ +Q      +   +I   +FD+H   K        + + P +Q  L+ +G
Sbjct: 304  SKEGEHMLSKAFQSHLKASEHASDIHMVSFDYHQMVKGGKAEKLHSVLKPQVQKFLD-YG 362

Query: 1231 WFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAFEG 1410
            +F +D +   V   Q G  R NCLDCLDRTN ++  +   +L   L   G+         
Sbjct: 363  FFYFDGSA--VQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLAKQLEALGLAEKPQLVTR 420

Query: 1411 MIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDG 1590
              +   ++W+ NGD+IS+IY GT AL+              L D  +SV+R  QN F D 
Sbjct: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGK----------AKLKDGARSVTRTIQNNFFDS 470

Query: 1591 KKQLTIDILVGVDGRNS----------------CKVKVYNPASEYIKSKLKEQENSFTSF 1722
             KQ  ID+L+  +  NS                   +    AS  +   + E    ++  
Sbjct: 471  SKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKNMCENFYKYSKP 530

Query: 1723 ENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPS-------SVQNGDGSLPDMYAIGLQ 1872
            + +++  GT+NVN    F  +  KN  LT WL  +         Q+      D++AIG +
Sbjct: 531  KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPTDIFAIGFE 590

Query: 1873 ELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKV 2052
            E++ELNA +I+NA  +    W+  L + ++    D +YVLL +E +  + LF++++    
Sbjct: 591  EMVELNAGNIVNASTTNQKLWAVELQKTISR---DNKYVLLASEQLVGVCLFVFIRPQHA 647

Query: 2053 SYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTI 2232
             ++  VA  + KTG+GG   NKGA  IR LF TTS  FV  H AAG   V ER  D+  I
Sbjct: 648  PFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNEDFVEI 707

Query: 2233 MQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDR 2412
             + L FP    +  HD+V W GD NYRID+PN E ++L+    +  L+  DQL  ++   
Sbjct: 708  ARKLSFPMGRMLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAG 767

Query: 2413 GAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
              F  F EG V F PTYK+D ++ DYDTSEK RTP+WTDRVL+
Sbjct: 768  QIFRGFLEGKVTFAPTYKYDLFSEDYDTSEKCRTPAWTDRVLW 810


>O18964|SYNJ1|SYJ1_BOVIN (SP: Bos taurus (Bovine)) Synaptojanin 1 (EC
            3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate
            5-phosphatase 1) (p150) (Fragment).
          Length = 1324

 Score =  381 bits (978), Expect = e-104
 Identities = 262/823 (31%), Positives = 403/823 (48%), Gaps = 36/823 (4%)
 Frame = +1

Query: 181  DVFGCLGLIYVE--DQI--YLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +G LG++ +   D +  YL ++TG ++     I+   V ++ S +F+SL  D  D   
Sbjct: 58   DAYGLLGVLRLNLGDIMLHYLVLVTGCMS--VGKIQESEVFRVTSTEFISLRVDSSD--- 112

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSNDFDLTSLLQNR 528
                                   DR +       E+RK+L++G+FY++      SL    
Sbjct: 113  ----------------------EDRIS-------EVRKVLNSGNFYFAWSASGVSL---- 139

Query: 529  GVSSPDTRIN---SIDHYKPE--YMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
                 D  +N   S+  +  +  + WN  L   L H+  N   +   ++     + T+  
Sbjct: 140  -----DLSLNAHRSLQEHTTDNRFSWNQSLHLHLKHYGVNCADWLLRLMCGGVEIRTIYA 194

Query: 694  GFAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIF 873
               +            +IS+ S +RAGTR+N RG +D+G+VANFVETE + Y     S+ 
Sbjct: 195  AHKQA--------KACLISRLSCERAGTRFNVRGTNDDGHVANFVETEQVVY--LDDSVS 244

Query: 874  TFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSK 1050
            +F QIRGSVP FWEQ    + + ++ ++R  +A  P F++HF  +   YG   IV+LL  
Sbjct: 245  SFIQIRGSVPLFWEQPGLQVGSHRVRMSRGFEANAPAFDRHFRTLKNLYGKQIIVNLLG- 303

Query: 1051 TKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFG 1230
            +K  E  +S+ +Q      +   +I    FD+H   K        + + P +Q  L+ +G
Sbjct: 304  SKEGEHMLSKAFQSHLKASEHAADIQMVNFDYHQMVKGGKAEKLHSVLKPQVQKFLD-YG 362

Query: 1231 WFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAFEG 1410
             F +D +  EV   Q G  R NCLDCLDRTN ++  +   +L   L   G+         
Sbjct: 363  IFHFDGS--EVQRCQSGTVRTNCLDCLDRTNSVQAFLGLEMLTKQLEALGLAEKPQLVTR 420

Query: 1411 MIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDG 1590
              +   ++W+ NGD+IS+IY GT AL+              L D  +SVSR  QN F D 
Sbjct: 421  FQEVFRSMWSVNGDSISKIYAGTGALEGK----------AKLKDGARSVSRTIQNNFFDS 470

Query: 1591 KKQLTIDILVGVDGRNS----------------CKVKVYNPASEYIKSKLKEQENSFTSF 1722
             KQ  ID+L+  +  NS                   +    AS  +   + E    ++  
Sbjct: 471  SKQEAIDVLLLGNTLNSDLADKARALLTTGSLRVSEQTLQSASSKVLKSMCENFYKYSKP 530

Query: 1723 ENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPS-------SVQNGDGSLPDMYAIGLQ 1872
            + +++  GT+NVN    F  +  KN  LT WL  +         Q+      D++ IG +
Sbjct: 531  KKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGIQEFQDKRSKPMDIFPIGFE 590

Query: 1873 ELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKV 2052
            E++ELNA +I+NA  +    W+  L + ++    D +YVLL +E +  + LF++++    
Sbjct: 591  EMVELNAGNIVNASTTNQKLWAAELQKTISR---DNKYVLLASEQLVGVCLFVFIRPQHA 647

Query: 2053 SYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTI 2232
             ++  VA  + KTG+GG   NKGA  IR LF TTS  FV  H AAG   V ER +D+  I
Sbjct: 648  PFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVCSHFAAGQSQVKERNDDFLEI 707

Query: 2233 MQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDR 2412
             + L FP    +  HD+V W GD NYRID+PN E ++L+    +  L+  DQL  ++   
Sbjct: 708  ARKLSFPMGRLLFSHDYVFWCGDFNYRIDLPNEEVKELIRQQNWDSLIAGDQLINQKNAG 767

Query: 2413 GAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
              F  F EG V F PTYK+D +++DYDTSEK RTP+WTDRVL+
Sbjct: 768  QIFRGFLEGKVTFAPTYKYDLFSDDYDTSEKCRTPAWTDRVLW 810


>Q9USQ6|SPBC577.13|Q9USQ6 (TrEMBL: Schizosaccharomyces pombe (Fission
            yeast)) Putative inositol polyphosphate phosphatase
            family member.
          Length = 889

 Score =  374 bits (959), Expect = e-102
 Identities = 279/909 (30%), Positives = 439/909 (48%), Gaps = 27/909 (2%)
 Frame = +1

Query: 1    MKLLYKEHPRTLVLYSDTFSLSFRIKSSKELDSKKPTVNVDLIPNTNITKEQGYRTLIRR 180
            M+   K   R++   ++ ++   +  S K+ D     +    I      K + Y  L   
Sbjct: 1    MQCYLKRKERSVAFITEKYAAIIQKPSVKDSDC---IITFTCISLEEFEKIKEYELLFGG 57

Query: 181  D-VFGCLGLI-YV----EDQIYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWD- 339
            + + G LGL  YV    ++ ++L +   A   V R    + + K+ +V F+SL+ + WD 
Sbjct: 58   EKILGTLGLFNYVCEDMKEGVFLCVARKAKL-VLRIGNRDPISKLENVSFISLDQELWDE 116

Query: 340  --FVELDSSGYPIVVNEEQXXXXXXITSDRYARVQ--------------HPCFELRKLLS 471
              F  +  +  P             I  D     +              H   +L  LL+
Sbjct: 117  ELFEPMPRNSSPSSTFSTSTSDLNNIEKDNLVNSEYSSKYSSTTRIYPYHSLSQLTDLLT 176

Query: 472  NGSFYYSNDFDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSN---LDT 642
            +GSFY S +    S  Q+     P          K  Y WN FL+ EL +  S    L+ 
Sbjct: 177  DGSFYVSTNISCFSRFQSEQPYGP----------KDIYCWNRFLITELDNHFSEAHILEK 226

Query: 643  YNQLILDDNRFLTTVIRGFAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVAN 822
            +  L+L          RG+ +   I S   S++IISK S   +   Y   GIDD+   + 
Sbjct: 227  FPNLLLH-------CFRGYVERMFIDSM--SMSIISKVSSYGSRQTYPPSGIDDSSYCSM 277

Query: 823  FVETEYIYYNPSKSSIFTFTQIRGSVPTFWEQD-SSLMNPKITLTRSTQATQPVFNKHFG 999
            FVETE+I       ++F+F Q+RG+VP FWE+  SS   P I+  RS+QA+Q +FN HF 
Sbjct: 278  FVETEFIV--EIAQTVFSFVQVRGTVPCFWEEQFSSWYGPSISFLRSSQASQSLFNFHFS 335

Query: 1000 DILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFA 1179
             + ++YG  +++DLL +TK  E  + + Y+    H             FH     A    
Sbjct: 336  KLYKAYGDIYVIDLL-QTKGFEASLYEAYK----HHLMLLPFPAVVKKFHFTPDPARPDI 390

Query: 1180 GATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLE 1359
               ++   L D L   G+    +    + + Q G+FR+N LDCL RTN+I+  I R VL+
Sbjct: 391  DP-RLETDLADDLKEMGYTQKSIENDMLESFQKGVFRINDLDCLGRTNVIQYQISRLVLK 449

Query: 1360 NILTNQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALS 1539
            +I  N  I    + F  +++    LW++NGDAI+++ TG  ++ SS +R G+ + AG+LS
Sbjct: 450  DIFFNLQI---GVTFN-ILEYLRHLWSNNGDAIAKLITGVGSIGSSATRRGRKSIAGSLS 505

