BLASTX 2.2.6 [Apr-09-2003]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= Candida_albicans_chr7-r2-273406-268112-32
         (5292 letters)

Database: sptrembl 
           1,070,300 sequences; 339,323,595 total letters

Searching.................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

P15442|GCN2|GCN2_YEAST (SP: Saccharomyces cerevisiae (Baker's ye...   881   0.0  
O74297|CPC-3|O74297 (TrEMBL: Neurospora crassa) CPC3 protein.         471   e-131
Q9HGN1|SPBC36B7.09|Q9HGN1 (TrEMBL: Schizosaccharomyces pombe (Fi...   297   1e-78
Q9ESB8|EIF2AK4|Q9ESB8 (TrEMBL: Mus musculus (Mouse)) GCN2alpha.       294   7e-78
Q9ESB6|EIF2AK4|Q9ESB6 (TrEMBL: Mus musculus (Mouse)) GCN2gamma.       294   7e-78
Q9ESB7|EIF2AK4|Q9ESB7 (TrEMBL: Mus musculus (Mouse)) GCN2beta.        294   7e-78
Q9QZ05|EIF2AK4|Q9QZ05 (TrEMBL: Mus musculus (Mouse)) GCN2 eIF2al...   293   2e-77
Q9P2K8|KIAA1338|Q9P2K8 (TrEMBL: Homo sapiens (Human)) Hypothetic...   291   5e-77
Q9HDW2|SPBP18G5.01|Q9HDW2 (TrEMBL: Schizosaccharomyces pombe (Fi...   274   1e-71
Q86B04||Q86B04 (TrEMBL: Dictyostelium discoideum (Slime mold)) S...   268   7e-70
Q869P4||Q869P4 (TrEMBL: Dictyostelium discoideum (Slime mold)) S...   266   2e-69
Q9NSQ3|DKFZP434F1312|Q9NSQ3 (TrEMBL: Homo sapiens (Human)) Hypot...   239   3e-61
Q8H2D3|GCN2|Q8H2D3 (TrEMBL: Arabidopsis thaliana (Mouse-ear cres...   206   2e-51
O61651|GCN2|O61651 (TrEMBL: Drosophila melanogaster (Fruit fly))...   205   4e-51
Q9V9X8|GCN2|Q9V9X8 (TrEMBL: Drosophila melanogaster (Fruit fly))...   205   4e-51
O01712|GCN2|O01712 (TrEMBL: Drosophila melanogaster (Fruit fly))...   204   9e-51
Q9LX30|F25L23_270|Q9LX30 (TrEMBL: Arabidopsis thaliana (Mouse-ea...   200   2e-49
Q9H5K1||Q9H5K1 (TrEMBL: Homo sapiens (Human)) Hypothetical prote...   185   6e-45
Q96GN6||Q96GN6 (TrEMBL: Homo sapiens (Human)) Hypothetical protein.   184   8e-45
Q9XVY4|Y81G3A.3|Q9XVY4 (TrEMBL: Caenorhabditis elegans) Y81G3A.3...   182   3e-44
Q86A61||Q86A61 (TrEMBL: Dictyostelium discoideum (Slime mold)) S...   176   4e-42
Q8I739||Q8I739 (TrEMBL: Bombyx mori (Silk moth)) EIF 2a kinase.       144   9e-33
Q8C5S0||Q8C5S0 (TrEMBL: Mus musculus (Mouse)) Eukaryotic transla...   132   3e-29
Q9Z1Z1|EIF2AK3|E2K3_RAT (SP: Rattus norvegicus (Rat)) Eukaryotic...   121   1e-25
Q9Z2B5|EIF2AK3|E2K3_MOUSE (SP: Mus musculus (Mouse)) Eukaryotic ...   117   1e-24
Q9NZJ5|EIF2AK3|E2K3_HUMAN (SP: Homo sapiens (Human)) Eukaryotic ...   117   2e-24
Q9NIV1|EIF2AK3|E2K3_DROME (SP: Drosophila melanogaster (Fruit fl...   112   5e-23
Q9SDY1||Q9SDY1 (TrEMBL: Glycine max (Soybean)) Phosphoenolpyruva...   107   1e-21
Q8GRP7|PPCK1|Q8GRP7 (TrEMBL: Glycine max (Soybean)) Phosphoenolp...   107   1e-21
Q98SS6||Q98SS6 (TrEMBL: Gallus gallus (Chicken)) Eukaryotic init...   106   4e-21

>P15442|GCN2|GCN2_YEAST (SP: Saccharomyces cerevisiae (Baker's yeast))
            Protein kinase GCN2 (EC 2.7.1.-).
          Length = 1590

 Score =  881 bits (2277), Expect = 0.0
 Identities = 593/1746 (33%), Positives = 883/1746 (50%), Gaps = 52/1746 (2%)
 Frame = +1

Query: 211  TPTYPLSPPKVKLLNARNLLKINIAKLEKKCKDLIKEYPEQEVSFTIISELIFMLDEIQT 390
            TP YP + P+++  N +N++   +  L+ + K +      QE+ F I S     LDE Q 
Sbjct: 2    TPMYPYTAPEIEFKNVQNVMDSQLQMLKSEFKKIHNTSRGQEIIFEITSFTQEKLDEFQN 61

Query: 391  TTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRKKQNKELNEQIQKIQGEFXXXX 570
                                                 R  + + ++E +Q+ + E     
Sbjct: 62   VVNTQSLEDDRLQRIKETKEQLEKEEREKQQETIKK-RSDEQRRIDEIVQR-ELEKRQDD 119

Query: 571  XXXXXXXMSTTNDNNNSLIPLDKDQFFIFENAMEATIPNTRRKFKFRAILGFIRYNQKGV 750
                    +T  D       +   +  +F   ++A +PN    FKF+A++          
Sbjct: 120  DDDLLFNRTTQLDLQPPSEWVASGEAIVFSKTIKAKLPNNSM-FKFKAVVNPKPIKLTSD 178

Query: 751  FNSIGSQYIVKPFIDNEIRNKIENKGSDLA----FLLTVIDLTNEYWQTDKGKREIQDLE 918
              S   Q++VKP+I  E         S++     +LL+ I+L N Y+ T  GK+EI +LE
Sbjct: 179  IFSFSKQFLVKPYIPPESPLADFLMSSEMMENFYYLLSEIELDNSYFNTSNGKKEIANLE 238

Query: 919  SELQSIMSINHSNILKLIGFQIDK------TNVWRVRLLTEFSPVSETLYDILPTAEFIN 1080
             EL++++   H N+ +L G+ +++      T VW++RLLTE+      L D++ +  F+N
Sbjct: 239  KELETVLKAKHDNVNRLFGYTVERMGRNNATFVWKIRLLTEYCNYYP-LGDLIQSVGFVN 297

Query: 1081 WALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQNSTNELLSNSIXXXX 1260
             A AR W+I+LL  +E +H  G +HK I   T+++ ++ D                    
Sbjct: 298  LATARIWMIRLLEGLEAIHKLGIVHKCINLETVILVKDAD-------------------- 337

Query: 1261 XXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQVNPPAWLAPEL---K 1431
                         + KL H +YGY +L M+  +PN+  +   S +++P  W+APEL    
Sbjct: 338  ---------FGSTIPKLVHSTYGYTVLNMLSRYPNKNGS---SVELSPSTWIAPELLKFN 385

Query: 1432 TSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGAEEYASLVYDVL 1611
             +     +DIW LGVLF++++ G DI+   + TP +F++  S+ +          +YD+L
Sbjct: 386  NAKPQRLTDIWQLGVLFIQIISGSDIV-MNFETPQEFLDSTSMDE---------TLYDLL 435

Query: 1612 SKMLQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDLVSSTNTRHVQI 1791
            SKML     KR   LEL  +KFLR    I    +  NL  + ++V ++ +  T    + +
Sbjct: 436  SKMLNNDPKKRLGTLELLPMKFLRTN--IDSTINRFNL--VSESVNSNSLELTPGDTITV 491

Query: 1792 QGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQRNMGRYARDFE 1971
            +G+   + +         Q+  RRR  N        G   S I P+       RYA DFE
Sbjct: 492  RGNGGRTLS---------QSSIRRRSFN-------VGSRFSSINPA----TRSRYASDFE 531

Query: 1972 EIGKLGRGGFGEVVKARSRMEGIFYAVKKIKHRADKLDSLLSEVLSLARLNHQYIVRYYG 2151
            EI  LG+G FG+VVKAR+ ++  +YA+KKI+H  +KL ++LSEV+ LA LNHQY+VRYY 
Sbjct: 532  EIAVLGQGAFGQVVKARNALDSRYYAIKKIRHTEEKLSTILSEVMLLASLNHQYVVRYYA 591

Query: 2152 TWVEELE-DTSAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXXSSRVGRSSSVLP 2328
             W+EE   D +   S    +  S                              R++  L 
Sbjct: 592  AWLEEDSMDENVFESTDEESDLSESSSDFEENDLLDQSSIFK----------NRTNHDL- 640

Query: 2329 SYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANSTDDISNNETEDRXXXXXX 2508
              DNS   D+IS S  P I                  VF NS+ D  N + +        
Sbjct: 641  --DNS-NWDFISGSGYPDI------------------VFENSSRDDENEDLDHDTSSTSS 679

Query: 2509 XXXXXXXXXXXNSSKNA-------------SPKSILYIQMEFCENNTLLNLIE-QGLPNN 2646
                        S +N                KS L+IQME+CEN TL +LI  + L   
Sbjct: 680  SESQDDTDKESKSIQNVPRRRNFVKPMTAVKKKSTLFIQMEYCENRTLYDLIHSENLNQQ 739

Query: 2647 PDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNSQFSSVVLT 2826
             DEYWRLFRQ+LEA+SYIH +G IHRDLKPMNIFID S N+K+GDFGLAKN   S  +L 
Sbjct: 740  RDEYWRLFRQILEALSYIHSQGIIHRDLKPMNIFIDESRNVKIGDFGLAKNVHRSLDILK 799

Query: 2827 --NNQVEAKDNELSTVVGTLFYTANEV--ATGQYDEKVDMYSLGIIFFEMCYPLATGMQR 2994
              +  +    + L++ +GT  Y A EV   TG Y+EK+DMYSLGIIFFEM YP +TGM+R
Sbjct: 800  LDSQNLPGSSDNLTSAIGTAMYVATEVLDGTGHYNEKIDMYSLGIIFFEMIYPFSTGMER 859

Query: 2995 AKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQDQ 3174
               L  LR  S+EFP +F  +K K EKKIIRLL+DHDP  RP A  LL SGWLPV+HQD+
Sbjct: 860  VNILKKLRSVSIEFPPDFDDNKMKVEKKIIRLLIDHDPNKRPGARTLLNSGWLPVKHQDE 919

Query: 3175 VIQEALKSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLL 3354
            VI+EALKSL++P+SPWQQQVRE+LFNQ Y L  D++FD           V   T    +L
Sbjct: 920  VIKEALKSLSNPSSPWQQQVRESLFNQSYSLTNDILFDNS---------VPTSTPFANIL 970

Query: 3355 FDKIMKELTKIFTNHGAIENLNTNLVLPKAPSQSRELVYDFLDRSGAVLTLPYDLTLPTA 3534
              ++ +E+ KIF  HG IEN     + PKAP    + VY+ LD+ G VL L YDLT P A
Sbjct: 971  RSQMTEEVVKIFRKHGGIENNAPPRIFPKAPIYGTQNVYEVLDKGGTVLQLQYDLTYPMA 1030

Query: 3535 RFLSKTDMTIPKTFRHEFVYRP--NVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAEC 3708
            R+LSK    I K +R + VYRP  + R    P ++  ++FDI   +  + +    +DAE 
Sbjct: 1031 RYLSKNPSLISKQYRMQHVYRPPDHSRSSLEPRKFGEIDFDI---ISKSSSESGFYDAES 1087

Query: 3709 LKVIDEIVNTLPCFK--NTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGID 3882
            LK+IDEI+   P F+  NT  ++NH DIL++V +F+     ID  ++  +  +LSQ+G  
Sbjct: 1088 LKIIDEILTVFPVFEKTNTFFILNHADILESVFNFT----NIDKAQRPLVSRMLSQVGFA 1143

Query: 3883 KSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVERARQKLQKLMVDSPPLLKVERAYTY 4062
            +S  E+K  L+    +  T   DL E F+F  + E A+++L KLM+DSP L K+E + ++
Sbjct: 1144 RSFKEVKNELKAQLNISSTALNDL-ELFDFRLDFEAAKKRLYKLMIDSPHLKKIEDSLSH 1202

Query: 4063 LIEVVKILKHTNIKTSMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTRVVTGGRYDSL 4242
            + +V+  LK   +  +++ +PLSNYNS +Y  GIMF AV+    S+    +  GGRYD+L
Sbjct: 1203 ISKVLSYLKPLEVARNVVISPLSNYNSAFYKGGIMFHAVYDDGSSR--NMIAAGGRYDTL 1260

Query: 4243 IESFSNVTTTTKQITPHGVGFSLTTSLLFILMKT---------LISRGKSKLDLVNKWKG 4395
            I  F+  +      T   VGF+L    +F + +          +  R +   D    WK 
Sbjct: 1261 ISFFARPSGKKSSNTRKAVGFNLAWETIFGIAQNYFKLASGNRIKKRNRFLKDTAVDWKP 1320

Query: 4396 NRCKVLISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVI 4575
            +RC VLISS     L  +G  +++  W +NI AD+    +   D++      +G  WI++
Sbjct: 1321 SRCDVLISSFSNSLLDTIGVTILNTLWKQNIKADMLRDCSSV-DDVVTGAQQDGIDWILL 1379

Query: 4576 IRLLPTTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPLKLRNIITGKDIDLD 4755
            I+                                         KPLK++ + T  DIDLD
Sbjct: 1380 IK----------------------------QQAYPLTNHKRKYKPLKIKKLSTNVDIDLD 1411

Query: 4756 YDEVIDYLVTELLEDSEHEENDQDNGTMTNXXXXXXXXXXXXKTNQEEELLNGPIDSVEI 4935
             DE     +T   +++ ++    D+ T+ +                 +E   G ID V  
Sbjct: 1412 LDE----FLTLYQQETGNKSLINDSLTLGDKADEFKRWDENSSAGSSQE---GDIDDVVA 1464

Query: 4936 ----DQKIIVVKNDAPRSRK-NKRDKWESENDAKLAGQQCIKNLSGGPVVVIDA-RDEIL 5097
                +QK+I V N A RS+K NKR+KW  E+ A+ +    + NLS  P++ +DA RDE L
Sbjct: 1465 GSTNNQKVIYVPNMATRSKKANKREKWVYEDAARNSSNMILHNLSNAPIITVDALRDETL 1524

Query: 5098 DMISITSIHQQDEWIRKVVYTTNN-FPKSFAMNIYNTLIKEFNKGSIWCILVSSRTQHTT 5274
            ++ISITS+ Q++EW+RKV  + NN  P+SFA +IYN L KE +KG+ W IL   +T  ++
Sbjct: 1525 EIISITSLAQKEEWLRKVFGSGNNSTPRSFATSIYNNLSKEAHKGNRWAILYCHKTGKSS 1584

Query: 5275 IVDLRR 5292
            ++DL+R
Sbjct: 1585 VIDLQR 1590


>O74297|CPC-3|O74297 (TrEMBL: Neurospora crassa) CPC3 protein.
          Length = 1646

 Score =  471 bits (1213), Expect = e-131
 Identities = 433/1811 (23%), Positives = 769/1811 (42%), Gaps = 62/1811 (3%)
 Frame = +1

Query: 40   QQDEISSISSIYGDIFKDITPTGLVWNKKPSPHFQVFLSSSNNPDRPTVSITLDIEFTPT 219
            Q+ E+  + +IYG+ F         W K   P F + +  S++ +   +S+TL +    T
Sbjct: 48   QESEVMVLQAIYGEDFTQHEAAHGAWQKS-EPRFDIKIKPSSDQE---LSVTLGVVMVAT 103

Query: 220  YPLSPPKVKLLNARNLLKINIAKLEKKCKDLIKEYPEQEVSFTIISELIFMLDEIQTTTX 399
            YP +PP + + +  +L +    K++K  +   K Y + E    +I +++  + +I     
Sbjct: 104  YPKTPPLLTIKDDHSLRESTKFKIQKFVETQPKIYAQAEQE--MIDQIVEGIRDILEEAA 161

Query: 400  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRKKQNKELNEQIQKIQGEFXXXXXXX 579
                                               +K+ +E  E+ + ++          
Sbjct: 162  QKKVQGLEIPSLEEERAAHEAELARLAQSEKEREERKKLEESKEEERVLEDMLQEELKRQ 221

Query: 580  XXXXMSTTNDNNNSLIPLDK--------DQFFIFENAMEATIPNTRRKFKFRAILGFIRY 735
                  +   N +  +  D+        D+  +F+   + T  +    F F+ ++G    
Sbjct: 222  RNKAKESRKKNRSHQLSPDRAPQDPGETDETLMFDQPCKITDGSGNALF-FQTVIG---- 276

Query: 736  NQKGVFNS--IGSQYIVKPFIDNEIRNKIENKGSDLAFLLTVIDLTNEYWQTDKGKREIQ 909
              K VF    I + Y VKP +               +  L  +++ +    + + K+++Q
Sbjct: 277  --KTVFREGPITTVYKVKPVLSARTVRP--------SLALKQVEVKSHGKDSAQFKKQLQ 326

Query: 910  DLESELQSIMSINHSNILKLIGFQIDK---------TNVWRVRLLTEFSPVSETLYDILP 1062
             LES+++++  + H N+L  + F+ID+           +W V +LT  +     + ++L 
Sbjct: 327  YLESQMETLKKLRHQNLLPFLDFRIDRGISDTDSSAPTIWTVSILTPLA-TKGPIEELLD 385

Query: 1063 TAEFINWALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQNSTNELLSN 1242
             A  I+   A+ W   LL A+ +LHN G IH+ + P  I++        Y+N   +++  
Sbjct: 386  LAGHIDTNKAKIWTADLLEALAFLHNNGIIHQDLHPANILL--------YRNEAGDIVPK 437

Query: 1243 SIXXXXXXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQVNPPAWLAP 1422
                         +   +++  LC                 + +TL  S       W  P
Sbjct: 438  ITD----------SFYQRELHNLC----------------TKIKTLTSSKAAKSAYWFPP 471

Query: 1423 ELK---TSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGAEEYAS 1593
            E+       Y  K+D+WD G++FL+++ G D++   YH+PS  ++  S+         ++
Sbjct: 472  EIAGVTKPQYTQKTDVWDFGIVFLQMIFGLDVVEK-YHSPSALMDSLSL---------SA 521

Query: 1594 LVYDVLSKMLQVKLSKRPSPLELNAVKFLR-DGPIISKLQSETNLSRMKKNVETDLVSST 1770
             + +++SK  +    KRP   EL++ +FL  + PII                        
Sbjct: 522  PLEELVSKFFKSDPKKRPRAFELSSSEFLATNAPII------------------------ 557

Query: 1771 NTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQRNMG 1950
            +   + + G        T    + H ++SR  +S+                         
Sbjct: 558  DDEDIAVPGSLMPMPQMTPQ-RMRHDSMSRGPMSS------------------------- 591

Query: 1951 RYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKIKHRADK-LDSLLSEVLSLARLNH 2127
            RY +D+ E  +LG+GGFGEVV+AR  ++G  YA+KKI  R+ + L  +L EV  L+++NH
Sbjct: 592  RYRQDYVEEARLGKGGFGEVVRARKMIDGHLYAIKKITQRSQETLSEILKEVRLLSQMNH 651

Query: 2128 QYIVRYYGTWVEELEDTSAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXXSSRVG 2307
              +VRYY TW+EE+ D +    ++++   +                            + 
Sbjct: 652  PAVVRYYNTWLEEVPDYADTEGDTSTEGGATDVTDNSQVT------------------IS 693