Query: 1540 DVTKSVSRMYQNTFVDGKKQLTIDILVGVDGRNSCKVKVYNPASEYIKSKLKEQENSFTS 1719
            D++KS  RMY   + D + Q  I +L+G    N   V +    S YI+  L+++ + +  
Sbjct: 506  DISKSFGRMYVGRYPDVESQNAILLLLGCFP-NQSPVLISESVSSYIQGVLRQRRSEYRV 564

Query: 1720 FENVKIFTGTYNVNAFNPLMTKNIDLTSWLFPSSVQNGDGSLPDMYAIGLQELIELNASS 1899
              +  IF+ T+N N   P      +    L P   +    S  D+Y + +QE+I LN S 
Sbjct: 565  ERDFSIFSSTFNANGKVP---STDEFKRLLLPFGERT---SAYDLYVVAVQEIITLNMSH 618

Query: 1900 ILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYVTRVAGS 2079
            ++++   +   W + +   LNS   + +Y+L+ +  +A + L ++++K     V++V  +
Sbjct: 619  LVSSSNQKLRIWEEKILMILNSRDSNNKYMLISSIQMAGVFLGVFIRKDDHLVVSKVTKT 678

Query: 2080 SKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQGLVFPRN 2259
            ++KTG GG +ANKGA  I      + F FV+ H A     ++ER  +Y++I   LVFP  
Sbjct: 679  TRKTGFGGFSANKGAVAIEMNVCDSDFCFVSSHFAPKVNNISERNMEYTSISDNLVFPSG 738

Query: 2260 YYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRGAFNEFKEG 2439
              I DH +++W GD NYRID  N E R+LV      +L   DQL  E +    F+   E 
Sbjct: 739  MKIYDHTNILWMGDFNYRIDSDNEEVRKLVELDDLDKLASYDQLCTEMKKGTVFHGLVEP 798

Query: 2440 LVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSAIDVLYS 2619
             + F PTYKFD  TNDYDTS+KQR PSWTDR+L                 Y S  D+  S
Sbjct: 799  QLTFLPTYKFDNGTNDYDTSDKQRVPSWTDRIL--------ATKSFTRNCYKSC-DIRCS 849

Query: 2620 DHKAVYASF 2646
            DH+ V+A+F
Sbjct: 850  DHRPVFATF 858


>Q8IZA8||Q8IZA8 (TrEMBL: Homo sapiens (Human)) Synaptojanin 2A.
          Length = 1288

 Score =  372 bits (956), Expect = e-101
 Identities = 271/843 (32%), Positives = 421/843 (49%), Gaps = 33/843 (3%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ----IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + ++       +L ++TG  T+V R I +  + KI + DF  L  +      
Sbjct: 59   DAYGCLGELRLKSGGTSLSFLVLVTGC-TSVGR-IPDAEIYKITATDFYPLQEE------ 110

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS--ND---FDLTS 513
                                      A+ +     L+K+LS+G FY+S  ND   FDLT 
Sbjct: 111  --------------------------AKEEERLIALKKILSSGVFYFSWPNDGSRFDLTV 144

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMW-NSFLMDELIHFRSNLDTYNQLILDDNRFLTTVI 690
              Q +G  S +              W NSF  ++L+H        +Q+   D  +L  +I
Sbjct: 145  RTQKQGDDSSE--------------WGNSFFWNQLLHVPLR---QHQVSCCD--WLLKII 185

Query: 691  RGFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKS 864
             G    +T           ++S+ S +R GTR++TRG++D+G+V+NFVETE + Y     
Sbjct: 186  CGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY--MDD 243

Query: 865  SIFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDL 1041
             + +F QIRGSVP FWEQ    + +  + L R  +A  P F++H   + + YG   +V+L
Sbjct: 244  GVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNL 303

Query: 1042 LSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLN 1221
            L      EV +++ +++L        +     FDFH   K  GG     K+   L+  L 
Sbjct: 304  LGSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFHQFAK--GG--KLEKLETLLRPQLK 358

Query: 1222 LFGWFTYDM--NRQEVITR-QDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNN 1392
            L  W  +D+    + V  R Q G  R+NCLDCLDRTN ++  I   VL   L   G+ ++
Sbjct: 359  LH-WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL-SS 416

Query: 1393 RMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQ 1572
            +   +  ++    +W+ NG ++S+++TG+ AL+      GK    G L D  +S+SR  Q
Sbjct: 417  KPIVDRFVESFKAMWSLNGHSLSKVFTGSRALE------GKAK-VGKLKDGARSMSRTIQ 469

Query: 1573 NTFVDGKKQLTIDILV-----GVDGRNSCKVKVYNPA---SEYIKSKLKEQENSFTSFEN 1728
            + F DG KQ  I +L+     G +  +   + + + A   +  I   + E+++ FT+F+ 
Sbjct: 470  SNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKR 529

Query: 1729 VKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG------DGSLPDMYAIGLQELI 1881
            ++I  GT+NVN    F   + +  +LT WL  S   +G      D S  D++A+G +E++
Sbjct: 530  IRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMV 589

Query: 1882 ELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYV 2061
            EL+A +I+NA  +    W + L + ++       Y+LL +  +  + L+++V+   V ++
Sbjct: 590  ELSAGNIVNASTTNKKMWGEQLQKAISR---SHRYILLTSAQLVGVCLYIFVRPYHVPFI 646

Query: 2062 TRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQG 2241
              VA  + KTG+GG A NKGA GIR  F +TSF F+  HL AG   V ER  DY  I Q 
Sbjct: 647  RDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQK 706

Query: 2242 LVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRGAF 2421
            L FP    +  HD+V W GD NYRID+   E    V    +K+LLE DQL  ++     F
Sbjct: 707  LCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIF 766

Query: 2422 NEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSA 2601
             +F EG + F PTYK+D  +  YDTS+K RTP+WTDRVL+                 DS 
Sbjct: 767  KDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSD 826

Query: 2602 IDV 2610
            +DV
Sbjct: 827  LDV 829


>O15056|SYNJ2|SYJ2_HUMAN (SP: Homo sapiens (Human)) Synaptojanin 2 (EC
            3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate
            5-phosphatase 2) (Fragment).
          Length = 1443

 Score =  372 bits (956), Expect = e-101
 Identities = 271/843 (32%), Positives = 421/843 (49%), Gaps = 33/843 (3%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ----IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + ++       +L ++TG  T+V R I +  + KI + DF  L  +      
Sbjct: 6    DAYGCLGELRLKSGGTSLSFLVLVTGC-TSVGR-IPDAEIYKITATDFYPLQEE------ 57

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS--ND---FDLTS 513
                                      A+ +     L+K+LS+G FY+S  ND   FDLT 
Sbjct: 58   --------------------------AKEEERLIALKKILSSGVFYFSWPNDGSRFDLTV 91

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMW-NSFLMDELIHFRSNLDTYNQLILDDNRFLTTVI 690
              Q +G  S +              W NSF  ++L+H        +Q+   D  +L  +I
Sbjct: 92   RTQKQGDDSSE--------------WGNSFFWNQLLHVPLR---QHQVSCCD--WLLKII 132

Query: 691  RGFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKS 864
             G    +T           ++S+ S +R GTR++TRG++D+G+V+NFVETE + Y     
Sbjct: 133  CGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY--MDD 190

Query: 865  SIFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDL 1041
             + +F QIRGSVP FWEQ    + +  + L R  +A  P F++H   + + YG   +V+L
Sbjct: 191  GVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNL 250

Query: 1042 LSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLN 1221
            L      EV +++ +++L        +     FDFH   K  GG     K+   L+  L 
Sbjct: 251  LGSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFHQFAK--GG--KLEKLETLLRPQLK 305

Query: 1222 LFGWFTYDM--NRQEVITR-QDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNN 1392
            L  W  +D+    + V  R Q G  R+NCLDCLDRTN ++  I   VL   L   G+ ++
Sbjct: 306  LH-WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL-SS 363

Query: 1393 RMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQ 1572
            +   +  ++    +W+ NG ++S+++TG+ AL+      GK    G L D  +S+SR  Q
Sbjct: 364  KPIVDRFVESFKAMWSLNGHSLSKVFTGSRALE------GKAK-VGKLKDGARSMSRTIQ 416

Query: 1573 NTFVDGKKQLTIDILV-----GVDGRNSCKVKVYNPA---SEYIKSKLKEQENSFTSFEN 1728
            + F DG KQ  I +L+     G +  +   + + + A   +  I   + E+++ FT+F+ 
Sbjct: 417  SNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKR 476

Query: 1729 VKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG------DGSLPDMYAIGLQELI 1881
            ++I  GT+NVN    F   + +  +LT WL  S   +G      D S  D++A+G +E++
Sbjct: 477  IRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMV 536

Query: 1882 ELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYV 2061
            EL+A +I+NA  +    W + L + ++       Y+LL +  +  + L+++V+   V ++
Sbjct: 537  ELSAGNIVNASTTNKKMWGEQLQKAISR---SHRYILLTSAQLVGVCLYIFVRPYHVPFI 593

Query: 2062 TRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQG 2241
              VA  + KTG+GG A NKGA GIR  F +TSF F+  HL AG   V ER  DY  I Q 
Sbjct: 594  RDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQK 653

Query: 2242 LVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRGAF 2421
            L FP    +  HD+V W GD NYRID+   E    V    +K+LLE DQL  ++     F
Sbjct: 654  LCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIF 713

Query: 2422 NEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSA 2601
             +F EG + F PTYK+D  +  YDTS+K RTP+WTDRVL+                 DS 
Sbjct: 714  KDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSD 773

Query: 2602 IDV 2610
            +DV
Sbjct: 774  LDV 776


>Q9H226||Q9H226 (TrEMBL: Homo sapiens (Human)) Synaptojanin 2.
          Length = 1496

 Score =  372 bits (956), Expect = e-101
 Identities = 271/843 (32%), Positives = 421/843 (49%), Gaps = 33/843 (3%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ----IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + ++       +L ++TG  T+V R I +  + KI + DF  L  +      
Sbjct: 59   DAYGCLGELRLKSGGTSLSFLVLVTGC-TSVGR-IPDAEIYKITATDFYPLQEE------ 110

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS--ND---FDLTS 513
                                      A+ +     L+K+LS+G FY+S  ND   FDLT 
Sbjct: 111  --------------------------AKEEERLIALKKILSSGVFYFSWPNDGSRFDLTV 144

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMW-NSFLMDELIHFRSNLDTYNQLILDDNRFLTTVI 690
              Q +G  S +              W NSF  ++L+H        +Q+   D  +L  +I
Sbjct: 145  RTQKQGDDSSE--------------WGNSFFWNQLLHVPLR---QHQVSCCD--WLLKII 185

Query: 691  RGFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKS 864
             G    +T           ++S+ S +R GTR++TRG++D+G+V+NFVETE + Y     
Sbjct: 186  CGVVTIRTVYASHKQAKACLVSRVSCERTGTRFHTRGVNDDGHVSNFVETEQMIY--MDD 243

Query: 865  SIFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDL 1041
             + +F QIRGSVP FWEQ    + +  + L R  +A  P F++H   + + YG   +V+L
Sbjct: 244  GVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFDRHMVLLKEQYGQQVVVNL 303

Query: 1042 LSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLN 1221
            L      EV +++ +++L        +     FDFH   K  GG     K+   L+  L 
Sbjct: 304  LGSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFHQFAK--GG--KLEKLETLLRPQLK 358

Query: 1222 LFGWFTYDM--NRQEVITR-QDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNN 1392
            L  W  +D+    + V  R Q G  R+NCLDCLDRTN ++  I   VL   L   G+ ++
Sbjct: 359  LH-WEDFDVFTKGENVSPRFQKGTLRMNCLDCLDRTNTVQSFIALEVLHLQLKTLGL-SS 416

Query: 1393 RMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQ 1572
            +   +  ++    +W+ NG ++S+++TG+ AL+      GK    G L D  +S+SR  Q
Sbjct: 417  KPIVDRFVESFKAMWSLNGHSLSKVFTGSRALE------GKAK-VGKLKDGARSMSRTIQ 469

Query: 1573 NTFVDGKKQLTIDILV-----GVDGRNSCKVKVYNPA---SEYIKSKLKEQENSFTSFEN 1728
            + F DG KQ  I +L+     G +  +   + + + A   +  I   + E+++ FT+F+ 
Sbjct: 470  SNFFDGVKQEAIKLLLVGDVYGEEVADKGGMLLDSTALLVTPRILKAMTERQSEFTNFKR 529

Query: 1729 VKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG------DGSLPDMYAIGLQELI 1881
            ++I  GT+NVN    F   + +  +LT WL  S   +G      D S  D++A+G +E++
Sbjct: 530  IRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDSQDDSSPADIFAVGFEEMV 589

Query: 1882 ELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYV 2061
            EL+A +I+NA  +    W + L + ++       Y+LL +  +  + L+++V+   V ++
Sbjct: 590  ELSAGNIVNASTTNKKMWGEQLQKAISR---SHRYILLTSAQLVGVCLYIFVRPYHVPFI 646

Query: 2062 TRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQG 2241
              VA  + KTG+GG A NKGA GIR  F +TSF F+  HL AG   V ER  DY  I Q 
Sbjct: 647  RDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYKEITQK 706

Query: 2242 LVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRGAF 2421
            L FP    +  HD+V W GD NYRID+   E    V    +K+LLE DQL  ++     F
Sbjct: 707  LCFPMGRNVFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLLEFDQLQLQKSSGKIF 766

Query: 2422 NEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSA 2601
             +F EG + F PTYK+D  +  YDTS+K RTP+WTDRVL+                 DS 
Sbjct: 767  KDFHEGAINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPFDKTAGELNLLDSD 826

Query: 2602 IDV 2610
            +DV
Sbjct: 827  LDV 829


>Q9XUD3|JC8.10|Q9XUD3 (TrEMBL: Caenorhabditis elegans) JC8.10a protein
            (Synaptojanin UNC-26B).
          Length = 1113

 Score =  371 bits (953), Expect = e-101
 Identities = 257/856 (30%), Positives = 421/856 (49%), Gaps = 22/856 (2%)
 Frame = +1

Query: 148  KEQGYRTLIRRDVFGCLGLIYV-EDQIYLAIITGALTNVARPIENETVDKIYSVDFVSLN 324
            + + Y+ ++  D +G LG++ + +D+  L  +TG L+          V ++Y  D + + 
Sbjct: 49   ERRSYQKIV--DAYGILGVLAITKDEAVLVAVTGVLS----------VGQLYGADILKIT 96

Query: 325  NDDWDFVELDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSN--D 498
            N +  F+ L + G                       V     +L++LLS+  FY+S+   
Sbjct: 97   NVE--FISLRTFG-------------------SVENVDSRIIDLQRLLSSQMFYFSSLQS 135

Query: 499  FDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFL 678
            +DLT   Q+R         +S D     + WN  L     HF     ++ +  +D + +L
Sbjct: 136  YDLTRSAQHR---------DSHDCSDARFFWNRSL-----HF-----SFQRYGIDTDNWL 176

Query: 679  TTVIRG--FAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYN 852
               + G    +   +G+N   + +IS+ S +R GTR+N RG +  GNVANFVETE +   
Sbjct: 177  LKCMAGSVLVRVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLLLF 236

Query: 853  PSKSSIFTFTQIRGSVPTFWEQDSSLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHI 1032
              K    +  QIRGS+P FWEQ    +       R+ + + P +++H   +   YG   I
Sbjct: 237  DEKEC--SLLQIRGSIPLFWEQPGVNVGSHKVKLRAFETSLPAYHRHLSQLQHRYGEFAI 294

Query: 1033 VDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQD 1212
            V+LL + K  E  +   ++  +        +D+  FD+H + KI+       ++   +  
Sbjct: 295  VNLLGR-KEGERVLGDAFKTQHKSSHFAPLVDFIDFDYHAQMKISK--EAIVQLKKKMSP 351

Query: 1213 SLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNN 1392
             +   G+F Y M + E++ RQ G+ R NCLDCLDRTN ++  I   +  + +    +   
Sbjct: 352  HMTKHGFF-YSMGK-EIVKRQTGVIRTNCLDCLDRTNAVQTAIGLQMSHDQVAFLNLNAG 409

Query: 1393 RMAFEGMIQKH-NTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMY 1569
            ++  E  +++    LW  NGD  S IY GT AL       GK      L D ++S++R  
Sbjct: 410  KVNVEQRVEEILRDLWQKNGDQCSTIYAGTGAL------DGKSK----LKDASRSLARTI 459

Query: 1570 QNTFVDGKKQLTIDILV---GVDGR---NSCKVKVYNPASEYIK--SKLKEQENSFTSFE 1725
            QN  +DG KQ + D+ +     D R    +C +   +   EY    S+L E+       +
Sbjct: 460  QNNLMDGAKQESFDLFLTGAAYDPRLFDRACNILPPSLIQEYADAVSQLVERSPEIAEPQ 519

Query: 1726 NVKIFTGTYNVNA----FNPLMTKNIDLTSWLFPSS----VQNGDGSLPDMYAIGLQELI 1881
            ++KIF GT+NVN      N        L+ W+F +S    V   D  L D+ AIG++EL+
Sbjct: 520  SIKIFVGTWNVNGGKNIHNVAFRNESSLSHWIFANSMTRLVSVEDEQLADIVAIGVEELV 579

Query: 1882 ELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVSYV 2061
            +LNAS+++ A  +    W + + + L+       +VL+ +E +  + LFL+ +     Y+
Sbjct: 580  DLNASNMVKASTTNQRMWCESIRKTLSE---KAPFVLIGSEQLVGVCLFLFARPRVSPYL 636

Query: 2062 TRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIMQG 2241
               A +S KTG+GG   NKG+   R +  +TS  F+  H AAG   + +R  D++T ++ 
Sbjct: 637  KDFAVASVKTGMGGATGNKGSVAFRIVVFSTSICFICSHFAAGQNEIRDRNEDFATTLKK 696

Query: 2242 LVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRGAF 2421
            + FP    I  HD + W GD NYRI++   E +  V NG Y +L+ENDQLT+++     F
Sbjct: 697  IRFPLGREIDSHDVIFWLGDFNYRINLSGDEVKNAVRNGDYAKLVENDQLTQQKALGQTF 756

Query: 2422 NEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXXXXXYDSA 2601
              F EG + F PTYK+D +++DYDTSEK R P+WTDR+L+                YD +
Sbjct: 757  VGFNEGQLTFAPTYKYDTFSDDYDTSEKCRAPAWTDRILWKDQ---RKKGKTQLLSYDRS 813

Query: 2602 IDVLYSDHKAVYASFE 2649
             ++  SDH+ V A F+
Sbjct: 814  -ELKTSDHRPVGAVFK 828


>Q9W296|SYNAPTOJANIN|Q9W296 (TrEMBL: Drosophila melanogaster (Fruit
            fly)) CG6562 protein.
          Length = 1218

 Score =  370 bits (950), Expect = e-101
 Identities = 270/904 (29%), Positives = 424/904 (46%), Gaps = 59/904 (6%)
 Frame = +1

Query: 181  DVFGCLGLIYVE----DQIYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + +       ++L ++TG ++     I +  + +I    FVSL N       
Sbjct: 59   DAYGCLGALQLNAGESTVLFLVLVTGCVS--MGKIGDIEIFRITQTTFVSLQN------- 109

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSND---------- 498
                      NE++                    E+RKLL++G+FY+++           
Sbjct: 110  -------AAPNEDKIS------------------EVRKLLNSGTFYFAHTNASASASGAS 144

Query: 499  ---FDLTSLLQNRG-VSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDD 666
               FD+T   Q R      D R          + WN  +   L+ F           +D 
Sbjct: 145  SYRFDITLCAQRRQQTQETDNR----------FFWNRMMHIHLMRFG----------IDC 184

Query: 667  NRFLTTVIRGFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEY 840
              +L   + G    +T  IG+      IIS+ S +RAGTR+N RG +D G VANFVETE 
Sbjct: 185  QSWLLQAMCGSVEVRTVYIGAKQARAAIISRLSCERAGTRFNVRGTNDEGYVANFVETEQ 244

Query: 841  IYYNPSKSSIFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSY 1017
            + Y      + ++ Q RGSVP FWEQ    + + K+ L+R  + +   F++H   + Q Y
Sbjct: 245  VIY--VDGDVTSYVQTRGSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRY 302

Query: 1018 GVCHIVDLLSKT----KSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGA 1185
            G   +V+LL  +    K  E  +S  +Q+ ++     +++ +  FD+H E +  G F+  
Sbjct: 303  GYQTVVNLLGSSLVGSKEGEAMLSNEFQR-HHGMSAHKDVPHVVFDYHQECR-GGNFSAL 360

Query: 1186 TKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLE-- 1359
             K+   +      +G F    +  +V+  Q G+ R NCLDCLDRTN ++  +    L   
Sbjct: 361  AKLKERIVACGANYGVF--HASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQ 418