Query: 2308 RSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANSTDDISNNETED 2487
               ++  +   S  +D++S+S  P I                     +  +D S+N++ D
Sbjct: 694  HGINIEFAESKSRGLDFMSSSGHPGIEYDYSSSEEEDDDEDE-----DDEEDESDNDSND 748

Query: 2488 RXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLIEQGLPNNPDEYWRL 2667
                                      K+++YI ME+CE  TL +LI + L     E WRL
Sbjct: 749  DAATVSGKNHLGVTGRRPRRGSARPYKTVMYISMEYCEKRTLRDLISRNLSKETAEIWRL 808

Query: 2668 FRQLLEAVSYIHREGFIHRDLKPMNIFI----DRSNNIKVGDFGLAKNSQFSSVVLTNNQ 2835
            FRQ+LE + +IH    +HRDLKP NIFI    D  +N+K+GDFGLA + Q   + +  + 
Sbjct: 809  FRQILEGLCHIHSLNIVHRDLKPENIFISSGPDGLDNVKIGDFGLATSGQ---LAIDRST 865

Query: 2836 VEAKDNELSTVVGTLFYTANEVAT---GQYDEKVDMYSLGIIFFEMCYPLATGMQRAKTL 3006
                 ++++  +GT  Y A EV T   G Y  KVDMYSLG+IFFEM YP   GMQRA  L
Sbjct: 866  ASLDASDMTRSIGTAVYVAPEVRTGGSGSYTSKVDMYSLGVIFFEMSYPPMLGMQRAMVL 925

Query: 3007 NDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQDQVIQE 3186
              LR      P +F     K   +++  LL H+PK RPS+++L++SG LP++ + + I+ 
Sbjct: 926  EQLRQSPPILPADF-KHMDKNHLEVLLSLLTHNPKERPSSSELMKSGKLPIQMESEAIRR 984

Query: 3187 ALKSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLLFDKI 3366
            A+  L+DP SP+ Q++ E LF++P   AKD  +D  +   S  +          L+   I
Sbjct: 985  AIAGLSDPNSPYYQKMLETLFSRPIEQAKDYAWDMSSSGPSPQE----------LMRQFI 1034

Query: 3367 MKE-LTKIFTNHGAIENLNTNLVLPKAPSQSRELVYDFLDRSGAVLTLPYDLTLPTARFL 3543
            +K+ L  IF  HGA+E   T  + P +    +  V+  LD++G VL LP+DL +  AR L
Sbjct: 1035 VKDTLISIFRRHGAVE-APTVCLYPSSSHYGQNAVH-LLDQNGTVLQLPFDLMMGHARSL 1092

Query: 3544 SK--TDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKV 3717
            ++      + K++    ++R    G G PD Y  V+FDI   +  +   L   +AE +KV
Sbjct: 1093 ARITNSPVVQKSYSFGNIFRDR-HGGGQPDVYGEVDFDI---VTSDALDLALKEAEVIKV 1148

Query: 3718 IDEIVNTLPCFKNTIIV--INHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGI-DKS 3888
            +DEI    P   +T I   + H D+L+ +    F   G++   +     VLS+L I + +
Sbjct: 1149 LDEIATAFPTVSSTPICFQLGHSDLLNLI----FEYCGVEVGTRRAAAEVLSKLNIRNFT 1204

Query: 3889 PDEIKRYLREDFQVPHTVTKDLVENFNFTCEVERARQKLQKLMVDSPPLLKVERAYTYLI 4068
              +++  LR         + D ++ F+F     +A  K++ L   +    +      +L 
Sbjct: 1205 WQKVRGELRSPMVGISATSVDELQRFDFRDTPSKAIAKIKLLFEGTEYYQQASSTLAHLK 1264

Query: 4069 EVVKILKHTNIKTSMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTRVVTGGRYDSLIE 4248
            EV +  K   ++  +   PLS+ N  ++  GI+F  ++     K       GGRYDSLI+
Sbjct: 1265 EVYEYTKRFGVQNKIYIAPLSSINEAFFRGGILFSCLYD---KKVKDVFAAGGRYDSLIK 1321

Query: 4249 SFSNVTTTTKQITPHGVGFSLTTSLLF------ILMKTLISRGKSKLDLVNKWKGNRCKV 4410
                     +    H VGFSL               KT + +   + +    +   RC V
Sbjct: 1322 E-HRPKIGNRFEERHAVGFSLNWEKQLAKPVPKATGKTFLKKAAEE-ESQGLFNIKRCDV 1379

Query: 4411 LISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVIIRLLP 4590
            L++S   + L   G +LV   W  +ISA++    A++ +++      E  +W+VII+   
Sbjct: 1380 LVASFDPEVLRSSGIELVQTLWAHSISAELAR-DARSPEDLLSKYRDESYLWVVIIK--- 1435

Query: 4591 TTXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKPLKLRNII--TGKDIDLDYDE 4764
                                                    LK++++      D D+   E
Sbjct: 1436 ------------------------------------QDNMLKIKSMARKDAPDADIPAKE 1459

Query: 4765 VIDYLVTELLEDSEHEENDQDNGTMTNXX---------XXXXXXXXXXKTNQEEELLNGP 4917
            ++++L  E+ E+ +       +G++++                      TN  E  LN  
Sbjct: 1460 LLNWLKAEMRENRDALMRGTGSGSISSGAAIKFRGGGGSGGGGGLSSFGTNNSE--LNSG 1517

Query: 4918 I---DSVEIDQKIIVVKNDAPRSRKNKRDKWESENDAKLAGQQCIKNLSGGPVVVIDARD 5088
            +      E +Q++ V+       + N+R   E    A+++  + +++   GP+  I+  D
Sbjct: 1518 LFLGADGEREQEVHVLVAQTKSKKFNRRQVVE---QAQMSAAKLLQSFLDGPIAAIETSD 1574

Query: 5089 EILDMISITSIHQQDEWIRKVVYTTNNFPKSFAMNIYNTLIK-----EFNKGSIWCILVS 5253
             ++DMI  TS+   + W R+V +      K +   I++ L       E  KGS    + +
Sbjct: 1575 SVMDMIRRTSLSDAESW-RRVEHNVGTSEKKYVKEIHDMLKGWRWEWEAKKGSEHAFVYN 1633

Query: 5254 SRTQHTTIVDL 5286
             RT      DL
Sbjct: 1634 FRTGRCIYYDL 1644


>Q9HGN1|SPBC36B7.09|Q9HGN1 (TrEMBL: Schizosaccharomyces pombe (Fission
            yeast)) Eif-2alpha kinase (Fragment).
          Length = 903

 Score =  297 bits (760), Expect = 1e-78
 Identities = 280/1054 (26%), Positives = 438/1054 (41%), Gaps = 32/1054 (3%)
 Frame = +1

Query: 40   QQDEISSISSIYGDIFKDITPTGLVWNKKPSPHFQVFLSSSNNPDRPTVSITLDIEFTPT 219
            Q++EI ++ +I+ D F+++      WN      + + L S +   +    + L IE   +
Sbjct: 14   QENEIEALKAIFMDDFEELKVRN-AWNVTNGHVYCIHLCSRSANSKSIAKLDLCIELGRS 72

Query: 220  YPLSPPKVKLLNARNLLKINIAKLEKKCKDLIKEYPEQEVSFTIISELIFMLDEIQTTTX 399
            YP   P +KL N  N+L   I  L  K     K+   +E    +I EL  ++ +      
Sbjct: 73   YPYVKPVIKLQNGENVLNSQIRFLLDKLDTKAKDLLGEE----MIFELASIVQDYLNDWQ 128

Query: 400  XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRKKQNKELNEQI--QKIQGEFXXXXX 573
                                              R+K      EQ    KIQ E      
Sbjct: 129  SDLSSQFASLEEERAVQLKHDRERAEVDLQLRLKREKDALFEEEQTLQNKIQDELQRRSY 188

Query: 574  XX--XXXXMSTTNDNNNSLIPLDKDQFFIFENAMEATIPNTRRKFKFRAILGFIRYNQKG 747
                      T +    SL  L    +F    ++     +      F  +L     +   
Sbjct: 189  ETPQSSSKKKTNSKETTSLETLPTSIYFDCSISVRDCHDSL---VTFNRVLPLYTISH-- 243

Query: 748  VFNSIGSQYIVKPFIDNEIRNKIENKGSDLAFLLTVIDLTNEYWQTDKGKREIQDLESEL 927
              +++ +  +VKP          E    D  FLL  + ++  YW T+ GKREIQ+LE EL
Sbjct: 244  --SNLSTLTLVKP-------ESKEISLQDCVFLLRTVRISTPYWSTEDGKREIQELEYEL 294

Query: 928  QSIMSINHSNILKLIGFQIDKTNV---WRVRLLTEFSPVSETLYDILPTAEFINWALART 1098
            +S+  I H  +  +  +Q+++      WR+ +L E+SP   TL+ +L T   ++    R 
Sbjct: 295  ESLKVIRHDLLASIYEYQLERETRGYGWRLYVLQEYSP-KFTLFSLLQTVLTLDVETVRA 353

Query: 1099 WLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQNSTNELLSNSIXXXXXXXEDS 1278
            +   +L  +  LH  G  HK +    +V+F    + +                       
Sbjct: 354  FSNNILEGLAELHRLGISHKSLHLDNVVLFHSGHRTF----------------------- 390

Query: 1279 LTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQVNPPAWLAPELKTSGY---HY 1449
                     KL    +   L +M   HP    +   +  + P     PE+  S +     
Sbjct: 391  --------AKLMDFGFTRTLRDMNASHPFNINSQSIT-NILPEGLYPPEVSESSFAAASR 441

Query: 1450 KSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGAEEYASL---VYDVLSKM 1620
            K+DIW  G+L L+++ G  +LN           KFS    +       L     D++ + 
Sbjct: 442  KTDIWCFGLLVLQMLCGAHVLN-----------KFSSLKLIMTHVIPLLPGSYQDLVRRC 490

Query: 1621 LQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDLVSSTNTRHVQIQGH 1800
            L     KRPS ++L +   +R G  +     +   S+  +                    
Sbjct: 491  LMRDSRKRPSAIDLLSSHVIRLGTAVLPPVEQGTFSKSAR-------------------- 530

Query: 1801 EQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQRNMGRYARDFEEIG 1980
                                          P +G     I+    ++++ RY  DFEE+ 
Sbjct: 531  ------------------------------PSYGGQQDGIIDLLYRKSVSRYETDFEELE 560

Query: 1981 KLGRGGFGEVVKARSRMEGIFYAVKKIKHRADKLDS--LLSEVLSLARLNHQYIVRYYGT 2154
             LGRGGFGEVVK ++R++G FYAVKK+   +D  ++  +L EV++L+RL+H+++VRYY  
Sbjct: 561  FLGRGGFGEVVKVKNRIDGRFYAVKKLVLLSDDKENSRILREVMTLSRLHHEHVVRYYTA 620

Query: 2155 WVE-ELEDT--SAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXXSSRVGRSSSVL 2325
            WVE E  DT    I S+S S   S                              R SS L
Sbjct: 621  WVETEANDTVTEIISSDSESLSQSLNMAVDF-----------------------RQSSSL 657

Query: 2326 P-----SYDNSFQVDYISTSF--DPRIXXXXXXXXXXXXXXXXPFVFANSTDDISNNETE 2484
            P     S D  F+ DY S++   DP                   F ++N++D   +++ +
Sbjct: 658  PADKLSSLDIHFEDDYNSSADEEDPEASDIS-------------FQYSNTSDKEGSSDKD 704

Query: 2485 DRXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLIEQGLPNNPDEYWR 2664
                                +  NA+    LYIQME+CE  +L ++I   +P   DE WR
Sbjct: 705  S-------SIEEASSVKTQENGLNAT----LYIQMEYCEKLSLQDIIRDKIP--VDEMWR 751

Query: 2665 LFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLA---KNSQFSSVVLTNNQ 2835
            LFRQ+LEA++YIH  G +HRDLKP NIF+D + N+K+GDFGLA   +N Q ++    N Q
Sbjct: 752  LFRQILEALAYIHSRGMMHRDLKPGNIFLDENRNVKLGDFGLATENENYQDNNDKWKNRQ 811

Query: 2836 VEAKDNELSTVVGTLFYTANEVATG----QYDEKVDMYSLGIIFFEMCYPLATGMQRAKT 3003
              + D +L+T VGT  Y A E+ +     +YD KVDMYSLGII FEMC   +T M+R + 
Sbjct: 812  --SADEDLTTGVGTALYVAPELLSRRNGVRYDAKVDMYSLGIILFEMCMTFSTSMERIRI 869

Query: 3004 LNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHD 3105
            ++ +R  S+ FP+ F  S+   E K+I  LL HD
Sbjct: 870  IDTIRSPSISFPSTFPFSRASHEFKVIHCLLQHD 903


>Q9ESB8|EIF2AK4|Q9ESB8 (TrEMBL: Mus musculus (Mouse)) GCN2alpha.
          Length = 1370

 Score =  294 bits (753), Expect = 7e-78
 Identities = 326/1275 (25%), Positives = 526/1275 (41%), Gaps = 52/1275 (4%)
 Frame = +1

Query: 865  TNEYWQTDKGKREIQDLESELQSIMSINHSNILKLIGFQI--DKTNVWRVRLLTEFSPVS 1038
            + E  + DK KR+IQ  E+E  S++ ++H NI++        ++ ++    L    S +S
Sbjct: 48   SQEKEKIDKCKRQIQGAETEFSSLVKLSHPNIVRYFAMNSREEEDSIVIDILAEHVSGIS 107

Query: 1039 ETLYDILPTAEFINWALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQN 1218
               +  L  +  +     R +  QLL  ++YLH+   +HK++                  
Sbjct: 108  LATH--LSHSGPVPAHQLRKYTAQLLAGLDYLHSNSVVHKVL------------------ 147

Query: 1219 STNELLSNSIXXXXXXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQV 1398
                               S+ + A+  +K+   S   RL ++      E   +  S   
Sbjct: 148  ----------------SASSVLVDAEGTVKITDYSISKRLADICKEDVFEQARVRFSDSA 191

Query: 1399 NPPAWLAPELKTSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGA 1578
             P        KT     K D+W LG+L L +  G +        PSD    F        
Sbjct: 192  LP-------YKTGK---KGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQ------- 234

Query: 1579 EEYASLVYDVLSKMLQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDL 1758
                    D L K + +   +R SP +L    F+   P +  ++     S  +  +ET +
Sbjct: 235  --------DFLKKCVCLDDKERWSPQQLLKHSFINPQPKLPLVEQSPEDSGGQDYIETVI 286

Query: 1759 VSSTNTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQ 1938
             S                                    NQ     +F E         +Q
Sbjct: 287  PS------------------------------------NQLPSAAFFSE---------TQ 301

Query: 1939 RNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKI--KHRADKLDSLLSEVLSL 2112
            +   RY  +FEE+  LG+G FG V+K +++++G  YAVK+I     +     +  EV  L
Sbjct: 302  KQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLL 361

Query: 2113 ARLNHQYIVRYYGTWVEELEDTSAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXX 2292
            +RL+H+ IVRYY  W+E  E   A+P                                  
Sbjct: 362  SRLHHENIVRYYNAWIERHE-RPAVPGTPPPDCTPQAQDSPATYGKTSGDTEELGSVEAA 420

Query: 2293 ------SSRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANS 2454
                  SS V  S+S   S    F V    +S D                    F+ A+ 
Sbjct: 421  APPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEE------DEDERDGVFSQSFLPASD 474

Query: 2455 TDD--ISNNETED-RXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLI 2625
            +D   I +NE E+ +                   S  A     LYIQME+CE +TL + I
Sbjct: 475  SDSDIIFDNEDENSKSQNQDEDCNQKDGSHEVEPSVTAEAVHYLYIQMEYCEKSTLRDTI 534

Query: 2626 EQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNS- 2802
            +QGL  +    WRLFR++L+ ++YIH +G IHRDLKP+NIF+D  +++K+GDFGLA +  
Sbjct: 535  DQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 594

Query: 2803 QFSSVVLTNNQVEAK------DNELSTVVGTLFYTANEV---ATGQYDEKVDMYSLGIIF 2955
             F++    + Q   +         L+ +VGT  Y + EV       Y++KVD++SLGIIF
Sbjct: 595  AFTAEGKQDGQAGDRVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIF 654

Query: 2956 FEMCY-PLATGMQRAKTLNDLR-LKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAA 3129
            FEM Y P+ T  +R   LN LR   S +FP +F   ++  +K +I  LL+HDP  RP+A 
Sbjct: 655  FEMSYHPMVTASERIFVLNQLRDPTSPKFPDDFDDGEHTKQKSVISWLLNHDPAKRPTAM 714

Query: 3130 QLLQSGWL-PVEHQDQVIQEAL-KSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEH 3303
            +LL+S  L P + ++  + E L  +LA+      + +   LF Q    A D  +D     
Sbjct: 715  ELLKSELLPPPQMEESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYDS---- 770

Query: 3304 NSHNKHVELDTSNDYLLFDKIM----KELTKIFTNHGAIENLNTNLVLPKAPSQSRELVY 3471
                   ++   N  +   KI     + + ++F  HGA++ L T L+LP+        +Y
Sbjct: 771  -------DILKGNFLIRTAKIQQLVCETIVRVFKRHGAVQ-LCTPLLLPR-----NRQIY 817

Query: 3472 D------FLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRY 3633
            +      F+D SG ++ LP+DL +P AR++++ ++   K +  E V+RP       P   
Sbjct: 818  EHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKEL 877

Query: 3634 SAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSF 3807
                FDI      + A      AE +  I E++   P    +N  I +NH  +L A++  
Sbjct: 878  LECAFDIV----TSTANSSLPTAETIYTIYEVIQEFPALQERNYSIYLNHTMLLKAILL- 932

Query: 3808 SFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVE 3987
               + GI + K   ++ +L     +K     +R +   F      +  L   + F     
Sbjct: 933  ---HCGIPEDKLSQVYVILYDAVTEKL---TRREVEAKFCNLSLSSNSLCRLYKFI---- 982

Query: 3988 RARQKLQKLMVDSPPLLKVERAYTYLI--------EVVKILKHTNIKTSMIFNPLSNYNS 4143
              +  LQ L      L+K +     L+        EVV +LK   +K  +  N    Y  
Sbjct: 983  EQKGDLQDLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKLGVKLQVSINLGLVYKV 1042

Query: 4144 KYYIHGIMFQAVFKPDRSKRYTRVV-----TGGRYDSLIESFSNVTTTTKQITPHGVGFS 4308
            + + +GI+FQ +     SKR  RVV      GGRYD LI  F           P  VG S
Sbjct: 1043 QQH-NGIIFQFL---AFSKRRQRVVPEILAAGGRYDLLIPKFRGPQALGP--VPTAVGVS 1096

Query: 4309 LTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNI 4488
            +    +F  +          L++      + C +L+ S  Q  +S+    L  K W   I
Sbjct: 1097 IAIDKIFAAV----------LNMGEPVTVSSCDLLVVSAGQMSMSR-AINLTQKLWTAGI 1145

Query: 4489 SADITSVAAKTQDEI 4533
            +A+I    +++Q+E+
Sbjct: 1146 TAEIMYDWSQSQEEL 1160


>Q9ESB6|EIF2AK4|Q9ESB6 (TrEMBL: Mus musculus (Mouse)) GCN2gamma.
          Length = 1570

 Score =  294 bits (753), Expect = 7e-78
 Identities = 326/1275 (25%), Positives = 526/1275 (41%), Gaps = 52/1275 (4%)
 Frame = +1

Query: 865  TNEYWQTDKGKREIQDLESELQSIMSINHSNILKLIGFQI--DKTNVWRVRLLTEFSPVS 1038
            + E  + DK KR+IQ  E+E  S++ ++H NI++        ++ ++    L    S +S
Sbjct: 248  SQEKEKIDKCKRQIQGAETEFSSLVKLSHPNIVRYFAMNSREEEDSIVIDILAEHVSGIS 307

Query: 1039 ETLYDILPTAEFINWALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQN 1218
               +  L  +  +     R +  QLL  ++YLH+   +HK++                  
Sbjct: 308  LATH--LSHSGPVPAHQLRKYTAQLLAGLDYLHSNSVVHKVL------------------ 347

Query: 1219 STNELLSNSIXXXXXXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQV 1398
                               S+ + A+  +K+   S   RL ++      E   +  S   
Sbjct: 348  ----------------SASSVLVDAEGTVKITDYSISKRLADICKEDVFEQARVRFSDSA 391

Query: 1399 NPPAWLAPELKTSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGA 1578
             P        KT     K D+W LG+L L +  G +        PSD    F        
Sbjct: 392  LP-------YKTGK---KGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQ------- 434

Query: 1579 EEYASLVYDVLSKMLQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDL 1758
                    D L K + +   +R SP +L    F+   P +  ++     S  +  +ET +
Sbjct: 435  --------DFLKKCVCLDDKERWSPQQLLKHSFINPQPKLPLVEQSPEDSGGQDYIETVI 486

Query: 1759 VSSTNTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQ 1938
             S                                    NQ     +F E         +Q
Sbjct: 487  PS------------------------------------NQLPSAAFFSE---------TQ 501

Query: 1939 RNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKI--KHRADKLDSLLSEVLSL 2112
            +   RY  +FEE+  LG+G FG V+K +++++G  YAVK+I     +     +  EV  L
Sbjct: 502  KQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLL 561

Query: 2113 ARLNHQYIVRYYGTWVEELEDTSAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXX 2292
            +RL+H+ IVRYY  W+E  E   A+P                                  
Sbjct: 562  SRLHHENIVRYYNAWIERHE-RPAVPGTPPPDCTPQAQDSPATYGKTSGDTEELGSVEAA 620

Query: 2293 ------SSRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANS 2454
                  SS V  S+S   S    F V    +S D                    F+ A+ 
Sbjct: 621  APPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEE------DEDERDGVFSQSFLPASD 674

Query: 2455 TDD--ISNNETED-RXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLI 2625
            +D   I +NE E+ +                   S  A     LYIQME+CE +TL + I
Sbjct: 675  SDSDIIFDNEDENSKSQNQDEDCNQKDGSHEVEPSVTAEAVHYLYIQMEYCEKSTLRDTI 734

Query: 2626 EQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNS- 2802
            +QGL  +    WRLFR++L+ ++YIH +G IHRDLKP+NIF+D  +++K+GDFGLA +  
Sbjct: 735  DQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 794

Query: 2803 QFSSVVLTNNQVEAK------DNELSTVVGTLFYTANEV---ATGQYDEKVDMYSLGIIF 2955
             F++    + Q   +         L+ +VGT  Y + EV       Y++KVD++SLGIIF
Sbjct: 795  AFTAEGKQDGQAGDRVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIF 854

Query: 2956 FEMCY-PLATGMQRAKTLNDLR-LKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAA 3129
            FEM Y P+ T  +R   LN LR   S +FP +F   ++  +K +I  LL+HDP  RP+A 
Sbjct: 855  FEMSYHPMVTASERIFVLNQLRDPTSPKFPDDFDDGEHTKQKSVISWLLNHDPAKRPTAM 914

Query: 3130 QLLQSGWL-PVEHQDQVIQEAL-KSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEH 3303
            +LL+S  L P + ++  + E L  +LA+      + +   LF Q    A D  +D     
Sbjct: 915  ELLKSELLPPPQMEESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYDS---- 970

Query: 3304 NSHNKHVELDTSNDYLLFDKIM----KELTKIFTNHGAIENLNTNLVLPKAPSQSRELVY 3471
                   ++   N  +   KI     + + ++F  HGA++ L T L+LP+        +Y
Sbjct: 971  -------DILKGNFLIRTAKIQQLVCETIVRVFKRHGAVQ-LCTPLLLPR-----NRQIY 1017

Query: 3472 D------FLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRY 3633
            +      F+D SG ++ LP+DL +P AR++++ ++   K +  E V+RP       P   
Sbjct: 1018 EHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKEL 1077

Query: 3634 SAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSF 3807
                FDI      + A      AE +  I E++   P    +N  I +NH  +L A++  
Sbjct: 1078 LECAFDIV----TSTANSSLPTAETIYTIYEVIQEFPALQERNYSIYLNHTMLLKAILL- 1132

Query: 3808 SFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVE 3987
               + GI + K   ++ +L     +K     +R +   F      +  L   + F     
Sbjct: 1133 ---HCGIPEDKLSQVYVILYDAVTEKL---TRREVEAKFCNLSLSSNSLCRLYKFI---- 1182

Query: 3988 RARQKLQKLMVDSPPLLKVERAYTYLI--------EVVKILKHTNIKTSMIFNPLSNYNS 4143
              +  LQ L      L+K +     L+        EVV +LK   +K  +  N    Y  
Sbjct: 1183 EQKGDLQDLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKLGVKLQVSINLGLVYKV 1242

Query: 4144 KYYIHGIMFQAVFKPDRSKRYTRVV-----TGGRYDSLIESFSNVTTTTKQITPHGVGFS 4308
            + + +GI+FQ +     SKR  RVV      GGRYD LI  F           P  VG S
Sbjct: 1243 QQH-NGIIFQFL---AFSKRRQRVVPEILAAGGRYDLLIPKFRGPQALGP--VPTAVGVS 1296

Query: 4309 LTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNI 4488
            +    +F  +          L++      + C +L+ S  Q  +S+    L  K W   I
Sbjct: 1297 IAIDKIFAAV----------LNMGEPVTVSSCDLLVVSAGQMSMSR-AINLTQKLWTAGI 1345

Query: 4489 SADITSVAAKTQDEI 4533
            +A+I    +++Q+E+
Sbjct: 1346 TAEIMYDWSQSQEEL 1360


>Q9ESB7|EIF2AK4|Q9ESB7 (TrEMBL: Mus musculus (Mouse)) GCN2beta.
          Length = 1648

 Score =  294 bits (753), Expect = 7e-78
 Identities = 326/1275 (25%), Positives = 526/1275 (41%), Gaps = 52/1275 (4%)
 Frame = +1

Query: 865  TNEYWQTDKGKREIQDLESELQSIMSINHSNILKLIGFQI--DKTNVWRVRLLTEFSPVS 1038
            + E  + DK KR+IQ  E+E  S++ ++H NI++        ++ ++    L    S +S
Sbjct: 326  SQEKEKIDKCKRQIQGAETEFSSLVKLSHPNIVRYFAMNSREEEDSIVIDILAEHVSGIS 385

Query: 1039 ETLYDILPTAEFINWALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQN 1218
               +  L  +  +     R +  QLL  ++YLH+   +HK++                  
Sbjct: 386  LATH--LSHSGPVPAHQLRKYTAQLLAGLDYLHSNSVVHKVL------------------ 425

Query: 1219 STNELLSNSIXXXXXXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQV 1398
                               S+ + A+  +K+   S   RL ++      E   +  S   
Sbjct: 426  ----------------SASSVLVDAEGTVKITDYSISKRLADICKEDVFEQARVRFSDSA 469

Query: 1399 NPPAWLAPELKTSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGA 1578
             P        KT     K D+W LG+L L +  G +        PSD    F        
Sbjct: 470  LP-------YKTGK---KGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQ------- 512

Query: 1579 EEYASLVYDVLSKMLQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDL 1758
                    D L K + +   +R SP +L    F+   P +  ++     S  +  +ET +
Sbjct: 513  --------DFLKKCVCLDDKERWSPQQLLKHSFINPQPKLPLVEQSPEDSGGQDYIETVI 564

Query: 1759 VSSTNTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQ 1938
             S                                    NQ     +F E         +Q
Sbjct: 565  PS------------------------------------NQLPSAAFFSE---------TQ 579

Query: 1939 RNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKI--KHRADKLDSLLSEVLSL 2112
            +   RY  +FEE+  LG+G FG V+K +++++G  YAVK+I     +     +  EV  L
Sbjct: 580  KQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLL 639

Query: 2113 ARLNHQYIVRYYGTWVEELEDTSAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXX 2292
            +RL+H+ IVRYY  W+E  E   A+P                                  
Sbjct: 640  SRLHHENIVRYYNAWIERHE-RPAVPGTPPPDCTPQAQDSPATYGKTSGDTEELGSVEAA 698

Query: 2293 ------SSRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANS 2454
                  SS V  S+S   S    F V    +S D                    F+ A+ 
Sbjct: 699  APPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEE------DEDERDGVFSQSFLPASD 752

Query: 2455 TDD--ISNNETED-RXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLI 2625
            +D   I +NE E+ +                   S  A     LYIQME+CE +TL + I
Sbjct: 753  SDSDIIFDNEDENSKSQNQDEDCNQKDGSHEVEPSVTAEAVHYLYIQMEYCEKSTLRDTI 812

Query: 2626 EQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNS- 2802
            +QGL  +    WRLFR++L+ ++YIH +G IHRDLKP+NIF+D  +++K+GDFGLA +  
Sbjct: 813  DQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 872

Query: 2803 QFSSVVLTNNQVEAK------DNELSTVVGTLFYTANEV---ATGQYDEKVDMYSLGIIF 2955
             F++    + Q   +         L+ +VGT  Y + EV       Y++KVD++SLGIIF
Sbjct: 873  AFTAEGKQDGQAGDRVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIF 932

Query: 2956 FEMCY-PLATGMQRAKTLNDLR-LKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAA 3129
            FEM Y P+ T  +R   LN LR   S +FP +F   ++  +K +I  LL+HDP  RP+A 
Sbjct: 933  FEMSYHPMVTASERIFVLNQLRDPTSPKFPDDFDDGEHTKQKSVISWLLNHDPAKRPTAM 992

Query: 3130 QLLQSGWL-PVEHQDQVIQEAL-KSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEH 3303
            +LL+S  L P + ++  + E L  +LA+      + +   LF Q    A D  +D     
Sbjct: 993  ELLKSELLPPPQMEESELHEVLHHTLANTDGKAYRTMMSQLFCQHSSPAIDYTYDS---- 1048

Query: 3304 NSHNKHVELDTSNDYLLFDKIM----KELTKIFTNHGAIENLNTNLVLPKAPSQSRELVY 3471
                   ++   N  +   KI     + + ++F  HGA++ L T L+LP+        +Y
Sbjct: 1049 -------DILKGNFLIRTAKIQQLVCETIVRVFKRHGAVQ-LCTPLLLPR-----NRQIY 1095

Query: 3472 D------FLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRY 3633
            +      F+D SG ++ LP+DL +P AR++++ ++   K +  E V+RP       P   
Sbjct: 1096 EHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKEL 1155

Query: 3634 SAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSF 3807
                FDI      + A      AE +  I E++   P    +N  I +NH  +L A++  
Sbjct: 1156 LECAFDIV----TSTANSSLPTAETIYTIYEVIQEFPALQERNYSIYLNHTMLLKAILL- 1210

Query: 3808 SFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVE 3987
               + GI + K   ++ +L     +K     +R +   F      +  L   + F     
Sbjct: 1211 ---HCGIPEDKLSQVYVILYDAVTEKL---TRREVEAKFCNLSLSSNSLCRLYKFI---- 1260

Query: 3988 RARQKLQKLMVDSPPLLKVERAYTYLI--------EVVKILKHTNIKTSMIFNPLSNYNS 4143
              +  LQ L      L+K +     L+        EVV +LK   +K  +  N    Y  
Sbjct: 1261 EQKGDLQDLTPTINSLIKQKTGIAQLVKYSLKDLEEVVGLLKKLGVKLQVSINLGLVYKV 1320

Query: 4144 KYYIHGIMFQAVFKPDRSKRYTRVV-----TGGRYDSLIESFSNVTTTTKQITPHGVGFS 4308
            + + +GI+FQ +     SKR  RVV      GGRYD LI  F           P  VG S
Sbjct: 1321 QQH-NGIIFQFL---AFSKRRQRVVPEILAAGGRYDLLIPKFRGPQALGP--VPTAVGVS 1374

Query: 4309 LTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNI 4488
            +    +F  +          L++      + C +L+ S  Q  +S+    L  K W   I
Sbjct: 1375 IAIDKIFAAV----------LNMGEPVTVSSCDLLVVSAGQMSMSR-AINLTQKLWTAGI 1423

Query: 4489 SADITSVAAKTQDEI 4533
            +A+I    +++Q+E+
Sbjct: 1424 TAEIMYDWSQSQEEL 1438



 Score = 46.2 bits (108), Expect = 0.004
 Identities = 28/115 (24%), Positives = 54/115 (46%)
 Frame = +1

Query: 37  RQQDEISSISSIYGDIFKDITPTGLVWNKKPSPHFQVFLSSSNNPDRPTVSITLDIEFTP 216
           RQ  E+ ++ +IYG  F+D+ P      ++P     V        +   V + L ++  P
Sbjct: 22  RQDHELQALEAIYGSDFQDLRPDARGRVREPPEINLVLYPQGLAGEEVYVQVELQVKCPP 81

Query: 217 TYPLSPPKVKLLNARNLLKINIAKLEKKCKDLIKEYPEQEVSFTIISELIFMLDE 381
           TYP   P+++L NA+ L   ++  L+   ++L K+   + + F +   +   L E
Sbjct: 82  TYPDVVPEIELKNAKGLSNESVNLLKSHLEELAKKQCGEVMIFELAHHVQSFLSE 136


>Q9QZ05|EIF2AK4|Q9QZ05 (TrEMBL: Mus musculus (Mouse)) GCN2 eIF2alpha
            kinase.
          Length = 1648

 Score =  293 bits (750), Expect = 2e-77
 Identities = 325/1275 (25%), Positives = 526/1275 (41%), Gaps = 52/1275 (4%)
 Frame = +1

Query: 865  TNEYWQTDKGKREIQDLESELQSIMSINHSNILKLIGFQI--DKTNVWRVRLLTEFSPVS 1038
            + E  + DK KR+IQ  E+E  S++ ++H NI++        ++ ++    L    S +S
Sbjct: 326  SQEKEKIDKCKRQIQGAETEFSSLVKLSHPNIVRYFAMNSREEEDSIVIDILAEHVSGIS 385

Query: 1039 ETLYDILPTAEFINWALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQN 1218
               +  L  +  +     R +  QLL  ++YLH+   +HK++                  
Sbjct: 386  LATH--LSHSGPVPAHQLRKYTAQLLAGLDYLHSNSVVHKVL------------------ 425

Query: 1219 STNELLSNSIXXXXXXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQV 1398
                               S+ + A+  +K+   S   RL ++      E   +  S   
Sbjct: 426  ----------------SASSVLVDAEGTVKITDYSISKRLADICKEDVFEQARVRFSDSA 469

Query: 1399 NPPAWLAPELKTSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGA 1578
             P        KT     K D+W LG+L L +  G +        PSD    F        
Sbjct: 470  LP-------YKTGK---KGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQ------- 512

Query: 1579 EEYASLVYDVLSKMLQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDL 1758
                    D L K + +   +R SP +L    F+   P +  ++     S  +  +ET +
Sbjct: 513  --------DFLKKCVCLDDKERWSPQQLLKHSFINPQPKLPLVEQSPEDSGGQDYIETVI 564

Query: 1759 VSSTNTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQ 1938
             S                                    NQ     +F E         +Q
Sbjct: 565  PS------------------------------------NQLPSAAFFSE---------TQ 579

Query: 1939 RNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKI--KHRADKLDSLLSEVLSL 2112
            +   RY  +FEE+  LG+G FG V+K +++++G  YAVK+I     +     +  EV  L
Sbjct: 580  KQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLL 639

Query: 2113 ARLNHQYIVRYYGTWVEELEDTSAIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXXXX 2292
            +RL+H+ IVRYY  W+E  E   A+P                                  
Sbjct: 640  SRLHHENIVRYYNAWIERHE-RPAVPGTPPPDCTPQAQDSPATCGKTSGDTEELGSVEAA 698

Query: 2293 ------SSRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANS 2454
                  SS V  S+S   S    F V    +S D                    F+ A+ 
Sbjct: 699  APPPILSSSVEWSTSAERSTSTRFPVTGQDSSSDEE------DEDERDGVFSQSFLPASD 752

Query: 2455 TDD--ISNNETED-RXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLI 2625
            +D   I +NE E+ +                   S  A     LYIQME+CE +TL + I
Sbjct: 753  SDSDIIFDNEDENSKSQNQDEDCNQKDGSHEIEPSVTAEAVHYLYIQMEYCEKSTLRDTI 812

Query: 2626 EQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNS- 2802
            +QGL  +    WRLFR++L+ ++YIH +G IHRDLKP+NIF+D  +++K+GDFGLA +  
Sbjct: 813  DQGLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHL 872

Query: 2803 QFSSVVLTNNQV------EAKDNELSTVVGTLFYTANEV---ATGQYDEKVDMYSLGIIF 2955
             F++    ++Q             L+ +VGT  Y + EV       Y++KVD++SLGIIF
Sbjct: 873  AFTAEGKQDDQAGDGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIF 932

Query: 2956 FEMCY-PLATGMQRAKTLNDLR-LKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAA 3129
            FEM Y P+ T  +R   LN LR   S +FP +F   ++  +K +I  LL+HDP  RP+A 
Sbjct: 933  FEMSYHPMVTASERIFVLNQLRDPTSPKFPDDFDDGEHTKQKSVISWLLNHDPAKRPTAM 992

Query: 3130 QLLQSGWL-PVEHQDQVIQEAL-KSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEH 3303
            +LL+S  L P + ++  + E L  +LA+      + +   +F Q    A D  +D     
Sbjct: 993  ELLKSELLPPPQMEESELHEVLHHTLANIDGKAYRTMMSQIFCQHISPAIDYTYDS---- 1048

Query: 3304 NSHNKHVELDTSNDYLLFDKIM----KELTKIFTNHGAIENLNTNLVLPKAPSQSRELVY 3471
                   ++   N  +   KI     + + ++F  HGA++ L T L+LP+        +Y
Sbjct: 1049 -------DILKGNFLIRTAKIQQLVCETIVRVFKRHGAVQ-LCTPLLLPR-----NRQIY 1095

Query: 3472 D------FLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRY 3633
            +      F+D SG ++ LP+DL +P AR++++ ++   K +  E V+RP       P   
Sbjct: 1096 EHNEAALFMDHSGMLVMLPFDLRVPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKEL 1155

Query: 3634 SAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSF 3807
                FDI      +        AE +  I EI+   P    +N  I +NH  +L A++  
Sbjct: 1156 LECAFDIV----TSTTNSSLPTAETIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILL- 1210

Query: 3808 SFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVE 3987
               + GI + K   ++ +L     +K     +R +   F      +  L   + F     
Sbjct: 1211 ---HCGIPEDKLSQVYVILYDAVTEKL---TRREVEAKFCNLSLSSNSLCRLYKFI---- 1260

Query: 3988 RARQKLQKLMVDSPPLLKVERAYTYLI--------EVVKILKHTNIKTSMIFNPLSNYNS 4143
              +  LQ L      L+K +     L+        +VV +LK   +K  +  N    Y  
Sbjct: 1261 EQKGDLQDLTPTINSLIKQKTGVAQLVKYSLKDLEDVVGLLKKLGVKLQVSINLGLVYKV 1320

Query: 4144 KYYIHGIMFQAVFKPDRSKRYTRVV-----TGGRYDSLIESFSNVTTTTKQITPHGVGFS 4308
            + +  GI+FQ +     SKR  RVV      GGRYD LI  F    T      P  VG S
Sbjct: 1321 QQHT-GIIFQFL---AFSKRRQRVVPEILAAGGRYDLLIPKFRGPQTVGP--VPTAVGVS 1374

Query: 4309 LTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNI 4488
            +    +F ++          L++      + C +L+ S  Q  +S+    L  K W   I
Sbjct: 1375 IAIDKIFAVV----------LNMEEPVTVSSCDLLVVSVGQMSMSR-AINLTQKLWTAGI 1423