Query: 1360 -NILTNQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGAL 1536
               L   G   N   FE + ++   +W +NG+ +S+IY GT A++              L
Sbjct: 419  LEALKMGGKQQNISRFEEIFRQ---MWINNGNEVSKIYAGTGAIQGG----------SKL 465

Query: 1537 SDVTKSVSRMYQNTFVDGKKQLTIDILV---GVDGRNSCKVKVYNP-----ASEYIKSKL 1692
             D  +S +R  QN  +D  KQ  ID+L+    +    + + ++  P     A   +  +L
Sbjct: 466  MDGARSAARTIQNNLLDNSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLREL 525

Query: 1693 KEQENSFTSFENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPS----------SVQNG 1833
             ++   +      ++  GTYNVN    F  ++ K+  L  WL              V N 
Sbjct: 526  CKRYTEYVRPRMARVAVGTYNVNGGKHFRSIVFKD-SLADWLLDCHALARSKALVDVNNP 584

Query: 1834 DGSLP---DMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTE 2004
              ++    D+YAIG +E+++LNAS+I+ A    A  W++ L + ++    D +YVLL  +
Sbjct: 585  SENVDHPVDIYAIGFEEIVDLNASNIMAASTDNAKLWAEELQKTISR---DNDYVLLTYQ 641

Query: 2005 SIATMALFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLA 2184
             +  + L++Y++     ++  VA    KTGLGG   NKGAC IR +   TS  FV  H A
Sbjct: 642  QLVGVCLYIYIRPEHAPHIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFA 701

Query: 2185 AGTLAVTERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAY 2364
            AG   V ER  DY+ I + L FP    +K HD V W GD NYRID+   E ++ V NG  
Sbjct: 702  AGQSQVAERNADYAEITRKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDL 761

Query: 2365 KELLENDQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFL 2544
              +LE DQL +E+     F EF EG + F PTYK+D +++DYDTSEKQR P+WTDRVL+ 
Sbjct: 762  STVLEFDQLRKEQEAGNVFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWR 821

Query: 2545 -------SDXXXXXXXXXXXXXYDSAIDVLYSDHKAVYASFETTAKIINEQIKKNKLNEI 2703
                    D             Y  + ++  SDH+ V A  +     I++Q ++    ++
Sbjct: 822  RRKALAEGDFAASAWNPGKLIHYGRS-ELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQV 880

Query: 2704 ILSL 2715
            I  L
Sbjct: 881  IRDL 884


>Q9GT42|JC8.10|Q9GT42 (TrEMBL: Caenorhabditis elegans) Synaptojanin
            UNC-26A (JC8.10b protein).
          Length = 1119

 Score =  366 bits (940), Expect = e-100
 Identities = 256/863 (29%), Positives = 423/863 (49%), Gaps = 29/863 (3%)
 Frame = +1

Query: 148  KEQGYRTLIRRDVFGCLGLIYV-EDQIYLAIITGALTNVARPIENETVDKIYSVDFVSLN 324
            + + Y+ ++  D +G LG++ + +D+  L  +TG L+          V ++Y  D + + 
Sbjct: 49   ERRSYQKIV--DAYGILGVLAITKDEAVLVAVTGVLS----------VGQLYGADILKIT 96

Query: 325  NDDWDFVELDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYSN--D 498
            N +  F+ L + G                       V     +L++LLS+  FY+S+   
Sbjct: 97   NVE--FISLRTFG-------------------SVENVDSRIIDLQRLLSSQMFYFSSLQS 135

Query: 499  FDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFL 678
            +DLT   Q+R         +S D     + WN  L     HF     ++ +  +D + +L
Sbjct: 136  YDLTRSAQHR---------DSHDCSDARFFWNRSL-----HF-----SFQRYGIDTDNWL 176

Query: 679  TTVIRG--FAKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYN 852
               + G    +   +G+N   + +IS+ S +R GTR+N RG +  GNVANFVETE +   
Sbjct: 177  LKCMAGSVLVRVVYVGANTGRVALISRLSCERVGTRFNVRGANYLGNVANFVETEQLLLF 236

Query: 853  PSKSSIFTFTQIRGSVPTFWEQDSSLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHI 1032
              K    +  QIRGS+P FWEQ    +       R+ + + P +++H   +   YG   I
Sbjct: 237  DEKEC--SLLQIRGSIPLFWEQPGVNVGSHKVKLRAFETSLPAYHRHLSQLQHRYGEFAI 294

Query: 1033 VDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQD 1212
            V+LL + K  E  +   ++  +        +D+  FD+H + KI+       ++   +  
Sbjct: 295  VNLLGR-KEGERVLGDAFKTQHKSSHFAPLVDFIDFDYHAQMKISK--EAIVQLKKKMSP 351

Query: 1213 SLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNN 1392
             +   G+F Y M + E++ RQ G+ R NCLDCLDRTN ++  I   +  + +    +   
Sbjct: 352  HMTKHGFF-YSMGK-EIVKRQTGVIRTNCLDCLDRTNAVQTAIGLQMSHDQVAFLNLNAG 409

Query: 1393 RMAFEGMIQKH-NTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMY 1569
            ++  E  +++    LW  NGD  S IY GT AL       GK      L D ++S++R  
Sbjct: 410  KVNVEQRVEEILRDLWQKNGDQCSTIYAGTGAL------DGKSK----LKDASRSLARTI 459

Query: 1570 QNTFVDGKKQLTIDILV---GVDGR---NSCKVK---------VYNPASEYIKSKLKEQE 1704
            QN  +DG KQ + D+ +     D R    +C +           Y+  ++ + S+L E+ 
Sbjct: 460  QNNLMDGAKQESFDLFLTGAAYDPRLFDRACNILPPSLIQESYYYHEYADAV-SQLVERS 518

Query: 1705 NSFTSFENVKIFTGTYNVNA----FNPLMTKNIDLTSWLFPSS----VQNGDGSLPDMYA 1860
                  +++KIF GT+NVN      N        L+ W+F +S    V   D  L D+ A
Sbjct: 519  PEIAEPQSIKIFVGTWNVNGGKNIHNVAFRNESSLSHWIFANSMTRLVSVEDEQLADIVA 578

Query: 1861 IGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVK 2040
            IG++EL++LNAS+++ A  +    W + + + L+       +VL+ +E +  + LFL+ +
Sbjct: 579  IGVEELVDLNASNMVKASTTNQRMWCESIRKTLSE---KAPFVLIGSEQLVGVCLFLFAR 635

Query: 2041 KSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYND 2220
                 Y+   A +S KTG+GG   NKG+   R +  +TS  F+  H AAG   + +R  D
Sbjct: 636  PRVSPYLKDFAVASVKTGMGGATGNKGSVAFRIVVFSTSICFICSHFAAGQNEIRDRNED 695

Query: 2221 YSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRE 2400
            ++T ++ + FP    I  HD + W GD NYRI++   E +  V NG Y +L+ENDQLT++
Sbjct: 696  FATTLKKIRFPLGREIDSHDVIFWLGDFNYRINLSGDEVKNAVRNGDYAKLVENDQLTQQ 755

Query: 2401 RRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFLSDXXXXXXXXXX 2580
            +     F  F EG + F PTYK+D +++DYDTSEK R P+WTDR+L+             
Sbjct: 756  KALGQTFVGFNEGQLTFAPTYKYDTFSDDYDTSEKCRAPAWTDRILWKDQ---RKKGKTQ 812

Query: 2581 XXXYDSAIDVLYSDHKAVYASFE 2649
               YD + ++  SDH+ V A F+
Sbjct: 813  LLSYDRS-ELKTSDHRPVGAVFK 834


>Q91ZD8||Q91ZD8 (TrEMBL: Rattus norvegicus (Rat)) Synaptojanin 2B2.
          Length = 1496

 Score =  358 bits (918), Expect = 3e-97
 Identities = 260/833 (31%), Positives = 398/833 (47%), Gaps = 46/833 (5%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ----IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + ++       +L ++TG  T+V R I +  + KI   +F  L  +      
Sbjct: 59   DAYGCLGELSLKSGGVPLSFLVLVTGC-TSVGR-IPDAEIYKITGTEFYPLQEE------ 110

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS--ND---FDLTS 513
                                      A+ +     L+K+LS+G FY++  ND   FDLT 
Sbjct: 111  --------------------------AKEEDRLPALKKILSSGVFYFAWPNDGACFDLTI 144

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
              Q +G        +    +   + WN  L   L   + N   +          L  VI 
Sbjct: 145  RAQKQG--------DDCSEWGTSFFWNQLLHVPLRQHQVNCHDW----------LLKVIC 186

Query: 694  GFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSS 867
            G    +T           +IS+ S +RAG R+ TRG++D+G+V+NFVETE   Y      
Sbjct: 187  GVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIY--MDDG 244

Query: 868  IFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLL 1044
            + +F QIRGSVP FWEQ    + +  + L R  +A  P F +H   + + YG   +V+LL
Sbjct: 245  VSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLL 304

Query: 1045 SKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNL 1224
                  EV +++ +++L        +     FDFH   K          + P L+   + 
Sbjct: 305  GSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDD 363

Query: 1225 FGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAF 1404
            FG F    N       Q G  R+NCLDCLDRTN ++  I   VL   L + G+ N++   
Sbjct: 364  FGVFAKGENVSPRF--QKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGL-NSKPIT 420

Query: 1405 EGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFV 1584
            +  ++    +W+ NG  +S+++TG+ AL+      GK    G L D  +S+SR  Q+ F 
Sbjct: 421  DRFVESFKAMWSLNGHGLSKVFTGSRALE------GKAK-VGKLKDGARSMSRTIQSNFF 473

Query: 1585 DGKKQLTIDILV-------------------------GVDGRNSCKVKVYNPASEYIKSK 1689
            DG KQ  I +L+                         G + +NS    +   A+  I   
Sbjct: 474  DGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKA 533

Query: 1690 LKEQENSFTSFENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG------DGS 1842
            + E+++ FT+F+ ++I  GT+NVN    F   +    +LT WL  +   +G      DG 
Sbjct: 534  MTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGG 593

Query: 1843 LPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMA 2022
              D++A+G +E++EL+A +I+NA  +    W + L + ++       Y+LL +  +  + 
Sbjct: 594  PADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISR---SHRYILLTSAQLVGVC 650

Query: 2023 LFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAV 2202
            L+++V+   V ++  VA  + KTG+GG A NKGA GIR  F +TSF F+  HL AG   V
Sbjct: 651  LYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQV 710

Query: 2203 TERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLEN 2382
             ER  DY  I   L FP    I  HD+V W GD NYRID+   E    V    +K+L+E 
Sbjct: 711  KERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEF 770

Query: 2383 DQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
            DQL  ++     F +F EG + F PTYK+D  +  YDTS+K RTP+WTDRVL+
Sbjct: 771  DQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLW 823


>Q91ZD9||Q91ZD9 (TrEMBL: Rattus norvegicus (Rat)) Synaptojanin 2B1.
          Length = 1451

 Score =  358 bits (918), Expect = 3e-97
 Identities = 260/833 (31%), Positives = 398/833 (47%), Gaps = 46/833 (5%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ----IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + ++       +L ++TG  T+V R I +  + KI   +F  L  +      
Sbjct: 59   DAYGCLGELSLKSGGVPLSFLVLVTGC-TSVGR-IPDAEIYKITGTEFYPLQEE------ 110

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS--ND---FDLTS 513
                                      A+ +     L+K+LS+G FY++  ND   FDLT 
Sbjct: 111  --------------------------AKEEDRLPALKKILSSGVFYFAWPNDGACFDLTI 144

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
              Q +G        +    +   + WN  L   L   + N   +          L  VI 
Sbjct: 145  RAQKQG--------DDCSEWGTSFFWNQLLHVPLRQHQVNCHDW----------LLKVIC 186

Query: 694  GFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSS 867
            G    +T           +IS+ S +RAG R+ TRG++D+G+V+NFVETE   Y      
Sbjct: 187  GVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIY--MDDG 244

Query: 868  IFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLL 1044
            + +F QIRGSVP FWEQ    + +  + L R  +A  P F +H   + + YG   +V+LL
Sbjct: 245  VSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLL 304

Query: 1045 SKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNL 1224
                  EV +++ +++L        +     FDFH   K          + P L+   + 
Sbjct: 305  GSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDD 363

Query: 1225 FGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAF 1404
            FG F    N       Q G  R+NCLDCLDRTN ++  I   VL   L + G+ N++   
Sbjct: 364  FGVFAKGENVSPRF--QKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGL-NSKPIT 420

Query: 1405 EGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFV 1584
            +  ++    +W+ NG  +S+++TG+ AL+      GK    G L D  +S+SR  Q+ F 
Sbjct: 421  DRFVESFKAMWSLNGHGLSKVFTGSRALE------GKAK-VGKLKDGARSMSRTIQSNFF 473

Query: 1585 DGKKQLTIDILV-------------------------GVDGRNSCKVKVYNPASEYIKSK 1689
            DG KQ  I +L+                         G + +NS    +   A+  I   
Sbjct: 474  DGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKA 533

Query: 1690 LKEQENSFTSFENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG------DGS 1842
            + E+++ FT+F+ ++I  GT+NVN    F   +    +LT WL  +   +G      DG 
Sbjct: 534  MTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGG 593

Query: 1843 LPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMA 2022
              D++A+G +E++EL+A +I+NA  +    W + L + ++       Y+LL +  +  + 
Sbjct: 594  PADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISR---SHRYILLTSAQLVGVC 650

Query: 2023 LFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAV 2202
            L+++V+   V ++  VA  + KTG+GG A NKGA GIR  F +TSF F+  HL AG   V
Sbjct: 651  LYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQV 710

Query: 2203 TERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLEN 2382
             ER  DY  I   L FP    I  HD+V W GD NYRID+   E    V    +K+L+E 
Sbjct: 711  KERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEF 770

Query: 2383 DQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
            DQL  ++     F +F EG + F PTYK+D  +  YDTS+K RTP+WTDRVL+
Sbjct: 771  DQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLW 823


>O55207|SYNJ2|SYJ2_RAT (SP: Rattus norvegicus (Rat)) Synaptojanin 2
            (EC 3.1.3.36) (Synaptic inositol-1,4,5-trisphosphate
            5-phosphatase 2).
          Length = 1248

 Score =  358 bits (918), Expect = 3e-97
 Identities = 260/833 (31%), Positives = 398/833 (47%), Gaps = 46/833 (5%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ----IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWDFVE 348
            D +GCLG + ++       +L ++TG  T+V R I +  + KI   +F  L  +      
Sbjct: 59   DAYGCLGELSLKSGGVPLSFLVLVTGC-TSVGR-IPDAEIYKITGTEFYPLQEE------ 110

Query: 349  LDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS--ND---FDLTS 513
                                      A+ +     L+K+LS+G FY++  ND   FDLT 
Sbjct: 111  --------------------------AKEEDRLPALKKILSSGVFYFAWPNDGACFDLTI 144

Query: 514  LLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIR 693
              Q +G        +    +   + WN  L   L   + N   +          L  VI 
Sbjct: 145  RAQKQG--------DDCSEWGTSFFWNQLLHVPLRQHQVNCHDW----------LLKVIC 186

Query: 694  GFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNPSKSS 867
            G    +T           +IS+ S +RAG R+ TRG++D+G+V+NFVETE   Y      
Sbjct: 187  GVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIY--MDDG 244

Query: 868  IFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLL 1044
            + +F QIRGSVP FWEQ    + +  + L R  +A  P F +H   + + YG   +V+LL
Sbjct: 245  VSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLL 304

Query: 1045 SKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNL 1224
                  EV +++ +++L        +     FDFH   K          + P L+   + 
Sbjct: 305  GSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDD 363

Query: 1225 FGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLENILTNQGIYNNRMAF 1404
            FG F    N       Q G  R+NCLDCLDRTN ++  I   VL   L + G+ N++   
Sbjct: 364  FGVFAKGENVSPRF--QKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGL-NSKPIT 420

Query: 1405 EGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFV 1584
            +  ++    +W+ NG  +S+++TG+ AL+      GK    G L D  +S+SR  Q+ F 
Sbjct: 421  DRFVESFKAMWSLNGHGLSKVFTGSRALE------GKAK-VGKLKDGARSMSRTIQSNFF 473

Query: 1585 DGKKQLTIDILV-------------------------GVDGRNSCKVKVYNPASEYIKSK 1689
            DG KQ  I +L+                         G + +NS    +   A+  I   
Sbjct: 474  DGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKA 533

Query: 1690 LKEQENSFTSFENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG------DGS 1842
            + E+++ FT+F+ ++I  GT+NVN    F   +    +LT WL  +   +G      DG 
Sbjct: 534  MTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGG 593

Query: 1843 LPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMA 2022
              D++A+G +E++EL+A +I+NA  +    W + L + ++       Y+LL +  +  + 
Sbjct: 594  PADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISR---SHRYILLTSAQLVGVC 650

Query: 2023 LFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAV 2202
            L+++V+   V ++  VA  + KTG+GG A NKGA GIR  F +TSF F+  HL AG   V
Sbjct: 651  LYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQV 710

Query: 2203 TERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLEN 2382
             ER  DY  I   L FP    I  HD+V W GD NYRID+   E    V    +K+L+E 
Sbjct: 711  KERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEF 770

Query: 2383 DQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
            DQL  ++     F +F EG + F PTYK+D  +  YDTS+K RTP+WTDRVL+
Sbjct: 771  DQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLW 823


>O88399|SYNJ2|O88399 (TrEMBL: Mus musculus (Mouse)) Synaptojanin 2 (EC
            3.1.3.56) (Synaptic inositol-1,4,5-trisphosphate
            5-phosphatase 2).
          Length = 1479

 Score =  356 bits (913), Expect = 1e-96
 Identities = 246/721 (34%), Positives = 366/721 (50%), Gaps = 25/721 (3%)
 Frame = +1

Query: 454  LRKLLSNGSFYYS--ND---FDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELI 618
            L+K+LS+G FY++  ND   FDLT   Q +G    +        +   + WN  L   L 
Sbjct: 120  LKKILSSGVFYFAWPNDGACFDLTIRAQKQGDDGSE--------WGTSFFWNQLLHVPLR 171

Query: 619  HFRSNLDTYNQLILDDNRFLTTVIRGFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTR 792
              + N           + +L  VI G    +T           +IS+ S +RAG R+ TR
Sbjct: 172  QHQVNC----------HNWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTR 221

Query: 793  GIDDNGNVANFVETEYIYYNPSKSSIFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQA 969
            G++D+G+V+NFVETE   Y      + +F QIRGSVP FWEQ    + +  + L R   A
Sbjct: 222  GVNDDGHVSNFVETEQTIY--MDDGVSSFVQIRGSVPLFWEQPRLQVGSHHLRLHRGLGA 279

Query: 970  TQPVFNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFH 1149
              P F +H   + + YG   +V+L       EV +++ +++L        +     FDFH
Sbjct: 280  NAPAFERHMVLLKEQYGKQVVVNLPGSRGGEEV-LNRAFKKLLWASCHAGDTPMINFDFH 338

Query: 1150 HETKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLI 1329
               K          + P LQ     FG F    N       Q G  R+NCLDCLDRTN +
Sbjct: 339  QFAKGRKLEKLENLLRPQLQLHWEDFGVFAKGENVSPRF--QKGTLRMNCLDCLDRTNTV 396

Query: 1330 EQVICRSVLENILTNQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRS 1509
            +  I   VL   L + G+ N++   +  ++    +W+ NG ++S+++TG+ AL+      
Sbjct: 397  QCFIALEVLHLQLESLGL-NSKPIIDRFVESFKAMWSLNGHSLSKVFTGSRALE------ 449

Query: 1510 GKMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVGVDGRNS-----CKVKVYNPA-- 1668
            GK    G L D  +S+SR  Q+ F DG KQ  I +L+  D  N       ++ + N A  
Sbjct: 450  GKAK-VGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALL 508

Query: 1669 -SEYIKSKLKEQENSFTSFENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSVQNG- 1833
             +  I   + E+++ FT+F+ ++I  GT+NVN    F   +    +LT WL  +   +G 
Sbjct: 509  ATPRILKAMTERQSEFTNFKRIQIAVGTWNVNGGKQFRSNLLGTAELTDWLLDAPQLSGA 568

Query: 1834 -----DGSLPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLR 1998
                 DGS  D++AIG +E++EL+A +I+NA  +    W + L + ++       Y+LL 
Sbjct: 569  VDSQDDGSPADVFAIGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISR---SHRYILLT 625