Query: 4489 SADITSVAAKTQDEI 4533
            +A+I    +++Q+E+
Sbjct: 1424 TAEIMYDWSQSQEEL 1438



 Score = 46.2 bits (108), Expect = 0.004
 Identities = 28/115 (24%), Positives = 54/115 (46%)
 Frame = +1

Query: 37  RQQDEISSISSIYGDIFKDITPTGLVWNKKPSPHFQVFLSSSNNPDRPTVSITLDIEFTP 216
           RQ  E+ ++ +IYG  F+D+ P      ++P     V        +   V + L ++  P
Sbjct: 22  RQDHELQALEAIYGSDFQDLRPDARGRVREPPEINLVLYPQGLAGEEVYVQVELQVKCPP 81

Query: 217 TYPLSPPKVKLLNARNLLKINIAKLEKKCKDLIKEYPEQEVSFTIISELIFMLDE 381
           TYP   P+++L NA+ L   ++  L+   ++L K+   + + F +   +   L E
Sbjct: 82  TYPDVVPEIELKNAKGLSNESVNLLKSHLEELAKKQCGEVMIFELAHHVQSFLSE 136


>Q9P2K8|KIAA1338|Q9P2K8 (TrEMBL: Homo sapiens (Human)) Hypothetical
            protein KIAA1338 (Fragment).
          Length = 1495

 Score =  291 bits (746), Expect = 5e-77
 Identities = 317/1265 (25%), Positives = 530/1265 (41%), Gaps = 42/1265 (3%)
 Frame = +1

Query: 865  TNEYWQTDKGKREIQDLESELQSIMSINHSNILKLIGFQI-DKTNVWRVRLLTE-FSPVS 1038
            + E  + DK K++IQ  E+E  S++ ++H N+++ +   + ++ +   V +L E  S VS
Sbjct: 173  SQEKEKIDKCKKQIQGTETEFNSLVKLSHPNVVRYLAMNLKEQDDSIVVDILVEHISGVS 232

Query: 1039 ETLYDILPTAEFINWALARTWLIQLLPAMEYLHNAGFIHKLICPMTIVIFQEKDQLYYQN 1218
               +  L  +  I     R +  QLL  ++YLH+   +HK++    +++           
Sbjct: 233  LAAH--LSHSGPIPVHQLRRYTAQLLSGLDYLHSNSVVHKVLSASNVLV----------- 279

Query: 1219 STNELLSNSIXXXXXXXEDSLTISAKKVLKLCHPSYGYRLLEMILLHPNEGETLDRSPQV 1398
                                    A+  +K+   S   RL ++      E   +  S   
Sbjct: 280  -----------------------DAEGTVKITDYSISKRLADICKEDVFEQTRVRFSDNA 316

Query: 1399 NPPAWLAPELKTSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDFVGA 1578
             P        KT     K D+W LG+L L +  G +        PSD    F        
Sbjct: 317  LP-------YKTGK---KGDVWRLGLLLLSLSQGQECGEYPVTIPSDLPADFQ------- 359

Query: 1579 EEYASLVYDVLSKMLQVKLSKRPSPLELNAVKFLRDGPIISKLQSETNLSRMKKNVETDL 1758
                    D L K + +   +R SP +L    F+   P +  ++     S  +  VET +
Sbjct: 360  --------DFLKKCVCLDDKERWSPQQLLKHSFINPQPKMPLVEQSPEDSGGQDYVETVI 411

Query: 1759 VSSTNTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQ 1938
             S                                    N+     +F E         +Q
Sbjct: 412  PS------------------------------------NRLPSAAFFSE---------TQ 426

Query: 1939 RNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKK--IKHRADKLDSLLSEVLSL 2112
            R   RY  +FEE+  LG+G FG V+K +++++G  YAVK+  I   + +   +  EV  L
Sbjct: 427  RQFSRYFIEFEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRQFRRIKGEVTLL 486

Query: 2113 ARLNHQYIVRYYGTWVEELEDTS--AIPSNSTSAIASXXXXXXXXXXXXXXXXXXXXXXX 2286
            +RL+H+ IVRYY  W+E  E  +    P   +  +A                        
Sbjct: 487  SRLHHENIVRYYNAWIERHERPAGPGTPPPDSGPLAKDDRAARGQPASDTDGLDSVEAAA 546

Query: 2287 ---XXSSRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANST 2457
                 SS V  S+S   S    F      +S D                       ++S 
Sbjct: 547  PPPILSSSVEWSTSGERSASARFPATGPGSSDDEDDDEDEHGGVFSQSFLPA----SDSE 602

Query: 2458 DDISNNETEDRXXXXXXXXXXXXXXXXXNSSKNASPKSILY--IQMEFCENNTLLNLIEQ 2631
             DI  +  ++                   S  + + +++ Y  IQME+CE +TL + I+Q
Sbjct: 603  SDIIFDNEDENSKSQNQDEDCNEKNGCHESEPSVTTEAVHYLYIQMEYCEKSTLRDTIDQ 662

Query: 2632 GLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNS-QF 2808
            GL  +    WRLFR++L+ ++YIH +G IHRDLKP+NIF+D  +++K+GDFGLA +   F
Sbjct: 663  GLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAF 722

Query: 2809 SSVVLTNNQV-----EAKDNELSTVVGTLFYTANEV---ATGQYDEKVDMYSLGIIFFEM 2964
            S+    ++Q            L+ +VGT  Y + EV       Y++KVD++SLGIIFFEM
Sbjct: 723  SADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEM 782

Query: 2965 CY-PLATGMQRAKTLNDLR-LKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLL 3138
             Y P+ T  +R   LN LR   S +FP +F   ++  +K +I  LL+HDP  RP+A +LL
Sbjct: 783  SYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSVISWLLNHDPAKRPTATELL 842

Query: 3139 QSGWL-PVEHQDQVIQEAL-KSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEHNSH 3312
            +S  L P + ++  + E L  +L +      + +   +F+Q    A D  +D     +  
Sbjct: 843  KSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQRISPAIDYTYDS----DIL 898

Query: 3313 NKHVELDTSNDYLLFDKIMKELTKIFTNHGAIENLNTNLVLPKAPSQSRELVYD------ 3474
              +  + T+    +   + + + +IF  HGA++ L T L+LP+        +Y+      
Sbjct: 899  KGNFSIRTAK---MQQHVCETIIRIFKRHGAVQ-LCTPLLLPR-----NRQIYEHNEAAL 949

Query: 3475 FLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDI 3654
            F+D SG ++ LP+DL +P AR++++ ++   K +  E V+RP       P       FDI
Sbjct: 950  FMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFRPRKLDRFHPKELLECAFDI 1009

Query: 3655 AGGLEVNKATLFAHDAECLKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSFSFGNIGI 3828
                  +    F   AE +  I EI+   P    +N  I +NH  +L A++     + GI
Sbjct: 1010 V----TSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYLNHTMLLKAILL----HCGI 1061

Query: 3829 DDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVERARQKLQ 4008
             + K   ++ +L     +K     +R +   F      +  L   + F       +  LQ
Sbjct: 1062 PEDKLSQVYIILYDAVTEKL---TRREVEAKFCNLSLSSNSLCRLYKFI----EQKGDLQ 1114

Query: 4009 KLMVDSPPLLKVERAYTYLI--------EVVKILKHTNIKTSMIFNPLSNYNSKYYIHGI 4164
             LM     L+K +     L+        EVV +LK   IK  ++ N    Y  + + +GI
Sbjct: 1115 DLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKLQVLINLGLVYKVQQH-NGI 1173

Query: 4165 MFQAVFKPDRSKRYTR--VVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLLFILM 4338
            +FQ V    R +R     +  GGRYD LI  F           P  +G S+    +    
Sbjct: 1174 IFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGP--VPTAIGVSIAIDKI---- 1227

Query: 4339 KTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAK 4518
                    + L++      + C +L+ S  Q  +S+    L  K W   I+A+I    ++
Sbjct: 1228 ------SAAVLNMEESVTISSCDLLVVSVGQMSMSR-AINLTQKLWTAGITAEIMYDWSQ 1280

Query: 4519 TQDEI 4533
            +Q+E+
Sbjct: 1281 SQEEL 1285


>Q9HDW2|SPBP18G5.01|Q9HDW2 (TrEMBL: Schizosaccharomyces pombe (Fission
            yeast)) Putative eif-2alpha kinase, possibly involved in
            involved in general amino acid control response by
            similarity to yeast gcn2 (Fragment).
          Length = 755

 Score =  274 bits (700), Expect = 1e-71
 Identities = 222/824 (26%), Positives = 371/824 (45%), Gaps = 18/824 (2%)
 Frame = +1

Query: 2872 GTLFYTANEVATGQ----YDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFP 3039
            GT  Y A E+ + +    YD KVDMYSLGII FEMC   +T M+R + ++ +R  S+ FP
Sbjct: 1    GTALYVAPELLSRRNGVRYDAKVDMYSLGIILFEMCMTFSTSMERIRIIDTIRSPSISFP 60

Query: 3040 TNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQDQVIQEALKSLADPASP 3219
            + F  S+   E K+I  LL HDP  RPS+ +LL+S  +P +  ++ IQE L+ L++P +P
Sbjct: 61   STFPFSRASHEFKVIHCLLQHDPTKRPSSQELLESEAIPPKVGEEFIQEGLRLLSNPNTP 120

Query: 3220 WQQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLLFDKIMKELTKIFTNH 3399
            +  ++ + LF Q     KD  +D      S       D   D LL   +   + K+F  H
Sbjct: 121  YYLKLLKVLFGQVPDRHKDFTYDFNLSEESGVLSKVSDRGWDSLLACLVRDHVVKVFRRH 180

Query: 3400 GAIENLNTNLVLPKAPSQSRELV-YDFLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTF 3576
            GA E   ++++ PK+    ++      LD++G +L LPYD  LP AR +++  +   KT+
Sbjct: 181  GAKER-ESHILFPKSSQYDKDQASVSLLDKNGTLLQLPYDTVLPYARNVARNAVEEEKTY 239

Query: 3577 RHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCFKN 3756
                V+R   +G G P     ++FDI      N   L  +DAE +K +DE++  +P    
Sbjct: 240  LISDVFR-EAKGGGRPKAIKEISFDIT----TNSDNLDWYDAETIKALDEVLTEIPSLTE 294

Query: 3757 TIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPH 3936
            + I+INH DIL +++ +    + +   K+     +L Q+    +  +++  LR +  VP 
Sbjct: 295  SCILINHADILSSILDY----LQVSKDKRRMATHILGQINQRLTLSQVRNQLRIESLVPS 350

Query: 3937 TVTKDLVENFNFTCEVERARQKLQKLMVDSPPLLKVERAYTYLIEVVKILKHTNIKTSMI 4116
            T   DL   F+F    E    KL+K+     P  K+  A  Y+  VVK+L+   I   + 
Sbjct: 351  TTLDDL-SLFDFRENYEEGASKLRKIFGKEMP-QKMRTALNYMERVVKLLRALKISHQLY 408

Query: 4117 FNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTRVVTGGRYDSLIESFSNVTTTTKQITPHG 4296
            F PL  YN ++Y  G+MFQA+   ++S+    +  GGRYD L+  F      T +   H 
Sbjct: 409  FMPLCVYNFEFYDGGLMFQAINLAEKSE---LICAGGRYDKLVRFFDPPLMRTAR-KKHV 464

Query: 4297 VGFSLTTSLLFILMKTLISRGKSK----------LDLVNKWKGNRCKVLISSTQQQFLSQ 4446
            VG       L   M   I    SK          L  V  W   R  VL++S  +  + +
Sbjct: 465  VGICFALEKLVFSMLRYIRFHNSKQSSKHSPSPTLKSVGPWAPRRVDVLVTSIGKDSILE 524

Query: 4447 VGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVIIRLLPTTXXXXXXXXXX 4626
                L+ + W  NI ADI    A + +EI  +  SEG  W++++R   T           
Sbjct: 525  -KCSLLQELWALNIQADIVLRGASSLEEIVTHYRSEGINWVLVVRQKNTQMEHS------ 577

Query: 4627 XXXXXXXXXXXXXXXXXXXXXXXXXXKPLKLRNIITGKDIDLDYDEVIDYLVTELLEDSE 4806
                                        +K RNI+  +D ++ +DEV  +L+ E+ E   
Sbjct: 578  ----------------------------VKARNILKNEDDEIRFDEVGMWLLGEINERKR 609

Query: 4807 HEENDQDNGTMTNXXXXXXXXXXXXKTNQEEELLNGPIDSVEIDQKIIVVKNDAPRSRKN 4986
            +E   Q    + +            ++N              +D ++I +K+   R  K 
Sbjct: 610  NESMLQSKRILDSAQQDVAKFVDTSQSN--------------LDVQLISLKDVNDRKYKW 655

Query: 4987 KRDKWESENDAKLAGQQCIKNLSGGPV-VVIDARDEILDMISITSIHQQDEWIRKVVYTT 5163
            K  K  + N      Q  I+  S   + + +D   E ++ +  T+   ++ W ++++ + 
Sbjct: 656  KH-KQNAMNKVYDLVQSAIRESSEDAIALAVDCDSEAMEKLRSTTTLDEESW-KRLIESC 713

Query: 5164 NNFPKSFAMNIYNTLI--KEFNKGSIWCILVSSRTQHTTIVDLR 5289
                + +   +   L+   E +K  +W  + S RT    +  L+
Sbjct: 714  PASQREYMQRLQKKLVTLAEQDKKRVW--ICSFRTNEIYLYGLK 755


>Q86B04||Q86B04 (TrEMBL: Dictyostelium discoideum (Slime mold))
            Similar to derepression of GCN4 expression; Gcn2p.
          Length = 2388

 Score =  268 bits (684), Expect = 7e-70
 Identities = 234/771 (30%), Positives = 359/771 (46%), Gaps = 91/771 (11%)
 Frame = +1

Query: 2542 NSSKNASPKSI--LYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGF 2715
            +SS+   PK    LYIQME+C   TL  LI+       +E +RL RQ++E +++IH +  
Sbjct: 1380 SSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQI 1439

Query: 2716 IHRDLKPMNIFIDRSNNIKVGDFGLA--------KNSQFSSVVLTNNQVEAKDNELSTV- 2868
            IHRDLKP NIFID   N+K+GDFGLA         +   SS   T N +    +  ST  
Sbjct: 1440 IHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNTANNINLSSSTNSTAQ 1499

Query: 2869 -----------------VGTLFYTANEVA---TGQYDEKVDMYSLGIIFFEMCYPLATGM 2988
                             VGT FY   E+    T  Y  KVDMYSLGIIFFEMC+   T M
Sbjct: 1500 QTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQM 1559

Query: 2989 QRAKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQ 3168
            +R+  L DLR  +++FP  F ++K   + +IIR LL  DP  RPS  QLL+SG LP + +
Sbjct: 1560 ERSNILRDLR-DNLKFPPGFESTK-PDQTQIIRSLLSRDPTQRPSTKQLLESGLLPSKME 1617

Query: 3169 DQVIQEALKSLADPASPWQQQVREALF---NQPYLLAKDLMFDKQNEHNSHNKHVELDTS 3339
            D +++EA+K++A+P       + E LF   N  +++++ L     +    H         
Sbjct: 1618 DDILKEAIKTIANPTISLFSYLMEKLFCLSNDEHIMSRYLYTSNPSLTPMH--------- 1668

Query: 3340 NDYLLFDKIMKELTKIFTNHGAIENLNTNLVLPKAPSQSRE----LVYDFLDRSGAVLTL 3507
               +  +K    L KIF NHG+I  ++T  + PK P+ S       V  FLD SG V+ L
Sbjct: 1669 --LICREKTFSRLEKIFLNHGSI-RIDTPTLFPKNPTNSTHPGAANVAKFLDESGTVVYL 1725

Query: 3508 PYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATL 3687
            PYDLT+P AR +   ++   K +    VYR +  G    + Y   +FDI G  +    + 
Sbjct: 1726 PYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKELYEC-DFDIIGPSKSRHIS- 1783

Query: 3688 FAHDAECLKVIDEIVNTLPCFKNTI--------------------IVINHYDILDAVVSF 3807
               DAE L++I EI+     FK+ +                    I INHY +LD+++S 
Sbjct: 1784 ---DAETLRIIIEIMEE---FKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSILS- 1836

Query: 3808 SFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVE 3987
                 G++ +    ++  ++QL    +  ++ + L+E     H ++  +V N +      
Sbjct: 1837 ---ECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKE-----HGLSASIVSNIS---TYF 1885

Query: 3988 RARQKLQKLMVDSPPLLKVERAYTYLIEVVKI----LKHTNIKTSMIFNPLSNYNSKYYI 4155
            R R +L + +     LL   +  T  I  +KI    L+  NI    + +    +N +YY 
Sbjct: 1886 RQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYY- 1944

Query: 4156 HGIMFQA-VFKPDRS--KRYTRVVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLL 4326
             G++FQA + +P  S   R   +++GGRYD LI+S     + +  I   GVG +L    +
Sbjct: 1945 EGLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIV-SGVGVTLACEKI 2003

Query: 4327 F-------------ILMKTLISRGKSKLDLVNKWKGNRCKVLIS------STQQQFLSQV 4449
                              T   R K   +  N    N     +S      S  + F+  +
Sbjct: 2004 VNSVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFVCSL 2063

Query: 4450 G-------YQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVIIR 4581
            G        Q+ S+ W+  I AD +     + ++I+ N    G  W+VI+R
Sbjct: 2064 GSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILR 2114



 Score = 79.3 bits (194), Expect = 5e-13
 Identities = 39/87 (44%), Positives = 59/87 (67%), Gaps = 7/87 (8%)
 Frame = +1

Query: 1939 RNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKIK-------HRADKLDSLLS 2097
            R   RY  DFEEI  +G+GGFG VVK+R++++  +YA+KKIK       ++    + LL 
Sbjct: 1015 RYHSRYRTDFEEIEMIGKGGFGVVVKSRNKLDCRYYAIKKIKTKGYTDSNQEPLTNKLLR 1074

Query: 2098 EVLSLARLNHQYIVRYYGTWVEELEDT 2178
            EV +L+RL+HQ++VRYY  W+E+  D+
Sbjct: 1075 EVTTLSRLHHQFVVRYYQAWIEKSCDS 1101



 Score = 43.5 bits (101), Expect = 0.028
 Identities = 38/158 (24%), Positives = 68/158 (43%), Gaps = 25/158 (15%)
 Frame = +1

Query: 2566 KSILYIQMEFCENNTLLN-LIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMN 2742
            ++ LYI  E+    TL   ++  G+     +  +   QLL  + Y+H +   HRD K  N
Sbjct: 574  QNTLYIFQEYNSTLTLQQKILSNGIGFEESQVKKFTYQLLLGLLYLHSQHIPHRDFKSHN 633

Query: 2743 IFIDRS-----------NNIKVGD-------------FGLAKNSQFSSVVLTNNQVEAKD 2850
            IF ++S            NIK+ D             +  + N+  +++   NN     +
Sbjct: 634  IFFNQSTSKMLLSNYGGRNIKIFDHFEKLNSLKNLNSWISSTNNSINNINNINNNNNNNN 693

Query: 2851 NELSTVVGTLFYTANEVATGQYDEKVDMYSLGIIFFEM 2964
            N ++T       T N++   + D + D+ +LGI+  EM
Sbjct: 694  NNINTTT-----TQNQI-NNEIDRREDIINLGIVVLEM 725



 Score = 36.2 bits (82), Expect = 4.5
 Identities = 26/87 (29%), Positives = 47/87 (54%), Gaps = 3/87 (3%)
 Frame = +1

Query: 16  ITLDLEHRQQ--DEISSISSIYGDIFKDITPTGLVWNKKPSPHFQVFL-SSSNNPDRPTV 186
           +TLD ++ Q   +EI  + SIY D F+++ PT  V  +     F++ L     N  +   
Sbjct: 35  MTLDPDNNQSQLEEIECLKSIYRDEFEEL-PTEAVCRR-----FKITLIPHPTNQYQNFC 88