Query: 1999 TESIATMALFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCH 2178
            +  +  + L+++V+   V ++  VA  + KTG+GG A NKGA GIR    +TSF FV  H
Sbjct: 626  SAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQLHSTSFCFVCSH 685

Query: 2179 LAAGTLAVTERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANG 2358
            L AG   V ER  DY  I   L FP    I  HD+V W GD NYRID+   E    V   
Sbjct: 686  LTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQ 745

Query: 2359 AYKELLENDQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVL 2538
             +K+L+E DQL  ++     F +F EG V F PTYK+D  +  YDTS+K RTP+WTDRVL
Sbjct: 746  DWKKLMEFDQLQLQKSSGKIFKDFHEGAVNFGPTYKYDVGSAAYDTSDKCRTPAWTDRVL 805

Query: 2539 F 2541
            +
Sbjct: 806  W 806


>Q9DGN7||Q9DGN7 (TrEMBL: Lampetra fluviatilis (River lamprey))
            Synaptojanin 1.
          Length = 1291

 Score =  352 bits (904), Expect = 1e-95
 Identities = 254/835 (30%), Positives = 404/835 (48%), Gaps = 48/835 (5%)
 Frame = +1

Query: 181  DVFGCLGLIYVEDQ-------IYLAIITGALTNVARPIENETVDKIYSVDFVSLNNDDWD 339
            D +GCLG++ +           YL ++TG   +V   +++E + +I SV+ VSL  D  D
Sbjct: 58   DAYGCLGMLRLNMDGKGEVILRYLVLVTGC-ASVDHIVDSEVM-RITSVEMVSLQGDPSD 115

Query: 340  FVELDSSGYPIVVNEEQXXXXXXITSDRYARVQHPCFELRKLLSNGSFYYS------NDF 501
                                      DR A       +LR+LLS G+FY+S      N +
Sbjct: 116  -------------------------EDRVA-------DLRRLLSTGTFYFSSSGGVGNTY 143

Query: 502  DLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTYNQLILDDNRFLT 681
            DL+   Q +G   P         + P + WN+ L   L           Q  +    +L 
Sbjct: 144  DLSVRAQLQGQGDPA-------QHNP-FCWNAALHVPL----------RQCGVGCGAWLL 185

Query: 682  TVIRGFA--KTTPIGSNGDSLTIISKQSWKRAGTRYNTRGIDDNGNVANFVETEYIYYNP 855
             V+ G    +T         + ++++ S  RAGTR+N RG DD+G VANF ETE I +  
Sbjct: 186  RVVCGGVGVRTLYAAHQQAKVCVLARVSCARAGTRFNVRGADDSGQVANFCETEQIIFID 245

Query: 856  SKSSIFTFTQIRGSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHI 1032
             +  + +F Q+RGSVP FWEQ    + + ++ ++R  +A  P  ++HF  + + YG   +
Sbjct: 246  DE--VTSFVQLRGSVPLFWEQPGLQVGSHRVKMSRGYEANAPALDRHFAMLKELYGKQMV 303

Query: 1033 VDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFH--------HETKIAGGFAGAT 1188
            V+LL  +K  E  +S+ +Q          +I    FD+H           ++  G    T
Sbjct: 304  VNLLG-SKEGEHMLSKAFQSHMQASRHASDIPMLNFDYHLLLKGSSQRSERLQSGLG--T 360

Query: 1189 KILPYLQDSLNLFGWFTYDMNRQEVITR-QDGIFRVNCLDCLDRTNLIEQVICRSVLENI 1365
            K+ P+L+      G++ +    + V++R Q G  R NCLDCLDRTN ++      +L+  
Sbjct: 361  KVRPFLEQC----GFYCF---HEGVVSRVQKGTVRTNCLDCLDRTNSVQTHFAVDMLKRQ 413

Query: 1366 LTNQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDV 1545
            L + G+           +   +LW+  GD +S++Y GT AL+      GK      L D 
Sbjct: 414  LEDLGLAEKPQMVARFDEVFRSLWSAVGDLVSKMYAGTGALE------GKTK----LKDG 463

Query: 1546 TKSVSRMYQNTFVDGKKQLTIDILV--------GVDGRNSCKVKVYNPASEYIKS----- 1686
             +SV+R  QN F DG KQ  +D+L+          D   +        A  ++++     
Sbjct: 464  ARSVTRTIQNNFFDGAKQEAMDLLLLGCVLNSEAADKARTLITPTTRGAENFLQTASVRL 523

Query: 1687 --KLKEQENSFTSFENVKIFTGTYNVNAFNPLMT---KNIDLTSWLFPSSVQNG-----D 1836
               L E+   +T  + +++   T+NVN    + +   K+  L+ WL  +  Q       D
Sbjct: 524  LRSLCERHGEYTHPKRLRVAIATWNVNGGKTMRSIAFKHQTLSDWLLDNHKQAAISTFQD 583

Query: 1837 GSLPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIAT 2016
             +  D++AIG QE++ELNA +I++A      +WS  L + ++    D +Y+L+ +E +  
Sbjct: 584  DTPVDVFAIGFQEMVELNAGNIVSASTENQKRWSVELQKTISR---DHKYILVTSEQLVG 640

Query: 2017 MALFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTL 2196
            + LF++++     +V  VA  + KTG+GG   NKG   IR    ++S  FV  H AAG  
Sbjct: 641  VCLFVFLRPHHAPHVRDVAVDTVKTGMGGATGNKGGVAIRLQMYSSSLCFVCSHFAAGQS 700

Query: 2197 AVTERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELL 2376
               ER  DY+ I + + FP    +  HD+V W GD NYRID+   E ++LV    ++ L 
Sbjct: 701  HTRERNEDYAEIARKISFPMGRGLFSHDYVFWCGDFNYRIDLSGDEVKELVRQKNWETLQ 760

Query: 2377 ENDQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLF 2541
            + DQL ++R     F  F EG   FPPTYK+D +++DYDTSEK R P+WTDRVL+
Sbjct: 761  QADQLVQQRNLSAVFRGFHEGRTNFPPTYKYDIFSDDYDTSEKCRIPAWTDRVLW 815


>Q8MR94|SYNAPTOJANIN|Q8MR94 (TrEMBL: Drosophila melanogaster (Fruit
            fly)) SD04710p (Fragment).
          Length = 959

 Score =  309 bits (791), Expect = 2e-82
 Identities = 203/647 (31%), Positives = 319/647 (49%), Gaps = 39/647 (6%)
 Frame = +1

Query: 892  GSVPTFWEQDS-SLMNPKITLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSKT----K 1056
            GSVP FWEQ    + + K+ L+R  + +   F++H   + Q YG   +V+LL  +    K
Sbjct: 1    GSVPLFWEQPGVQVGSHKVKLSRGFETSAAAFDRHMSMMRQRYGYQTVVNLLGSSLVGSK 60

Query: 1057 SSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFGWF 1236
              E  +S  +Q+ ++     +++ +  FD+H E +  G F+   K+   +      +G F
Sbjct: 61   EGEAMLSNEFQR-HHGMSAHKDVPHVVFDYHQECR-GGNFSALAKLKERIVACGANYGVF 118

Query: 1237 TYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQVICRSVLE---NILTNQGIYNNRMAFE 1407
                +  +V+  Q G+ R NCLDCLDRTN ++  +    L      L   G   N   FE
Sbjct: 119  --HASNGQVLREQFGVVRTNCLDCLDRTNCVQTYLGLDTLGIQLEALKMGGKQQNISRFE 176

Query: 1408 GMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVD 1587
             + ++   +W +NG+ +S+IY GT A++              L D  +S +R  QN  +D
Sbjct: 177  EIFRQ---MWINNGNEVSKIYAGTGAIQGG----------SKLMDGARSAARTIQNNLLD 223

Query: 1588 GKKQLTIDILV---GVDGRNSCKVKVYNP-----ASEYIKSKLKEQENSFTSFENVKIFT 1743
              KQ  ID+L+    +    + + ++  P     A   +  +L ++   +      ++  
Sbjct: 224  NSKQEAIDVLLVGSTLSSELADRARILLPSNMLHAPTTVLRELCKRYTEYVRPRMARVAV 283

Query: 1744 GTYNVNA---FNPLMTKNIDLTSWLFPS----------SVQNGDGSLP---DMYAIGLQE 1875
            GTYNVN    F  ++ K+  L  WL              V N   ++    D+YAIG +E
Sbjct: 284  GTYNVNGGKHFRSIVFKD-SLADWLLDCHALARSKALVDVNNPSENVDHPVDIYAIGFEE 342

Query: 1876 LIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEYVLLRTESIATMALFLYVKKSKVS 2055
            +++LNAS+I+ A    A  W++ L + ++    D +YVLL  + +  + L++Y++     
Sbjct: 343  IVDLNASNIMAASTDNAKLWAEELQKTISR---DNDYVLLTYQQLVGVCLYIYIRPEHAP 399

Query: 2056 YVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAFVTCHLAAGTLAVTERYNDYSTIM 2235
            ++  VA    KTGLGG   NKGAC IR +   TS  FV  H AAG   V ER  DY+ I 
Sbjct: 400  HIRDVAIDCVKTGLGGATGNKGACAIRFVLHGTSMCFVCAHFAAGQSQVAERNADYAEIT 459

Query: 2236 QGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQLVANGAYKELLENDQLTRERRDRG 2415
            + L FP    +K HD V W GD NYRID+   E ++ V NG    +LE DQL +E+    
Sbjct: 460  RKLAFPMGRTLKSHDWVFWCGDFNYRIDMEKDELKECVRNGDLSTVLEFDQLRKEQEAGN 519

Query: 2416 AFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWTDRVLFL-------SDXXXXXXXX 2574
             F EF EG + F PTYK+D +++DYDTSEKQR P+WTDRVL+         D        
Sbjct: 520  VFGEFLEGEITFDPTYKYDLFSDDYDTSEKQRAPAWTDRVLWRRRKALAEGDFAASAWNP 579

Query: 2575 XXXXXYDSAIDVLYSDHKAVYASFETTAKIINEQIKKNKLNEIILSL 2715
                 Y  + ++  SDH+ V A  +     I++Q ++    ++I  L
Sbjct: 580  GKLIHYGRS-ELKQSDHRPVIAIIDAEIMEIDQQRRRAVFEQVIRDL 625


>Q9D2G5|SYNJ2|Q9D2G5 (TrEMBL: Mus musculus (Mouse)) Synaptojanin 2.
          Length = 824