Query: 187 SITLDIEFTPTYPLSPPKVKLLNARNL 267
           ++ L ++++P YP+S P ++L   R L
Sbjct: 89  AVRLYVKYSPNYPVSLPTIELEKVRGL 115


>Q869P4||Q869P4 (TrEMBL: Dictyostelium discoideum (Slime mold))
            Similar to derepression of GCN4 expression; Gcn2p.
          Length = 1261

 Score =  266 bits (681), Expect = 2e-69
 Identities = 233/771 (30%), Positives = 358/771 (46%), Gaps = 91/771 (11%)
 Frame = +1

Query: 2542 NSSKNASPKSI--LYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGF 2715
            +SS+   PK    LYIQME+C   TL  LI+       +E +RL RQ++E +++IH +  
Sbjct: 253  SSSRKKPPKETHTLYIQMEYCSKKTLKTLIDNVGGIAEEEAFRLLRQIVEGLNHIHSQQI 312

Query: 2716 IHRDLKPMNIFIDRSNNIKVGDFGLAK------------------------NSQFSSVVL 2823
            IHRDLKP NIFID   N+K+GDFGLA                         +S  +S   
Sbjct: 313  IHRDLKPANIFIDNEQNVKIGDFGLATSGAPVSKSDDLNSSTSNAANNINLSSSTNSTAQ 372

Query: 2824 TNNQVEAKDNELSTV--VGTLFYTANEVA---TGQYDEKVDMYSLGIIFFEMCYPLATGM 2988
                 +  D  LS    VGT FY   E+    T  Y  KVDMYSLGIIFFEMC+   T M
Sbjct: 373  QTPMWDLNDENLSMTGGVGTPFYCCPEILEKNTKHYGTKVDMYSLGIIFFEMCFQFQTQM 432

Query: 2989 QRAKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQ 3168
            +R+  L DLR  +++FP  F ++K   + +IIR LL  DP  RPS  QLL+SG LP + +
Sbjct: 433  ERSNILRDLR-DNLKFPPGFESTK-PDQTQIIRSLLSRDPTQRPSTKQLLESGLLPSKME 490

Query: 3169 DQVIQEALKSLADPASPWQQQVREALF---NQPYLLAKDLMFDKQNEHNSHNKHVELDTS 3339
            D +++EA+K++A+P       + E LF   N  +++++ L     +    H         
Sbjct: 491  DDILKEAIKTIANPTISLFSYLMEKLFCLSNDEHIMSRYLYTSNPSLTPMH--------- 541

Query: 3340 NDYLLFDKIMKELTKIFTNHGAIENLNTNLVLPKAPSQSRE----LVYDFLDRSGAVLTL 3507
               +  +K    L KIF NHG+I  ++T  + PK P+ S       V  FLD SG V+ L
Sbjct: 542  --LICREKTFSRLEKIFLNHGSI-RIDTPTLFPKNPTNSTHPGAANVAKFLDESGTVVYL 598

Query: 3508 PYDLTLPTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATL 3687
            PYDLT+P AR +   ++   K +    VYR +  G    + Y   +FDI G  +    + 
Sbjct: 599  PYDLTIPWARHVVIHNIQQAKRYTFSKVYRRSQPGFSPKELYEC-DFDIIGPSKSRHIS- 656

Query: 3688 FAHDAECLKVIDEIVNTLPCFKNTI--------------------IVINHYDILDAVVSF 3807
               DAE L++I EI+     FK+ +                    I INHY +LD+++S 
Sbjct: 657  ---DAETLRIIIEIMEE---FKDELFGNNSGSNSGSGSGGSINYKIRINHYGLLDSILS- 709

Query: 3808 SFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKDLVENFNFTCEVE 3987
                 G++ +    ++  ++QL    +  ++ + L+E     H ++  +V N +      
Sbjct: 710  ---ECGVEKRFFTVVYQTVAQLHWRLNWAQVAQSLKE-----HGLSASIVSNIS---TYF 758

Query: 3988 RARQKLQKLMVDSPPLLKVERAYTYLIEVVKI----LKHTNIKTSMIFNPLSNYNSKYYI 4155
            R R +L + +     LL   +  T  I  +KI    L+  NI    + +    +N +YY 
Sbjct: 759  RQRGELAQCVTQLESLLANHKEATTGISDLKILVRNLQMINIIPRFLLDLSLIHNHQYY- 817

Query: 4156 HGIMFQA-VFKPDRS--KRYTRVVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLL 4326
             G++FQA + +P  S   R   +++GGRYD LI+S     + +  I   GVG +L    +
Sbjct: 818  EGLVFQAYIERPTLSNPSRTEIIMSGGRYDKLIKSLHPNPSLSNNIV-SGVGVTLACEKI 876

Query: 4327 F-------------ILMKTLISRGKSKLDLVNKWKGNRCKVLIS------STQQQFLSQV 4449
                              T   R K   +  N    N     +S      S  + F+  +
Sbjct: 877  VNSVLNYRQHLLNNCFNTTYTRRNKDPPNSNNNPNNNNLNNNVSIFTKFQSHIEVFVCSL 936

Query: 4450 G-------YQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVIIR 4581
            G        Q+ S+ W+  I AD +     + ++I+ N    G  W+VI+R
Sbjct: 937  GSSLLGEKLQVASQLWSAGIKADYSQTDYYSSEDIYSNCRENGIPWVVILR 987


>Q9NSQ3|DKFZP434F1312|Q9NSQ3 (TrEMBL: Homo sapiens (Human))
            Hypothetical protein (Fragment).
          Length = 938

 Score =  239 bits (609), Expect = 3e-61
 Identities = 202/684 (29%), Positives = 330/684 (48%), Gaps = 31/684 (4%)
 Frame = +1

Query: 2575 LYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFID 2754
            LYIQME+CE +TL + I+QGL  +    WRLFR++L+ ++YIH +G IHRDLKP+NIF+D
Sbjct: 87   LYIQMEYCEKSTLRDTIDQGLYRDTVRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLD 146

Query: 2755 RSNNIKVGDFGLAKNS-QFSSVVLTNNQV-----EAKDNELSTVVGTLFYTANEV---AT 2907
              +++K+GDFGLA +   FS+    ++Q            L+ +VGT  Y + EV     
Sbjct: 147  SDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGTALYVSPEVQGSTK 206

Query: 2908 GQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLR-LKSVEFPTNFIASKYKTEKKI 3081
              Y++KVD++SLGIIFFEM Y P+ T  +R   LN LR   S +FP +F   ++  +K +
Sbjct: 207  SAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPEDFDDGEHAKQKSV 266

Query: 3082 IRLLLDHDPKIRPSAAQLLQSGWL-PVEHQDQVIQEAL-KSLADPASPWQQQVREALFNQ 3255
            I  LL+HDP  RP+A +LL+S  L P + ++  + E L  +L +      + +   +F+Q
Sbjct: 267  ISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDGKAYRTMMAQIFSQ 326

Query: 3256 PYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLLFDKIMKELTKIFTNHGAIENLNTNLVL 3435
                A D  +D     +    +  + T+    +   + + + +IF  HGA++ L T L+L
Sbjct: 327  RISPAIDYTYDS----DILKGNFSIRTAK---MQQHVCETIIRIFKRHGAVQ-LCTPLLL 378

Query: 3436 PKAPSQSRELVYD------FLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYR 3597
            P+        +Y+      F+D SG ++ LP+DL +P AR++++ ++   K +  E V+R
Sbjct: 379  PR-----NRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNILNLKRYCIERVFR 433

Query: 3598 PNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCF--KNTIIVI 3771
            P       P       FDI      +    F   AE +  I EI+   P    +N  I +
Sbjct: 434  PRKLDRFHPKELLECAFDIV----TSTTNSFLPTAEIIYTIYEIIQEFPALQERNYSIYL 489

Query: 3772 NHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTKD 3951
            NH  +L A++     + GI + K   ++ +L     +K     +R +   F      +  
Sbjct: 490  NHTMLLKAILL----HCGIPEDKLSQVYIILYDAVTEKL---TRREVEAKFCNLSLSSNS 542

Query: 3952 LVENFNFTCEVERARQKLQKLMVDSPPLLKVERAYTYLI--------EVVKILKHTNIKT 4107
            L   + F       +  LQ LM     L+K +     L+        EVV +LK   IK 
Sbjct: 543  LCRLYKFI----EQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLEEVVGLLKKLGIKL 598

Query: 4108 SMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTR--VVTGGRYDSLIESFSNVTTTTKQ 4281
             ++ N    Y  + + +GI+FQ V    R +R     +  GGRYD LI  F         
Sbjct: 599  QVLINLGLVYKVQQH-NGIIFQFVAFIKRRQRAVPEILAAGGRYDLLIPQFRGPQALGP- 656

Query: 4282 ITPHGVGFSLTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQL 4461
              P  +G S+    +            + L++      + C +L+ S  Q  +S+    L
Sbjct: 657  -VPTAIGVSIAIDKI----------SAAVLNMEESVTISSCDLLVVSVGQMSMSR-AINL 704

Query: 4462 VSKFWNKNISADITSVAAKTQDEI 4533
              K W   I+A+I    +++Q+E+
Sbjct: 705  TQKLWTAGITAEIMYDWSQSQEEL 728


>Q8H2D3|GCN2|Q8H2D3 (TrEMBL: Arabidopsis thaliana (Mouse-ear cress))
            GCN2 homologue.
          Length = 1241

 Score =  206 bits (524), Expect = 2e-51
 Identities = 196/700 (28%), Positives = 326/700 (46%), Gaps = 25/700 (3%)
 Frame = +1

Query: 2554 NASPKSILYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLK 2733
            N    + LYIQME+C   TL  + E     + D  W L RQ++E +++IH +G IHRD  
Sbjct: 530  NNLESTYLYIQMEYCPR-TLRQVFESYNHFDKDFAWHLIRQIVEGLAHIHGQGIIHRDFT 588

Query: 2734 PMNIFIDRSNNIKVGDFGLAKNSQFSSVVLT---NNQVEAKDNELSTVVGTLFYTANEVA 2904
            P NIF D  N+IK+GDFGLAK  +   +      +  V     + +   GT FYTA E+ 
Sbjct: 589  PNNIFFDARNDIKIGDFGLAKFLKLEQLDQDGGFSTDVAGSGVDSTGQAGTYFYTAPEIE 648

Query: 2905 TG--QYDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEKK 3078
                + DEK DMYSLG++FFE+ +P  T M+R   L +L+LK  E P  ++ +++  +  
Sbjct: 649  QDWPKIDEKADMYSLGVVFFELWHPFGTAMERHVILTNLKLKG-ELPLKWV-NEFPEQAS 706

Query: 3079 IIRLLLDHDPKIRPSAAQLLQSGWLPVEHQDQVIQEALKSL-ADPASPWQQQVREALFNQ 3255
            ++R L+   P  RPSA +LL+  + P   + +++   L+ +     S    +V   +F++
Sbjct: 707  LLRRLMSPSPSDRPSATELLKHAF-PPRMESELLDNILRIMQTSEDSSVYDRVVSVIFDE 765

Query: 3256 PYLLAKDLMFDKQN--EHNSHNKHVELDTSNDYLLFDKIMKELTKIFTNHGA--IENLNT 3423
              L  K     +      +S+ ++ E++T     L D +++   ++F  H A  +E +  
Sbjct: 766  EVLEMKSHQSSRSRLCADDSYIQYTEINTE----LRDYVVEITKEVFRQHCAKHLEVIPM 821

Query: 3424 NLVLPKAPSQSRELVYDFLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYRPN 3603
             L L   P  SR+ V   L   G +L L Y+L LP   ++S    +  K +    VYR  
Sbjct: 822  RL-LSDCPQFSRKTV-KLLTNGGDMLELCYELRLPFVHWISVNQKSSFKRYEISHVYRRA 879

Query: 3604 VRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCFKNTIIVINHYD 3783
            + G   P+     +FDI GG      TL   +AE LKVI +I   +    +  I +NH D
Sbjct: 880  I-GHSPPNPCLQADFDIVGG------TLSLTEAEVLKVIVDITTHIFHRGSCDIHLNHGD 932

Query: 3784 ILDAVVSFSFGNIGIDDKKKL-DIFGVLSQLGIDKSPDEIK-----RYLREDFQVPHTVT 3945
            +LDA+  +S+  I  + ++K+ ++  ++  L    S  ++K     R L ++ ++P  V 
Sbjct: 933  LLDAI--WSWAGIKAEHRRKVAELLSMMGSLRPQSSERKLKWVFIRRQLLQELKLPEAVV 990

Query: 3946 KDLVENFNFTC-EVERARQKLQ-KLMVDSP---PLLKVERAYTYLIEVVKILKHTNIKTS 4110
              L    +  C + ++A  +L+  L  D P    L ++    TYL  V +I +H +I   
Sbjct: 991  NRLQTVASRFCGDADQALPRLRGALRADRPTRKALDELSNLLTYL-RVWRIEEHVHI--D 1047

Query: 4111 MIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTR----VVTGGRYDSLIESFSNVTTTTK 4278
            ++  P  +Y+       + FQ     + S   +     +  GGRYD L++   +     K
Sbjct: 1048 VLMPPTESYH-----RNLFFQVFLTKENSSGTSNDGVLLAVGGRYDWLVQEVCD--REHK 1100

Query: 4279 QITPHGVGFSLTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVGYQ 4458
               P  VG SL    +F  +          +DL          VL+ S     L     +
Sbjct: 1101 MNLPGAVGVSLALETIFQHL---------PMDLRPIRNEVSTSVLVCSRGGGGLLVQRME 1151

Query: 4459 LVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVII 4578
            LV++ W K+I A+       +  E ++  N      +VII
Sbjct: 1152 LVAELWEKSIKAEFVPTPDPSLTEQYEYANEHEIKCLVII 1191



 Score = 75.5 bits (184), Expect = 7e-12
 Identities = 42/103 (40%), Positives = 60/103 (58%), Gaps = 6/103 (5%)
 Frame = +1

Query: 1873 NQN---TQHPYFGENSSLIMPSGSQRNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIF 2043
            NQN   T  P F E  S      +     RY  DFEE+  LG+GGFG VV  +++++G  
Sbjct: 391  NQNMASTSVPQFWEPPSDSCEPNASLPSSRYLNDFEELKPLGQGGFGHVVLCKNKLDGRQ 450

Query: 2044 YAVKKIKHRADKL---DSLLSEVLSLARLNHQYIVRYYGTWVE 2163
            YAVKKI+ +  ++     ++ EV +L+RL HQ++VRYY  W E
Sbjct: 451  YAVKKIRLKDKEIPVNSRIVREVATLSRLQHQHVVRYYQAWFE 493


>O61651|GCN2|O61651 (TrEMBL: Drosophila melanogaster (Fruit fly))
            EIF-2ALPHA kinase.
          Length = 1589

 Score =  205 bits (522), Expect = 4e-51
 Identities = 208/726 (28%), Positives = 330/726 (45%), Gaps = 50/726 (6%)
 Frame = +1

Query: 2551 KNASPK---SILYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIH 2721
            K  SPK    ++YIQMEFCE  TL   I+  L N+ D  WRLFR++ E +++IH++G IH
Sbjct: 683  KTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIH 742

Query: 2722 RDLKPMNIFIDRSNNIKVGDFGLAKNS------QFSSVVLTNNQVEAKDNELSTVVGTLF 2883
            RDLKP+NIF+D  + IK+GDFGLA  S        ++    N    A+D   +  VGT  
Sbjct: 743  RDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTL 802

Query: 2884 YTANEV----ATGQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLRLKSVEFPTNF 3048
            Y A E+    +   Y++KVDMY+LGII FEMC  P  T M+RA+T+  LR  S+  P   
Sbjct: 803  YVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAM 862

Query: 3049 IAS-KYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWL-PVEHQDQVIQEALK-SLADPASP 3219
            +   KY+   K+++ LL+HDP  RP+A +LL S  + P + +   +QE L+ +LA+P S 
Sbjct: 863  LKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSK 922

Query: 3220 WQQQVREALFNQPYLLAKDLMFDKQNEHNSH-NKHVELDTSNDYLLFDKIMK-------- 3372
              + +      Q          D+  EH  H      + + N  ++ D I+         
Sbjct: 923  AYKNLVARCLQQE--------SDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNPVIEFV 974

Query: 3373 --ELTKIFTNHGAIENLNTNLVLP----KAPSQSRELVYDFLDRSGAVLTLPYDLTLPTA 3534
              ++  +F  HGAIE +++ L+ P     + + +       +  SG V+ LP DL    A
Sbjct: 975  KAKVVNLFRKHGAIE-VDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDLRTQFA 1033

Query: 3535 RFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAH--DAEC 3708
            R ++   + + + +  + VYR        P +    +FDI         T  +H  DAE 
Sbjct: 1034 RHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIA------PTTGSHLVDAEL 1087

Query: 3709 LKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGID 3882
            L +  EI + LP    KN  I +NH ++L A++ F   N+          +G L +  +D
Sbjct: 1088 LSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFC--NVPKAQ------YGALFEGTMD 1139

Query: 3883 KSPDEIKRY---------LREDFQVPHTVTKDLVENFNFTCEVERARQK-LQKLMVDSPP 4032
                 I R+         + +      T+   L+ NF  T          L+ LM     
Sbjct: 1140 FIESRISRFQFHSSITGIMEKSRTSAQTLMDMLLANFLLTGSRSTVDDSALKSLMRGKGE 1199

Query: 4033 LLKVER-AYTYLIEVVKILKHTNIKTSM-IFNPLSNYNSKYYIHGIMFQ--AVFKPDRSK 4200
               + R A   L  VV +     +K  + I+  L     +    GI++Q  A  KP+RS 
Sbjct: 1200 AASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSG 1259

Query: 4201 RYTRVVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLLFILMKTLISRGKSKLDLV 4380
              + +  G RYDS++  F           P   G      L F L K + + G   ++  
Sbjct: 1260 HPSVLAIGERYDSMLHEFQKQAQKFNPAMP-ARGVLSGAGLTFSLDKLVAAVG---VEYA 1315

Query: 4381 NKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGA 4560
               +     + +  T+   L  V Y ++   W+  I   I   A++  DE  Q+    GA
Sbjct: 1316 KDCRAIDVGICVCGTRPP-LKDVTY-IMRLLWSVGIRCGIVEAASELGDEA-QDLARLGA 1372

Query: 4561 IWIVII 4578
            + ++++
Sbjct: 1373 LHVILV 1378



 Score = 63.9 bits (154), Expect = 2e-08
 Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
 Frame = +1

Query: 1831 LNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQR---NMGRYARDFEEIGKLGRGGF 2001
            L  Y  N  ++ +     QHP   + +   MP        +  R   +FE +  LG+G F
Sbjct: 475  LRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAF 534

Query: 2002 GEVVKARSRMEGIFYAVKKIKHRADKLD---SLLSEVLSLARLNHQYIVRYYGTWVEELE 2172
            G+V+K R+ ++   YA+K+I   A        +  EV  L+RLNH+ +VRY+ +W+E ++
Sbjct: 535  GDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVD 594

Query: 2173 DTSA 2184
            D  A
Sbjct: 595  DADA 598



 Score = 38.9 bits (89), Expect = 0.69
 Identities = 15/43 (34%), Positives = 26/43 (60%)
 Frame = +1

Query: 2671 RQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKN 2799
            R +L+A+ ++H +G  H  L    +F+D + N++V DF L  N
Sbjct: 374  RGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPN 416


>Q9V9X8|GCN2|Q9V9X8 (TrEMBL: Drosophila melanogaster (Fruit fly)) GCN2
            protein.
          Length = 1589

 Score =  205 bits (522), Expect = 4e-51
 Identities = 208/726 (28%), Positives = 330/726 (45%), Gaps = 50/726 (6%)
 Frame = +1