 Score =  278 bits (712), Expect = 2e-73
 Identities = 176/485 (36%), Positives = 257/485 (52%), Gaps = 17/485 (3%)
 Frame = +1

Query: 1138 FDFHHETKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDR 1317
            FDFH   K          + P LQ     FG F    N       Q G  R+NCLDCLDR
Sbjct: 19   FDFHQFAKGRKLEKLENLLRPQLQLHWEDFGVFAKGENVSPRF--QKGTLRMNCLDCLDR 76

Query: 1318 TNLIEQVICRSVLENILTNQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTGTNALKSS 1497
            TN ++  I   VL   L + G+ N++   +  ++    +W+ NG ++S+++TG+ AL+  
Sbjct: 77   TNTVQCFIALEVLHLQLESLGL-NSKPIIDRFVESFKAMWSLNGHSLSKVFTGSRALE-- 133

Query: 1498 FSRSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVGVDGRNS-----CKVKVYN 1662
                GK    G L D  +S+SR  Q+ F DG KQ  I +L+  D  N       ++ + N
Sbjct: 134  ----GKAK-VGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDN 188

Query: 1663 PA---SEYIKSKLKEQENSFTSFENVKIFTGTYNVNA---FNPLMTKNIDLTSWLFPSSV 1824
             A   +  I   + E+++ FT+F+ ++I  GT+NVN    F   +    +LT WL  +  
Sbjct: 189  TALLATPRILKAMTERQSEFTNFKRIQIAVGTWNVNGGKQFRSNLLGTAELTDWLLDAPQ 248

Query: 1825 QNG------DGSLPDMYAIGLQELIELNASSILNADGSRALQWSQLLNEQLNSFQMDEEY 1986
             +G      DGS  D++AIG +E++EL+A +I+NA  +    W + L + ++       Y
Sbjct: 249  LSGAVDYQDDGSPADVFAIGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISR---SHRY 305

Query: 1987 VLLRTESIATMALFLYVKKSKVSYVTRVAGSSKKTGLGGMAANKGACGIRCLFGTTSFAF 2166
            +LL +  +  + L+++V+   V ++  VA  + KTG+GG A NKGA GIR    +TSF F
Sbjct: 306  ILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQLHSTSFCF 365

Query: 2167 VTCHLAAGTLAVTERYNDYSTIMQGLVFPRNYYIKDHDHVIWFGDLNYRIDIPNLECRQL 2346
            V  HL AG   V ER  DY  I   L FP    I  HD+V W GD NYRID+   E    
Sbjct: 366  VCSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYF 425

Query: 2347 VANGAYKELLENDQLTRERRDRGAFNEFKEGLVKFPPTYKFDKYTNDYDTSEKQRTPSWT 2526
            V    +K+L+E DQL  ++     F +F EG V F PTYK+D  +  YDTS+K RTP+WT
Sbjct: 426  VKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGAVNFGPTYKYDVGSAAYDTSDKCRTPAWT 485

Query: 2527 DRVLF 2541
            DRVL+
Sbjct: 486  DRVLW 490


>O60162|SPBC19F5.03|O60162 (TrEMBL: Schizosaccharomyces pombe (Fission
            yeast)) Possibly involved in secretion-by similarity.
          Length = 598

 Score =  209 bits (531), Expect = 2e-52
 Identities = 139/401 (34%), Positives = 208/401 (51%), Gaps = 11/401 (2%)
 Frame = +1

Query: 454  LRKLLSNGSFYYSNDFDLTSLLQ----NRGVSSPDTRINSIDHYKPEYMWNSFLMDELIH 621
            L+  L  G FY+S  +DLT+ LQ    + G +SP  R +        + WN F   + I 
Sbjct: 106  LQNHLKTGPFYFSYTWDLTNSLQRSCTDEGKASPILRSDK------RFFWNEFASKDFID 159

Query: 622  FRSNLDTYNQLILDDNRFLTTVIRGF--AKTTPIGSNGDSLTIISKQSWKRAGTRYNTRG 795
                +  ++++ L    F+T +I GF  + +T +     +L +IS++S +RAGTRY TRG
Sbjct: 160  L---IGAHSEVSL----FITPMIYGFITSASTIVKGRTITLALISRRSKQRAGTRYFTRG 212

Query: 796  IDDNGNVANFVETEYIYYNPSKSSIFTFT--QIRGSVPTFWEQDSSLMNPKITLTRSTQA 969
            +D+NGN ANF ETE I     + S  T++  Q RGSVP FW + ++L    + +  S   
Sbjct: 213  LDENGNPANFNETEQITIVSDEKSEVTYSHVQTRGSVPAFWAEVNNLRYKPLMVANSASM 272

Query: 970  TQPVFNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFH 1149
                  KHF + +  YG   +V+L++  K  E+ I Q Y+ +    D    I Y  FDFH
Sbjct: 273  AAAAAKKHFDEQISIYGDQVVVNLVN-CKGHELPIKQLYENVIRRLDNPH-IHYHYFDFH 330

Query: 1150 HETKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLI 1329
             E      +   + +L  +Q  L   G+ T D  +  V++RQ+G+ R NC+DCLDRTN++
Sbjct: 331  KECSHMR-WDRVSLLLNEIQPELEEQGYTTLDTQKYRVLSRQNGVVRSNCMDCLDRTNVV 389

Query: 1330 EQVICRSVLENILTNQGIYNNRMAFEGMIQKHN---TLWADNGDAISQIYTGTNALKSSF 1500
            +  I R VL N L   GI         +I   N    +W+DN D IS  Y+GT ALK+ F
Sbjct: 390  QSCIGRWVLTNQLRKCGIIGATHPLRSVIPLDNIFCNIWSDNADYISLSYSGTGALKTDF 449

Query: 1501 SRSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVG 1623
            +R+G     GA +D   S  R   N F DG +Q   D+++G
Sbjct: 450  TRTGIRTRKGAFNDFVNSAKRYILNNFYDGARQDAYDLVLG 490


>P32368|RSD1|RSD1_YEAST (SP: Saccharomyces cerevisiae (Baker's yeast))
            Recessive suppressor of secretory defect.
          Length = 623

 Score =  206 bits (525), Expect = 1e-51
 Identities = 153/485 (31%), Positives = 236/485 (48%), Gaps = 38/485 (7%)
 Frame = +1

Query: 466  LSNGSFYYSNDFDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFRSNLDTY 645
            L N +FY+S  +DLT+ LQ      P     + D     + WN +L ++L +F      +
Sbjct: 119  LKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADE---RFFWNHYLTEDLRNF-----AH 170

Query: 646  NQLILDDNRFLTTVIRGFAKTTPIGSNGDSLTI--ISKQSWKRAGTRYNTRGIDDNGNVA 819
                +D   F+  VI G+AKT     N   + +  I+++S  RAGTRY  RG+D +GNV 
Sbjct: 171  QDPRIDS--FIQPVIYGYAKTVDAVLNATPIVLGLITRRSIFRAGTRYFRRGVDKDGNVG 228

Query: 820  NFVETEYIYY--NPS--KSSIFTFTQIRGSVPTFWEQDSSLM-NPKITL-TRSTQATQPV 981
            NF ETE I    NP   K  +F+F Q RGSVP +W + ++L   P + L   S  AT+  
Sbjct: 229  NFNETEQILLAENPESEKIHVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATK-- 286

Query: 982  FNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHHETK 1161
              KHF    + YG  ++V+L+++ K  E+ + + Y+ +  H     +I Y  FDFHHE +
Sbjct: 287  --KHFDQQKELYGDNYLVNLVNQ-KGHELPVKEGYESVV-HALNDPKIHYVYFDFHHECR 342

Query: 1162 IAGGFAGATKILPYLQDSLNLFGWFTYDM---------NRQEVITRQDGIFRVNCLDCLD 1314
                       +  L D L   G    D          N  E++  Q  + R NC+DCLD
Sbjct: 343  KMQWHR-----VKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQHSVVRTNCMDCLD 397

Query: 1315 RTNLIEQVICRSVLENILTNQGIYNNRMAFEG---MIQKHNTLWADNGDAISQIYTGTNA 1485
            RTN+++ V+ + VL+    +  +      +E    ++  +  LWADN DA+S  Y+GT A
Sbjct: 398  RTNVVQSVLAQWVLQKEFESADVVATGSTWEDNAPLLTSYQNLWADNADAVSVAYSGTGA 457

Query: 1486 LKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVGVDGRNSCKVKVYNP 1665
            LK+ F+R+GK    GA +D   S SR YQN + DG +Q + D+ +G    ++  +K   P
Sbjct: 458  LKTDFTRTGKRTRLGAFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFP 517

Query: 1666 ----------------ASEYIKSKLKEQENSFTSFENVKIFTGTYNVNAFN-PLMTKN-I 1791
                            A   + + +   ++ FTS +N+  F G   V A +   M KN I
Sbjct: 518  DRRPVYIQLIPMIICAALTVLGATIFFPKDRFTSSKNLLYFAGASIVLALSTKFMFKNGI 577

Query: 1792 DLTSW 1806
               +W
Sbjct: 578  QFVNW 582


>Q8MRH8|CG7956|Q8MRH8 (TrEMBL: Drosophila melanogaster (Fruit fly))
            LD42233p.
          Length = 1000

 Score =  203 bits (517), Expect = 1e-50
 Identities = 132/397 (33%), Positives = 205/397 (51%), Gaps = 6/397 (1%)
 Frame = +1

Query: 451  ELRKLLSN-GSFYYSNDFDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFR 627
            EL K+     SFY+S D D+T+ LQ     S +++    + +     WN  ++ +LI+  
Sbjct: 194  ELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQSQPDERF----FWNKHMIRDLIN-- 247

Query: 628  SNLDTYNQLILDDNRFLTTVIRGF--AKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGID 801
                      L+D  ++  +I+GF   +   IG+   +L ++S++S  RAGTRY  RG+D
Sbjct: 248  ----------LNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVD 297

Query: 802  DNGNVANFVETEYIYYNPSKSSIFTFTQIRGSVPTFWEQDSSLMNPKITLTRSTQATQPV 981
            + GN AN+VETE I     +    +FTQ+RGSVP +W Q      P   L R    TQ  
Sbjct: 298  EKGNCANYVETEQIL--SFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQA 355