Query: 2551 KNASPK---SILYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIH 2721
            K  SPK    ++YIQMEFCE  TL   I+  L N+ D  WRLFR++ E +++IH++G IH
Sbjct: 683  KTNSPKPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIH 742

Query: 2722 RDLKPMNIFIDRSNNIKVGDFGLAKNS------QFSSVVLTNNQVEAKDNELSTVVGTLF 2883
            RDLKP+NIF+D  + IK+GDFGLA  S        ++    N    A+D   +  VGT  
Sbjct: 743  RDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTL 802

Query: 2884 YTANEV----ATGQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLRLKSVEFPTNF 3048
            Y A E+    +   Y++KVDMY+LGII FEMC  P  T M+RA+T+  LR  S+  P   
Sbjct: 803  YVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAM 862

Query: 3049 IAS-KYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWL-PVEHQDQVIQEALK-SLADPASP 3219
            +   KY+   K+++ LL+HDP  RP+A +LL S  + P + +   +QE L+ +LA+P S 
Sbjct: 863  LKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSK 922

Query: 3220 WQQQVREALFNQPYLLAKDLMFDKQNEHNSH-NKHVELDTSNDYLLFDKIMK-------- 3372
              + +      Q          D+  EH  H      + + N  ++ D I+         
Sbjct: 923  AYKNLVARCLQQE--------SDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNPVIEFV 974

Query: 3373 --ELTKIFTNHGAIENLNTNLVLP----KAPSQSRELVYDFLDRSGAVLTLPYDLTLPTA 3534
              ++  +F  HGAIE +++ L+ P     + + +       +  SG V+ LP DL    A
Sbjct: 975  KAKVVNLFRKHGAIE-VDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDLRTQFA 1033

Query: 3535 RFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAH--DAEC 3708
            R ++   + + + +  + VYR        P +    +FDI         T  +H  DAE 
Sbjct: 1034 RHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIA------PTTGSHLVDAEL 1087

Query: 3709 LKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGID 3882
            L +  EI + LP    KN  I +NH ++L A++ F   N+          +G L +  +D
Sbjct: 1088 LSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFC--NVPKAQ------YGALFEGTMD 1139

Query: 3883 KSPDEIKRY---------LREDFQVPHTVTKDLVENFNFTCEVERARQK-LQKLMVDSPP 4032
                 I R+         + +      T+   L+ NF  T          L+ LM     
Sbjct: 1140 FIESRISRFQFHSSITGIMEKSRTSAQTLMDMLLANFLLTGSRSTVDDSALKSLMRGKGE 1199

Query: 4033 LLKVER-AYTYLIEVVKILKHTNIKTSM-IFNPLSNYNSKYYIHGIMFQ--AVFKPDRSK 4200
               + R A   L  VV +     +K  + I+  L     +    GI++Q  A  KP+RS 
Sbjct: 1200 AASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSG 1259

Query: 4201 RYTRVVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLLFILMKTLISRGKSKLDLV 4380
              + +  G RYDS++  F           P   G      L F L K + + G   ++  
Sbjct: 1260 HPSVLAIGERYDSMLHEFQKQAQKFNPAMP-ARGVLSGAGLTFSLDKLVAAVG---VEYA 1315

Query: 4381 NKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGA 4560
               +     + +  T+   L  V Y ++   W+  I   I   A++  DE  Q+    GA
Sbjct: 1316 KDCRAIDVGICVCGTRPP-LKDVTY-IMRLLWSVGIRCGIVEAASELGDEA-QDLARLGA 1372

Query: 4561 IWIVII 4578
            + ++++
Sbjct: 1373 LHVILV 1378



 Score = 63.9 bits (154), Expect = 2e-08
 Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
 Frame = +1

Query: 1831 LNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQR---NMGRYARDFEEIGKLGRGGF 2001
            L  Y  N  ++ +     QHP   + +   MP        +  R   +FE +  LG+G F
Sbjct: 475  LRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAF 534

Query: 2002 GEVVKARSRMEGIFYAVKKIKHRADKLD---SLLSEVLSLARLNHQYIVRYYGTWVEELE 2172
            G+V+K R+ ++   YA+K+I   A        +  EV  L+RLNH+ +VRY+ +W+E ++
Sbjct: 535  GDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVD 594

Query: 2173 DTSA 2184
            D  A
Sbjct: 595  DADA 598



 Score = 38.9 bits (89), Expect = 0.69
 Identities = 15/43 (34%), Positives = 26/43 (60%)
 Frame = +1

Query: 2671 RQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKN 2799
            R +L+A+ ++H +G  H  L    +F+D + N++V DF L  N
Sbjct: 374  RGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPN 416


>O01712|GCN2|O01712 (TrEMBL: Drosophila melanogaster (Fruit fly))
            Eukaryotic initiation factor EIF-2 alpha kinase.
          Length = 1589

 Score =  204 bits (519), Expect = 9e-51
 Identities = 207/726 (28%), Positives = 330/726 (45%), Gaps = 50/726 (6%)
 Frame = +1

Query: 2551 KNASPK---SILYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIH 2721
            K  SP+    ++YIQMEFCE  TL   I+  L N+ D  WRLFR++ E +++IH++G IH
Sbjct: 683  KTNSPRPLMQVMYIQMEFCEKCTLRTAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIH 742

Query: 2722 RDLKPMNIFIDRSNNIKVGDFGLAKNS------QFSSVVLTNNQVEAKDNELSTVVGTLF 2883
            RDLKP+NIF+D  + IK+GDFGLA  S        ++    N    A+D   +  VGT  
Sbjct: 743  RDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTL 802

Query: 2884 YTANEV----ATGQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLRLKSVEFPTNF 3048
            Y A E+    +   Y++KVDMY+LGII FEMC  P  T M+RA+T+  LR  S+  P   
Sbjct: 803  YVAPELTGNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAM 862

Query: 3049 IAS-KYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWL-PVEHQDQVIQEALK-SLADPASP 3219
            +   KY+   K+++ LL+HDP  RP+A +LL S  + P + +   +QE L+ +LA+P S 
Sbjct: 863  LKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLVPPAQLEANELQEMLRHALANPQSK 922

Query: 3220 WQQQVREALFNQPYLLAKDLMFDKQNEHNSH-NKHVELDTSNDYLLFDKIMK-------- 3372
              + +      Q          D+  EH  H      + + N  ++ D I+         
Sbjct: 923  AYKNLVARCLQQE--------SDEVLEHTYHLGSSRAMKSWNSAIIIDDIVSLNPVIEFV 974

Query: 3373 --ELTKIFTNHGAIENLNTNLVLP----KAPSQSRELVYDFLDRSGAVLTLPYDLTLPTA 3534
              ++  +F  HGAIE +++ L+ P     + + +       +  SG V+ LP DL    A
Sbjct: 975  KAKVVNLFRKHGAIE-VDSPLLSPLSARNSTANANANAVHLMTHSGCVVVLPCDLRTQFA 1033

Query: 3535 RFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAH--DAEC 3708
            R ++   + + + +  + VYR        P +    +FDI         T  +H  DAE 
Sbjct: 1034 RHVTMNSVNLIRRYCVDRVYREERVFNFHPKQSYDCSFDIIA------PTTGSHLVDAEL 1087

Query: 3709 LKVIDEIVNTLPCF--KNTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGID 3882
            L +  EI + LP    KN  I +NH ++L A++ F   N+          +G L +  +D
Sbjct: 1088 LSLAFEITSELPRLREKNLAIRMNHTNLLRAILIFC--NVPKAQ------YGALFEGTMD 1139

Query: 3883 KSPDEIKRY---------LREDFQVPHTVTKDLVENFNFTCEVERARQK-LQKLMVDSPP 4032
                 I R+         + +      T+   L+ NF  T          L+ LM     
Sbjct: 1140 FIESRISRFQFHSSITGIMEKSRTSAQTLMDMLLANFLLTGSRSTVDDSALKSLMRGKGE 1199

Query: 4033 LLKVER-AYTYLIEVVKILKHTNIKTSM-IFNPLSNYNSKYYIHGIMFQ--AVFKPDRSK 4200
               + R A   L  VV +     +K  + I+  L     +    GI++Q  A  KP+RS 
Sbjct: 1200 AASLARGALRELETVVGLAYSLGVKCPIHIWAGLPISFDRASNGGIVWQMTADLKPNRSG 1259

Query: 4201 RYTRVVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLLFILMKTLISRGKSKLDLV 4380
              + +  G RYDS++  F           P   G      L F L K + + G   ++  
Sbjct: 1260 HPSVLAIGERYDSMLHEFQKQAQKFNPAMP-ARGVLSGAGLTFSLDKLVAAVG---VEYA 1315

Query: 4381 NKWKGNRCKVLISSTQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGA 4560
               +     + +  T+   L  V Y ++   W+  I   I   A++  DE  Q+    GA
Sbjct: 1316 KDCRAIDVGICVCGTRPP-LKDVTY-IMRLLWSVGIRCGIVEAASELGDEA-QDLARLGA 1372

Query: 4561 IWIVII 4578
            + ++++
Sbjct: 1373 LHVILV 1378



 Score = 63.9 bits (154), Expect = 2e-08
 Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 6/124 (4%)
 Frame = +1

Query: 1831 LNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQR---NMGRYARDFEEIGKLGRGGF 2001
            L  Y  N  ++ +     QHP   + +   MP        +  R   +FE +  LG+G F
Sbjct: 475  LRFYVDNGQQQVMPLPQQQHPNTVQRTGSAMPYQIPTLALSQSRLRTEFEVLMYLGKGAF 534

Query: 2002 GEVVKARSRMEGIFYAVKKIKHRADKLD---SLLSEVLSLARLNHQYIVRYYGTWVEELE 2172
            G+V+K R+ ++   YA+K+I   A        +  EV  L+RLNH+ +VRY+ +W+E ++
Sbjct: 535  GDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVD 594

Query: 2173 DTSA 2184
            D  A
Sbjct: 595  DADA 598



 Score = 38.9 bits (89), Expect = 0.69
 Identities = 15/43 (34%), Positives = 26/43 (60%)
 Frame = +1

Query: 2671 RQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKN 2799
            R +L+A+ ++H +G  H  L    +F+D + N++V DF L  N
Sbjct: 374  RGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLVPN 416


>Q9LX30|F25L23_270|Q9LX30 (TrEMBL: Arabidopsis thaliana (Mouse-ear
            cress)) Protein kinase like.
          Length = 1271

 Score =  200 bits (508), Expect = 2e-49
 Identities = 193/702 (27%), Positives = 323/702 (46%), Gaps = 27/702 (3%)
 Frame = +1

Query: 2554 NASPKSILYIQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLK 2733
            N    + LYIQME+C   TL  + E     + D  W L RQ++E +++IH +G IHRD  
Sbjct: 559  NNLESTYLYIQMEYCPR-TLRQVFESYNHFDKDFAWHLIRQIVEGLAHIHGQGIIHRDFT 617

Query: 2734 PMNIFIDRSNNIKVGDFGLAKNSQFSSVVLT---NNQVEAKDNELSTVVGTLFYTANEVA 2904
            P NIF D  N+IK+GDFGLAK  +   +      +  V     + +   GT FYTA E+ 
Sbjct: 618  PNNIFFDARNDIKIGDFGLAKFLKLEQLDQDGGFSTDVAGSGVDSTGQAGTYFYTAPEIE 677

Query: 2905 TG--QYDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEKK 3078
                + DEK DMYSLG++FFE+ +P  T M+R   L +L+LK  E P  ++ +++  +  
Sbjct: 678  QDWPKIDEKADMYSLGVVFFELWHPFGTAMERHVILTNLKLKG-ELPLKWV-NEFPEQAS 735

Query: 3079 IIRLLLDHDPKIRPSAAQLLQSGWLPVEHQDQVIQEALKSLADPASPWQQQVREALFNQP 3258
            ++R L+   P  RPSA +LL+  + P    + +  E    L      +  Q+   +  + 
Sbjct: 736  LLRRLMSPSPSDRPSATELLKHAFPPRMESELLDSEFFAVL------YLCQLHMNVLGRL 789

Query: 3259 YLLAKDLMFDKQNEHNSHNKHVELDTSNDYL-----LFDKIMKELTKIFTNHGA--IENL 3417
             ++  + + + ++  +S ++    D+   Y      L D +++   ++F  H A  +E +
Sbjct: 790  SVIFDEEVLEMKSHQSSRSRLCADDSYIQYTEINTELRDYVVEITKEVFRQHCAKHLEVI 849

Query: 3418 NTNLVLPKAPSQSRELVYDFLDRSGAVLTLPYDLTLPTARFLSKTDMTIPKTFRHEFVYR 3597
               L L   P  SR+ V   L   G +L L Y+L LP   ++S    +  K +    VYR
Sbjct: 850  PMRL-LSDCPQFSRKTV-KLLTNGGDMLELCYELRLPFVHWISVNQKSSFKRYEISHVYR 907

Query: 3598 PNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNTLPCFKNTIIVINH 3777
              + G   P+     +FDI GG      TL   +AE LKVI +I   +    +  I +NH
Sbjct: 908  RAI-GHSPPNPCLQADFDIVGG------TLSLTEAEVLKVIVDITTHIFHRGSCDIHLNH 960

Query: 3778 YDILDAVVSFSFGNIGIDDKKKL-DIFGVLSQLGIDKSPDEIK-----RYLREDFQVPHT 3939
             D+LDA+  +S+  I  + ++K+ ++  ++  L    S  ++K     R L ++ ++P  
Sbjct: 961  GDLLDAI--WSWAGIKAEHRRKVAELLSMMGSLRPQSSERKLKWVFIRRQLLQELKLPEA 1018

Query: 3940 VTKDLVENFNFTC-EVERARQKLQ-KLMVDSP---PLLKVERAYTYLIEVVKILKHTNIK 4104
            V   L    +  C + ++A  +L+  L  D P    L ++    TYL  V +I +H +I 
Sbjct: 1019 VVNRLQTVASRFCGDADQALPRLRGALRADRPTRKALDELSNLLTYL-RVWRIEEHVHI- 1076

Query: 4105 TSMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTR----VVTGGRYDSLIESFSNVTTT 4272
              ++  P  +Y+       + FQ     + S   +     +  GGRYD L++   +    
Sbjct: 1077 -DVLMPPTESYH-----RNLFFQVFLTKENSSGTSNDGVLLAVGGRYDWLVQEVCD--RE 1128

Query: 4273 TKQITPHGVGFSLTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISSTQQQFLSQVG 4452
             K   P  VG SL    +F  +          +DL          VL+ S     L    
Sbjct: 1129 HKMNLPGAVGVSLALETIFQHL---------PMDLRPIRNEVSTSVLVCSRGGGGLLVQR 1179

Query: 4453 YQLVSKFWNKNISADITSVAAKTQDEIFQNGNSEGAIWIVII 4578
             +LV++ W K+I A+       +  E ++  N      +VII
Sbjct: 1180 MELVAELWEKSIKAEFVPTPDPSLTEQYEYANEHEIKCLVII 1221



 Score = 69.3 bits (168), Expect = 5e-10
 Identities = 43/121 (35%), Positives = 60/121 (49%), Gaps = 24/121 (19%)
 Frame = +1

Query: 1873 NQN---TQHPYFGENSSLIMPSGSQRNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIF 2043
            NQN   T  P F E  S      +     RY  DFEE+  LG+GGFG VV  +++++G  
Sbjct: 402  NQNMASTSVPQFWEPPSDSCEPNASLPSSRYLNDFEELKPLGQGGFGHVVLCKNKLDGRQ 461

Query: 2044 YAVKKIKHRADKLD---------------------SLLSEVLSLARLNHQYIVRYYGTWV 2160
            YAVKKI+ +  ++                       +L EV +L+RL HQ++VRYY  W 
Sbjct: 462  YAVKKIRLKDKEIPVNSRIIGLEYNAKSVFTCARYEVLREVATLSRLQHQHVVRYYQAWF 521

Query: 2161 E 2163
            E
Sbjct: 522  E 522


>Q9H5K1||Q9H5K1 (TrEMBL: Homo sapiens (Human)) Hypothetical protein
            FLJ23358.
          Length = 806

 Score =  185 bits (469), Expect = 6e-45
 Identities = 178/637 (27%), Positives = 295/637 (46%), Gaps = 31/637 (4%)
 Frame = +1

Query: 2716 IHRDLKPMNIFIDRSNNIKVGDFGLAKNS-QFSSVVLTNNQV-----EAKDNELSTVVGT 2877
            IHRDLKP+NIF+D  +++K+GDFGLA +   FS+    ++Q            L+ +VGT
Sbjct: 2    IHRDLKPVNIFLDFDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGT 61

Query: 2878 LFYTANEV---ATGQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLR-LKSVEFPT 3042
              Y + EV       Y++KVD++SLGIIFFEM Y P+ T  +R   LN LR   S +FP 
Sbjct: 62   ALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPE 121

Query: 3043 NFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWL-PVEHQDQVIQEAL-KSLADPAS 3216
            +F   ++  +K +I  LL+HDP  RP+A +LL+S  L P + ++  + E L  +L +   
Sbjct: 122  DFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDG 181

Query: 3217 PWQQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLLFDKIMKELTKIFTN 3396
               + +   +F+Q    A D  +D     +    +  + T+    +   + + + +IF  
Sbjct: 182  KAYRTMMAQIFSQRISPAIDYTYDS----DILKGNFSIRTAK---MQQHVCETIIRIFKR 234

Query: 3397 HGAIENLNTNLVLPKAPSQSRELVYD------FLDRSGAVLTLPYDLTLPTARFLSKTDM 3558
            HGA++ L T L+LP+        +Y+      F+D SG ++ LP+DL +P AR++++ ++
Sbjct: 235  HGAVQ-LCTPLLLPR-----NRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNI 288

Query: 3559 TIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNT 3738
               K +  E V+RP       P       FDI      +    F   AE +  I EI+  
Sbjct: 289  LNLKRYCIERVFRPRKLDRFHPKELLECAFDIV----TSTTNSFLPTAEIIYTIYEIIQE 344

Query: 3739 LPCF--KNTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYL 3912
             P    +N  I +NH  +L A++     + GI + K   ++ +L     +K     +R +
Sbjct: 345  FPALQERNYSIYLNHTMLLKAILL----HCGIPEDKLSQVYIILYDAVTEKL---TRREV 397

Query: 3913 REDFQVPHTVTKDLVENFNFTCEVERARQKLQKLMVDSPPLLKVERAYTYLI-------- 4068
               F      +  L   + F       +  LQ LM     L+K +     L+        
Sbjct: 398  EAKFCNLSLSSNSLCRLYKFI----EQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLE 453

Query: 4069 EVVKILKHTNIKTSMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTR--VVTGGRYDSL 4242
            EVV +LK   IK  ++ N    Y  + + +GI+FQ V    R +R     +  GGRYD L
Sbjct: 454  EVVGLLKKLGIKLQVLINLGLVYKVQQH-NGIIFQFVAFIKRRQRAVPEILAAGGRYDLL 512

Query: 4243 IESFSNVTTTTKQITPHGVGFSLTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISS 4422
            I  F           P  +G S+    +            + L++      + C +L+ S
Sbjct: 513  IPQFRGPQALGP--VPTAIGVSIAIDKI----------SAAVLNMEESVTISSCDLLVVS 560

Query: 4423 TQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEI 4533
              Q  +S+    L  K W   I+A+I    +++Q+E+
Sbjct: 561  VGQMSMSR-AINLTQKLWTAGITAEIMYDWSQSQEEL 596


>Q96GN6||Q96GN6 (TrEMBL: Homo sapiens (Human)) Hypothetical protein.
          Length = 806

 Score =  184 bits (468), Expect = 8e-45
 Identities = 178/637 (27%), Positives = 295/637 (46%), Gaps = 31/637 (4%)
 Frame = +1