Query: 982  FNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDK--KEEIDYTAFDFHHE 1155
            F  HF   L++YG   IV+L+ ++   E  I   Y    +H  K   + + Y  FDFH  
Sbjct: 356  FELHFTKELETYGRVCIVNLVEQS-GKEKTIGDAYA---DHVIKLNNDRLIYVTFDFHDY 411

Query: 1156 TKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQ 1335
             +    F   + ++  +       G+   D  ++ +I  Q  +FRVNC+DCLDRTN+++ 
Sbjct: 412  CR-GMRFENVSALIDAVGPEAGAMGFHWQD--QRGMICNQKSVFRVNCMDCLDRTNVVQT 468

Query: 1336 VICRSVLENILTNQGIYNNRMAF-EGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSG 1512
             I ++VLE+ L   G+        E +      LWA+NGD IS+ Y GTNALK  ++R+G
Sbjct: 469  AIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTG 528

Query: 1513 KMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVG 1623
            +   +G + D   S +R Y   F D  +Q TID+++G
Sbjct: 529  ERKISGMMKDGMNSANRYYLARFKDSYRQATIDLMLG 565


>Q9VD98|CG7956|Q9VD98 (TrEMBL: Drosophila melanogaster (Fruit fly))
            CG7956 protein.
          Length = 987

 Score =  203 bits (516), Expect = 1e-50
 Identities = 132/397 (33%), Positives = 205/397 (51%), Gaps = 6/397 (1%)
 Frame = +1

Query: 451  ELRKLLSN-GSFYYSNDFDLTSLLQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHFR 627
            EL K+     SFY+S D D+T+ LQ     S +++    + +     WN  ++ +LI+  
Sbjct: 194  ELHKIFDETDSFYFSFDCDITNNLQRHEAKSEESQSQPDERF----FWNKHMIRDLIN-- 247

Query: 628  SNLDTYNQLILDDNRFLTTVIRGF--AKTTPIGSNGDSLTIISKQSWKRAGTRYNTRGID 801
                      L+D  ++  +I+GF   +   IG+   +L ++S++S  RAGTRY  RG+D
Sbjct: 248  ----------LNDKTWILPIIQGFMQVENCVIGNECFTLALVSRRSRHRAGTRYKRRGVD 297

Query: 802  DNGNVANFVETEYIYYNPSKSSIFTFTQIRGSVPTFWEQDSSLMNPKITLTRSTQATQPV 981
            + GN AN+VETE I     +    +FTQ+RGSVP +W Q      P   L R    TQ  
Sbjct: 298  EKGNCANYVETEQIL--SFRHHQLSFTQVRGSVPIYWSQPGYKYRPPPRLDRGVAETQQA 355

Query: 982  FNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDK--KEEIDYTAFDFHHE 1155
            F  HF   L++YG   IV+L+ ++   E  I   Y    +H  K   + + Y  FDFH  
Sbjct: 356  FELHFTKELETYGRVCIVNLVEQS-GKEKTIGDAYA---DHVIKLNNDRLIYVTFDFHDY 411

Query: 1156 TKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIEQ 1335
             +    F   + ++  +       G+   D  ++ +I  Q  +FRVNC+DCLDRTN+++ 
Sbjct: 412  CR-GMRFENVSALIDAVGPEAGAMGFHWRD--QRGMICNQKSVFRVNCMDCLDRTNVVQT 468

Query: 1336 VICRSVLENILTNQGIYNNRMAF-EGMIQKHNTLWADNGDAISQIYTGTNALKSSFSRSG 1512
             I ++VLE+ L   G+        E +      LWA+NGD IS+ Y GTNALK  ++R+G
Sbjct: 469  AIGKAVLESQLVKLGLSPPYTPIPEQLKSPFMVLWANNGDIISRQYAGTNALKGDYTRTG 528

Query: 1513 KMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVG 1623
            +   +G + D   S +R Y   F D  +Q TID+++G
Sbjct: 529  ERKISGMMKDGMNSANRYYLARFKDSYRQATIDLMLG 565


>Q86AE0||Q86AE0 (TrEMBL: Dictyostelium discoideum (Slime mold))
            Similar to Rattus norvegicus (Rat). phosphoinositide
            phosphatase SAC1.
          Length = 581

 Score =  202 bits (514), Expect = 2e-50
 Identities = 135/401 (33%), Positives = 209/401 (52%), Gaps = 7/401 (1%)
 Frame = +1

Query: 418  DRYARVQHPCFELRKLLSNGSFYYSNDFDLTSLLQNRGVSSPDTRINSI--DHYKPEYMW 591
            D+ A  QH    +R LLS+ +FY+S D+D T  LQ +  ++  T   S   +     + W
Sbjct: 108  DQDAEEQHLSM-IRWLLSSENFYFSYDYDFTLTLQRQYSTTTTTTSGSSLGERCDSRFFW 166

Query: 592  NSFLMDELIHFRSNLDTYNQLILDDNRFLTTVIRGFAKTTPIGSNGDSLTIISKQSWKRA 771
            N    ++ +   S        IL        +  GF ++  +G      T+IS+++  R+
Sbjct: 167  N----EKYVTILSKEHGLGDWILP-------ITMGFVESKTLGGTCQ-FTLISRRNLNRS 214

Query: 772  GTRYNTRGIDDNGNVANFVETEYIYYNPSKSSIFT-FTQIRGSVPTFWEQDSSLM-NPKI 945
            GTRYN RGID  GNVAN VETE I     K + FT F Q+RGS+P  W Q  +L   P +
Sbjct: 215  GTRYNVRGIDKKGNVANNVETEQII--EIKENTFTSFVQVRGSIPLLWSQFPTLKYKPSV 272

Query: 946  TLTRSTQATQPVFNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEI 1125
                  +       +HF  + Q YG   +V+L+ + K +E+++ + Y++        +++
Sbjct: 273  KFYGDEKENSQALEQHFKQLHQLYGSTTVVNLIDR-KGAELKLGEAYEE---RVKSLKDV 328

Query: 1126 DYTAFDFHHETKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLD 1305
             Y  FDFH   K    +   + ++  L+D L  +G+F  +  +  ++ +Q G+FR NC+D
Sbjct: 329  HYVWFDFHSICK-GMRYDKLSILMDQLKDDLKQYGFFFVEDGK--IVQKQQGVFRTNCID 385

Query: 1306 CLDRTNLIEQVICRSVLENILT---NQGIYNNRMAFEGMIQKHNTLWADNGDAISQIYTG 1476
             LDRTN+++ +I R  LEN +    N+ I +     +        +WAD+GDAIS  Y+G
Sbjct: 386  NLDRTNVVQSLITRHSLENQMASVLNKQIPSTTFKGDQFEYVFKNIWADHGDAISTQYSG 445

Query: 1477 TNALKSSFSRSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQ 1599
            T ALK+ F+R+GK NF G L D   SV R Y NTF DG +Q
Sbjct: 446  TGALKNDFTRTGKRNFQGVLRDGENSVKRYYLNTFKDGFRQ 486


>Q93641|F30A10.6|Q93641 (TrEMBL: Caenorhabditis elegans) F30A10.6
            protein.
          Length = 591

 Score =  201 bits (512), Expect = 4e-50
 Identities = 132/400 (33%), Positives = 197/400 (49%), Gaps = 10/400 (2%)
 Frame = +1

Query: 454  LRKLLSNGSFYYSNDFDLTSL---LQNRGVSSPDTRINSIDHYKPEYMWNSFLMDELIHF 624
            L  +LS G FYYS   D++     LQ   V    TR + +D     ++WN  L+ ++   
Sbjct: 127  LTHVLSIGGFYYSTTLDISRTFQWLQENAVPLFKTR-SMLDRASERFIWNGHLLSQI--- 182

Query: 625  RSNLDTYNQLILDDNRFLTTVIRGFAKTTPIGSNGDS--LTIISKQSWKRAGTRYNTRGI 798
                    + +    R+   VI GF     +  NG    LTIIS++S  RAG R+  RG+
Sbjct: 183  --------RQVPGAERYTLPVIHGFIGQNRVNVNGKEIKLTIISRRSIYRAGVRFYKRGV 234

Query: 799  DDNGNVANFVETEYI--YYNPSKSSIFTFTQIRGSVPTFWEQDSSLMNPKITLTRSTQAT 972
            D +G+ ANFVETE I  Y NP K  + +F Q+RGS+P  W Q  +L    +   + T   
Sbjct: 235  DVDGHAANFVETEQIVEYTNPDKH-LTSFVQLRGSIPLLWTQKPNLRWQPMPTLKPTDDQ 293

Query: 973  QPVFNKHFGDILQSYGVCHIVDLLSKTKSSEVQISQRYQQLYNHCDKKEEIDYTAFDFHH 1152
               FN+ F    Q YG  H++  L   K  E ++    +++    +  E + Y  FDFH 
Sbjct: 294  LAAFNRAFSWHKQHYGGKHVIVNLVNQKGREKKVGGELERISRQANI-EFVRYHQFDFHK 352

Query: 1153 ETKIAGGFAGATKILPYLQDSLNLFGWFTYDMNRQEVITRQDGIFRVNCLDCLDRTNLIE 1332
            E   +  +     +   L   ++ FG+F    N  E    Q G FR NC+DCLDRTN+++
Sbjct: 353  ECH-SMQWHRIDLLREQLSQEISSFGYFYLSPNSMETSRFQRGFFRTNCMDCLDRTNVVQ 411

Query: 1333 QVICRSVLENILTNQGIYNNRMAFEG---MIQKHNTLWADNGDAISQIYTGTNALKSSFS 1503
             ++ R  L   L   GI  +    +    +      +WADNGD  S+ Y GT ALK+ F+
Sbjct: 412  SMLARESLTEQLRMLGILYSEQKVQDIPLLEDAFKQMWADNGDECSRQYAGTGALKADFT 471

Query: 1504 RSGKMNFAGALSDVTKSVSRMYQNTFVDGKKQLTIDILVG 1623
            R G+  + GA+ D   +VSR  +N F DG +Q +ID+ +G
Sbjct: 472  RHGRRTYVGAMKDGVNAVSRYVRNNFGDGYRQDSIDLFLG 511


  Database: sptrembl
    Posted date:  Oct 14, 2003  6:47 PM
  Number of letters in database: 339,323,595
  Number of sequences in database:  1,070,300
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 905,259,445
Number of Sequences: 1070300
Number of extensions: 19156282
Number of successful extensions: 69940
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60824
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 68557
length of database: 339,323,595
effective HSP length: 132
effective length of database: 198,043,995
effective search space used: 198043995000
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)