Query: 2716 IHRDLKPMNIFIDRSNNIKVGDFGLAKNS-QFSSVVLTNNQV-----EAKDNELSTVVGT 2877
            IHRDLKP+NIF+D  +++K+GDFGLA +   FS+    ++Q            L+ +VGT
Sbjct: 2    IHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFSADSKQDDQTGDLIKSDPSGHLTGMVGT 61

Query: 2878 LFYTANEV---ATGQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLR-LKSVEFPT 3042
              Y + EV       Y++KVD++SLGIIFFEM Y P+ T  +R   LN LR   S +FP 
Sbjct: 62   ALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASERIFVLNQLRDPTSPKFPE 121

Query: 3043 NFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWL-PVEHQDQVIQEAL-KSLADPAS 3216
            +F   ++  +K +I  LL+HDP  RP+A +LL+S  L P + ++  + E L  +L +   
Sbjct: 122  DFDDGEHAKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEESELHEVLHHTLTNVDG 181

Query: 3217 PWQQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLLFDKIMKELTKIFTN 3396
               + +   +F+Q    A D  +D     +    +  + T+    +   + + + +IF  
Sbjct: 182  KAYRTMMAQIFSQRISPAIDYTYDS----DILKGNFSIRTAK---MQQHVCETIIRIFKR 234

Query: 3397 HGAIENLNTNLVLPKAPSQSRELVYD------FLDRSGAVLTLPYDLTLPTARFLSKTDM 3558
            HGA++ L T L+LP+        +Y+      F+D SG ++ LP+DL +P AR++++ ++
Sbjct: 235  HGAVQ-LCTPLLLPR-----NRQIYEHNEAALFMDHSGMLVMLPFDLRIPFARYVARNNI 288

Query: 3559 TIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAECLKVIDEIVNT 3738
               K +  E V+RP       P       FDI      +    F   AE +  I EI+  
Sbjct: 289  LNLKRYCIERVFRPRKLDRFHPKELLECAFDIV----TSTTNSFLPTAEIIYTIYEIIQE 344

Query: 3739 LPCF--KNTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGIDKSPDEIKRYL 3912
             P    +N  I +NH  +L A++     + GI + K   ++ +L     +K     +R +
Sbjct: 345  FPALQERNYSIYLNHTMLLKAILL----HCGIPEDKLSQVYIILYDAVTEKL---TRREV 397

Query: 3913 REDFQVPHTVTKDLVENFNFTCEVERARQKLQKLMVDSPPLLKVERAYTYLI-------- 4068
               F      +  L   + F       +  LQ LM     L+K +     L+        
Sbjct: 398  EAKFCNLSLSSNSLCRLYKFI----EQKGDLQDLMPTINSLIKQKTGIAQLVKYGLKDLE 453

Query: 4069 EVVKILKHTNIKTSMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTR--VVTGGRYDSL 4242
            EVV +LK   IK  ++ N    Y  + + +GI+FQ V    R +R     +  GGRYD L
Sbjct: 454  EVVGLLKKLCIKLQVLINLGLVYKVQQH-NGIIFQFVAFIKRRQRAVPEILAAGGRYDLL 512

Query: 4243 IESFSNVTTTTKQITPHGVGFSLTTSLLFILMKTLISRGKSKLDLVNKWKGNRCKVLISS 4422
            I  F           P  +G S+    +            + L++      + C +L+ S
Sbjct: 513  IPQFRGPQALGP--VPTAIGVSIAIDKI----------SAAVLNMEESVTISSCDLLVVS 560

Query: 4423 TQQQFLSQVGYQLVSKFWNKNISADITSVAAKTQDEI 4533
              Q  +S+    L  K W   I+A+I    +++Q+E+
Sbjct: 561  VGQMSMSR-AINLTQKLWTAGITAEIMYDWSQSQEEL 596


>Q9XVY4|Y81G3A.3|Q9XVY4 (TrEMBL: Caenorhabditis elegans) Y81G3A.3
            protein.
          Length = 1696

 Score =  182 bits (463), Expect = 3e-44
 Identities = 187/731 (25%), Positives = 322/731 (44%), Gaps = 62/731 (8%)
 Frame = +1

Query: 2572 ILYIQMEFCENNTLLNLIEQG-LPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIF 2748
            IL IQME+C+  TL   I++    N P E WR+F ++L  + Y+H    IHRD+KP+NIF
Sbjct: 777  ILCIQMEYCDRATLRQYIDENHCFNAPTEVWRIFSEVLCGLKYMHDMAMIHRDIKPLNIF 836

Query: 2749 IDRSNNIKVGDFGLAKNSQFSS----------------VVLTNNQVEAKDNELSTV--VG 2874
            +   N +K+GDFGLA     SS                 +L+ N V++K +++     +G
Sbjct: 837  LTSQNGVKIGDFGLATLEAMSSKGKIVGGAAEKSTSIEAMLSPNGVKSKGSDVHQTRDIG 896

Query: 2875 TLFYTANE------VATGQYDEKVDMYSLGIIFFEMCY-PLATGMQRAKTLNDLRLKSVE 3033
            T  Y A E      V    Y  K+D+YS G++ FEM Y PL   M R  TLN+LR   ++
Sbjct: 897  TQLYMAPELFVDELVHKAPYTSKIDIYSAGVVLFEMFYRPLPPSMDRVSTLNNLR-DDIK 955

Query: 3034 FPTNF----IASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQD-----QVIQE 3186
             P++F     A      ++ +  +L  +P  RP+A  LL    LP+  ++      + ++
Sbjct: 956  IPSDFGAGLAAPMAGLARRTVEKMLQRNPDERPTADDLLNDEDLPMHTKEDATFRNLCEK 1015

Query: 3187 ALKSLADPASPW---QQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSNDYLLF 3357
             +K      + W   +Q   E   +  Y    D+  ++   +N              +L 
Sbjct: 1016 VIKKRDGRMNAWLLDKQFKEEVPTSLNYCYDVDICLERAKYNNRE------------VLV 1063

Query: 3358 DKIMKELTKIFTNHGAIENLNTNLVLP----KAPSQSRELVYDFLDRSGAVLTLPYDLTL 3525
            + +  E  KI   H + E L+T+ ++P     A +  R    + LDRSG  + LP DL  
Sbjct: 1064 ETLRAEFCKILKIH-SFEKLHTHTLMPVSTALAAASVRTKPVEVLDRSGVPVALPMDLRQ 1122

Query: 3526 PTARFLSKTDMTIPKTFRHEFVYRPNVRGIGIPDRYSAVNFDIAGGLEVNKATLFAHDAE 3705
               RF  +  +   K F    VY          +R+      I  G + +  +L   +AE
Sbjct: 1123 NFVRFCVRNSVQRMKRFNFGRVYSQTSANGHPHERWECCVDCI--GPQCSSPSL---EAE 1177

Query: 3706 CLKVIDE-IVNTLPCFKNTIIVINHYDILDAVVSFSFGNIGIDDKKKLDIFGVLSQLGID 3882
             L V  E ++ +LP  K T + I H  +++A +     ++ + D  + ++   L  + + 
Sbjct: 1178 LLLVACEMMIGSLPGMKFT-LKIGHAQLIEAQIR----HLKLSDDVRAELLDALHLISVS 1232

Query: 3883 KSPDEIKRYL-----REDFQVPHTVTKDLVE-NFNFTCEVERARQKLQKLMVDSPPLLKV 4044
              P   K  +     +   +  + +TK L+    NF    E+     +KL VD+  +L V
Sbjct: 1233 DRPHSHKEKMDMLTPKIGAKAANIITKLLIPVEDNFGAFKEKVACFRKKLKVDAARVL-V 1291

Query: 4045 ERAYTYLIEVVKILKHTNIKT----SMIFNPLSNYNSKYYIHGIMFQ-AVFKP-----DR 4194
            ++A   L E+V   K    +     S++++  + Y  + +  G++FQ  V KP     ++
Sbjct: 1292 DKAIRDLEEIVGTFKFCRTEAIEQISIVYDSQTCYRPRTFGDGLLFQIQVEKPSTIANNK 1351

Query: 4195 SKRYTRVVTGGRYDSLIESFSNVTTTTKQITPHGVGFSLTTSLLFILMKTLISRGKSKLD 4374
              R   V+ GGRYDS +    +      +I     GF +   ++  +  ++     +K  
Sbjct: 1352 RGRRQNVLAGGRYDSALLRERHPRDFVYEIPLCISGFGVAMDVVSQIRDSI-----NKSA 1406

Query: 4375 LVNKWKGNRCKVLISSTQQQFLSQV---GYQLVSKFWNKNISADITSVAAKTQDEIFQNG 4545
             + K   N CKVLI S  Q   S +    ++L  K W+  I AD+  +     + + ++ 
Sbjct: 1407 NIPKTPQNHCKVLICSMVQPDGSNLITQKFELAKKLWSMGIEADVFHIPVDDLESLTEHR 1466

Query: 4546 NSEGAIWIVII 4578
            N      I+ +
Sbjct: 1467 NRASITHILAV 1477



 Score = 63.2 bits (152), Expect = 3e-08
 Identities = 40/101 (39%), Positives = 58/101 (57%), Gaps = 8/101 (7%)
 Frame = +1

Query: 1903 ENSSLIMPSGSQRNM-GRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKI--KHRA 2073
            E+ ++  P G   +  GR   D   I  LGRGGFG+VV  R++M+   YA+K+I    ++
Sbjct: 469  ESENIFTPFGGAMSPDGRMLADNVIIRVLGRGGFGDVVLVRNKMDSTDYAIKRIPLNAKS 528

Query: 2074 DKLD-SLLSEVLSLARLNHQYIVRYYGTWVEEL----EDTS 2181
            DKL+  +  E    A+LNH  +VRYY  W E+L    E+TS
Sbjct: 529  DKLNRKIAKEAKFFAKLNHPNMVRYYYAWAEDLIPIVEETS 569


>Q86A61||Q86A61 (TrEMBL: Dictyostelium discoideum (Slime mold))
            Similar to derepression of GCN4 expression; Gcn2p.
          Length = 1700

 Score =  176 bits (445), Expect = 4e-42
 Identities = 197/780 (25%), Positives = 322/780 (41%), Gaps = 189/780 (24%)
 Frame = +1

Query: 2467 SNNETEDRXXXXXXXXXXXXXXXXXNSSKNASPKS-----ILYIQMEFCENNTLLNLIEQ 2631
            SN++++ +                 +SSK  + K       LYIQME+C+   L NL E 
Sbjct: 732  SNSKSKSKSKSKSKSKSKSNSKKSISSSKLKNIKKSTSIPYLYIQMEYCQK-ILRNLTET 790

Query: 2632 GLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGL------- 2790
            G+    D+ W+LFRQ++E ++Y+H +G IHRDLKP NIF D   +IK+GDFGL       
Sbjct: 791  GMNLEDDDIWKLFRQIVEGMAYVHGQGIIHRDLKPSNIFFDSCGDIKIGDFGLAINNKTT 850

Query: 2791 ----------AKNSQFSSVVLTNNQVEAKDN----------------------------- 2853
                      +  S   S+  ++N V++  N                             
Sbjct: 851  STLSPTTNINSSTSSAGSLTTSSNSVQSVINTKQQQQQQQPQNYWEDEVEGQQQQQQQQQ 910

Query: 2854 --------------ELSTVVGTLFYTANEVATGQ-----YDEKVDMYSLGIIFFEMCYPL 2976
                          + +  VGTLFYT+ E   G      YD+KVDMYSLGI+FFEM Y  
Sbjct: 911  QQQQQQQQQQQQQQQHTARVGTLFYTSPEQEAGTNGDSAYDDKVDMYSLGIVFFEMWYVF 970

Query: 2977 ATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLP 3156
            +TG +R   L +LR K  EFP++F    +  +  +IR+L+D DP  RPSA QLLQS  +P
Sbjct: 971  STGHERVIVLRNLREK-FEFPSDF-ERNHSRQATLIRMLIDKDPAKRPSAQQLLQSELMP 1028

Query: 3157 VEHQDQVIQEALKSLADPASPWQQQVREALFNQPYL-LAKDLMFDKQNEHNSHNKHVELD 3333
             + +D+ I+ +++ + +P + + Q +  +LF+Q +  L   +   +Q+   S +    L 
Sbjct: 1029 PKMEDEYIKNSIRVITNPTNQFYQTMLNSLFSQNHQHLHSHIYHHQQSSVTSSSYSKSLF 1088

Query: 3334 TSNDYLLFDKIMKE-LTKIFTNHGAIENL------------------------------- 3417
             S D L   +++ + +  I   H A E L                               
Sbjct: 1089 CSLDLLQVKQLVDDVIITILKKHNANEMLTPQMSIIKEWNEQPNLFNNSSSSSSTTTTTS 1148

Query: 3418 ------NTN-LVLPKAPSQSRELVYD-------FLDRSGAVLTLPYDLTLPTARFLSKTD 3555
                  NTN +V+ K+ S S              +D SG +L L +DL +    F+    
Sbjct: 1149 TTNTANNTNSVVINKSTSTSNINKVSNKTGKSILMDDSGQLLELRHDLRVSFKSFIETEF 1208

Query: 3556 MTIPKTFRHEFVYRPNVRGIGI----------------PDRYSAVNFDIAGGLE-VNKAT 3684
            + +   ++H    + +VR                     D+ +     +   LE ++KA 
Sbjct: 1209 LNLGDHYKHHHQQQNDVRHDNSSNGNSNNNNSNDRHHDQDKSNTTTRSVDEILELLSKAP 1268

Query: 3685 LFAHDAECLKVIDEIVNTLP------CF-----------KNTIIVINH-YDILDAVVSFS 3810
            +  ++   +     +V  LP      CF             TI V    +D L +  +F 
Sbjct: 1269 IKRYEFGHVFRKPHLVGKLPKELSQFCFDVFGSSSLYSDAETIKVTTEIFDSLPSTQNFY 1328

Query: 3811 FGN-------------IGIDD-KKKLDIFGVLSQLGIDKSPDEIKRYLREDFQVPHTVTK 3948
            F               IGI D   K +I  V+SQL I +    +K+ L E F++P    +
Sbjct: 1329 FVRLNHFGIVEYMWKFIGITDLTLKNEISQVVSQL-IRQPWFTVKKVLLEKFKLPLKQVE 1387

Query: 3949 DLVENFNFTCEVERARQKLQKLMVDSPPL------------------LKVERAYTYLIEV 4074
             +         +    +KL     ++P L                  +++  ++T L+E 
Sbjct: 1388 RIANWVLVKGTIPDVLKKLDASQNNNPLLSGNGSLGNNNNNNNNNNNVRISSSFTDLLED 1447

Query: 4075 VKIL-----KHTNIKTSMIFNPLSNYNSKYYIHGIMFQAVFKPDRSKRYTRVVTGGRYDS 4239
            ++ L     K +     +IF+    ++  +Y  GIMFQ + K    +++  +  GGRYDS
Sbjct: 1448 IRQLAVYFEKMSISPHKVIFDLSYCFSENFYSTGIMFQVILK---EEKHECLAVGGRYDS 1504



 Score = 90.5 bits (223), Expect = 2e-16
 Identities = 57/171 (33%), Positives = 90/171 (52%), Gaps = 8/171 (4%)
 Frame = +1

Query: 1711 SETNLSRMKKNVETDLVSSTNTRHVQIQGHEQDSTATTKHLNIYHQNISRRRLSNQNTQH 1890
            ++ +LS +K NV++   ++ N+ H              K  +  ++      L    +  
Sbjct: 417  NDISLSDLKNNVDS---AANNSGHF-----------LNKFWDTLNKTNENSGLKKSPSTF 462

Query: 1891 PYFGENSSLIMPSGSQRN------MGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAV 2052
             Y GE     +  GS +         RY  DFEEI  LGRGGFG+VVK R++++G +YA+
Sbjct: 463  EYSGEGGGGGVGGGSSQKTINPHQQSRYHSDFEEIQLLGRGGFGQVVKVRNKLDGRYYAI 522

Query: 2053 KKIKHRADKL--DSLLSEVLSLARLNHQYIVRYYGTWVEELEDTSAIPSNS 2199
            KKIK  +++     +L EV++L+RL+HQ++VRYY  W+E  E  S    NS
Sbjct: 523  KKIKLDSNQSLNRRILREVITLSRLHHQHVVRYYQAWIESAESLSLTNDNS 573


>Q8I739||Q8I739 (TrEMBL: Bombyx mori (Silk moth)) EIF 2a kinase.
          Length = 579

 Score =  144 bits (364), Expect = 9e-33
 Identities = 130/469 (27%), Positives = 193/469 (41%), Gaps = 39/469 (8%)
 Frame = +1

Query: 1915 LIMPSGSQRNMGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKIKHRADKLDSL- 2091
            ++ PSG +    RY R+FEE+  +  GGFG V KAR R++G+ YAVKK+  ++  +DS+ 
Sbjct: 130  IVQPSGLE--WSRYHREFEELYFIAGGGFGSVFKARHRLDGVEYAVKKVYIKSSDVDSIM 187

Query: 2092 --LSEVLSLARLNHQYIVRYYGTWVEELEDTSAIPSNSTSAIASXXXXXXXXXXXXXXXX 2265
              LSEV ++A LNH  IV Y   W+E + +++                            
Sbjct: 188  SHLSEVKTIASLNHPNIVNYKAAWLEPMIESTVKKKGKYQMDTDSDEFSLSSDLISSAHP 247

Query: 2266 XXXXXXXXXSSRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVF 2445
                     +S+    +  L  +  SF+    S SF+                       
Sbjct: 248  NVINSFKTHNSKELTKNKSLSDFIISFKN---SNSFENLNS------------------- 285

Query: 2446 ANSTDDISNNETEDRXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFC--------- 2598
            +N    +S+++ E                   N S+     + L+IQM FC         
Sbjct: 286  SNEELQVSDSDDESVSQEENAVCNLFSSKEYENCSRINLKWATLFIQMTFCQQTLKQWLD 345

Query: 2599 ENNTLLNLIEQG-----LP-------------------NNPDEYWRLFRQLLEAVSYIHR 2706
            E N  +++  +G     LP                   N+ D    +F QL+  + YIH 
Sbjct: 346  ERNNHMSVSRKGSDDFTLPLHVCESPIEAKDITFPASINHIDLLIDMFTQLVRGLHYIHS 405

Query: 2707 EGFIHRDLKPMNIFIDRSNN---IKVGDFGLAKNSQFSSVVLTNNQVEAKDNELSTVVGT 2877
             G IH D+KP N+F+        +++GDFGLA   Q S   L               +GT
Sbjct: 406  RGIIHHDIKPSNVFVAPHEGGLLVQLGDFGLACPLQQSHSGLA--------------LGT 451

Query: 2878 LFYTANEVATGQYDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIAS 3057
              Y A E   GQ + K DMYSLGII  E+  P  T M+R KT+ DLR    + P +  A+
Sbjct: 452  HMYAAPEQLDGQCNPKSDMYSLGIILLELVEPFVTDMERVKTITDLR--KGQIPAHLTAN 509

Query: 3058 KYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWLPVEHQDQVIQEALKSLA 3204
             Y     II  L+   P  R   AQLL+      E++D  I+   + LA
Sbjct: 510  -YPKIAHIIGKLVQRKPSKRLDTAQLLEELKTLAENKDDTIRSLREELA 557


>Q8C5S0||Q8C5S0 (TrEMBL: Mus musculus (Mouse)) Eukaryotic translation
            initiation factor 2 alpha kinase 4.
          Length = 347

 Score =  132 bits (333), Expect = 3e-29
 Identities = 98/309 (31%), Positives = 164/309 (53%), Gaps = 24/309 (7%)
 Frame = +1

Query: 2665 LFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLAKNS-QFSSVVLTNNQV- 2838
            ++ + ++ +  + ++G IHRDLKP+NIF+D  +++K+GDFGLA +   F++    ++Q  
Sbjct: 25   VWEEAVDGLFIVFQQGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTAEGKQDDQAG 84

Query: 2839 -----EAKDNELSTVVGTLFYTANEV---ATGQYDEKVDMYSLGIIFFEMCY-PLATGMQ 2991
                       L+ +VGT  Y + EV       Y++KVD++SLGIIFFEM Y P+ T  +
Sbjct: 85   DGVIKSDPSGHLTGMVGTALYVSPEVQGSTKSAYNQKVDLFSLGIIFFEMSYHPMVTASE 144

Query: 2992 RAKTLNDLR-LKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQSGWL-PVEH 3165
            R   LN LR   S +FP +F   ++  +K +I  LL+HDP  RP+A +LL+S  L P + 
Sbjct: 145  RIFVLNQLRDPTSPKFPDDFDDGEHTKQKSVISWLLNHDPAKRPTAMELLKSELLPPPQM 204

Query: 3166 QDQVIQEAL-KSLADPASPWQQQVREALFNQPYLLAKDLMFDKQNEHNSHNKHVELDTSN 3342
            ++  + E L  +LA+      + +   +F Q    A D  +D            ++   N
Sbjct: 205  EESELHEVLHHTLANIDGKAYRTMMSQIFCQHISPAIDYTYDS-----------DILKGN 253

Query: 3343 DYLLFDKIM----KELTKIFTNHGAIENLNTNLVLPKAPSQSRELVYD------FLDRSG 3492
              +   KI     + + ++F  HGA++ L T L+LP+        +Y+      F+D SG
Sbjct: 254  FLIRTAKIQQLVCETIVRVFKRHGAVQ-LCTPLLLPR-----NRQIYEHNEAALFMDHSG 307

Query: 3493 AVLTLPYDL 3519
             ++ LP+DL
Sbjct: 308  MLVMLPFDL 316


>Q9Z1Z1|EIF2AK3|E2K3_RAT (SP: Rattus norvegicus (Rat)) Eukaryotic
            translation initiation factor 2-alpha kinase 3 precursor
            (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase)
            (Pancreatic eIF2-alpha kinase).
          Length = 1108

 Score =  121 bits (303), Expect = 1e-25
 Identities = 90/290 (31%), Positives = 138/290 (47%), Gaps = 7/290 (2%)
 Frame = +1

Query: 2296 SRVGRSSSVLPSYDNSFQVDYISTSFDPRIXXXXXXXXXXXXXXXXPFVFANSTDDISNN 2475
            SR G SSS++  +++S   D  S+  DPR+                   F +S+   S+ 
Sbjct: 790  SREGTSSSIV--FEDS-GCDNASSKEDPRMNRLHNGHHYVNKLTE----FKHSSSRSSSE 842

Query: 2476 ETEDRXXXXXXXXXXXXXXXXXNSSKNASPKSILYIQMEFCENNTLLNLIEQGLPNNPDE 2655
             T                    +  + +SPK  LYIQM+ C    L + + +       E
Sbjct: 843  ATLSTSPTRPTTLSLDFTRNTVDRLQPSSPKVYLYIQMQLCRKENLKDWMNRRCSMEDRE 902

Query: 2656 Y---WRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRSNNIKVGDFGLA---KNSQFSSV 2817
            +     +F Q+ EAV ++H +G +HRDLKP NIF    + +KVGDFGL       +    
Sbjct: 903  HRVCLHIFLQIAEAVQFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQT 962

Query: 2818 VLTNNQVEAKDNELSTVVGTLFYTANEVATG-QYDEKVDMYSLGIIFFEMCYPLATGMQR 2994
            VLT     A     +  VGT  Y + E   G  Y  KVD++SLG+I FE+ YP +T M+R
Sbjct: 963  VLTPMPAYATH---TGQVGTKLYMSPEQIHGNNYSHKVDIFSLGLILFELLYPFSTQMER 1019

Query: 2995 AKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPKIRPSAAQLLQS 3144
             +TL D+R  +++FP  F   KY  E  +++ +L   P  RP A  ++++
Sbjct: 1020 VRTLTDVR--NLKFPPLF-TQKYPQEHMMVQDMLSPSPMERPEATDIIEN 1066



 Score = 63.9 bits (154), Expect = 2e-08
 Identities = 31/75 (41%), Positives = 50/75 (66%), Gaps = 2/75 (2%)
 Frame = +1

Query: 1945 MGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKIK--HRADKLDSLLSEVLSLAR 2118
            + RY  DFE I  +GRGGFG V +A+++++   YA+K+I+  +R    + ++ EV +LA+
Sbjct: 578  VSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAK 637

Query: 2119 LNHQYIVRYYGTWVE 2163
            L H  IVRY+  W+E
Sbjct: 638  LEHPGIVRYFNAWLE 652


>Q9Z2B5|EIF2AK3|E2K3_MOUSE (SP: Mus musculus (Mouse)) Eukaryotic
            translation initiation factor 2-alpha kinase 3 precursor
            (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase)
            (Pancreatic eIF2-alpha kinase).
          Length = 1114

 Score =  117 bits (294), Expect = 1e-24
 Identities = 73/203 (35%), Positives = 109/203 (53%), Gaps = 7/203 (3%)
 Frame = +1

Query: 2557 ASPKSILYIQMEFCENNTLLNLIEQGLPNNPDEYW---RLFRQLLEAVSYIHREGFIHRD 2727
            +SPK  LYIQM+ C    L + + +       E+     +F Q+ EAV ++H +G +HRD
Sbjct: 876  SSPKVYLYIQMQLCRKENLKDWMNRRCSLEDREHGVCLHIFLQIAEAVEFLHSKGLMHRD 935

Query: 2728 LKPMNIFIDRSNNIKVGDFGLA---KNSQFSSVVLTNNQVEAKDNELSTVVGTLFYTANE 2898
            LKP NIF    + +KVGDFGL       +    VLT     A     +  VGT  Y + E
Sbjct: 936  LKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYATH---TGQVGTKLYMSPE 992

Query: 2899 VATG-QYDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEK 3075
               G  Y  KVD++SLG+I FE+ YP +T M+R + L D+R  +++FP  F   KY  E 
Sbjct: 993  QIHGNNYSHKVDIFSLGLILFELLYPFSTQMERVRILTDVR--NLKFPLLF-TQKYPQEH 1049

Query: 3076 KIIRLLLDHDPKIRPSAAQLLQS 3144
             +++ +L   P  RP A  ++++
Sbjct: 1050 MMVQDMLSPSPTERPEATDIIEN 1072



 Score = 63.9 bits (154), Expect = 2e-08
 Identities = 31/75 (41%), Positives = 50/75 (66%), Gaps = 2/75 (2%)
 Frame = +1

Query: 1945 MGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKIK--HRADKLDSLLSEVLSLAR 2118
            + RY  DFE I  +GRGGFG V +A+++++   YA+K+I+  +R    + ++ EV +LA+
Sbjct: 582  VSRYLTDFEPIQCMGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAK 641

Query: 2119 LNHQYIVRYYGTWVE 2163
            L H  IVRY+  W+E
Sbjct: 642  LEHPGIVRYFNAWLE 656


>Q9NZJ5|EIF2AK3|E2K3_HUMAN (SP: Homo sapiens (Human)) Eukaryotic
            translation initiation factor 2-alpha kinase 3 precursor
            (EC 2.7.1.-) (PRKR-like endoplasmic reticulum kinase)
            (Pancreatic eIF2-alpha kinase) (HsPEK).
          Length = 1115

 Score =  117 bits (293), Expect = 2e-24
 Identities = 74/203 (36%), Positives = 109/203 (53%), Gaps = 7/203 (3%)
 Frame = +1

Query: 2557 ASPKSILYIQMEFCENNTLLNLIEQGLPNNPDEY---WRLFRQLLEAVSYIHREGFIHRD 2727
            +SPK  LYIQM+ C    L + +         E      +F Q+ EAV ++H +G +HRD
Sbjct: 877  SSPKVYLYIQMQLCRKENLKDWMNGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRD 936

Query: 2728 LKPMNIFIDRSNNIKVGDFGLA---KNSQFSSVVLTNNQVEAKDNELSTVVGTLFYTANE 2898
            LKP NIF    + +KVGDFGL       +    VLT     A+    +  VGT  Y + E
Sbjct: 937  LKPSNIFFTMDDVVKVGDFGLVTAMDQDEEEQTVLTPMPAYARH---TGQVGTKLYMSPE 993

Query: 2899 VATG-QYDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEK 3075
               G  Y  KVD++SLG+I FE+ YP +T M+R +TL D+R  +++FP  F   KY  E 
Sbjct: 994  QIHGNSYSHKVDIFSLGLILFELLYPFSTQMERVRTLTDVR--NLKFPPLF-TQKYPCEY 1050

Query: 3076 KIIRLLLDHDPKIRPSAAQLLQS 3144
             +++ +L   P  RP A  ++++
Sbjct: 1051 VMVQDMLSPSPMERPEAINIIEN 1073



 Score = 64.7 bits (156), Expect = 1e-08
 Identities = 32/75 (42%), Positives = 50/75 (66%), Gaps = 2/75 (2%)
 Frame = +1

Query: 1945 MGRYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKIK--HRADKLDSLLSEVLSLAR 2118
            + RY  DFE I  LGRGGFG V +A+++++   YA+K+I+  +R    + ++ EV +LA+
Sbjct: 585  ISRYLTDFEPIQCLGRGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAK 644

Query: 2119 LNHQYIVRYYGTWVE 2163
            L H  IVRY+  W+E
Sbjct: 645  LEHPGIVRYFNAWLE 659


>Q9NIV1|EIF2AK3|E2K3_DROME (SP: Drosophila melanogaster (Fruit fly))
            Eukaryotic translation initiation factor 2-alpha kinase
            precursor (EC 2.7.1.-) (PRKR-like endoplasmic reticulum
            kinase) (PERK) (PEK) (DmPEK).
          Length = 1162

 Score =  112 bits (280), Expect = 5e-23
 Identities = 71/195 (36%), Positives = 105/195 (53%), Gaps = 5/195 (2%)
 Frame = +1

Query: 2566 KSILYIQMEFCENNTLLNLIEQGLPNNPDEY-WRLFRQLLEAVSYIHREGFIHRDLKPMN 2742
            K  LYIQM+ C   +L + +          +   +F Q+++AV Y+H +G IHRDLKP N
Sbjct: 926  KVYLYIQMQLCRKESLRDWLRDNRSETRAAHIGDIFHQIVDAVDYVHLKGLIHRDLKPSN 985

Query: 2743 IFIDRSNNIKVGDFGLAKN-SQFSSVVLTNNQVEAKDN--ELSTVVGTLFYTANEVATGQ 2913
            IF  +   IK+GDFGL  + +   ++V          +    +  VGT  Y + E   GQ
Sbjct: 986  IFFSQDGQIKIGDFGLVTDMADIPNLVAKCGDQSGLPSCARHTQQVGTHLYMSPEQLLGQ 1045

Query: 2914 -YDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEKKIIRL 3090
             YD KVD+YSLG+IFFE+    +T M+R KTL  LR    ++P +F A  Y  +  +++ 
Sbjct: 1046 HYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLR--DGQYPKDF-AVNYPQQYDLLQQ 1102

Query: 3091 LLDHDPKIRPSAAQL 3135
            +L   P+ RP   QL
Sbjct: 1103 MLSAQPEQRPQTKQL 1117



 Score = 54.7 bits (130), Expect = 1e-05
 Identities = 28/73 (38%), Positives = 44/73 (60%), Gaps = 2/73 (2%)
 Frame = +1

Query: 1951 RYARDFEEIGKLGRGGFGEVVKARSRMEGIFYAVKKI--KHRADKLDSLLSEVLSLARLN 2124
            R+  DFE +  LGRGGFG V +A+++++   YA+K+I   ++      +L E  +LA   
Sbjct: 637  RFQSDFELMQCLGRGGFGVVFEAKNKLDENRYAIKRITLPNKESSRQRVLREARTLASCE 696

Query: 2125 HQYIVRYYGTWVE 2163
            H  IVRY+ +W E
Sbjct: 697  HHNIVRYFHSWTE 709



 Score = 35.4 bits (80), Expect = 7.6
 Identities = 33/111 (29%), Positives = 52/111 (46%), Gaps = 3/111 (2%)
 Frame = +1

Query: 1393 QVNPPAWLAPE-LKTSGYHYKSDIWDLGVLFLRVMLGFDILNTTYHTPSDFINKFSVKDF 1569
            QV    +++PE L    Y YK DI+ LG++F  + + F        T     +    KDF
Sbjct: 1030 QVGTHLYMSPEQLLGQHYDYKVDIYSLGLIFFELHVYFSTEMERIKTLRSLRDGQYPKDF 1089

Query: 1570 VGAEEYASLVYDVLSKMLQVKLSKRPSPLELNAV--KFLRDGPIISKLQSE 1716
              A  Y    YD+L +ML  +  +RP   +L +     L+   ++S+ QSE
Sbjct: 1090 --AVNYPQ-QYDLLQQMLSAQPEQRPQTKQLKSQLRNILQLPHLLSEGQSE 1137


>Q9SDY1||Q9SDY1 (TrEMBL: Glycine max (Soybean)) Phosphoenolpyruvate
            carboxylase kinase (Fragment).
          Length = 274

 Score =  107 bits (268), Expect = 1e-21
 Identities = 66/194 (34%), Positives = 100/194 (51%), Gaps = 3/194 (1%)
 Frame = +1

Query: 2581 IQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRS 2760
            I +E C+ +TLL+ I    P        L +QLLEAV++ H +G  HRD+KP NI  D  
Sbjct: 79   IVLELCQPHTLLDRIAAQGPLTEPHAASLLKQLLEAVAHCHAQGLAHRDIKPENILFDEG 138

Query: 2761 NNIKVGDFGLAKNSQFSSVVLTNNQVEAKDNELSTVVGTLFYTANEVATG-QYDEKVDMY 2937
            N +K+ DFG A             +   + + +S VVGT +Y A EV  G +YDEKVD++
Sbjct: 139  NKLKLSDFGSA-------------EWLGEGSSMSGVVGTPYYVAPEVIMGREYDEKVDVW 185

Query: 2938 SLGIIFFEMC--YPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPK 3111
            S G+I + M   +P   G    +    +   ++ FP+   +S     K ++R ++  DP 
Sbjct: 186  SSGVILYAMLAGFPPFYGESAPEIFESVLRANLRFPSLIFSSVSAPAKDLLRKMISRDPS 245

Query: 3112 IRPSAAQLLQSGWL 3153
             R SA Q L+  W+
Sbjct: 246  NRISAHQALRHPWI 259


>Q8GRP7|PPCK1|Q8GRP7 (TrEMBL: Glycine max (Soybean))
            Phosphoenolpyruvate carboxylase kinase.
          Length = 282

 Score =  107 bits (268), Expect = 1e-21
 Identities = 66/194 (34%), Positives = 100/194 (51%), Gaps = 3/194 (1%)
 Frame = +1

Query: 2581 IQMEFCENNTLLNLIEQGLPNNPDEYWRLFRQLLEAVSYIHREGFIHRDLKPMNIFIDRS 2760
            I +E C+ +TLL+ I    P        L +QLLEAV++ H +G  HRD+KP NI  D  
Sbjct: 87   IVLELCQPHTLLDRIAAQGPLTEPHAASLLKQLLEAVAHCHAQGLAHRDIKPENILFDEG 146

Query: 2761 NNIKVGDFGLAKNSQFSSVVLTNNQVEAKDNELSTVVGTLFYTANEVATG-QYDEKVDMY 2937
            N +K+ DFG A             +   + + +S VVGT +Y A EV  G +YDEKVD++
Sbjct: 147  NKLKLSDFGSA-------------EWLGEGSSMSGVVGTPYYVAPEVIMGREYDEKVDVW 193

Query: 2938 SLGIIFFEMC--YPLATGMQRAKTLNDLRLKSVEFPTNFIASKYKTEKKIIRLLLDHDPK 3111
            S G+I + M   +P   G    +    +   ++ FP+   +S     K ++R ++  DP 
Sbjct: 194  SSGVILYAMLAGFPPFYGESAPEIFESVLRANLRFPSLIFSSVSAPAKDLLRKMISRDPS 253

Query: 3112 IRPSAAQLLQSGWL 3153
             R SA Q L+  W+
Sbjct: 254  NRISAHQALRHPWI 267


>Q98SS6||Q98SS6 (TrEMBL: Gallus gallus (Chicken)) Eukaryotic
            initiation factor 2 alpha kinase.
          Length = 635

 Score =  106 bits (264), Expect = 4e-21
 Identities = 80/240 (33%), Positives = 122/240 (50%), Gaps = 18/240 (7%)
 Frame = +1

Query: 2572 ILYIQMEFCE----------NNTLLNLIEQ--GLPNNPDEYW--RLFRQLLEAVSYIHRE 2709
            +LYIQM+ CE          N       E   GL +  D  W  ++F +LLE V YIH  
Sbjct: 383  MLYIQMQLCELSLWDWIAARNKRCNERTEDAAGLYHLVDVSWTMKIFEELLEGVCYIHSM 442

Query: 2710 GFIHRDLKPMNIFIDRSNN-IKVGDFGLA-KNSQFSSVVLTNNQVEAKDNELSTVVGTLF 2883
            G +HRD+KP NIF+  S++ +K+GDFGLA K+  +       +         ++ VGT  
Sbjct: 443  GVMHRDIKPRNIFLHGSDHQVKIGDFGLACKDLLWDDADQWFHTERINGLTHTSGVGTCL 502

Query: 2884 YTANEVATG-QYDEKVDMYSLGIIFFEMCYPLATGMQRAKTLNDLRLKSVEFPTNFIASK 3060
            Y + E   G  YD K DMYSLG+   E+  P  T M+RA+ + +LR  +   P NF   K
Sbjct: 503  YASPEQLQGSDYDFKSDMYSLGVTLLELFQPFGTEMERAEVITNLR--NGHIPHNF-CKK 559

Query: 3061 YKTEKKIIRLLLDHDPKIRPSAAQLLQSG-WLPVEHQDQVIQEALKSLADPASPWQQQVR 3237
            +  + K ++LL       RP+AAQL +S  +   EH    +Q+ ++   +     ++++R
Sbjct: 560  WPVQAKYVKLLTSQVSTERPTAAQLRESELFHTTEHVISNLQQKVREQEEEIEKLKEKLR 619



 Score = 72.0 bits (175), Expect = 7e-11
 Identities = 45/136 (33%), Positives = 76/136 (55%), Gaps = 3/136 (2%)
 Frame = +1

Query: 1804 QDSTATTKHLNIYHQNISRRRLSNQNTQHPYFGENSSLIMPSGSQRNMGRYARDFEEIGK 1983
            Q + A T+ +   ++ +    L N +++    GE   L+     +    RY  +F+EI +
Sbjct: 112  QHNRAITELMKAANRQVLNGELDNGDSRA--IGEKEVLL-----EAQTSRYLNEFDEIAR 164

Query: 1984 LGRGGFGEVVKARSRMEGIFYAVKKIK-HRADKLD--SLLSEVLSLARLNHQYIVRYYGT 2154
            LG+GG+G+V K R++++G FYA+KKI   +A + D   +L EV  LA L H  IV Y+  
Sbjct: 165  LGKGGYGQVYKVRNKLDGQFYAIKKINIKKATRRDCMKVLREVKVLAGLQHPNIVGYHTA 224

Query: 2155 WVEELEDTSAIPSNST 2202
            W+E ++  +A P + T
Sbjct: 225  WMEHVQ--TACPKDKT 238


  Database: sptrembl
    Posted date:  Oct 14, 2003  6:47 PM
  Number of letters in database: 339,323,595
  Number of sequences in database:  1,070,300
  
Lambda     K      H
   0.318    0.135    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,341,694,755
Number of Sequences: 1070300
Number of extensions: 27502449
Number of successful extensions: 113369
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 86590
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 0
Number of HSP's gapped (non-prelim): 108550
length of database: 339,323,595
effective HSP length: 136
effective length of database: 193,762,795
effective search space used: 315252067465
frameshift window, decay const: 50,  0.1
T: 12
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)